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2wrm

Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

RNA-DIRECTED RNA POLYMERASE

HEPATITIS C VIRUS

UniProt P26663

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 (3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC ACID × 6 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1a1q 1a1q 1a1q 1bt7 1nhu 1nhu 1nhv 1nhv 1os5 1quv 2awz 2awz

124 assemblies; showing the first 12

Homodimer
1c2p 1csj 1cu1 1gx5 1gx6 1ns3 1ns3 2wrm 3ciz 3mf5 3mf5 3rvb

24 assemblies; showing the first 12

Homotetramer
1jxp 1ns3

2 assemblies

Other homooligomers
1jxp 1ns3

2 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name POLG_HCVBK
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–536； UniProt 2420–2955

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2wrm
Deposition date deposition_date2009-09-01
Structure title titleIdentification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design
Keywords keywordsTRANSFERASE, NON-NUCLEOSIDE INHIBITOR, NNI, VIRAL PROTEIN; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2wrm__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2wrm__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2wrm__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.57 Å
Rg (electron density)32.77 Å
Total Rg33.29 Å
Atom count8402
Residues1062
Excluded volume149780 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2wrm__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2wrma_
Class classe — Multi-domain proteins (alpha and beta)
Fold Fold folde.8 — DNA/RNA polymerases
Superfamily Superfamily superfamilye.8.1 — DNA/RNA polymerases
Family Family familye.8.1.4 — RNA-dependent RNA-polymerase

CATH v4.4 (1 domains)

Domain ID domain_id2wrmA03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily270 — Reverse transcriptase/Diguanylate cyclase domain
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7. Citations (1)