2xay

Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli

Method: X-RAY DIFFRACTION D_max: 159.6 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA

ESCHERICHIA COLI

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 12 PDB 声明：dodecameric（12）与蛋白拷贝数一致	链 A； UniProt 1–761 链 B； UniProt 1–761	片段：RESIDUES 1-761 突变：YES 非标准单体：是（mmCIF未提供具体位点）	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA × 6 （P69924）	X-RAY DIFFRACTION X-ray结晶条件：pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.65 Å R-free 0.235
2	蛋白异源复合物异源复合物蛋白 × 12 PDB 声明：dodecameric（12）与蛋白拷贝数一致	链 C； UniProt 1–761	片段：RESIDUES 1-761 突变：YES 非标准单体：是（mmCIF未提供具体位点）	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA × 6 （P69924）	X-RAY DIFFRACTION X-ray结晶条件：pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.65 Å R-free 0.235

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 2XAY	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1QFN GLUTAREDOXIN-1-RIBONUCLEOTIDE REDUCTASE B1 MIXED DISULFIDE BOND 提交 1999-04-12	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 737–761（25 aa）片段：apha chain, B1 SUBUNIT	突变：C754S	未记录非水小分子	SOLUTION NMR NMR测量条件 pH 6.5；293 K；压力 1	分辨率未提供
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：Y730F 突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：Y730F 突变：Y730F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1RLR STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1 提交 1994-08-12	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–761（761 aa）	未记录	未记录非水小分子	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.50 Å
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2X0X Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution 提交 2009-12-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	未记录	SO4 SULFATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE APP 1.5M, SODIUM CITRATE BUFFER PH APP 6.	分辨率 2.30 Å R-free 0.224
2X0X Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution 提交 2009-12-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	SO4 SULFATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE APP 1.5M, SODIUM CITRATE BUFFER PH APP 6.	分辨率 2.30 Å R-free 0.224
2XAK Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli 提交 2010-03-31	突变/修饰不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.241
2XAK Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli 提交 2010-03-31	突变/修饰不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.241
2XAP Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution 提交 2010-03-31	突变/修饰不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.10 Å R-free 0.230
2XAP Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution 提交 2010-03-31	突变/修饰不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.10 Å R-free 0.230
2XAV Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.247
2XAV Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.247
2XAW Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 3.10 Å R-free 0.234
2XAW Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 3.10 Å R-free 0.234
2XAX Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.75 Å R-free 0.261
2XAX Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.75 Å R-free 0.261
2XAZ Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.60 Å R-free 0.246
2XAZ Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	突变：YES 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.60 Å R-free 0.246
2XO4 RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	突变/修饰不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.50 Å R-free 0.233
2XO4 RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	突变/修饰不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：RESIDUES 1-761 链 B 1–761（761 aa）片段：RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.50 Å R-free 0.233
2XO5 RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	构建体不同突变/修饰不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）片段：CATALYTIC SUBUNIT, RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.70 Å R-free 0.228
2XO5 RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	构建体不同突变/修饰不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）片段：CATALYTIC SUBUNIT, RESIDUES 1-761 链 B 1–761（761 aa）片段：CATALYTIC SUBUNIT, RESIDUES 1-761	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.70 Å R-free 0.228
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 15 PDB 声明：pentadecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 9 PDB 声明：nonameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白同源多聚体同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM AMPPNP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.287
3UUS Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex 提交 2011-11-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 8 FE FE (III) ION × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10.8% PEG 3350, 0.18M magnesium acetate, 0.09M MOPS pH 7.5, 0.01M iron (III) chloride, 4.5% glycerol , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 5.65 Å R-free 0.303
4ERM Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution 提交 2012-04-20	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 8 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant conditions: 10% PEG 3350, 0.1 M MOPS pH 7.5, 0.2 M Magnesium Acetate, 0.025 M Magnesium Chloride, 0.006 M n-Nonyl-beta-D-maltopyranoside, and 5% glycerol. Mixed 1:1 with protein., VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 3.95 Å R-free 0.284
4ERP Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex 提交 2012-04-20	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant solution: 25% PEG 3350, 0.1 M HEPES pH 7.5, 0.2 M ammonium acetate, 5% glycerol mixed 2:1 with protein and streak seeded from crystals grown under similar conditions. , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 4.45 Å R-free 0.267
4ERP Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex 提交 2012-04-20	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant solution: 25% PEG 3350, 0.1 M HEPES pH 7.5, 0.2 M ammonium acetate, 5% glycerol mixed 2:1 with protein and streak seeded from crystals grown under similar conditions. , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 4.45 Å R-free 0.267
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 10 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 15 PDB 声明：pentadecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：C292A 突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 5 PDB 声明：pentameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：C292A 突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–761（761 aa）	突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：C292A 突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：C292A 突变：C292A	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
5CNS Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	CDP CYTIDINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 8 DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；9.5% (w/v) PEG 3350, 100 mM MOPS, 250 mM Mg(CH3COO)2, 25 mM 394 MgCl2, 5% (v/v) glycerol	分辨率 2.98 Å R-free 0.214
5CNT Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	UDP URIDINE-5'-DIPHOSPHATE × 4 DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 12 MG MAGNESIUM ION × 8 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.25 Å R-free 0.221
5CNU Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 8 ADP ADENOSINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.40 Å R-free 0.221
5CNV Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–761（761 aa）链 B 1–761（761 aa）链 C 1–761（761 aa）链 D 1–761（761 aa）	未记录	GDP GUANOSINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 8 TTP THYMIDINE-5'-TRIPHOSPHATE × 8 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.20 Å R-free 0.219
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 10 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441A 突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 11 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 12 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441A 突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 C 1–761（761 aa）	突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 9 蛋白同源多聚体同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441A 突变：E441A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441D 突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441D 突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441D 突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）	突变：E441D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6W4X Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP 提交 2020-03-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 1 FEO MU-OXO-DIIRON × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.6 cryo-EM玻璃化条件冷冻剂 ETHANE；blot for 4.5 seconds before plunging	分辨率 3.60 Å
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 A 1–761（761 aa）	突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–761（761 aa）	突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 1–761（761 aa）	突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 C 1–761（761 aa）	突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441Q 突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441Q 突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–761（761 aa）	突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	突变：E441Q 突变：E441Q	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
8VHN Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to two ATP molecules 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 4 GOL GLYCEROL × 2 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293.15 K；8.0% (w/vol)PEG3350, 80 mM HEPES pH 7.3, 280 mM magnesium chloride, 4% (vol/vol) glycerol, 1.0% CYMAL-1 detergent	分辨率 2.62 Å R-free 0.209
8VHO Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to dATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277.15 K；6.8% (w/vol) PEG3350, 80mM HEPES pH7.3, 280mM MgCl2, 4% (vol/vol) glycerol, and 1.0% CYMAL-1 detergent	分辨率 2.55 Å R-free 0.205
8VHP Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–760（760 aa）链 B 1–760（760 aa）	突变：W28A 突变：W28A	SO4 SULFATE ION × 12 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 4 CDP CYTIDINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；291.15 K；1.9 M ammonium sulfate, 4% (w/vol) PEG MME 500, 0.1 M bis-Tris pH 6.5	分辨率 2.61 Å R-free 0.209
8VHP Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 1–760（760 aa）链 D 1–760（760 aa）	突变：W28A 突变：W28A	SO4 SULFATE ION × 12 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 4 CDP CYTIDINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；291.15 K；1.9 M ammonium sulfate, 4% (w/vol) PEG MME 500, 0.1 M bis-Tris pH 6.5	分辨率 2.61 Å R-free 0.209
8VHP Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 E 1–760（760 aa）链 F 1–760（760 aa）	突变：W28A 突变：W28A	SO4 SULFATE ION × 8 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 4 CDP CYTIDINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；291.15 K；1.9 M ammonium sulfate, 4% (w/vol) PEG MME 500, 0.1 M bis-Tris pH 6.5	分辨率 2.61 Å R-free 0.209
8VHP Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to CDP and two molecules of ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 1–760（760 aa）链 H 1–760（760 aa）	突变：W28A 突变：W28A	SO4 SULFATE ION × 8 ATP ADENOSINE-5'-TRIPHOSPHATE × 6 MG MAGNESIUM ION × 4 CDP CYTIDINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；291.15 K；1.9 M ammonium sulfate, 4% (w/vol) PEG MME 500, 0.1 M bis-Tris pH 6.5	分辨率 2.61 Å R-free 0.209
8VHQ Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–760（760 aa）链 B 1–760（760 aa）	突变：W28A 突变：W28A	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；6.5-7.0% (w/vol) PEG3350, 0.1M HEPES 7.0, 0.35M MgSO4, 5% (vol/vol) glycerol.	分辨率 3.40 Å R-free 0.233
8VHQ Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 1–760（760 aa）链 D 1–760（760 aa）	突变：W28A 突变：W28A	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；6.5-7.0% (w/vol) PEG3350, 0.1M HEPES 7.0, 0.35M MgSO4, 5% (vol/vol) glycerol.	分辨率 3.40 Å R-free 0.233
8VHR Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–760（760 aa）链 B 1–760（760 aa）	突变：W28A 突变：W28A	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；6.5-7.0% (w/vol) PEG3350, 0.1M HEPES 7.0, 0.35M MgSO4, 5% (vol/vol) glycerol	分辨率 3.55 Å R-free 0.243
8VHR Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 1–760（760 aa）链 D 1–760（760 aa）	突变：W28A 突变：W28A	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 4 GTP GUANOSINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；6.5-7.0% (w/vol) PEG3350, 0.1M HEPES 7.0, 0.35M MgSO4, 5% (vol/vol) glycerol	分辨率 3.55 Å R-free 0.243
8VHU Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–734（734 aa）链 B 1–734（734 aa）	突变：Truncated final 8 residues of alpha,fused C-terminal 35 residues of beta 突变：Truncated final 8 residues of alpha,fused C-terminal 35 residues of beta	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 3 MG MAGNESIUM ION × 3 NA SODIUM ION × 1 CL CHLORIDE ION × 6 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；1.4M NaCl, 8% (w/vol) PEG 6000	分辨率 2.10 Å R-free 0.192
9DB2 Class Ia ribonucleotide reductase with mechanism-based inhibitor N3CDP 提交 2024-08-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 1–761（761 aa）链 B 1–761（761 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 UNL UNKNOWN LIGAND × 1 A1A3L 4-amino-1-{(3xi)-3-C-amino-2-deoxy-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-beta-D-threo-pentofuranosyl}pyrimidin-2(1H)-one × 1 FEO MU-OXO-DIIRON × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.6 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.60 Å

共 33 个其他 PDB 条目、103 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	RIR1_ECOLI
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–761； UniProt 1–761 作者链 B； PDB构建体 1–761； UniProt 1–761 作者链 C； PDB构建体 1–761； UniProt 1–761

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA

物种未注明

UniProt P69924

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 12 PDB 声明：dodecameric（12）与蛋白拷贝数一致	链 D； UniProt 357–376 链 E； UniProt 357–376	片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA × 6 （P00452）	X-RAY DIFFRACTION X-ray结晶条件：pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.65 Å R-free 0.235
2	蛋白异源复合物异源复合物蛋白 × 12 PDB 声明：dodecameric（12）与蛋白拷贝数一致	链 F； UniProt 357–376	片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA × 6 （P00452）	X-RAY DIFFRACTION X-ray结晶条件：pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.65 Å R-free 0.235
3	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 P； UniProt 357–376	片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	无其他共同聚合物	X-RAY DIFFRACTION X-ray结晶条件：pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.65 Å R-free 0.235

数据库中的同蛋白其他状态

其他 PDB	相对当前条目 2XAY	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1AV8 RIBONUCLEOTIDE REDUCTASE R2 SUBUNIT FROM E. COLI 提交 1997-09-30	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–340（340 aa）链 B 1–340（340 aa）	未记录	FEO MU-OXO-DIIRON × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 7.6；PROTEIN WAS CRYSTALLIZED FROM 80% SATURATED NACL, NEAR PHYSIOLOGICAL PH (PH 7.6)	分辨率 2.80 Å R-free 0.192
1BIQ RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A 提交 1998-06-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）片段：BETA CHAIN 链 B 1–375（375 aa）片段：BETA CHAIN	突变：Y122F, E238A 非标准单体：是（mmCIF未提供具体位点）突变：Y122F, E238A	FE2 FE (II) ION × 3 FE FE (III) ION × 1 OH HYDROXIDE ION × 3 HG MERCURY (II) ION × 16	X-RAY DIFFRACTION X-ray结晶条件 pH 6；pH 6.0	分辨率 2.05 Å R-free 0.260
1JPR Mn substituted Ribonucleotide reductase R2 from E. coli oxidized by nitric oxide 提交 2001-08-03	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	MN MANGANESE (II) ION × 4 HG MERCURY (II) ION × 14	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG 4000, sodium chloride, EMTS, MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.88 Å R-free 0.213
1JQC Mn substituted Ribonucleotide reductase R2 from E. Coli oxidized by hydrogen peroxide and hydroxylamine 提交 2001-08-06	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	MN MANGANESE (II) ION × 4 HG MERCURY (II) ION × 13	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；peg 4000, MES, EMTS, sodium chloride, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.61 Å R-free 0.219
1MRR SUBSTITUTION OF MANGANESE FOR IRON IN RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA COLI. SPECTROSCOPIC AND CRYSTALLOGRAPHIC CHARACTERIZATION 提交 1992-07-28	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	MN MANGANESE (II) ION × 4 HG MERCURY (II) ION × 13	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.50 Å
1MXR High resolution structure of Ribonucleotide reductase R2 from E. coli in its oxidised (Met) form 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	FE FE (III) ION × 4 HG MERCURY (II) ION × 11 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG 4000, MES, NaCl, EMTS, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.42 Å R-free 0.185
1PFR RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN 提交 1996-12-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–340（340 aa）链 B 1–340（340 aa）	突变：S211A 突变：S211A	FE FE (III) ION × 4 HG MERCURY (II) ION × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；HANGING DROP VAPOR DIFFUSION. CRYSTALLISED FROM 20% PEG 4000, 0.2M NACL, 0.1M MES PH 6.0, 1MM ETHYLMERCURY SALICYLATE., vapor diffusion - hanging drop	分辨率 2.20 Å
1PIM DITHIONITE REDUCED E. COLI RIBONUCLEOTIDE REDUCTASE R2 SUBUNIT, D84E MUTANT 提交 2003-05-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：D84E 突变：D84E	FE FE (III) ION × 4 HG MERCURY (II) ION × 7	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 2.00 Å R-free 0.246
1PIU OXIDIZED RIBONUCLEOTIDE REDUCTASE R2-D84E MUTANT CONTAINING OXO-BRIDGED DIFERRIC CLUSTER 提交 2003-05-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：D84E 突变：D84E	FE FE (III) ION × 4 HG MERCURY (II) ION × 10 O OXYGEN ATOM × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 2.20 Å R-free 0.232
1PIY RIBONUCLEOTIDE REDUCTASE R2 SOAKED WITH FERROUS ION AT NEUTRAL PH 提交 2003-05-30	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	FE FE (III) ION × 4 HG MERCURY (II) ION × 14	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.68 Å R-free 0.246
1PIZ RIBONUCLEOTIDE REDUCTASE R2 D84E MUTANT SOAKED WITH FERROUS IONS AT NEUTRAL PH 提交 2003-05-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：D84E 突变：D84E	FE FE (III) ION × 4 HG MERCURY (II) ION × 11	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.90 Å R-free 0.242
1PJ0 RIBONUCLEOTIDE REDUCTASE R2-D84E/W48F MUTANT SOAKED WITH FERROUS IONS AT NEUTRAL PH 提交 2003-05-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：D84E, W48F 突变：D84E, W48F	FE FE (III) ION × 4 HG MERCURY (II) ION × 9	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.90 Å R-free 0.236
1PJ1 RIBONUCLEOTIDE REDUCTASE R2-D84E/W48F SOAKED WITH FERROUS IONS AT PH 5 提交 2003-05-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：D84E, W48F 突变：D84E, W48F	FE FE (III) ION × 4 HG MERCURY (II) ION × 15	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；20% PEG 4000, 200mM NaCl, 50mM MES, 0.3% dioxane, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.95 Å R-free 0.221
1PM2 CRYSTAL STRUCTURE OF MANGANESE SUBSTITUTED R2-D84E (D84E MUTANT OF THE R2 SUBUNIT OF E. COLI RIBONUCLEOTIDE REDUCTASE) 提交 2003-06-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–339（339 aa）链 B 1–339（339 aa）	突变：D84E 突变：D84E	MN MANGANESE (II) ION × 4 HG MERCURY (II) ION × 14	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.3；310 K；PEG 4000, MES, sodium chloride, sodium ethylmercurithiosalicylicate , pH 7.3, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.80 Å R-free 0.215
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 提交 1997-07-15	构建体不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 2.90 Å R-free 0.245
1R65 Crystal structure of ferrous soaked Ribonucleotide Reductase R2 subunit (wildtype) at pH 5 from E. coli 提交 2003-10-14	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）片段：Ribonucleotide Reductase R2 链 B 1–375（375 aa）片段：Ribonucleotide Reductase R2	未记录	FE2 FE (II) ION × 4 HG MERCURY (II) ION × 13	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；310 K；PEG4000, sodium chloride, EMTS, MES, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 310K	分辨率 1.95 Å R-free 0.236
1RIB STRUCTURE AND FUNCTION OF THE ESCHERICHIA COLI RIBONUCLEOTIDE REDUCTASE PROTEIN R2 提交 1993-01-19	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	未记录	FEO MU-OXO-DIIRON × 2	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.20 Å
1RNR AUTOCATALYTIC GENERATION OF DOPA IN THE ENGINEERED PROTEIN R2 F208Y FROM ESCHERICHIA COLI RIBONUCLEOTIDE REDUCTASE AND CRYSTAL STRUCTURE OF THE DOPA-208 PROTEIN 提交 1993-04-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	FE FE (III) ION × 4 HG MERCURY (II) ION × 14	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.50 Å
1RSR azide complex of the diferrous F208A mutant R2 subunit of ribonucleotide reductase 提交 2003-12-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：Y122F, F208A 突变：Y122F, F208A	FE2 FE (II) ION × 4 HG MERCURY (II) ION × 12 AZI AZIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；100mM MES, 200mM NaCl, 1mM EMTS (Thimerosal), 16-24% PEG 4000, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 2.00 Å R-free 0.289
1RSV azide complex of the diferrous E238A mutant R2 subunit of ribonucleotide reductase 提交 2003-12-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：Y122F, E238A 突变：Y122F, E238A	FE FE (III) ION × 4 HG MERCURY (II) ION × 12 AZI AZIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；100mM MES, 200mM NaCl, 1mM EMTS (Thimerosal), 16-24% PEG 4000, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 2.20 Å R-free 0.256
1XIK RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN 提交 1996-08-06	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）片段：BETA CHAIN 链 B 1–375（375 aa）片段：BETA CHAIN	未记录	FE2 FE (II) ION × 4 HG MERCURY (II) ION × 10	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；HANGING DROP VAPOR DIFFUSION METHOD, 20% PEG 4000, 0.2M NACL, 50MM MES BUFFER PH 6.0, 1MM ETHYLMERCURY SALICYLATE, vapor diffusion - hanging drop	分辨率 1.70 Å R-free 0.280
1YFD Crystal structure of the Y122H mutant of ribonucleotide reductase R2 protein from E. coli 提交 2004-12-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–375（375 aa）链 B 1–375（375 aa）	突变：Y122H 突变：Y122H	HG MERCURY (II) ION × 13 FEO MU-OXO-DIIRON × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；PEG 4000, 0.1M MES, 0.4M NACL, 1mM EMTS, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K	分辨率 1.90 Å R-free 0.206
2ALX Ribonucleotide Reductase R2 from Escherichia coli in space group P6(1)22 提交 2005-08-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 0–339（340 aa）片段：residues 0-339	未记录	MN MANGANESE (II) ION × 4 HG MERCURY (II) ION × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；ammonium sulfate, MES, manganese chloride, magnesium chloride, 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, ethylmercurithiosalicylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 2.60 Å R-free 0.276
2AV8 Y122F MUTANT OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA COLI 提交 1997-09-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–340（340 aa）链 B 1–340（340 aa）	突变：Y122F 突变：Y122F	FE2 FE (II) ION × 1 FEO MU-OXO-DIIRON × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 7.6；PROTEIN WAS CRYSTALLIZED FROM 80% SATURATED NACL, NEAR PHYSIOLOGICAL PH (PH 7.6)	分辨率 2.46 Å R-free 0.237
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 提交 1997-07-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM CDP WAS ALSO INCLUDED IN THE PROTEIN SOLUTION	分辨率 3.00 Å R-free 0.280
2X0X Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution 提交 2009-12-18	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	SO4 SULFATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE APP 1.5M, SODIUM CITRATE BUFFER PH APP 6.	分辨率 2.30 Å R-free 0.224
2X0X Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution 提交 2009-12-18	配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	SO4 SULFATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE APP 1.5M, SODIUM CITRATE BUFFER PH APP 6.	分辨率 2.30 Å R-free 0.224
2X0X Ribonucleotide reductase R1 subunit of E. coli to 2.3 A resolution 提交 2009-12-18	实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE APP 1.5M, SODIUM CITRATE BUFFER PH APP 6.	分辨率 2.30 Å R-free 0.224
2XAK Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.241
2XAK Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.241
2XAK Ribonucleotide reductase Y730NO2Y modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.241
2XAP Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.10 Å R-free 0.230
2XAP Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.10 Å R-free 0.230
2XAP Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution 提交 2010-03-31	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.10 Å R-free 0.230
2XAV Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.247
2XAV Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.247
2XAV Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.80 Å R-free 0.247
2XAW Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 3.10 Å R-free 0.234
2XAW Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 3.10 Å R-free 0.234
2XAW Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli 提交 2010-03-31	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 3.10 Å R-free 0.234
2XAX Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.75 Å R-free 0.261
2XAX Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.75 Å R-free 0.261
2XAX Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.75 Å R-free 0.261
2XAZ Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.60 Å R-free 0.246
2XAZ Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.60 Å R-free 0.246
2XAZ Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli 提交 2010-04-01	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.60 Å R-free 0.246
2XO4 RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.50 Å R-free 0.233
2XO4 RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376 链 E 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.50 Å R-free 0.233
2XO4 RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：RIBONUCLEOTIDE REDUCTASE R2-PEPTIDE, RESIDUES 357-376	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.50 Å R-free 0.233
2XO5 RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	构建体不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 357–376（20 aa）片段：R1 BINDING PEPTIDE	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.70 Å R-free 0.228
2XO5 RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	构建体不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 357–376（20 aa）片段：R1 BINDING PEPTIDE 链 E 357–376（20 aa）片段：R1 BINDING PEPTIDE	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.70 Å R-free 0.228
2XO5 RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 提交 2010-08-09	构建体不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 357–376（20 aa）片段：R1 BINDING PEPTIDE	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；LITHIUM SULPHATE 1.5M, SODIUM CHLORIDE BUFFER PH 6.	分辨率 2.70 Å R-free 0.228
2XOF Ribonucleotide reductase Y122NO2Y modified R2 subunit of E. coli 提交 2010-08-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	FEO MU-OXO-DIIRON × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 7.9；VAPOR DIFFUSION USING 90% OF SATURATED NACL, PH 7.9	分辨率 2.20 Å R-free 0.224
3UUS Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex 提交 2011-11-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 8 FE FE (III) ION × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；10.8% PEG 3350, 0.18M magnesium acetate, 0.09M MOPS pH 7.5, 0.01M iron (III) chloride, 4.5% glycerol , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 5.65 Å R-free 0.303
4ERM Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution 提交 2012-04-20	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 8 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant conditions: 10% PEG 3350, 0.1 M MOPS pH 7.5, 0.2 M Magnesium Acetate, 0.025 M Magnesium Chloride, 0.006 M n-Nonyl-beta-D-maltopyranoside, and 5% glycerol. Mixed 1:1 with protein., VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 3.95 Å R-free 0.284
4ERP Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex 提交 2012-04-20	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 F 2–376（375 aa）链 H 2–376（375 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant solution: 25% PEG 3350, 0.1 M HEPES pH 7.5, 0.2 M ammonium acetate, 5% glycerol mixed 2:1 with protein and streak seeded from crystals grown under similar conditions. , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 4.45 Å R-free 0.267
4ERP Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex 提交 2012-04-20	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 G 2–376（375 aa）	未记录	ATP ADENOSINE-5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；Precipitant solution: 25% PEG 3350, 0.1 M HEPES pH 7.5, 0.2 M ammonium acetate, 5% glycerol mixed 2:1 with protein and streak seeded from crystals grown under similar conditions. , VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 4.45 Å R-free 0.267
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 10 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 15 PDB 声明：pentadecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 5 PDB 声明：pentameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
4R1R RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 提交 1997-07-22	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0. THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20-FOLD EXCESS FO A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION. 10 MM DTTP AND 10 MM GDP WAS ADDED TO THE PROTEIN SOLUTION 48 H BEFORE FREEZING THE PROTEIN CRYSTALS	分辨率 3.20 Å R-free 0.308
5CNS Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	CDP CYTIDINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 8 DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；9.5% (w/v) PEG 3350, 100 mM MOPS, 250 mM Mg(CH3COO)2, 25 mM 394 MgCl2, 5% (v/v) glycerol	分辨率 2.98 Å R-free 0.214
5CNT Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	UDP URIDINE-5'-DIPHOSPHATE × 4 DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 12 MG MAGNESIUM ION × 8 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.25 Å R-free 0.221
5CNU Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 4 MG MAGNESIUM ION × 8 ADP ADENOSINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.40 Å R-free 0.221
5CNV Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution 提交 2015-07-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–376（375 aa）链 F 2–376（375 aa）链 G 2–376（375 aa）链 H 2–376（375 aa）	未记录	GDP GUANOSINE-5'-DIPHOSPHATE × 4 DAT 2'-DEOXYADENOSINE-5'-DIPHOSPHATE × 4 MG MAGNESIUM ION × 8 TTP THYMIDINE-5'-TRIPHOSPHATE × 8 FEO MU-OXO-DIIRON × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；2% (w/v) PEG 3350, 100 mM MOPS pH 7.5, 300 mM Mg(CH3COO)2, 30 mM MgCl2, and 5% (v/v) glycerol	分辨率 3.20 Å R-free 0.219
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 10 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 11 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 12 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
5R1R RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.227
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6R1R RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.240
6W4X Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP 提交 2020-03-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–376（376 aa）链 D 1–376（376 aa）	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	TTP THYMIDINE-5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 2 GDP GUANOSINE-5'-DIPHOSPHATE × 1 FEO MU-OXO-DIIRON × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.6 cryo-EM玻璃化条件冷冻剂 ETHANE；blot for 4.5 seconds before plunging	分辨率 3.60 Å
7AI8 Structure of Ribonucleotide reductase R2 from Escherichia coli collected by still serial crystallography on a COC membrane at a synchrotron source 提交 2020-09-26	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–376（376 aa）	未记录	FE FE (III) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；294 K；34-37 % PAA 2100, 100 mM HEPES 7.0, 250-450 mM NaCl, 200 mM ammonium sulfate [and] 26% PAA 2100, 100 mM HEPES 7.0, 150 NaCl, 100 Malonate	分辨率 2.10 Å R-free 0.219
7AI9 Structure of Ribonucleotide reductase R2 from Escherichia coli collected by rotation serial crystallography on a COC membrane at a synchrotron source 提交 2020-09-26	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–376（376 aa）	未记录	FE FE (III) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；294 K；34-37 % PAA 2100, 100 mM HEPES 7.0, 250-450 mM NaCl, 200 mM ammonium sulfate [and] 26% PAA 2100, 100 mM HEPES 7.0, 150 NaCl, 100 Malonate	分辨率 2.00 Å R-free 0.191
7BET Structure of Ribonucleotide reductase R2 from Escherichia coli collected by femtosecond serial crystallography on a COC membrane 提交 2020-12-24	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 1–376（376 aa）	未记录	FE FE (III) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；294 K；34-37 % PAA 2100, 100 mM HEPES 7.0, 250-450 mM NaCl, 200 mM ammonium sulfate [and] 26% PAA 2100, 100 mM HEPES 7.0, 150 NaCl, 100 Malonate	分辨率 2.30 Å R-free 0.245
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 3 PDB 声明：trimeric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 P 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 12 PDB 声明：dodecameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 F 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
7R1R RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 提交 1997-09-17	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 D 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES 链 E 356–375（20 aa）片段：C-TERMINAL PORTION, 20 RESIDUES	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 6；PROTEIN WAS CRYSTALLIZED FROM 1.7 M LITHIUM SULFATE, AND 10 MM MAGNESIUM SULFATE IN 25 MM CITRATE BUFFER AT PH 6.0 THE PROTEIN SOLUTION CONTAINED 17 MG/ML R1 PROTEIN, 20 FOLD EXCESS OF A 20-RESIDUE PEPTIDE CORRESPONDING TO THE C-TERMINUS OF THE R2 SUBUNIT AND IS ESSENTIAL FOR CRYSTALLIZATION	分辨率 3.10 Å R-free 0.231
8VHU Crystal structure of dATP bound E. coli class Ia ribonucleotide reductase alpha construct fused with the C-terminal tail of E. coli class Ia beta subunit 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 342–376（35 aa）链 B 342–376（35 aa）	突变：Truncated final 8 residues of alpha,fused C-terminal 35 residues of beta 突变：Truncated final 8 residues of alpha,fused C-terminal 35 residues of beta	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 3 MG MAGNESIUM ION × 3 NA SODIUM ION × 1 CL CHLORIDE ION × 6 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；277.15 K；1.4M NaCl, 8% (w/vol) PEG 6000	分辨率 2.10 Å R-free 0.192
9DB2 Class Ia ribonucleotide reductase with mechanism-based inhibitor N3CDP 提交 2024-08-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 C 1–376（376 aa）链 D 1–376（376 aa）	未记录	DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 2 MG MAGNESIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 UNL UNKNOWN LIGAND × 1 A1A3L 4-amino-1-{(3xi)-3-C-amino-2-deoxy-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-beta-D-threo-pentofuranosyl}pyrimidin-2(1H)-one × 1 FEO MU-OXO-DIIRON × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.6 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.60 Å
9SIG XFEL structure of oxidised Ribonucleotide reductase R2a Y122F mutant from E. coli 提交 2025-08-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	突变：Y122F 突变：Y122F	FE FE (III) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH MODE；pH 5.5；297 K；0.1M Bis-Tris pH 5.5, PEG 3350 25%	分辨率 1.90 Å R-free 0.185
9SIH XFEL structure of Ribonucleotide reductase R2a Y122F mutant from E. coli,reduced form 提交 2025-08-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	突变：Y122F 突变：Y122F	FE2 FE (II) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH MODE；pH 5.5；297 K；0.1M Bis-Tris pH 5.5, PEG 3350 25%	分辨率 1.70 Å R-free 0.191
9SJW Serial electron diffraction (SerialED) structure of Y122F mutant Ribonucleotide reductase R2 from E. coli in its oxidised (met) form 提交 2025-09-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE FE (III) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution, 25 mM HEPES-Na pH 7.0, 50 mM NaCl, and 20 uL crystallization buffer with seeds, 25 percent PEG 3350, 0.1 M Bis-Tris, pH 5.5. cryo-EM玻璃化条件冷冻剂 ETHANE；Excess liquid was manually blotted from the backside for approximately 10 seconds, followed by plunge freezing in liquid ethane.	分辨率 1.80 Å R-free 0.234
9SJX Serial electron diffraction (SerialED) structure of Y122F mutant Ribonucleotide reductase R2 from E. coli in its oxidised (met) form (re-oxidised) 提交 2025-09-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE FE (III) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution - 25 mM HEPES-Na pH 7.0, 50 mM NaCl and 50 mM sodium dithionite - and 20 uL crystallization buffer containing seeds, 25 percent PEG 3350, 0.1 M Bis-Tris pH 5.5 and 2 mM sodium dithioninte. The crystals were then oxidized through repeated wash with oxygen containing buffer of 12% PEG, 0.05 M Bis-Tris at pH 5.5. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.00 Å R-free 0.285
9SJY Serial electron diffraction (SerialED) structure of Ribonucleotide reductase R2 from E. coli in its oxidised (met) form 提交 2025-09-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE FE (III) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution, 25 mM HEPES-Na pH 7.0, 50 mM NaCl, and 20 uL crystallization buffer with seeds, 25 percent PEG 3350, 0.1 M Bis-Tris, pH 5.5. cryo-EM玻璃化条件冷冻剂 ETHANE；Excess liquid was manually blotted from the backside for approximately 10 seconds, followed by plunge freezing in liquid ethane.	分辨率 1.80 Å R-free 0.253
9SJZ Serial electron diffraction (SerialED) structure of Ribonucleotide reductase R2 from E. coli in its oxidised (met) form (re-oxidised) 提交 2025-09-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE FE (III) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution - 25 mM HEPES-Na pH 7.0, 50 mM NaCl and 50 mM sodium dithionite - and 20 uL crystallization buffer containing seeds, 25 percent PEG 3350, 0.1 M Bis-Tris pH 5.5 and 2 mM sodium dithioninte. The crystals were then oxidized through repeated wash with oxygen containing buffer of 12% PEG, 0.05 M Bis-Tris at pH 5.5. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 1.70 Å R-free 0.232
9SK1 Serial electron diffraction (SerialED) structure of Y122F mutant Ribonucleotide reductase R2 from E. coli in its reduced (red) form 提交 2025-09-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE2 FE (II) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution - 25 mM HEPES-Na pH 7.0, 50 mM NaCl and 50 mM sodium dithionite - and 20 uL crystallization buffer containing seeds, 25 percent PEG 3350, 0.1 M Bis-Tris pH 5.5 and 2 mM sodium dithioninte. cryo-EM玻璃化条件冷冻剂 ETHANE；Excess liquid was manually blotted from the backside for approximately 10 seconds, followed by plunge freezing in liquid ethane. Sample was prepared in an inert environment within a glove box.	分辨率 1.80 Å R-free 0.222
9SKG Serial electron diffraction (SerialED) structure of Ribonucleotide reductase R2 from E. coli in its reduced (red) form 提交 2025-09-02	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）链 B 2–376（375 aa）	未记录	FE2 FE (II) ION × 4	ELECTRON CRYSTALLOGRAPHY cryo-EM缓冲液 pH 5.5；Crystallization was performed using 23.5 uL protein solution - 25 mM HEPES-Na pH 7.0, 50 mM NaCl and 50 mM sodium dithionite - and 20 uL crystallization buffer containing seeds, 25 percent PEG 3350, 0.1 M Bis-Tris pH 5.5 and 2 mM sodium dithioninte. cryo-EM玻璃化条件冷冻剂 ETHANE；Excess liquid was manually blotted from the backside for approximately 10 seconds, followed by plunge freezing in liquid ethane. Sample was prepared in an inert environment within a glove box.	分辨率 1.80 Å R-free 0.247
9TCD XFEL structure of oxidised Ribonucleotide reductase R2a Y122F mutant from E. coli, hexagonal P6122 form 提交 2025-11-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）	突变：Y122F	FE FE (III) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH MODE；297 K；4M Sodium Formate	分辨率 2.70 Å R-free 0.254
9TCE XFEL structure of Ribonucleotide reductase R2a Y122F mutant from E. coli,reduced form, hexagonal P6122 提交 2025-11-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–376（375 aa）	突变：Y122F	FE2 FE (II) ION × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH MODE；297 K；4M Sodium Formate	分辨率 2.70 Å R-free 0.281

共 62 个其他 PDB 条目、124 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	RIR2_ECOLI
Isoform	—
PDB实体	2
链与序列区间	作者链 D； PDB构建体 1–20； UniProt 357–376 作者链 E； PDB构建体 1–20； UniProt 357–376 作者链 F； PDB构建体 1–20； UniProt 357–376 作者链 P； PDB构建体 1–20； UniProt 357–376

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2xay
沉积日期 deposition_date	2010-04-01
结构标题 title	Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli
关键词 keywords	OXIDOREDUCTASE, NUCLEOTIDE-BINDING, ALTERNATIVE INITIATION, DNA REPLICATION, ALLOSTERIC ENZYME; OXIDOREDUCTASE
实验方法 method	X-RAY DIFFRACTION

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	49.77 Å
回转半径 Rg (电子) rg_electron	49.47 Å
零角强度 I(0) i0	909485000.00
分子量 molecular_weight	252340.0 kDa
排除体积 excluded_volume	316060 Å³
包络体积 envelope_volume	437350 Å³
水化壳体积 shell_volume	72168 Å³
包络直径 envelope_diameter	157.4 Å
壳层 Rg shell_rg	54.79 Å
包络 Rg envelope_rg	48.40 Å
形状 Rg shape_rg	49.50 Å
总 Rg total_rg	49.57 Å
总原子数 total_atoms	17792
残基数 n_residues	2227
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	159.6 Å
Rg (实空间) rg_real	49.70 Å
Rg 误差 (实空间) rg_real_error	1.33 Å
I(0) (实空间) i0_real	9.0950e+08
I(0) 误差 (实空间) i0_real_error	1.7100e+07
Rg (倒空间) rg_reciprocal	49.77 Å
I(0) (倒空间) i0_reciprocal	909600000.0000
解质量估计 total_estimate	0.8773
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	74.8 Å
偏度 Skewness skewness	0.147
峰度 Kurtosis kurtosis	-0.752
角度范围 angular_range	— – 0.1600 Å⁻¹
当前正则化参数 α current_alpha	0.0001
最高正则化参数 α highest_alpha	105300000.0000
实空间数据点数 n_real_points	33
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.924; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.990; Smooth: 0.640

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA
分子量 formula_weight	85890.0 kDa
EC 编号 ec_number	1.17.4.1
突变 mutation	YES
来源方法 src_method	man
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C
原子数 atom_count	18579

MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLALEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI

来源 Source

来源生物 organism	ESCHERICHIA COLI
NCBI 分类编号 ncbi_taxonomy_id	83333
宿主生物 host_organism	ESCHERICHIA COLI

实体 2 Entity 2 polymer

描述 description	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
分子量 formula_weight	2271.4 kDa
EC 编号 ec_number	1.17.4.1
来源方法 src_method	syn
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	D,E,F,P

YLVGQIDSEVDTDDLSNFQL

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	787

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7. 折叠分类 (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

结构域编号 domain_id	2xayA02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2xayB02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2xayC02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	20 — Alpha-Beta Barrel
拓扑 Topology topology	70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
同源超家族 H-superfamily homologous superfamily	20 —

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8. 引用文献 (2)

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晶胞边长 a length_a	224.498 Å
晶胞边长 b length_b	224.498 Å
晶胞边长 c length_c	337.839 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	72

空间群 space_group	H 3 2
空间群编号 int_tables_number	155
晶系 crystal_system	—

分辨率 resolution	2.650 Å
最低分辨率 resolution_low	169.031 Å
R 因子 r_factor	0.1850
R_work r_work	0.1823
R_free r_free	0.2353

fit	/app/data/saxs_computation/xa/2xay/2xay.fit
pddf	/app/data/pr_computation/xa/2xay/2xay.pr.out
profile	/app/data/saxs_computation/xa/2xay/2xay.dat

Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli

1. 蛋白身份与相关结构 Protein Identity & Related Structures

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA

当前结构中的状态

数据库中的同蛋白其他状态

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA

当前结构中的状态

数据库中的同蛋白其他状态

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

2. 结构基本信息 2. Structure Basics

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

5. 晶体学与实验 5. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

6. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

实体 3 Entity 3 water

7. 折叠分类 (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

8. 引用文献 (2)

9. 文件与曲线 (10)

Files (7)

Curves (3)