Ig gamma-1 chain C region
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Other combination Homooligomer Protein × 2 其他Polymer 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 108–330 Chain B； UniProt 108–330 | Fragment：Fc fragment | ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 ZN ZINC ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：MICRODIALYSIS；pH 7；277 K；deionized water, 20% 2,3-butanediol, pH 7.0, MICRODIALYSIS, temperature 277K | Resolution 2.00 Å R-free 0.239 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 3AVE | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1AJ7 IMMUNOGLOBULIN 48G7 GERMLINE FAB ANTIBODY COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID. AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY Deposited 1997-05-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
Fragment：VARIABLE DOMAINS OF LIGHT AND HEAVY CHAINS AND CONSTANT DOMAINS OF LIGHT AND HEAVY CHAINS
|
Not recorded | NPE 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；10-15 MG/ML FAB IN 100MM NACL, 10MM TRIS PH 8.0, 1MM METHIONINE, 1MM SODIUM AZIDE, 0.5 MM EDTA.
|
Resolution 2.10 Å R-free 0.258 |
| 1AQK THREE-DIMENSIONAL STRUCTURE OF A HUMAN FAB WITH HIGH AFFINITY FOR TETANUS TOXOID Deposited 1997-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
21–250（230 aa）
Fragment：FAB
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；pH 8.5
|
Resolution 1.84 Å |
| 1AXS MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN Deposited 1997-10-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–101（101 aa）
Fragment：FAB FRAGMENT
|
Not recorded | CD CADMIUM ION × 5 HOP (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.6；PROTEIN WAS CRYSTALLIZED FROM 25%PEG 1000, 0.1 M SODIUM ACETATE, PH 4.6, 0.3 M CDCL2 AND 0.1 M AMMONIUM SULFATE IN THE PRESENCE OF 2MM HAPTEN.
|
Resolution 2.60 Å R-free 0.305 |
| 1AXS MATURE OXY-COPE CATALYTIC ANTIBODY WITH HAPTEN Deposited 1997-10-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–101（101 aa）
Fragment：FAB FRAGMENT
|
Not recorded | CD CADMIUM ION × 3 HOP (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.6；PROTEIN WAS CRYSTALLIZED FROM 25%PEG 1000, 0.1 M SODIUM ACETATE, PH 4.6, 0.3 M CDCL2 AND 0.1 M AMMONIUM SULFATE IN THE PRESENCE OF 2MM HAPTEN.
|
Resolution 2.60 Å R-free 0.305 |
| 1DFB STRUCTURE OF A HUMAN MONOCLONAL ANTIBODY FAB FRAGMENT AGAINST GP41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I Deposited 1992-03-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.70 Å |
| 1E4K CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX Deposited 2000-07-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
106–330（225 aa）
Fragment：FC FRAGMENT
Chain B
106–330（225 aa）
Fragment：FC FRAGMENT
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；0.1M MES/TRIS PH 5.6, 0.2M K/NA TARTRATE, 6.0% PEG8000
|
Resolution 3.20 Å R-free 0.357 |
| 1FC1 CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF A HUMAN FC FRAGMENT AND ITS COMPLEX WITH FRAGMENT B OF PROTEIN A FROM STAPHYLOCOCCUS AUREUS AT 2.9-AND 2.8-ANGSTROMS RESOLUTION Deposited 1981-05-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
106–329（224 aa）
Chain B
106–329（224 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.90 Å |
| 1FCC CRYSTAL STRUCTURE OF THE C2 FRAGMENT OF STREPTOCOCCAL PROTEIN G IN COMPLEX WITH THE FC DOMAIN OF HUMAN IGG Deposited 1995-01-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
121–326（206 aa）
Chain B
121–326（206 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.20 Å R-free 0.357 |
| 1GAF 48G7 HYBRIDOMA LINE FAB COMPLEXED WITH HAPTEN 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID Deposited 1996-02-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
Fragment：VARIABLE DOMAINS OF LIGHT AND HEAVY CHAINS AND CONSTANT DOMAINS OF LIGHT AND HEAVY CHAINS
|
Not recorded | NPE 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.95 Å R-free 0.307 |
| 1HKL FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY Deposited 1996-12-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
Fragment：VARIABLE DOMAINS OF LIGHT AND HEAVY CHAINS AND CONSTANT DOMAINS OF LIGHT AND HEAVY CHAINS
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.68 Å R-free 0.244 |
| 1I7Z ANTIBODY GNC92H2 BOUND TO LIGAND Deposited 2001-03-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–103（103 aa）
|
Not recorded | COC COCAINE × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.265 |
| 1I7Z ANTIBODY GNC92H2 BOUND TO LIGAND Deposited 2001-03-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1–103（103 aa）
|
Not recorded | COC COCAINE × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.265 |
| 1N7M Germline 7G12 with N-methylmesoporphyrin Deposited 2002-11-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
1–102（102 aa）
|
Not recorded | MMP N-METHYLMESOPORPHYRIN × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.2；277 K；22% PEG2000MME, 0.2M Ammonium Sulfate, 10mM Cd Sulfate, 1mM NMP, 0.1M sodium acetate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.80 Å R-free 0.253 |
| 1VGE TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY Deposited 1996-01-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
Fragment：FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 2DTS Crystal Structure of the Defucosylated Fc Fragment from Human Immunoglobulin G1 Deposited 2006-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Fragment：Fc Fragment
Chain B
108–330（223 aa）
Fragment：Fc Fragment
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 7；277 K；Deionized water, pH 7.0, MICRODIALYSIS, temperature 277K
|
Resolution 2.20 Å R-free 0.251 |
| 2GJ7 Crystal Structure of a gE-gI/Fc complex Deposited 2006-03-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
106–330（225 aa）
Fragment：Fc fragment
Chain B
106–330（225 aa）
Fragment：Fc fragment
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.9-1.1 M sodium malonate, 0.1 M Hepes or 0.1 M MES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 5.00 Å |
| 2IWG COMPLEX BETWEEN THE PRYSPRY DOMAIN OF TRIM21 AND IGG FC Deposited 2006-06-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
120–326（207 aa）
Fragment：RESIDUES 120-326
Chain D
120–326（207 aa）
Fragment：RESIDUES 120-326
|
Not recorded | FUC alpha-L-fucopyranose × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.35 Å R-free 0.253 |
| 2J6E Crystal Structure of an Autoimmune Complex between a Human IgM Rheumatoid Factor and IgG1 Fc reveals a Novel Fc Epitope and Evidence for Affinity Maturation Deposited 2006-09-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
99–330（232 aa）
Fragment：FC DOMAIN, RESIDUES 99-330
Chain B
99–330（232 aa）
Fragment：FC DOMAIN, RESIDUES 99-330
|
Not recorded | CD CADMIUM ION × 1 ZN ZINC ION × 2 CAC CACODYLATE ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 6 ACT ACETATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；10% MPEG 5000, 3 MM ZINC ACETATE, 3 MM CDCL2, 100 MM SODIUM CACODYLATE PH 6.5
|
Resolution 3.00 Å R-free 0.288 |
| 2RCS IMMUNOGLOBULIN 48G7 GERMLINE FAB-AFFINITY MATURATION OF AN ESTEROLYTIC ANTIBODY Deposited 1997-05-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
Fragment：VARIABLE DOMAINS OF LIGHT AND HEAVY CHAINS AND CONSTANT DOMAINS OF LIGHT AND HEAVY CHAINS
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；10-15 MG/ML FAB IN 0.1M AMMONIUM ACETATE, 0.1M SODIUM CACODYLATE PH 6.0, 18% PEG 4000, 1% DIOXANE
|
Resolution 2.10 Å R-free 0.259 |
| 2WAH Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2) Deposited 2009-02-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–328（209 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 120-328
Chain B
120–328（209 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 120-328
|
Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；20% PEG 6000, 0.1 M MES PH 6.0
|
Resolution 2.51 Å R-free 0.268 |
| 3AGV Crystal structure of a human IgG-aptamer complex Deposited 2010-04-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein–RNA Homooligomer；Protein × 2 PDB declaration: tetrameric |
Chain A
120–330（211 aa）
Fragment：Fc fragment, residues 120-330
Chain B
120–330（211 aa）
Fragment：Fc fragment, residues 120-330
|
Not recorded | CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；The solution stirring technique with a rotary shaker produced the best diffracting crystals, pH 8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.15 Å R-free 0.277 |
| 3AY4 Crystal structure of nonfucosylated Fc complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa Deposited 2011-04-28 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
108–330（223 aa）
Fragment：Fc fragment
Chain B
108–330（223 aa）
Fragment：Fc fragment
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；12% PEG 20000, 0.1M MES, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.263 |
| 3D6G Fc fragment of IgG1 (Herceptin) with protein-A mimetic peptide dendrimer ligand. Deposited 2008-05-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–328（210 aa）
Fragment：Fc fragment
Chain B
119–328（210 aa）
Fragment：Fc fragment
|
Not recorded | X12 2-[[(2S)-2,6-bis[[(2S)-2,6-bis[[(2R)-2-[[(2R,3R)-2-[[(2R)-2-amino-5-carbamimidamido-pentanoyl]amino]-3-hydroxy-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]hexanoyl]amino]ethanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；10-20% PEG 20K, 0.1M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.257 |
| 3DJ9 Crystal Structure of an isolated, unglycosylated antibody CH2 domain Deposited 2008-06-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
119–225（107 aa）
Fragment：CH2 constant domain
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；292 K；30% PEG 1500, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 292K
|
Resolution 1.75 Å R-free 0.227 |
| 3DO3 Human 1gG1 Fc fragment, 2.5 Angstrom structure Deposited 2008-07-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–330（212 aa）
Fragment：Fc domain including CH2 and CH3 regions: UNP Residues 119-330
Chain B
119–330（212 aa）
Fragment：Fc domain including CH2 and CH3 regions: UNP Residues 119-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.4；298 K；20% PEG 3350, 0.2M NaCl pH 6.4, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.50 Å R-free 0.330 |
| 3FJT Crystal structure of a human Fc fragment engineered for extended serum half-life Deposited 2008-12-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–327（209 aa）
Fragment：UNP residues 119-327
Chain B
119–327（209 aa）
Fragment：UNP residues 119-327
|
Mutation：M252Y, S254T, T256E Mutation：M252Y, S254T, T256E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；15% PEG 6000, 5% MPD, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.50 Å R-free 0.291 |
| 3O11 Anti-beta-amyloid antibody c706 fab in space group c2 Deposited 2010-07-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 3.5；293 K；0.1 M CITRATE PH 3.5, 18% PEG 8000 CRYO CONDITIONS, 0.1 M CITRATE PH 3.5, 25% PEG 8000, 20% GLYCEROL, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.304 |
| 3O11 Anti-beta-amyloid antibody c706 fab in space group c2 Deposited 2010-07-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–103（103 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 3.5；293 K；0.1 M CITRATE PH 3.5, 18% PEG 8000 CRYO CONDITIONS, 0.1 M CITRATE PH 3.5, 25% PEG 8000, 20% GLYCEROL, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.304 |
| 3RY6 Complex of fcgammariia (CD32) and the FC of human IGG1 Deposited 2011-05-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
114–327（214 aa）
Fragment：UNP residues 114-327
Chain B
114–327（214 aa）
Fragment：UNP residues 114-327
|
Not recorded | GOL GLYCEROL × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.4；20% (W/V) PEG 3350, 5MM TRIS, 0.15M NACL, 2MM MOPS, 0.2M TRI-POTASSIUM ACETATE, PH 7.40, VAPOR DIFFUSION, TEMPERATURE 291.0K
|
Resolution 3.80 Å R-free 0.426 |
| 3S7G Aglycosylated human igg1 fc fragment Deposited 2011-05-26 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：CH2 and CH3 regions, UNP RESIDUES 104-330
Chain B
104–330（227 aa）
Fragment：CH2 and CH3 regions, UNP RESIDUES 104-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；10% PEG 1000, 20% PEG 6000, 0.1M MAGNESIUM CHLORIDE, 0.2M TRIS, PH 7.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K
|
Resolution 3.13 Å R-free 0.323 |
| 3S7G Aglycosylated human igg1 fc fragment Deposited 2011-05-26 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
104–330（227 aa）
Fragment：CH2 and CH3 regions, UNP RESIDUES 104-330
Chain D
104–330（227 aa）
Fragment：CH2 and CH3 regions, UNP RESIDUES 104-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；10% PEG 1000, 20% PEG 6000, 0.1M MAGNESIUM CHLORIDE, 0.2M TRIS, PH 7.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K
|
Resolution 3.13 Å R-free 0.323 |
| 3SGJ Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgIII and antibodies lacking core fucose Deposited 2011-06-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
106–330（225 aa）
Fragment：unp residues 106-330
Chain B
106–330（225 aa）
Fragment：unp residues 106-330
|
Not recorded | MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；1.4 Sodium Malonate, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.252 |
| 3SGJ Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgIII and antibodies lacking core fucose Deposited 2011-06-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
106–330（225 aa）
Fragment：unp residues 106-330
Chain B
106–330（225 aa）
Fragment：unp residues 106-330
|
Not recorded | MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；1.4 Sodium Malonate, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.252 |
| 3SGK Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose Deposited 2011-06-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
106–330（225 aa）
Fragment：unp residues 106-330
Chain B
106–330（225 aa）
Fragment：unp residues 106-330
|
Not recorded | MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；1.4 M Sodium malonate, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.250 |
| 3SGK Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose Deposited 2011-06-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
106–330（225 aa）
Fragment：unp residues 106-330
Chain B
106–330（225 aa）
Fragment：unp residues 106-330
|
Not recorded | MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；1.4 M Sodium malonate, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.250 |
| 3TV3 Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with Man9 Deposited 2011-09-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–104（104 aa）
Fragment：PGT128 heavy chain
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 4 AML AMYLAMINE × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；11% PEG 4000, 0.1M HEPES, 10% isopropanol, 6.5mM Man9, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.29 Å R-free 0.184 |
| 3TWC Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with Man9 Deposited 2011-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–104（104 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | AML AMYLAMINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；14% PEG 4000, 0.1M HEPES pH, 8.5% isopropanol, 15% glycerol, 6.5mM Man9, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.65 Å R-free 0.215 |
| 3TYG Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3) Deposited 2011-09-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
1–104（104 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；24% PEG 3350, 0.29M CaCl2, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 3.25 Å R-free 0.257 |
| 3U0W AD related murine antibody Fragment Deposited 2011-09-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–103（103 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；100mM citric acid, 20%(v/v) 2-propanol, 20%(w/v) PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.235 |
| 3U7W Crystal structure of NIH45-46 Fab Deposited 2011-10-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
1–104（104 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 3 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；12% polyethylene glycol 20,000, 0.1 M sodium acetate pH 5.0, 0.1 M sodium/potassium tartrate, 0.02 M ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.60 Å R-free 0.238 |
| 3U7Y Structure of NIH45-46 Fab in complex with gp120 of 93TH057 HIV Deposited 2011-10-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
1–104（104 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | FLC CITRATE ANION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；12% isopropanol, 10% polyethylene glycol 10,000, 0.1 M sodium citrate pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.45 Å R-free 0.256 |
| 3V7M Crystal structure of monoclonal human anti-Rhesus D Fc IgG1 T125(YB2/0) in the presence of Zn2+ Deposited 2011-12-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–327（209 aa）
Fragment：unp residues 119-327
|
Not recorded | ZN ZINC ION × 6 IMD IMIDAZOLE × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.1；316 K；8% MPEG 5000, 300 MICRO-M ZNCL2, 100 MICRO-M
NICL2, 0.1 M SODIUM CACODYLATE, pH 5.1, VAPOR DIFFUSION, SITTING DROP, temperature 316KK
|
Resolution 2.02 Å R-free 0.286 |
| 3V8C Crystal structure of monoclonal human anti-rhesus D Fc IgG1 t125(yb2/0) double mutant (H310 and H435 in K) Deposited 2011-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–330（212 aa）
Fragment：unp residues 119-330
Chain B
119–330（212 aa）
Fragment：unp residues 119-330
|
Mutation：H310K, H345K Mutation：H310K, H345K | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 GOL GLYCEROL × 3 MAN alpha-D-mannopyranose × 5 GAL beta-D-galactopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.1；293 K；17% MPEG 5000; 21.5% ETHYLENE GLYCOL, 0.1M SODIUM CACODYLATE, pH 5.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.77 Å R-free 0.316 |
| 3V95 Crystal structure of monoclonal human anti-rhesus D Fc and IgG1 t125(yb2/0) in the presence of EDTA Deposited 2011-12-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–330（212 aa）
Fragment：unp residues 119-330
Chain B
119–330（212 aa）
Fragment：unp residues 119-330
|
Not recorded | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.1；293 K；12.8% MPEG 5000, 21.5% ETHYLENE GLYCOL, 0.002M EDTA, 0.1 M SODIUM CACODYLATE, pH 5.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.70 Å R-free 0.321 |
| 3WJJ Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb Deposited 2013-10-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
Chain B
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
|
Mutation：P238D Mutation：P238D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；17% PEG 3350, 0.1M Bis-Tris, 0.2M ammonium acetate, 2.7% D-galactose, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.60 Å R-free 0.272 |
| 3WJL Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb Deposited 2013-10-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
99–328（230 aa）
Fragment：UNP RESIDUES 216-445
Chain B
99–328（230 aa）
Fragment：UNP RESIDUES 216-445
|
Mutation：E233D, G237D, P238D, H268D, P271G, A330R Mutation：E233D, G237D, P238D, H268D, P271G, A330R | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；19% PEG 3350, 0.1M Bis-Tris, 0.2M potassium phosphate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.86 Å R-free 0.270 |
| 3WKN Crystal structure of the artificial protein AFFinger p17 (AF.p17) complexed with Fc fragment of human IgG Deposited 2013-10-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
119–330（212 aa）
Fragment：UNP residues 119-330
Chain C
119–330（212 aa）
Fragment：UNP residues 119-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；40% PEG 4000, 0.1M sodium citrate, 0.2M ammonium acetate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.242 |
| 3WKN Crystal structure of the artificial protein AFFinger p17 (AF.p17) complexed with Fc fragment of human IgG Deposited 2013-10-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
119–330（212 aa）
Fragment：UNP residues 119-330
Chain D
119–330（212 aa）
Fragment：UNP residues 119-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；40% PEG 4000, 0.1M sodium citrate, 0.2M ammonium acetate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.242 |
| 3WKN Crystal structure of the artificial protein AFFinger p17 (AF.p17) complexed with Fc fragment of human IgG Deposited 2013-10-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
119–330（212 aa）
Fragment：UNP residues 119-330
Chain J
119–330（212 aa）
Fragment：UNP residues 119-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；40% PEG 4000, 0.1M sodium citrate, 0.2M ammonium acetate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.242 |
| 3WKN Crystal structure of the artificial protein AFFinger p17 (AF.p17) complexed with Fc fragment of human IgG Deposited 2013-10-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain M
119–330（212 aa）
Fragment：UNP residues 119-330
Chain N
119–330（212 aa）
Fragment：UNP residues 119-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；293 K；40% PEG 4000, 0.1M sodium citrate, 0.2M ammonium acetate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.242 |
| 3WN5 Crystal structure of asymmetrically engineered Fc variant in complex with FcgRIIIa Deposited 2013-12-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
Chain B
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
|
Mutation：C220S, D270E, K326D, A330K, K334E, D356C, T366S, L368A, Y407V Mutation：C220S, L234Y, L235Y, G236W, S239M, H268D, S298A, A327D, Y349C, T366W | IOD IODIDE ION × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.25；293 K；14.5% PEG 3350, 0.1M Bis-Tris, 0.2M Sodium Iodide, Streak seeding, pH 6.25, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.78 Å R-free 0.274 |
| 3WN5 Crystal structure of asymmetrically engineered Fc variant in complex with FcgRIIIa Deposited 2013-12-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
Chain E
99–328（230 aa）
Fragment：UNP RESIDUES 99-328
|
Mutation：C220S, D270E, K326D, A330K, K334E, D356C, T366S, L368A, Y407V Mutation：C220S, L234Y, L235Y, G236W, S239M, H268D, S298A, A327D, Y349C, T366W | IOD IODIDE ION × 9 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.25；293 K；14.5% PEG 3350, 0.1M Bis-Tris, 0.2M Sodium Iodide, Streak seeding, pH 6.25, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.78 Å R-free 0.274 |
| 4ACP Deactivation of human IgG1 Fc by endoglycosidase treatment Deposited 2011-12-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
101–329（229 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 101-329
Chain B
101–329（229 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 101-329
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4；25% W/V POLYETHYLENE GLYCOL 1500, 0.1 M SPG SYSTEM BUFFER PH 4
|
Resolution 2.49 Å R-free 0.234 |
| 4B7I Crystal Structure of Human IgG Fc Bearing Hybrid-type Glycans Deposited 2012-08-20 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–329（210 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 120-329
Chain B
120–329（210 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 120-329
|
Not recorded | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.5；20% W/V PEG 3350 PH 5.5, 0.2 M SODIUM/POTASSIUM PHOSPHATE
|
Resolution 2.36 Å R-free 0.266 |
| 4BM7 Crystal Structure of IgG Fc F241A mutant with native glycosylation Deposited 2013-05-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
106–329（224 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 101-329
|
Mutation：YES | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；28% POLYETHYLENE GLYCOL MONOMETHYL ETHER 2,000 IN 0.1M BIS-TRIS BUFFER AT PH 6.5
|
Resolution 1.95 Å R-free 0.234 |
| 4BM7 Crystal Structure of IgG Fc F241A mutant with native glycosylation Deposited 2013-05-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
106–329（224 aa）
Fragment：IMMUNOGLOBULIN GAMMA, FC, RESIDUES 101-329
|
Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；28% POLYETHYLENE GLYCOL MONOMETHYL ETHER 2,000 IN 0.1M BIS-TRIS BUFFER AT PH 6.5
|
Resolution 1.95 Å R-free 0.234 |
| 4BSV Heterodimeric Fc Antibody Azymetric Variant 1 Deposited 2013-06-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
106–330（225 aa）
Fragment：IG GAMMA 1 FC DOMAIN, RESIDUES 106-330
Chain B
106–330（225 aa）
Fragment：IG GAMMA 1 FC DOMAIN, RESIDUES 106-330
|
Mutation：YES Mutation：YES | EDO 1,2-ETHANEDIOL × 9 IOD IODIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VIA HANGING DROP VAPOR DIFFUSION METHOD AT A RATIO OF 2:1 OF 8.5 MG/ML OF AZYMETRIC VARIANT ABOVE A MOTHER LIQUOR SOLUTION COMPOSED OF 5% (V/V) ETHYLENE GLYCOL, 18% (W/V) POLYETHYLENE GLYCOL 3350, AND 0.15 M AMMONIUM IODIDE WITH AID OF MICROSEEDING.
|
Resolution 1.75 Å R-free 0.208 |
| 4BSW Heterodimeric Fc Antibody Azymetric Variant 2 Deposited 2013-06-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
106–330（225 aa）
Fragment：IG GAMMA 1 FC DOMAIN, RESIDUES 106-330
Chain B
106–330（225 aa）
Fragment：IG GAMMA 1 FC DOMAIN, RESIDUES 106-330
|
Mutation：YES Mutation：YES | EDO 1,2-ETHANEDIOL × 5 IOD IODIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；VIA HANGING DROP VAPOR DIFFUSION METHOD AT A RATIO OF 2:1 OF 8.5 MG/ML OF AZYMETRIC VARIANT 2 ABOVE A MOTHER LIQUOR SOLUTION COMPOSED OF 5% (V/V) ETHYLENE GLYCOL, 18% (W/V) POLYETHYLENE GLYCOL 3350, AND 0.15 M AMMONIUM IODIDE WITH AID OF MICROSEEDING.
|
Resolution 2.15 Å R-free 0.259 |
| 4BYH Crystal structure of sialylated IgG Fc Deposited 2013-07-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
106–329（224 aa）
Fragment：RESIDUES 106-329
Chain B
106–329（224 aa）
Fragment：RESIDUES 106-329
|
Not recorded | CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4；4M NACL, 0.1 M CITRATE PH 4.0
|
Resolution 2.30 Å R-free 0.262 |
| 4CDH Crystallographic structure of the Human Igg1 alpha 2-6 sialilated Fc-Fragment Deposited 2013-10-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
101–330（230 aa）
Fragment：FC, RESIDUES 101-330
Chain B
101–330（230 aa）
Fragment：FC, RESIDUES 101-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；CRYSTALLIZATION TRIALS WERE PERFORMED AT 18 C BY THE SITTING DROP VAPOUR DIFFUSION METHOD. CRYSTALS GROWN BY MIXING 1 UL OF FC-SIAL (9 MG/ML IN PBS) WITH 3 UL OF PRECIPITANT SOLUTION CONSISTING OF 0.1M HEPES PH7, 16% PEG 6000, VAPOR DIFFUSION, TEMPERATURE 298K
|
Resolution 2.30 Å R-free 0.282 |
| 4D9Q Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D Deposited 2012-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
23–102（80 aa）
|
Not recorded | GOL GLYCEROL × 3 ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；0.1 M MES pH 6.5, 25% PEG 550 MME, 0.01 M zinc sulfate and 3% 6-aminohexanoic acid, VAPOR DIFFUSION, SITTING DROP, temperature 292K
|
Resolution 2.28 Å R-free 0.230 |
| 4D9Q Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D Deposited 2012-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
23–102（80 aa）
|
Not recorded | GOL GLYCEROL × 7 ZN ZINC ION × 3 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；0.1 M MES pH 6.5, 25% PEG 550 MME, 0.01 M zinc sulfate and 3% 6-aminohexanoic acid, VAPOR DIFFUSION, SITTING DROP, temperature 292K
|
Resolution 2.28 Å R-free 0.230 |
| 4D9Q Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D Deposited 2012-01-11 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain E
23–102（80 aa）
Chain H
23–102（80 aa）
|
Not recorded | GOL GLYCEROL × 10 ZN ZINC ION × 7 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；292 K；0.1 M MES pH 6.5, 25% PEG 550 MME, 0.01 M zinc sulfate and 3% 6-aminohexanoic acid, VAPOR DIFFUSION, SITTING DROP, temperature 292K
|
Resolution 2.28 Å R-free 0.230 |
| 4D9R Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D Deposited 2012-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
1–103（103 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.1 M Tris-HCl, 0.02 M NH4PO4, MPD 50.0% v/v, 0.01 M hexamine cobalt (III) chloride, pH 8.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.42 Å R-free 0.251 |
| 4D9R Inhibiting Alternative Pathway Complement Activation by Targeting the Exosite on Factor D Deposited 2012-01-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
1–103（103 aa）
|
Not recorded | CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.1 M Tris-HCl, 0.02 M NH4PO4, MPD 50.0% v/v, 0.01 M hexamine cobalt (III) chloride, pH 8.5, vapor diffusion, hanging drop, temperature 277K
|
Resolution 2.42 Å R-free 0.251 |
| 4DAG Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site Deposited 2012-01-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
18–98（81 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；16% PEG 5000 MME, 15% Glycerol, 100 mM Citrate pH 5.6. Crystals appeared after 7-15 days with two distinct morphologies: a square-like crystal and a longer, pointed crystal form., VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.39 Å R-free 0.289 |
| 4DAG Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site Deposited 2012-01-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain H
18–98（81 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；16% PEG 5000 MME, 15% Glycerol, 100 mM Citrate pH 5.6. Crystals appeared after 7-15 days with two distinct morphologies: a square-like crystal and a longer, pointed crystal form., VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.39 Å R-free 0.289 |
| 4DZ8 human IgG1 Fc fragment Heterodimer Deposited 2012-02-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Fragment：unp residues 108-330
Chain B
108–330（223 aa）
Fragment：unp residues 108-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；50 mM Hepes, pH 7.0, 1% Tryptone, and 20% PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.91 Å R-free 0.237 |
| 4KU1 Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering Deposited 2013-05-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：UNP residues 120-327
Chain B
120–327（208 aa）
Fragment：UNP residues 120-327
|
Not recorded | PG4 TETRAETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；Sitting drop 1:1 drop using 0.1 M sodium acetate and 30% polyethylene glycol 1,500, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.90 Å R-free 0.258 |
| 4LLD Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IgG1 CH1:Clambda) at 1.19A Deposited 2013-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–103（103 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；294 K；35% PEG 4K, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 1.19 Å R-free 0.170 |
| 4LLM Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant redesign 1, CRD1) at 1.75A Deposited 2013-07-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–103（103 aa）
|
Mutation：D163K, V200F, F185T | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.2；294 K；40% PEG 6K + 10mM tri-Sodium Citrate dihydrate, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 1.75 Å R-free 0.220 |
| 4N0U Ternary complex between Neonatal Fc receptor, serum albumin and Fc Deposited 2013-10-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric |
Chain E
119–327（209 aa）
Fragment：IgG1 Fc, unp reisdues 119-327
|
Mutation：M252Y, S254T, T256E | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 5.2；298 K；4% Tacsimate, pH 4.0, 12% PEG 3350, VAPOR DIFFUSION, temperature 298K
|
Resolution 3.80 Å R-free 0.303 |
| 4NQS Knob-into-hole IgG Fc Deposited 2013-11-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
118–330（213 aa）
Fragment：UNP residues 118-330
Chain B
118–330（213 aa）
Fragment：UNP residues 118-330
|
Mutation：T366S/L368A/Y407V Mutation：T366W | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；20% PEG2000 MME, 10% 2-propanol, 0.1 M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.64 Å R-free 0.266 |
| 4NQS Knob-into-hole IgG Fc Deposited 2013-11-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain G
118–330（213 aa）
Fragment：UNP residues 118-330
Chain H
118–330（213 aa）
Fragment：UNP residues 118-330
|
Mutation：T366S/L368A/Y407V Mutation：T366W | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；20% PEG2000 MME, 10% 2-propanol, 0.1 M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.64 Å R-free 0.266 |
| 4NQT anti-parallel Fc-hole(T366S/L368A/Y407V) homodimer Deposited 2013-11-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
118–330（213 aa）
Fragment：UNP residues 118-330
|
Mutation：T366S/L368A/Y407V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；291 K；25% PEG1500, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.10 Å R-free 0.253 |
| 4NQU anti-parallel Fc-knob (T366W) homodimer Deposited 2013-11-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
118–330（213 aa）
Fragment：UNP residues 118-330
|
Mutation：T366W | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；20% PEG2000 MME, 0.2 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.50 Å R-free 0.287 |
| 4NWT Crystal structure of the anti-human NGF Fab APE1531 Deposited 2013-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
9–95（87 aa）
|
Not recorded | MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 ACT ACETATE ION × 4 PGE TRIETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；295 K；12% PEG 20000, 0.1M NaCl, 0.1M MES pH6.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.75 Å R-free 0.181 |
| 4NWU Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in CDR H1 Deposited 2013-12-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain H
9–105（97 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；295 K；16% PEG 6000, 0.1 M Citric acid pH6.0-7.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 1.60 Å R-free 0.198 |
| 4Q6Y Crystal structure of a chemoenzymatic glycoengineered disialylated Fc (di-sFc) Deposited 2014-04-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
109–329（221 aa）
Fragment：UNP residues 109-329
Chain B
109–329（221 aa）
Fragment：UNP residues 109-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293.15 K；0.2 M magnesium chloride, 0.1 M sodium acetate pH 5, and 20% (w/v) PEG 6000, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
Resolution 3.00 Å R-free 0.280 |
| 4Q6Y Crystal structure of a chemoenzymatic glycoengineered disialylated Fc (di-sFc) Deposited 2014-04-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
109–329（221 aa）
Fragment：UNP residues 109-329
Chain D
109–329（221 aa）
Fragment：UNP residues 109-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293.15 K；0.2 M magnesium chloride, 0.1 M sodium acetate pH 5, and 20% (w/v) PEG 6000, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
Resolution 3.00 Å R-free 0.280 |
| 4Q74 F241A Fc Deposited 2014-04-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–329（222 aa）
Fragment：UNP residues 108-329
Chain B
108–329（222 aa）
Fragment：UNP residues 108-329
|
Mutation：F241A Mutation：F241A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；30% PEG 1500 at 20 C and cryopreserved in well solution containing 25% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 293.15K
|
Resolution 2.19 Å R-free 0.232 |
| 4Q7D Wild type Fc (wtFc) Deposited 2014-04-24 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
109–329（221 aa）
Fragment：UNP residues 109-329
Chain B
109–329（221 aa）
Fragment：UNP residues 109-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；18% PEG 3350, 0.1M Sodium Cacodylate. Cryopreserved with 25% glycerol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.15K
|
Resolution 2.35 Å R-free 0.264 |
| 4W4N Crystal structure of human Fc at 1.80 A Deposited 2014-08-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
107–329（223 aa）
Fragment：UNP residues 107-329
Chain B
107–329（223 aa）
Fragment：UNP residues 107-329
|
Not recorded | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.1；293 K；0.2M calcium acetate, 0.1M sodium cacodylate, 19% PEG 8000
|
Resolution 1.80 Å R-free 0.244 |
| 4W4O High-resolution crystal structure of Fc bound to its human receptor Fc-gamma-RI Deposited 2014-08-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
107–330（224 aa）
Fragment：UNP residues 107-330
Chain B
107–330（224 aa）
Fragment：UNP residues 107-330
|
Not recorded | ZN ZINC ION × 6 ACT ACETATE ION × 9 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；293 K；0.1M sodium acetate, 0.1 M zinc acetate, 4% 1,4-butanediol, 12% PEG 4,000
|
Resolution 1.80 Å R-free 0.215 |
| 4WI2 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc (wild-type) Deposited 2014-09-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：unp residues 120-327
Chain B
120–327（208 aa）
Fragment：unp residues 120-327
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 1.90 Å R-free 0.269 |
| 4WI3 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A Deposited 2014-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：unp residues 120-327
Chain B
120–327（208 aa）
Fragment：unp residues 120-327
|
Mutation：I253A Mutation：I253A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.70 Å R-free 0.296 |
| 4WI4 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A Deposited 2014-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
121–327（207 aa）
Fragment：unp residues 120-317
Chain B
121–327（207 aa）
Fragment：unp residues 120-317
|
Mutation：S254A Mutation：S254A | EDO 1,2-ETHANEDIOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.80 Å R-free 0.308 |
| 4WI5 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A Deposited 2014-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：unp residues 120-327
Chain B
120–327（208 aa）
Fragment：unp residues 120-327
|
Mutation：H310A Mutation：H310A | EDO 1,2-ETHANEDIOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.80 Å R-free 0.301 |
| 4WI6 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A Deposited 2014-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：unp residues 120-327
Chain B
120–327（208 aa）
Fragment：unp residues 120-327
|
Mutation：N434A Mutation：N434A | EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.20 Å R-free 0.291 |
| 4WI7 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H435A Deposited 2014-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Chain B
120–327（208 aa）
|
Mutation：H435A Mutation：H435A | EDO 1,2-ETHANEDIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 1.90 Å R-free 0.273 |
| 4WI8 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation Y436A Deposited 2014-09-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Chain B
120–327（208 aa）
|
Mutation：Y436A Mutation：Y436A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.80 Å R-free 0.294 |
| 4WI9 Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A/H310A Deposited 2014-09-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
120–327（208 aa）
Fragment：unp residues 120-327
Chain B
120–327（208 aa）
Fragment：unp residues 120-327
|
Mutation：I253A/H310A Mutation：I253A/H310A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；PEG 6000, 0.1 M MES, 25% v/v ethylene glycol
|
Resolution 2.65 Å R-free 0.274 |
| 4X4M Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding Deposited 2014-12-03 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
Chain B
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；PEG8000, 10mM Hepes(pH7.5), 50mM Lithium sulfate
|
Resolution 3.48 Å R-free 0.296 |
| 4X4M Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high affinity IgG binding Deposited 2014-12-03 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
Chain D
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FUL beta-L-fucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；295 K；PEG8000, 10mM Hepes(pH7.5), 50mM Lithium sulfate
|
Resolution 3.48 Å R-free 0.296 |
| 4X98 Immunoglobulin Fc heterodimer variant Deposited 2014-12-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–327（220 aa）
Fragment：UNP RESIDUES 108-327
Chain B
121–327（207 aa）
Fragment：UNP RESIDUES 121-327
|
Mutation：K360E, K409W Mutation：Q347R, D399V, F405T | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；293 K；3M NaCl, 0.1M sodium acetate, pH 4.5
|
Resolution 2.50 Å R-free 0.274 |
| 4X99 Immunoglobulin Fc heterodimers variant Deposited 2014-12-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Fragment：UNP RESIDUES 108-330
Chain B
108–330（223 aa）
Fragment：UNP RESIDUES 108-330
|
Mutation：Y349C, K360E, K409W Mutation：Q347R, S354C, D399V, F405T | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；293 K；3M NaCl, 0.1M sodium acetate, pH 4.5
|
Resolution 2.50 Å R-free 0.283 |
| 4ZNE IgG1 Fc-FcgammaRI ecd complex Deposited 2015-05-04 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
104–330（227 aa）
Fragment：unp residues 104-330
Chain J
104–330（227 aa）
Fragment：unp residues 104-330
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.8；295 K；50 mM Zinc acetate dehydrate and 20% PEG 3350
|
Resolution 2.42 Å R-free 0.254 |
| 5BW7 Crystal structure of nonfucosylated Fc Y296W mutant complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa Deposited 2015-06-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Fragment：UNP residues 108-330
Chain B
108–330（223 aa）
Fragment：UNP residues 108-330
|
Mutation：Y296W Mutation：Y296W | CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；12% PEG20,000
0.1 M MES (pH 6.5)
1% Zwittergent 3-08
|
Resolution 3.00 Å R-free 0.250 |
| 5C7K Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 Deposited 2015-06-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 18 PDB declaration: octadecameric |
Chain E
1–106（106 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；280 K；0.05 M lithium sulfate, 0.05 M sodium sulfate, 26% (w/v) PEG 400 and 0.1 M Tris-HCl pH 8.3
|
Resolution 4.60 Å R-free 0.295 |
| 5D4Q Crystal structure of GASDALIE IgG1 Fc Deposited 2015-08-08 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
109–329（221 aa）
Fragment：UNP residues 109-329
Chain B
109–329（221 aa）
Fragment：UNP residues 109-329
|
Mutation：G236A, S239D, A330L, I332E Mutation：G236A, S239D, A330L, I332E | FUC alpha-L-fucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；0.2 M ammonium formate and 20% (w/v) PEG 3350
|
Resolution 2.39 Å R-free 0.258 |
| 5D6D Crystal structure of GASDALIE IgG1 Fc in complex with FcgRIIIa Deposited 2015-08-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
108–329（222 aa）
Fragment：UNP residues 109-329
Chain B
108–329（222 aa）
Fragment：UNP residues 109-329
|
Mutation：G236A, S239D,A330L, I332E Mutation：G236A, S239D,A330L, I332E | FUC alpha-L-fucopyranose × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；grown in sitting drop vapor diffusion by mixing equal volumes of protein (10 mg/ml) with a solution containing 0.04 M potassium dihydrogen phosphate and 16% (w/v) PEG 8000 at 293.15 K
|
Resolution 3.13 Å R-free 0.296 |
| 5DI8 Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V Deposited 2015-08-31 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Hepes pH 7.5 + 2% Isopropanol + 18% PEG 8K + 100mM Sodium Acetate
|
Resolution 1.90 Å R-free 0.275 |
| 5DJ0 Fc Heterodimer Design 11.2 Y349S/K370Y + E357D/S364Q Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349S, K370Y Mutation：E357D, S364Q | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；13% PEG 3350 + 200mM Magnesium Formate dihydrate
|
Resolution 2.28 Å R-free 0.251 |
| 5DJ2 Fc Heterodimer Design 7.4 Y407A + T366V/K409V Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y407A Mutation：T366V, K409V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；17% PEG 3350 + 100mM Magnesium Formate dihydrate
|
Resolution 2.56 Å R-free 0.243 |
| 5DJ6 Fc Heterodimer Design 6.1 F405W/Y407A + T366M Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：F405W, Y407A Mutation：T366M | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；20% PEG 3350 + 200mM Magnesium Formate dihydrate
|
Resolution 2.00 Å R-free 0.282 |
| 5DJ8 Fc Heterodimer Design 7.7 D399M/Y407A + T366V/K409I Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：D399M, Y407A Mutation：T366V, K409I | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；31% PEG 3350 + 100mM Ammonium Iodide
|
Resolution 2.40 Å R-free 0.260 |
| 5DJA Fc Heterodimer Design 9.1 Y407M + T366I Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y407M Mutation：T366I | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；17% PEG 3350 + 100mM Ammonium Iodide
|
Resolution 2.90 Å R-free 0.281 |
| 5DJC Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：L368V, Y407A Mutation：T366V, K409F | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；17% PEG 3350 + 100mM Ammonium Iodide
|
Resolution 2.10 Å R-free 0.285 |
| 5DJC Fc Heterodimer Design 8.1 L368V/Y407A + T366V/K409F Deposited 2015-09-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
104–330（227 aa）
Fragment：UNP residues 104-330
Chain E
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：L368V, Y407A Mutation：T366V, K409F | IOD IODIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；17% PEG 3350 + 100mM Ammonium Iodide
|
Resolution 2.10 Å R-free 0.285 |
| 5DJD Fc Heterodimer Design 5.1 T366V + Y407F Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：T366V Mutation：Y407F | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Imidazole pH 7 + 20% PEG 6000
|
Resolution 2.30 Å R-free 0.276 |
| 5DJX Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：L368M, K370E Mutation：E357A, S364G | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；5% Glycerol + 15% PEG 6K
|
Resolution 2.25 Å R-free 0.256 |
| 5DJX Fc Heterodimer Design 2.9 L368M/K370E + E357A/S364G Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
104–330（227 aa）
Fragment：UNP residues 104-330
Chain E
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：L368M, K370E Mutation：E357A, S364G | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；5% Glycerol + 15% PEG 6K
|
Resolution 2.25 Å R-free 0.256 |
| 5DJY Fc Heterodimer Design 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349S, T366V, K370Y, K409V Mutation：E357D, S364Q, Y407A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Tris HCl pH 8.5 + 20% PEG 10K
|
Resolution 2.15 Å R-free 0.277 |
| 5DJZ Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：D399M, Y407A Mutation：T366V, K409V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；15% PEG 6K + 10mM Magnesium Chloride + 50mM Potassium Chloride
|
Resolution 1.90 Å R-free 0.277 |
| 5DK0 Fc Heterodimer Design 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349S, T366M, K370Y, K409V Mutation：E356G, E357D, S364Q, Y407A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Tris pH 8.5 + 20% PEG 4K + 200mM Calcium Chloride
|
Resolution 2.30 Å R-free 0.273 |
| 5DK2 Fc Heterodimer E356K/D399K + K392D/K409D Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：E356K, D399K Mutation：K392D, K409D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM MES pH 6.5 + 12% PEG 8K + 200mM Sodium Acetate
|
Resolution 2.60 Å R-free 0.289 |
| 5DK2 Fc Heterodimer E356K/D399K + K392D/K409D Deposited 2015-09-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
104–330（227 aa）
Fragment：UNP residues 104-330
Chain E
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：E356K, D399K Mutation：K392D, K409D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM MES pH 6.5 + 12% PEG 8K + 200mM Sodium Acetate
|
Resolution 2.60 Å R-free 0.289 |
| 5DVK Fc Design 7.7 B chain homodimer T366V/K409I Deposited 2015-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：T366V, K409I | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Hepes pH 7.5 + 10% Isopropanol + 20% PEG 4K
|
Resolution 2.60 Å R-free 0.289 |
| 5DVL Fc Design 20.8.37 A chain homodimer Y349S/T366M/K370Y/K409V Deposited 2015-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349S, T366M, K370Y, K409V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Tris HCl pH 8.5 + 15% PEG 20K
|
Resolution 1.90 Å R-free 0.222 |
| 5DVM Fc Design 20.8.37 B chain homodimer E357D/S364R/Y407A Deposited 2015-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：E357D, S364R, Y407A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Sodium Cacodylate pH 6.5 + 20% PEG 8K + 200mM Magnesium Acetate tetrahydrate
|
Resolution 2.95 Å R-free 0.288 |
| 5DVN Fc K392D/K409D homodimer Deposited 2015-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：K392D, K409D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Tris pH 8.5 + 25% PEG MME 5K + 200mM Lithium Sulfate
|
Resolution 2.50 Å R-free 0.244 |
| 5DVO Fc K392D/K409D homodimer Deposited 2015-09-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：K392D, K409D Mutation：K392D, K409D | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；294 K；100mM Sodium Acetate pH 4.5 + 2000mM Ammonium Sulfate
|
Resolution 2.50 Å R-free 0.261 |
| 5GSQ Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity Deposited 2016-08-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
106–330（225 aa）
Fragment：UNP residues 106-330
Chain B
106–330（225 aa）
Fragment：UNP residues 106-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；293 K；0.1M sodium acetate trihydrate, pH4.5, 30% (w/v) PEG 3350
|
Resolution 1.85 Å R-free 0.267 |
| 5GSQ Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity Deposited 2016-08-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
106–330（225 aa）
Fragment：UNP residues 106-330
Chain D
106–330（225 aa）
Fragment：UNP residues 106-330
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；293 K；0.1M sodium acetate trihydrate, pH4.5, 30% (w/v) PEG 3350
|
Resolution 1.85 Å R-free 0.267 |
| 5HSF 1.52 Angstrom Crystal Structure of Fc fragment of Human IgG1. Deposited 2016-01-25 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
221–330（110 aa）
Chain B
221–330（110 aa）
|
Not recorded | PGE TRIETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8.3；295 K；Protein: 11.0 mg/ml, 0.25M Sodium chloride, 0.1M Tris HCl (pH 8.3);
Screen: PEGs II (F4), 0.2M Ammonium sulfate, 0.1M Sodium acetate, 22% (w/v) PEG 4000
|
Resolution 1.52 Å R-free 0.188 |
| 5HY9 Glycosylated, disulfide-linked Knob-into-Hole Fc fragment Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Chain B
104–330（227 aa）
|
Mutation：T366W, S354C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；2.5 M sodium chloride, 0.1 M acetate
|
Resolution 2.70 Å R-free 0.272 |
| 5HYE Glycosylated Knob-Knob Fc fragment (P212121) Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain C
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：T366W, S354C Mutation：T366W, S354C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；1.0 M ammonium phosphate, 0.1 M citrate, 0.2 M sodium chloride
|
Resolution 1.89 Å R-free 0.275 |
| 5HYF Glycosylated Knob-Knob Fc fragment (P6122) Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：T366W, S354C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；2.5 M sodium chloride, 0.1 M acetate
|
Resolution 1.80 Å R-free 0.248 |
| 5HYI Glycosylated, disulfide-linked Hole-Hole Fc fragment Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349C, T366S, L368A, Y407V Mutation：Y349C, T366S, L368A, Y407V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.2；293 K；20% PEG8000, 0.1 M phosphate-citrate, 0.2 M sodium chloride, 0.55% n-dodecyl-N,N-dimethylamine-N-oxide
|
Resolution 2.90 Å R-free 0.235 |
| 5HYI Glycosylated, disulfide-linked Hole-Hole Fc fragment Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
104–330（227 aa）
Fragment：UNP residues 104-330
Chain D
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：Y349C, T366S, L368A, Y407V Mutation：Y349C, T366S, L368A, Y407V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.2；293 K；20% PEG8000, 0.1 M phosphate-citrate, 0.2 M sodium chloride, 0.55% n-dodecyl-N,N-dimethylamine-N-oxide
|
Resolution 2.90 Å R-free 0.235 |
| 5IQ7 Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. Deposited 2016-03-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
1–102（102 aa）
|
Mutation：S74W,S74W | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；40% PEG400, 0.1M NaCitrate, 0.1M Tris-HCl, 7.5
|
Resolution 3.29 Å R-free 0.282 |
| 5IQ9 Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. Deposited 2016-03-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–101（101 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；15% PEG3350, 25% Isopropanol, 0.1M Tris-HCl, 8.5, 10% Jeffamine.
|
Resolution 2.40 Å R-free 0.236 |
| 5IQ9 Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide. Deposited 2016-03-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
1–101（101 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；15% PEG3350, 25% Isopropanol, 0.1M Tris-HCl, 8.5, 10% Jeffamine.
|
Resolution 2.40 Å R-free 0.236 |
| 5IW3 anti-CD20 monoclonal antibody Fc fragment Deposited 2016-03-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–326（208 aa）
Fragment：D379E, L381M
|
Mutation：UNP residues 119-326 | SO4 SULFATE ION × 6 ACT ACETATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；30% PEG 400, 0.1 M NaAc pH4.6, 0.1M CdSO4
|
Resolution 2.05 Å R-free 0.207 |
| 5IW6 anti-CD20 monoclonal antibody Fc fragment Deposited 2016-03-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
119–327（209 aa）
Fragment：UNP residues 119-327
Chain B
122–326（205 aa）
Fragment：UNP residues 122-326
|
Mutation：D379E, L381M Mutation：D379E, L381M | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；PEG 12000, Na HEPES
|
Resolution 2.34 Å R-free 0.259 |
| 5JIH Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19) Deposited 2016-04-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
Chain B
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
|
Mutation：10 mutations: L358Y;T359L;K360S;N361D;Q362S;D413P;K414R;S415H;Q418A;Q419H. 5 insertions: S415a;E415b;T415c;M415d;R415e Mutation：10 mutations: L358Y;T359L;K360S;N361D;Q362S;D413P;K414R;S415H;Q418A;Q419H. 5 insertions: S415a;E415b;T415c;M415d;R415e | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.05 M TRIS,
22% (w/v) PEG 3350
|
Resolution 1.66 Å R-free 0.231 |
| 5JII Crystal structure of human IgG1-Fc Deposited 2016-04-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
Chain B
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
|
Not recorded | PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；0.05 M Sodium phosphate,
16% (w/v) PEG 3350
|
Resolution 1.79 Å R-free 0.221 |
| 5JIK Crystal structure of HER2 binding IgG1-Fc (Fcab H10-03-6) Deposited 2016-04-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
Chain B
108–329（222 aa）
Fragment：Hinge-CH2-CH3, UNP Residues 108-329
|
Mutation：10 mutations: L358Y;T359L;K360Y;N361G;Q362D;D413P;K414R;S415H;Q418A;Q419H. 5 insertions: S415a;A415b;R415c;M415d;W415e Mutation：10 mutations: L358Y;T359L;K360Y;N361G;Q362D;D413P;K414R;S415H;Q418A;Q419H. 5 insertions: S415a;A415b;R415c;M415d;W415e | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；295 K；0.05 M HEPES,
24% (w/v) PEG 3350
|
Resolution 1.82 Å R-free 0.259 |
| 5K33 Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19 Deposited 2016-05-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
108–329（222 aa）
|
Mutation：L358Y;T359L;K360S;N361D;Q362S;D413P;K414R;S415H; Q418A;Q418H 5 insertion at position 415a to 415e: SETMR | GOL GLYCEROL × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；0.05 M MES,
10% w/v PEG3350
|
Resolution 3.30 Å R-free 0.271 |
| 5K64 Crystal structure of VEGF binding IgG1-Fc (Fcab 448) Deposited 2016-05-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Chain B
108–330（223 aa）
|
Mutation：T359R, K360F, N361Y, E388D, N389I, 389aF, 389bP, 389cN, 389dG, 389eL, D413P, K414Y, S415P, R416S, Q418L, Q419M, N421T, V422R Mutation：T359R, K360F, N361Y, E388D, N389I, 389aF, 389bP, 389cN, 389dG, 389eL, D413P, K414Y, S415P, R416S, Q418L, Q419M, N421T, V422R | GOL GLYCEROL × 3 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；0.05 M MES, 10% (w/v) PEG 3350
|
Resolution 2.44 Å R-free 0.249 |
| 5K65 Crystal structure of VEGF binding IgG1-Fc (Fcab CT6) Deposited 2016-05-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Chain B
108–330（223 aa）
|
Mutation：;T359R, K360F, N361Y, E388D, N389I, 389aF, 389bP, 389cN, 389dG, 389eL, D413P, K414Y, S415P, R416S, Q418L, Q419M, N421T, V422R, S440H. S442E, L443Y, S444Q, P445W, G446P, K447T ; Mutation：;T359R, K360F, N361Y, E388D, N389I, 389aF, 389bP, 389cN, 389dG, 389eL, D413P, K414Y, S415P, R416S, Q418L, Q419M, N421T, V422R, S440H. S442E, L443Y, S444Q, P445W, G446P, K447T ; | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；Morpheus_C6
0.03M of each NPS: (sodium nitrate, disodium hydrogen phosphate, ammonium sulfate).
0.1M MOPS/HEPES-Na pH 7.5
10% w/v PEG 8000, 20% v/v ethylene glycol
|
Resolution 2.50 Å R-free 0.246 |
| 5K8D Crystal structure of rFVIIIFc Deposited 2016-05-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
104–329（226 aa）
|
Not recorded | CA CALCIUM ION × 3 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.3；297 K；5% Ethanol, 100mM TRIS pH 7.3
|
Resolution 4.19 Å R-free 0.362 |
| 5KWG Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6 Deposited 2016-07-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
108–330（223 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；50 mM Citric acid,
18% (w/v) PEG 3350
|
Resolution 4.30 Å R-free 0.369 |
| 5M3V BEAT Fc Deposited 2016-10-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
104–223（120 aa）
Chain B
104–330（227 aa）
|
Mutation：;S364K T366V K370T K392Y F405S Y407V K409W T411N,S364K T366V K370T K392Y F405S Y407V K409W T411N,S364K T366V K370T K392Y F405S Y407V K409W T411N,S364K T366V K370T K392Y F405S Y407V K409W T411N ; Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Q347E Y349A L351F S364T T366V K370T T394D V397L D399E F405A Y407S K409R T411R Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；CRYSTALS GROWN BY VAPOR DIFFUSION BY MIXING 10.2 MG/ML PROTEIN IN 10 MM TRIS-HCL PH8.0, 100 MM NACL, 1 MM EDTA, EQUALLY WITH 27.00 %(W/V)
PEG 1500
|
Resolution 1.97 Å R-free 0.279 |
| 5TPS Structure of a Fc heterodimer Deposited 2016-10-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–330（227 aa）
Fragment：UNP residues 104-330
Chain B
104–330（227 aa）
Fragment：UNP residues 104-330
|
Mutation：S354C,T366W,K409A Mutation：C349Y,T366S,L368A,F405K,Y407V | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；15% PEG 3350, 1M LiCl, 0.1M MES pH6.0
|
Resolution 2.70 Å R-free 0.271 |
| 5V43 Engineered human IgG Fc domain aglyco801 Deposited 2017-03-08 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–329（226 aa）
Fragment：residues 104-329
Chain B
104–329（226 aa）
Fragment：residues 104-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；50 mM sodium citrate pH 5.0
0.44 M NaCl
24% w/v PEG 4000
|
Resolution 2.32 Å R-free 0.225 |
| 5V4E Engineered human IgG Fc domain glyco801 (Fc801) Deposited 2017-03-09 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–329（226 aa）
Fragment：residues 104-329
Chain B
104–329（226 aa）
Fragment：residues 104-329
|
Not recorded | K POTASSIUM ION × 1 MAN alpha-D-mannopyranose × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；40 mM potassium phosphate
16% w/v PEG 8000
20% v/v glycerol
|
Resolution 3.22 Å R-free 0.281 |
| 5V4E Engineered human IgG Fc domain glyco801 (Fc801) Deposited 2017-03-09 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
104–329（226 aa）
Fragment：residues 104-329
Chain D
104–329（226 aa）
Fragment：residues 104-329
|
Not recorded | K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；40 mM potassium phosphate
16% w/v PEG 8000
20% v/v glycerol
|
Resolution 3.22 Å R-free 0.281 |
| 5V4E Engineered human IgG Fc domain glyco801 (Fc801) Deposited 2017-03-09 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
104–329（226 aa）
Fragment：residues 104-329
Chain F
104–329（226 aa）
Fragment：residues 104-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；40 mM potassium phosphate
16% w/v PEG 8000
20% v/v glycerol
|
Resolution 3.22 Å R-free 0.281 |
| 5V4E Engineered human IgG Fc domain glyco801 (Fc801) Deposited 2017-03-09 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
104–329（226 aa）
Fragment：residues 104-329
Chain H
104–329（226 aa）
Fragment：residues 104-329
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；40 mM potassium phosphate
16% w/v PEG 8000
20% v/v glycerol
|
Resolution 3.22 Å R-free 0.281 |
| 6G1E BEAT Fc with improved heterodimerization (Q3A-D84.4Q) Deposited 2018-03-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
104–113（10 aa）
|
Mutation：L234A, L235A, Q347A, S364K, T366V, K370T, N392Y, F405S, Y407V, K409W, T411N Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.15 K；CRYSTALS GROWN BY VAPOR DIFFUSION BY MIXING 12.0 MG/ML PROTEIN IN 10 MM HEPES PH8.0, 100 MM NACL, 1 MM EDTA, EQUALLY WITH 33.00 %(W/V) PEG 1500
|
Resolution 1.88 Å R-free 0.272 |
| 6YT7 GLYCOSYLATED KNOB/DUMMY-HOLE FC FRAGMENT Deposited 2020-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
104–330（227 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；294 K；25% (w/v) PEG2000 MME, 0.1M HEPES
|
Resolution 1.55 Å R-free 0.273 |
| 7LUR Stable Effector Functionless 2 (SEFL2) IgG1 Fc Scaffold Bound to a Minimized Version of the B-domain (Mini-Z) from Protein A Called Z34C Deposited 2021-02-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
104–330（227 aa）
Chain B
104–330（227 aa）
|
Mutation：N297G, R292C, V302C Mutation：N297G, R292C, V302C | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.2 M ammonium tartrate, 20% (w/v) PEG 3350, 10% NDSB-221
|
Resolution 1.95 Å R-free 0.260 |
| 8DIN The complex structure between human IgG1 Fc and its high affinity receptor FcgRI H174R variant Deposited 2022-06-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
Chain B
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20% PEG3350, 0.2M Magnesium formate
|
Resolution 2.50 Å R-free 0.223 |
| 8DIR The complex structure between human IgG1 Fc and its high affinity receptor FcgRI H174R variant Deposited 2022-06-29 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
Chain B
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
|
Not recorded | NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20% PEG3350, 0.2M Sodium Formate (pH6.6)
|
Resolution 2.30 Å R-free 0.233 |
| 8DJ7 The complex structure between human IgG1 Fc and its high affinity receptor FcgRI H174R variant Deposited 2022-06-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
Chain B
112–330（219 aa）
Fragment：CH2 and CH3 regions, residues 112-330
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20% PEG3350, 0.2M Magnesium Sulfate
|
Resolution 2.39 Å R-free 0.266 |
| 8YP1 Crystal structure of HARS WHEP domain fused with Fc Deposited 2024-03-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
104–328（225 aa）
Chain B
104–328（225 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；289 K；100mM BIS-TRIS pH 5.5, 25% PEG 3350
|
Resolution 2.79 Å R-free 0.256 |
| 8YP1 Crystal structure of HARS WHEP domain fused with Fc Deposited 2024-03-15 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
104–328（225 aa）
Chain D
104–328（225 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；289 K；100mM BIS-TRIS pH 5.5, 25% PEG 3350
|
Resolution 2.79 Å R-free 0.256 |
| 9HIZ Complex of the Nanofitin Sac7d-C3(C24A) with a human IgG1 Fc fragment Deposited 2024-11-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
119–327（209 aa）
Chain B
119–327（209 aa）
Chain C
119–327（209 aa）
Chain D
119–327（209 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；24 % (w/v) PEG8000, 0.1 M Tris/HCl pH 8.5
|
Resolution 2.90 Å R-free 0.279 |
| 9JMJ Cryo-EM structure of the GD-BatCoV (BtCoV/Ii/GD/2014-422) RBD in complex with human DPP4 Deposited 2024-09-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
99–330（232 aa）
Chain B
99–330（232 aa）
Fragment：RBD,RBD
Chain C
99–330（232 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9JMM Cryo-EM structure of the SE-PangolinCoV (MjHKU4r-CoV-1) RBD in complex with human DPP4 Deposited 2024-09-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 3 PDB declaration: trimeric |
Chain B
99–330（232 aa）
Fragment：RBD
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9MVX Crystal structure of knob-in-hole immunoglobulin G1 Fc heterodimer with P374A Deposited 2025-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
108–330（223 aa）
Chain B
108–330（223 aa）
|
Mutation：I253D, T366S, L368A, P374A, Y407V Mutation：T366W, P374A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；5% MPD, 0.1 M HEPES pH 7.5, 10% PEG 1000
|
Resolution 1.84 Å R-free 0.255 |
134 other PDB entries and 162 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | IGHG1_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–223； UniProt 108–330 Author chain B； PDBConstruct 1–223； UniProt 108–330 |
