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1bth

STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

THROMBIN

Bos taurus

UniProt P00734

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 BOVINE PANCREATIC TRYPSIN INHIBITOR × 1 （P00974） water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 BOVINE PANCREATIC TRYPSIN INHIBITOR × 1 （P00974） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cgl 1cgl 1jwt 1mh0 1mh0 3nxp 3sqe 3sqh 4h6t 4hzh 4hzh 4nzq

19 assemblies; showing the first 12

Homodimer
1abj 1awh 1awh 1hai 1jou 1jou 1jou 1ppb 1sfq 1sfq 1sg8 1sg8

74 assemblies; showing the first 12

Homotetramer
1sg8 1tq0 2a0q 2afq 2hnt 3jz1 3r3g 6p9u 6p9u 6p9u 6p9u

11 assemblies

Other homooligomers
2hpq

1 assemblies

Heteromeric or nucleic-acid complex
1a2c 1a3b 1a3e 1a46 1a4w 1a5g 1a61 1abi 1ad8 1ae8 1afe 1aht

460 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name THRB_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain J； PDBConstruct 1–36； UniProt 328–363 Author chain L； PDBConstruct 1–36； UniProt 328–363 Author chain H； PDBConstruct 1–259； UniProt 364–622 Author chain K； PDBConstruct 1–259； UniProt 364–622

BOVINE PANCREATIC TRYPSIN INHIBITOR

OrganismNot specified

UniProt P00974

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 THROMBIN × 1 （P00734） THROMBIN × 1 （P00734） water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 THROMBIN × 1 （P00734） THROMBIN × 1 （P00734） water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aal 1aal 1bpi 1bpt 1bti 1fan 1g6x 1jv8 1jv9 1k6u 1ld5 1ld6

59 assemblies; showing the first 12

Homodimer
1g6x 1k09 2zjx 2zvx

4 assemblies

Homotetramer

None

Other homooligomers
1b0c 1bhc 1bz5 2hex 2hex 3ldi 3ldm 6f1f

8 assemblies

Heteromeric or nucleic-acid complex
1brb 1bth 1bth 1bzx 1cbw 1cbw 1cbw 1co7 1d0d 1eaw 1eaw 1ejm

195 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name BPT1_BOVIN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain P； PDBConstruct 1–58； UniProt 36–93 Author chain Q； PDBConstruct 1–58； UniProt 36–93

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1bth
Deposition date deposition_date1996-12-03
Structure title titleSTRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
Keywords keywords;THROMBIN INHIBITOR, SERINE PROTEINASE KUNITZ-LIKE INHIBITOR, (SERINE PROTEASE/INHIBITOR), COMPLEX (SERINE PROTEASE-INHIBITOR) COMPLEX ;; COMPLEX (SERINE PROTEASE/INHIBITOR)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1bth__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1bth__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1bth__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.72 Å
Rg (electron density)19.73 Å
Total Rg20.69 Å
Atom count2904
Residues343
Excluded volume48992 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1bth__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1bth__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd1bth.1
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1bth.2
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1bthp_
Class classg — Small proteins
Fold Fold foldg.8 — BPTI-like
Superfamily Superfamily superfamilyg.8.1 — BPTI-like
Family Family familyg.8.1.1 — Small Kunitz-type inhibitors & BPTI-like toxins
Domain ID domain_idd1bthq_
Class classg — Small proteins
Fold Fold foldg.8 — BPTI-like
Superfamily Superfamily superfamilyg.8.1 — BPTI-like
Family Family familyg.8.1.1 — Small Kunitz-type inhibitors & BPTI-like toxins

CATH v4.4 (6 domains)

Domain ID domain_id1bthH01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1bthH02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1bthK01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1bthK02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1bthP00
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology410 — Factor Xa Inhibitor
Homologous superfamily homologous superfamily10 — Pancreatic trypsin inhibitor Kunitz domain
Domain ID domain_id1bthQ00
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology410 — Factor Xa Inhibitor
Homologous superfamily homologous superfamily10 — Pancreatic trypsin inhibitor Kunitz domain
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7. Citations (4)