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5o66

Asymmetric AcrABZ-TolC

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Outer membrane protein TolC

Escherichia coli K12

UniProt P02930

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 15 Multidrug efflux pump subunit AcrA × 6 （P0AE07） Multidrug efflux pump subunit AcrB × 3 （P31224） Multidrug efflux pump accessory protein AcrZ × 3 （P0AAX1） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1ek9 1tqq 2vdd 2vde 2wmz 2xmn 6wxi

7 assemblies

Heteromeric or nucleic-acid complex
5ng5 5nik 5nil 5o66 5v5s 6wxh 8zal 8zar 9qgy 9tg4 9v52 9v53

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TOLC_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–493； UniProt 1–493 Author chain B； PDBConstruct 1–493； UniProt 1–493 Author chain C； PDBConstruct 1–493； UniProt 1–493

Multidrug efflux pump subunit AcrA

Escherichia coli O157:H7

UniProt P0AE07

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 15 Outer membrane protein TolC × 3 （P02930） Multidrug efflux pump subunit AcrB × 3 （P31224） Multidrug efflux pump accessory protein AcrZ × 3 （P0AAX1） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5o66 5v5s

2 assemblies

View Construct and Data Evidence
UniProt name ACRA_ECO57
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 1–373； UniProt 25–397 Author chain E； PDBConstruct 1–373； UniProt 25–397 Author chain F； PDBConstruct 1–373； UniProt 25–397 Author chain G； PDBConstruct 1–373； UniProt 25–397 Author chain H； PDBConstruct 1–373； UniProt 25–397 Author chain I； PDBConstruct 1–373； UniProt 25–397

Multidrug efflux pump subunit AcrB

Escherichia coli K12

UniProt P31224

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 15 Outer membrane protein TolC × 3 （P02930） Multidrug efflux pump subunit AcrA × 6 （P0AE07） Multidrug efflux pump accessory protein AcrZ × 3 （P0AAX1） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
9fdp 9fdq

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1iwg 1oy6 1oy8 1oy9 1oyd 1oye 1t9t 1t9u 1t9v 1t9w 1t9x 1t9y

63 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2j8s 2rdd 3noc 3nog 4c48 4cdi 4dx5 4dx6 4dx7 4u8v 4u8y 4u95

60 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACRB_ECOLI
Isoform —
PDB entities 3
Chains and sequence ranges Author chain J； PDBConstruct 1–1049； UniProt 1–1049 Author chain K； PDBConstruct 1–1049； UniProt 1–1049 Author chain L； PDBConstruct 1–1049； UniProt 1–1049

Multidrug efflux pump accessory protein AcrZ

Escherichia coli O157:H7

UniProt P0AAX1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 15 Outer membrane protein TolC × 3 （P02930） Multidrug efflux pump subunit AcrA × 6 （P0AE07） Multidrug efflux pump subunit AcrB × 3 （P31224） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5nc5 5o66

2 assemblies

View Construct and Data Evidence
UniProt name ACRZ_ECO57
Isoform —
PDB entities 4
Chains and sequence ranges Author chain M； PDBConstruct 1–49； UniProt 1–49 Author chain N； PDBConstruct 1–49； UniProt 1–49 Author chain O； PDBConstruct 1–49； UniProt 1–49

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5o66
Deposition date deposition_date2017-06-05
Structure title titleAsymmetric AcrABZ-TolC
Keywords keywordsmultidrug efflux pump, membrane transporter, membrane protein; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5o66__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5o66__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5o66__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）85.84 Å
Rg (electron density)88.27 Å
Total Rg87.75 Å
Atom count49671
Residues6544
Excluded volume889310 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5o66__assembly_1__model_1 pentadecameric （15） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)