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2rse

NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Peptidyl-prolyl cis-trans isomerase FKBP1A

Homo sapiens

UniProt P62942

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase mTOR × 1 （P42345） TERBIUM(III) ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1f40 1fkb 1fkg 1fkh

79 assemblies; showing the first 12

Homodimer
1a7x 1bkf 1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1eym 1fkd

22 assemblies; showing the first 12

Homotetramer
1fkd 1fkj 1qpf 2fke

4 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1b6c 1b6c 1b6c 1b6c 1b6c 1bl4 1fap 1nsg 1tco 21kr 21ks 21kt

67 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FKB1A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–107； UniProt 2–108

Serine/threonine-protein kinase mTOR

Homo sapiens

UniProt P42345

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Peptidyl-prolyl cis-trans isomerase FKBP1A × 1 （P62942） TERBIUM(III) ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aue 1aue 2gaq 2npu 3jbz 5wbh 5wbh 5wbh 5wbh

9 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fap 1nsg 2fap 2rse 3fap 4drh 4drh 4dri 4drj 4fap 4jsn 4jsn

76 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MTOR_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–94； UniProt 2019–2112

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2rse
Deposition date deposition_date2012-01-25
Structure title titleNMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS
Keywords keywordsFKBP12, rapamycin, FK506, lanthanide, PCS, ISOMERASE-TRANSFERASE complex; ISOMERASE/TRANSFERASE
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2rse__assembly_1__model_20

Assembly 1 · Model 20 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2rse__assembly_1__model_20 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2rse__assembly_1__model_20 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.58 Å
Rg (electron density)19.21 Å
Total Rg20.86 Å
Atom count3196
Residues201
Excluded volume28986 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2rse__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2rse__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2rse__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2rse__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2rse__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2rse__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2rse__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2rse__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2rse__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2rse__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2rse__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2rse__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2rse__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2rse__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2rse__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2rse__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2rse__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2rse__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2rse__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2rse__assembly_1__model_20 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id2rseA00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
Domain ID domain_id2rseB00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
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7. Citations (1)