2otk

Structure of Alzheimer Ab peptide in complex with an engineered binding protein

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Amyloid beta A4 protein

OrganismNot specified

UniProt P05067

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 ZAb3 Affibody dimer × 2 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name A4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain C; PDBConstruct 1–40; UniProt 672–711

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2otk
Deposition date deposition_date2007-02-08
Structure title titleStructure of Alzheimer Ab peptide in complex with an engineered binding protein
Keywords keywordsprotein-peptide complex, beta-hairpin, intermolecular beta-sheet, DE NOVO PROTEIN, PEPTIDE BINDING PROTEIN; DE NOVO PROTEIN, PEPTIDE BINDING PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2otk__assembly_1__model_16

Assembly 1 · Model 16 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2otk__assembly_1__model_16 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2otk__assembly_1__model_16 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)14.69 Å
Rg (electron density)13.01 Å
Total Rg14.31 Å
Atom count1655
Residues111
Excluded volume14811 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2otk__assembly_1__model_1 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2otk__assembly_1__model_2 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2otk__assembly_1__model_3 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2otk__assembly_1__model_4 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2otk__assembly_1__model_5 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2otk__assembly_1__model_6 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2otk__assembly_1__model_7 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2otk__assembly_1__model_8 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2otk__assembly_1__model_9 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2otk__assembly_1__model_10 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2otk__assembly_1__model_11 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2otk__assembly_1__model_12 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2otk__assembly_1__model_13 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2otk__assembly_1__model_14 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2otk__assembly_1__model_15 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2otk__assembly_1__model_16 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2otk__assembly_1__model_17 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2otk__assembly_1__model_18 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2otk__assembly_1__model_19 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2otk__assembly_1__model_20 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 2otk__assembly_1__model_21 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 2otk__assembly_1__model_22 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 2otk__assembly_1__model_23 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 2otk__assembly_1__model_24 trimeric (3) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2otke_
Class classa — All alpha proteins
Fold Fold folda.8 — immunoglobulin/albumin-binding domain-like
Superfamily Superfamily superfamilya.8.1 — Bacterial immunoglobulin/albumin-binding domains
Family Family familya.8.1.1 — Immunoglobulin-binding protein A modules
Domain ID domain_idd2otkf_
Class classa — All alpha proteins
Fold Fold folda.8 — immunoglobulin/albumin-binding domain-like
Superfamily Superfamily superfamilya.8.1 — Bacterial immunoglobulin/albumin-binding domains
Family Family familya.8.1.1 — Immunoglobulin-binding protein A modules

CATH v4.4 (2 domains)

Domain ID domain_id2otkE00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily420 — Immunoglobulin FC, subunit C
Domain ID domain_id2otkF00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily420 — Immunoglobulin FC, subunit C
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7. Citations (2)