Magainin-2
OrganismNot specified
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 83–105 | Not recorded | No other associated polymer | SOLUTION NMR NMR measurement conditions：pH 7.2；298 K；Ionic strength (raw mmCIF value) 105；Pressure ambient NMR sample composition：1 mM magainin, 5 mM TRIS, 0.05 % TSP, 100 mM [U-2H] SDS, 90% H2O/10% D2O | 90% H2O/10% D2O | Resolution not provided |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 2LSA | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1D9J SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE Deposited 1999-10-28 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
129–140（12 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.06；298 K；Pressure 1
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; 90% H2O, 10% D2O
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; D2O
|
Resolution not provided |
| 1D9L SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2 HYBRID PEPTIDE ANALOGUE(P1) Deposited 1999-10-28 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
224–232（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.29；303 K；Pressure 1
NMR measurement conditions
pH 4.29；298 K；Pressure 1
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; 90% H2O, 10% D2O
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; D2O
|
Resolution not provided |
| 1D9M SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2 HYBRID PEPTIDE ANALOGUE(P2) Deposited 1999-10-28 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
223–232（10 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.78；303 K；Pressure 1
NMR measurement conditions
pH 4.78；298 K；Pressure 1
NMR measurement conditions
pH 4.78；318 K；Pressure 1
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; 90% H2O, 10% D2O
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; D2O
|
Resolution not provided |
| 1D9O SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE ANALOGUE(P3) Deposited 1999-10-29 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
129–140（12 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.05；303 K；Pressure 1
NMR measurement conditions
pH 4.05；298 K；Pressure 1
NMR measurement conditions
pH 4.05；318 K；Pressure 1
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; 90% H2O, 10% D2O
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; D2O
|
Resolution not provided |
| 1D9P SOLUTION STRUCTURE OF CECROPIN A(1-8)-MAGAININ 2(1-12) HYBRID PEPTIDE ANALOGUE(P4) Deposited 1999-10-29 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
129–140（12 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 3.64；298 K；Pressure 1
NMR measurement conditions
pH 3.64；313 K；Pressure 1
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; 90% H2O, 10% D2O
NMR sample composition
2MM PEPTIDE; 90MM DPC MICELLES; D2O
|
Resolution not provided |
| 1DUM NMR STRUCTURE OF [F5Y, F16W] MAGAININ 2 BOUND TO PHOSPHOLIPID VESICLES Deposited 2000-01-18 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
129–151（23 aa）
Chain B
129–151（23 aa）
|
Mutation：F5Y, F16W Mutation：F5Y, F16W | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5.2；318 K；Ionic strength (raw mmCIF value) 50mM；Pressure ambient
NMR sample composition
5mM [F5Y, F16W] magainin 2,
0.5mM DLPC-d64 | 90% H2O/10% D2O
|
Resolution not provided |
| 1F0D Cecropin A(1-8)-magainin 2(1-12) in dodecylphosphocholine micelles Deposited 2000-05-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
83–94（12 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.06；298 K
NMR sample composition
DODECYLPHOSPHOCHOLINE-d38 MICELLES | 90% H2O/10% D2O
|
Resolution not provided |
| 1F0E Cecropin A(1-8)-magainin 2(1-12) modified gig to P in dodecylphosphocholine micelles Deposited 2000-05-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
86–94（9 aa）
|
Mutation：GIG TO P IN MAGAININ SEGMENT Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.78；298 K
NMR sample composition
DODECYLPHOSPHOCHOLINE-d38 MICELLES | 90% H2O/10% D2O
|
Resolution not provided |
| 1F0F Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles Deposited 2000-05-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
86–94（9 aa）
|
Mutation：GIG DELETION IN MAGAININ SEGMENT Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.29；298 K
NMR sample composition
DODECYLPHOSPHOCHOLINE-d38 MICELLES | 90% H2O/10% D2O
|
Resolution not provided |
| 1F0G Cecropin A(1-8)-magainin 2(1-12) L2 in dodecylphosphocholine micelles Deposited 2000-05-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
83–94（12 aa）
|
Mutation：W28L Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 3.64；298 K
NMR sample composition
DODECYLPHOSPHOCHOLINE-d38 MICELLES | 90% H2O/10% D2O
|
Resolution not provided |
| 1F0H Cecropin A(1-8)-magainin 2(1-12) A2 in dodecylphosphocholine micelles Deposited 2000-05-16 | Different construct Different mutation/modification Different oligomeric state Different experimental conditions | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
83–94（12 aa）
|
Mutation：A28L Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.05；298 K
NMR sample composition
DODECYLPHOSPHOCHOLINE-d38 MICELLES | 90% H2O/10% D2O
|
Resolution not provided |
| 2MAG NMR STRUCTURE OF MAGAININ 2 IN DPC MICELLES, 10 STRUCTURES Deposited 1997-12-19 | Different construct Different mutation/modification Different experimental conditions | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
267–289（23 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.1；303 K
|
Resolution not provided |
| 4MGP Structure of racemic Ala-(8,13,18) Magainin 2 Deposited 2013-08-28 | Different construct Different mutation/modification Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
83–105（23 aa）
Fragment：UNP residues 83-105
|
Mutation：S8A, G13A, G18A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；298 K；Precipitant solution contained 0.1 M sodium citrate tribasic, pH 5.6, and 35% v/v tert-butanol. No additional cryoprotectant was necessary for vitrification of crystals in LN2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.75 Å R-free 0.233 |
| 9HVN Atomic resolution crystal structure of the hexameric antimicrobial peptide Magainin-2 Deposited 2024-12-31 | Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
83–105（23 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；35% MPD, 20 mM HEPES, pH 7
|
Resolution 1.05 Å R-free 0.177 |
| 9HVN Atomic resolution crystal structure of the hexameric antimicrobial peptide Magainin-2 Deposited 2024-12-31 | Different oligomeric state Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
83–105（23 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；35% MPD, 20 mM HEPES, pH 7
|
Resolution 1.05 Å R-free 0.177 |
14 other PDB entries and 15 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | MAGA_XENLA |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–23； UniProt 83–105 |
