Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein heterocomplex | Heteromer | Protein 2 | Cellular tumor antigen p53 × 1 （P04637） | Consistent with protein count |
| UniProt name | HMGB1_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–83； UniProt 2–84 |
Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein heterocomplex | Heteromer | Protein 2 | High mobility group protein B1 × 1 （P09429） | Consistent with protein count |
| UniProt name | P53_HUMAN |
| Isoform | — |
| PDB entities | 2 |
| Chains and sequence ranges | Author chain B； PDBConstruct 1–93； UniProt 1–93 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 2ly4 |
| Deposition date deposition_date | 2012-09-12 |
| Structure title title | HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail |
| Keywords keywords | HMG, p53, TAD, NUCLEAR PROTEIN-ANTITUMOUR PROTEIN complex; NUCLEAR PROTEIN/ANTITUMOUR PROTEIN |
| Experimental Method method | SOLUTION NMR |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 18.09 Å |
| Rg (electron density) | 17.61 Å |
| Total Rg | 18.49 Å |
| Atom count | 2084 |
| Residues | 130 |
| Excluded volume | 18681 ų |
| Maximum q | 0.500 Å⁻¹ |
| Assembly | Model | Structure unit | Oligomeric description | Status | CRYSOL | Actions |
|---|---|---|---|---|---|---|
| 1 | 1 | 2ly4__assembly_1__model_1 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 2 | 2ly4__assembly_1__model_2 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 3 | 2ly4__assembly_1__model_3 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 4 | 2ly4__assembly_1__model_4 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 5 | 2ly4__assembly_1__model_5 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 6 | 2ly4__assembly_1__model_6 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 7 | 2ly4__assembly_1__model_7 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 8 | 2ly4__assembly_1__model_8 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 9 | 2ly4__assembly_1__model_9 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 1 | 10 | 2ly4__assembly_1__model_10 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| Domain ID domain_id | d2ly4a_ |
| Class class | a — All alpha proteins |
| Fold Fold fold | a.21 — HMG-box |
| Superfamily Superfamily superfamily | a.21.1 — HMG-box |
| Family Family family | a.21.1.1 — HMG-box |
| Domain ID domain_id | 2ly4A00 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 30 — DNA Binding (I), subunit A |
| Homologous superfamily homologous superfamily | 10 — High mobility group box domain |