SAXSdb — 2xmn

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Outer membrane protein TolC

Escherichia coli (strain K12)

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 3	CHLORIDE ION × 3 DODECYL-BETA-D-MALTOSIDE × 1 water × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TOLC_ECOLI
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–428； UniProt 23–450 Author chain B； PDBConstruct 1–428； UniProt 23–450 Author chain C； PDBConstruct 1–428； UniProt 23–450

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2xmn
Deposition date deposition_date	2010-07-28
Structure title title	High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices
Keywords keywords	TRANSPORT PROTEIN, OUTER-MEMBRANE, DRUG-EFFLUX, TYPE-I SECRETION; TRANSPORT PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2xmn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2xmn__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

2xmn__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	41.20 Å
Rg (electron density)	41.11 Å
Total Rg	41.23 Å
Atom count	9924
Residues	1284
Excluded volume	174390 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`2xmn__assembly_1__model_1`	trimeric （3）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Outer membrane protein TolC
Molecular weight formula_weight	46917.7 kDa
Mutation mutation	YES
Source method src_method	man
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C
Atom count atom_count	9944

ENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANELTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSGSKTRGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGFSVGTSTIVDVLDATTTLYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPE

Source Source

Source organism organism	Escherichia coli (strain K12)
NCBI taxonomy ID ncbi_taxonomy_id	83333
Host organism host_organism	Escherichia coli

Entity 2 Entity 2 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 3 Entity 3 non-polymer

Description description	DODECYL-BETA-D-MALTOSIDE
Molecular weight formula_weight	510.6 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	20

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

Domain ID domain_id	d2xmna_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.5 — Outer membrane efflux proteins (OEP)
Superfamily Superfamily superfamily	f.5.1 — Outer membrane efflux proteins (OEP)
Family Family family	f.5.1.1 — Outer membrane efflux proteins (OEP)

Domain ID domain_id	d2xmnb_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.5 — Outer membrane efflux proteins (OEP)
Superfamily Superfamily superfamily	f.5.1 — Outer membrane efflux proteins (OEP)
Family Family family	f.5.1.1 — Outer membrane efflux proteins (OEP)

Domain ID domain_id	d2xmnc_
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.5 — Outer membrane efflux proteins (OEP)
Superfamily Superfamily superfamily	f.5.1 — Outer membrane efflux proteins (OEP)
Family Family family	f.5.1.1 — Outer membrane efflux proteins (OEP)

CATH v4.4 (3 domains)

Domain ID domain_id	2xmnA00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1600 — Outer membrane efflux proteins (OEP)
Homologous superfamily homologous superfamily	10 — Outer membrane efflux proteins (OEP)

Domain ID domain_id	2xmnB00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1600 — Outer membrane efflux proteins (OEP)
Homologous superfamily homologous superfamily	10 — Outer membrane efflux proteins (OEP)

Domain ID domain_id	2xmnC00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1600 — Outer membrane efflux proteins (OEP)
Homologous superfamily homologous superfamily	10 — Outer membrane efflux proteins (OEP)

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Unit-cell length a length_a	134.124 Å
Unit-cell length b length_b	135.524 Å
Unit-cell length c length_c	136.343 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	12

Space group space_group	P 21 21 21
Space-group number int_tables_number	19
Crystal system crystal_system	—

Resolution resolution	2.850 Å
Low-resolution limit resolution_low	16.941 Å
R factor r_factor	0.2733
R_work r_work	0.2714
R_free r_free	0.3093

High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices

1. Protein Identity and Related Structures Protein Identity & Related Structures

Outer membrane protein TolC

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2xmn__assembly_1__model_1

2xmn__assembly_1__model_1 | I(q)

2xmn__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

CATH v4.4 (3 domains)

7. Citations (1)

High resolution snapshots of defined TolC open states present an iris- like movement of periplasmic entrance helices

1. Protein Identity and Related Structures Protein Identity & Related Structures

Outer membrane protein TolC

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2xmn__assembly_1__model_1

2xmn__assembly_1__model_1 | I(q)

2xmn__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

CATH v4.4 (3 domains)

7. Citations (1)