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2kai

REFINED 2.5 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY PORCINE KALLIKREIN A AND THE BOVINE PANCREATIC TRYPSIN INHIBITOR. CRYSTALLIZATION, PATTERSON SEARCH, STRUCTURE DETERMINATION, REFINEMENT, STRUCTURE AND COMPARISON WITH ITS COMPONENTS AND WITH THE BOVINE TRYPSIN-PANCREATIC TRYPSIN INHIBITOR COMPLEX

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

KALLIKREIN A

Sus scrofa

UniProt P00752

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 BOVINE PANCREATIC TRYPSIN INHIBITOR × 1 （P00974） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
2pka 2pka

2 assemblies

Homotetramer
2pka

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1hia 1hia 2kai

3 assemblies

View Construct and Data Evidence
UniProt name KLK_PIG
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–80； UniProt 8–87 Author chain B； PDBConstruct 1–152； UniProt 95–246

BOVINE PANCREATIC TRYPSIN INHIBITOR

Bos taurus

UniProt P00974

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 KALLIKREIN A × 1 （P00752） KALLIKREIN A × 1 （P00752） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aal 1aal 1bpi 1bpt 1bti 1fan 1g6x 1jv8 1jv9 1k6u 1ld5 1ld6

59 assemblies; showing the first 12

Homodimer
1g6x 1k09 2zjx 2zvx

4 assemblies

Homotetramer

None

Other homooligomers
1b0c 1bhc 1bz5 2hex 2hex 3ldi 3ldm 6f1f

8 assemblies

Heteromeric or nucleic-acid complex
1brb 1bth 1bth 1bzx 1cbw 1cbw 1cbw 1co7 1d0d 1eaw 1eaw 1ejm

195 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name BPT1_BOVIN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain I； PDBConstruct 1–58； UniProt 36–93

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2kai
Deposition date deposition_date1984-05-21
Structure title titleREFINED 2.5 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY PORCINE KALLIKREIN A AND THE BOVINE PANCREATIC TRYPSIN INHIBITOR. CRYSTALLIZATION, PATTERSON SEARCH, STRUCTURE DETERMINATION, REFINEMENT, STRUCTURE AND COMPARISON WITH ITS COMPONENTS AND WITH THE BOVINE TRYPSIN-PANCREATIC TRYPSIN INHIBITOR COMPLEX
Keywords keywordsCOMPLEX (PROTEINASE-INHIBITOR); COMPLEX (PROTEINASE-INHIBITOR)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2kai__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2kai__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2kai__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.53 Å
Rg (electron density)18.49 Å
Total Rg19.46 Å
Atom count2237
Residues289
Excluded volume39421 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2kai__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 5 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2kai.1
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd2kaii_
Class classg — Small proteins
Fold Fold foldg.8 — BPTI-like
Superfamily Superfamily superfamilyg.8.1 — BPTI-like
Family Family familyg.8.1.1 — Small Kunitz-type inhibitors & BPTI-like toxins

CATH v4.4 (3 domains)

Domain ID domain_id2kaiA00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id2kaiB00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id2kaiI00
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology410 — Factor Xa Inhibitor
Homologous superfamily homologous superfamily10 — Pancreatic trypsin inhibitor Kunitz domain
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7. Citations (2)