|
1KUP
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Deposited 2002-01-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
742–766（25 aa）
Fragment：Membrane proximal region
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 5.2；298 K；Pressure ambient
NMR sample composition
2 mM aIIb/b3 peptides; pH 5.2 (unbuffered), 90% H2O 10% D2O | 90% H2O/10% D2O
NMR sample composition
2 mM aIIb/b3 peptides; pH 5.2 (unbuffered), 100% D2O | 100% D2O
|
Resolution not provided
|
|
1KUZ
Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins
Deposited 2002-01-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
742–766（25 aa）
Fragment：Membrane proximal region
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 5.2；298 K；Pressure ambient
NMR sample composition
2 mM aIIb/b3 peptides; pH 5.2 (unbuffered), 90% H2O 10% D2O | 90% H2O/10% D2O
NMR sample composition
2 mM aIIb/b3 peptides; pH 5.2 (unbuffered), 100% D2O | 100% D2O
|
Resolution not provided
|
|
1L5G
CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
Deposited 2002-03-06
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
Fragment：Beta 3 subunit polypeptide (CD61), Residues 27-718
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MN MANGANESE (II) ION × 8
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG 4000, MES, calcium chloride followed by soaking of peptide in manganese chloride buffer, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.20 Å
R-free 0.328
|
|
1M1X
CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
Deposited 2002-06-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–718（692 aa）
Fragment：RESIDUES 27-718
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MN MANGANESE (II) ION × 6
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；278 K；PEG, MES, Mn, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 3.30 Å
R-free 0.323
|
|
1M8O
Platelet integrin alfaIIb-beta3 cytoplasmic domain
Deposited 2002-07-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
742–788（47 aa）
Fragment：cytoplasmic domain
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.3
NMR sample composition
1mM 15N/13C MBP-beta3,
1.3 mM unlabeled alfaIIb, | 20 mM phosphate buffer pH6.3
5mM Ca
NMR sample composition
1mM 15N/13C MBP-alfaiib,
1.3 mM unlabeled beta3, | 20 mM phosphate buffer pH6.3
5mM Ca
NMR sample composition
1mM unlabeled alfaIIB,
0.1 mM unlabeled MBP-beta3,
0.2 mM unlabeled talin head domain | 20 mM phosphate buffer pH6.3
5mM Ca
|
Resolution not provided
|
|
1MIZ
Crystal structure of an integrin beta3-talin chimera
Deposited 2002-08-23
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain A
765–769（5 aa）
Fragment：Residues 739-743
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；pH 7.0, VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.90 Å
R-free 0.246
|
|
1MK7
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain A
765–775（11 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-749)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M TRIS-HCL, 18% (W/V) PEG-MME 2000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å
R-free 0.250
|
|
1MK7
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain C
765–775（11 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-749)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；0.1 M TRIS-HCL, 18% (W/V) PEG-MME 2000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å
R-free 0.250
|
|
1MK9
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain A
765–776（12 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-750)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.6；277 K；PEG 8000, MAGNESIUM CHLORIDE, TRIS-HCL, pH 8.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å
R-free 0.327
|
|
1MK9
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain C
765–776（12 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-750)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.6；277 K；PEG 8000, MAGNESIUM CHLORIDE, TRIS-HCL, pH 8.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å
R-free 0.327
|
|
1MK9
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 3
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain E
765–776（12 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-750)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.6；277 K；PEG 8000, MAGNESIUM CHLORIDE, TRIS-HCL, pH 8.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å
R-free 0.327
|
|
1MK9
CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Deposited 2002-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 4
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain G
765–776（12 aa）
Fragment：PARTIAL CYTOPLASMIC TAIL (Residues 739-750)
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.6；277 K；PEG 8000, MAGNESIUM CHLORIDE, TRIS-HCL, pH 8.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å
R-free 0.327
|
|
1S4X
NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles
Deposited 2004-01-19
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
742–788（47 aa）
Fragment：cytoplasmic domain (residues 742-788)
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.3；313 K
NMR sample composition
1mM peptide, 300mM dDPC, 95/5% H2O/D2O | 95/5% H2O/D2O
|
Resolution not provided
|
|
1TYE
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Deposited 2004-07-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–466（440 aa）
Fragment：residues 1-440
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
CAC CACODYLATE ION × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M magnesium acetate, 0.1 M sodium cacodylate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.254
|
|
1TYE
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Deposited 2004-07-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain D
27–466（440 aa）
Fragment：residues 1-440
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
CAC CACODYLATE ION × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M magnesium acetate, 0.1 M sodium cacodylate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.254
|
|
1TYE
Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Deposited 2004-07-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 3
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain F
27–466（440 aa）
Fragment：residues 1-440
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
CAC CACODYLATE ION × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M magnesium acetate, 0.1 M sodium cacodylate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.254
|
|
1U8C
A novel adaptation of the integrin PSI domain revealed from its crystal structure
Deposited 2004-08-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–718（692 aa）
Fragment：residues 27-718
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
CA CALCIUM ION × 6
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；PEG, MES, CA, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å
R-free 0.367
|
|
2H7D
Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide
Deposited 2006-06-02
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
742–765（24 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.1；298 K；Ionic strength (raw mmCIF value) 100mM NaCl；Pressure ambient
NMR sample composition
1.2mM Talin F3 U-15N; 1.4mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
1.5mM Talin F3; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 99.96% D2O | 99.96% D2O
NMR sample composition
1.9mM Talin F3 U-15N,2H; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
1.9mM Talin F3 U-15N,2H; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 99.96% D2O | 99.96% D2O
NMR sample composition
0.9mM Talin F3 U-15N,13C; 1.1mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2H7E
Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure
Deposited 2006-06-02
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
742–765（24 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.1；298 K；Ionic strength (raw mmCIF value) 100mM NaCl；Pressure ambient
NMR sample composition
1.2mM Talin F3 U-15N; 1.4mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
1.5mM Talin F3; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 99.96% D2O | 99.96% D2O
NMR sample composition
1.9mM Talin F3 U-15N,2H; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
NMR sample composition
1.9mM Talin F3 U-15N,2H; 1.5mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 99.96% D2O | 99.96% D2O
NMR sample composition
0.9mM Talin F3 U-15N,13C; 1.1mM chimeric peptide; 50mM phosphate buffer pH 6.1, 100mM NaCl; 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2K9J
Integrin alphaIIb-beta3 transmembrane complex
Deposited 2008-10-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
711–753（43 aa）
Fragment：Transmembrane domain
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 7.4；301.2 K；Ionic strength (raw mmCIF value) 0.025；Pressure ambient
NMR sample composition
1.2 mM [U-100% 13C; U-100% 15N; 80% 2H] Integrin alpha-IIb light chain, 1.2 mM [U-100% 13C; U-100% 15N; 80% 2H] Integrin beta-3, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2KNC
Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex
Deposited 2009-08-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
715–788（74 aa）
Fragment：transmembrane and cytoplasmic domains, residues 715-788
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
25 K；Ionic strength (raw mmCIF value) 0；Pressure AMBIENT
NMR sample composition
0.2 MM [U-100% 13C U-100% 15N] AIIBTMCD, 0.6 MM B3TMCD, 50% CD3CN/50% H2O, 0.1% TFA | 50% CD3CN/50% H2O
NMR sample composition
0.2 MM [U-100% 13C U-100% 15N] B3TMCD, 0.6 MM AIIBTMCD, 50% CD3CN/50% H2O, 0.1% TFA | 50% CD3CN/50% H2O
NMR sample composition
0.4 MM [U-100% 2H U-100% 15N] B3TMCD, 1.2 MM AIIBTMCD, 50% CD3CN/50% H2O, 0.1% TFA | 50% CD3CN/50% H2O
NMR sample composition
0.4 MM [U-100% 2H U-100% 15N] AIIBTMCD, 1.2 MM B3TMCD, 50% CD3CN/50% H2O, 0.1% TFA | 50% CD3CN/50% H2O
|
Resolution not provided
|
|
2KV9
Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain
Deposited 2010-03-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain B
739–788（50 aa）
Fragment：UNP residues 739-788
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6；310 K；Ionic strength (raw mmCIF value) not calculated；Pressure ambient
NMR sample composition
5 mM sodium phosphate-1, 100 mM [U-99% 2H] DPC-2, 0.02 % sodium azide-3, 25 mM TFA-4, 1 mM [U-99% 13C; U-99% 15N] entity_beta3-5, 1 mM entity_alphaIIb-6, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
5 mM sodium phosphate-7, 100 mM [U-99% 2H] DPC-8, 0.02 % sodium azide-9, 25 mM TFA-10, 1 mM [U-10% 13C; U-99% 15N] entity_beta3-11, 1 mM entity_alphaIIb-12, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided
|
|
2L1C
Shc-PTB:biphosphorylated integrin beta3 cytoplasmic tail complex (1:1)
Deposited 2010-07-27
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
762–788（27 aa）
Fragment：UNP residues 762-788
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.5；308 K；Pressure ambient
NMR sample composition
0.4 mM [U-99% 13C; U-99% 15N] Shc, 0.8 mM integrin beta3, 5 mM DTT, 50 mM sodium chloride, 50 mM sodium phosphate, 1 mM DSS, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided
|
|
2L91
Structure of the Integrin beta3 (A711P,K716A) Transmembrane Segment
Deposited 2011-01-27
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
711–753（43 aa）
Fragment：sequence database residues 711-753
|
Mutation：C687S, A711P, K716A
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 7.4；308.2 K；Ionic strength (raw mmCIF value) 0.025；Pressure ambient
NMR sample composition
0.5 mM [U-100% 13C; U-100% 15N; U-80% 2H] protein, 350 mM DHPC, 105 mM POPC, 25 mM HEPES, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2LJD
monophosphorylated (747pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions
Deposited 2011-09-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
742–788（47 aa）
Fragment：Cytoplasmic domain residues 742-788
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 5.9；313 K；Pressure ambient
NMR sample composition
0.4 mM [U-100% 13C; U-100% 15N] protein, 150-300 mM [U-100% 2H] DPC, 1 mM DSS, 20 mM sodium phosphate, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2LJE
Biphosphorylated (747pY, 759pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions
Deposited 2011-09-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
742–788（47 aa）
Fragment：Cytoplasmic domain residues 742-788
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 5.9；313 K；Pressure ambient
NMR sample composition
0.2 mM [U-100% 13C; U-100% 15N] protein, 1 mM DSS, 150-300 mM [U-100% 2H] DPC, 20 mM sodium phosphate, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2LJF
Monophosphorylated (747pY) beta3 integrin cytoplasmic tail under aqueous conditions
Deposited 2011-09-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
742–788（47 aa）
Fragment：Cytoplasmic domain residues 742-788
|
Non-standard monomer：Yes (specific site not provided by mmCIF)
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 5.9；298 K；Pressure ambient
NMR sample composition
0.4 mM [U-100% 15N] protein, 1 mM DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2MTP
The structure of Filamin repeat 21 bound to integrin
Deposited 2014-08-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain C
742–788（47 aa）
Fragment：UNP residues 742-788
|
Mutation：L717K, L718K
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.4；298 K；Ionic strength (raw mmCIF value) 25；Pressure ambient
NMR sample composition
1 mM [U-100% 13C; U-100% 15N; U-80% 2H] protein, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided
|
|
2N9Y
Structure of the Integrin alphaIIb-beta3(A711P) Transmembrane Complex
Deposited 2015-12-14
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
712–753（42 aa）
Fragment：Helical transmembrane residues 712-753
|
Mutation：C687S, G690C, A711P
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 7.4；313 K；Ionic strength (raw mmCIF value) 0.05；Pressure ambient
NMR sample composition
0.8 mM [U-15N; U-2H] alphaIIb, 0.8 mM beta3, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition
0.8 mM alphaIIb, 0.8 mM [U-15N; U-2H] beta3, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition
0.8 mM [U-99% 13C; U-99% 15N; 80% 2H] alphaIIb, 0.8 mM [U-99% 13C; U-99% 15N; 80% 2H] beta3, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided
|
|
2Q6W
The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with fetal and neonatal alloimmune thrombocytopenia
Deposited 2007-06-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain C
50–61（12 aa）
Fragment：sequence database residues 50-61
|
Mutation：C26R
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.4；297 K；10-20% PEG 8000, 0.1M sodium acetate, 10% (v/v) glycerol, 0.01M Cd2+, pH 4.4, VAPOR DIFFUSION, HANGING DROP, temperature 297.0K
|
Resolution 2.25 Å
R-free 0.265
|
|
2Q6W
The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with fetal and neonatal alloimmune thrombocytopenia
Deposited 2007-06-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Protein heterocomplex
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain F
50–61（12 aa）
Fragment：sequence database residues 50-61
|
Mutation：C26R
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.4；297 K；10-20% PEG 8000, 0.1M sodium acetate, 10% (v/v) glycerol, 0.01M Cd2+, pH 4.4, VAPOR DIFFUSION, HANGING DROP, temperature 297.0K
|
Resolution 2.25 Å
R-free 0.265
|
|
2RMZ
Bicelle-embedded integrin beta3 transmembrane segment
Deposited 2007-12-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
712–753（42 aa）
Fragment：UNP residues 712-753
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.5；298.2 K；Ionic strength (raw mmCIF value) 0.05；Pressure ambient
NMR sample composition
0.6mM [U-100% 13C; U-100% 15N; 80% 2H] Integrin beta-3, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2RN0
Micelle-embedded integrin beta3 transmembrane segment
Deposited 2007-12-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein monomer
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
712–753（42 aa）
Fragment：UNP residues 712-753
|
Not recorded
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 6.5；298.2 K；Ionic strength (raw mmCIF value) 0.05；Pressure ambient
NMR sample composition
0.6mM [U-100% 13C; U-100% 15N; 80% 2H] Integrin beta-3, 95% H2O/5% D2O | 95% H2O/5% D2O
|
Resolution not provided
|
|
2VC2
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758
Deposited 2007-09-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
MG MAGNESIUM ION × 2
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
180 2-(S)-[N-(3-PYRIDYLSULFONYL)AMINO]-3-[[2-CARBONYL-5-[2-(PIPERIDIN-4-YL)ETHYL]-THIENO[2,3-B]THIOPHENEYL]AMINO]-PROPIONIC ACID × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；10-12% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M IMIDAZOLE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 3.10 Å
R-free 0.217
|
|
2VDK
Re-refinement of Integrin AlphaIIbBeta3 Headpiece
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
CAC CACODYLATE ION × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.80 Å
R-free 0.205
|
|
2VDL
Re-refinement of Integrin AlphaIIbBeta3 Headpiece
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
CAC CACODYLATE ION × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.75 Å
R-free 0.191
|
|
2VDM
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
AGG TIROFIBAN × 1
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；10-12% PEG3350, 0.7 M MAGNESIUM ACETATE, 0.1 M IMIDAZOLE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.90 Å
R-free 0.206
|
|
2VDN
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M IMIDAZOLE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.90 Å
R-free 0.213
|
|
2VDO
Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.51 Å
R-free 0.190
|
|
2VDP
Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.80 Å
R-free 0.204
|
|
2VDQ
Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.59 Å
R-free 0.190
|
|
2VDR
Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide, LGGAKQRGDV
Deposited 2007-10-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–487（461 aa）
Fragment：HEADPIECE, RESIDUES 27-487
|
Not recorded
|
GOL GLYCEROL × 2
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；11% PEG 3350, 0.7 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K
|
Resolution 2.40 Å
R-free 0.193
|
|
3FCU
Structure of headpiece of integrin aIIBb3 in open conformation
Deposited 2008-11-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–487（461 aa）
Fragment：UNP residues 27-487
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 2
CAC CACODYLATE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.197
|
|
3FCU
Structure of headpiece of integrin aIIBb3 in open conformation
Deposited 2008-11-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain D
27–487（461 aa）
Fragment：UNP residues 27-487
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 2
CAC CACODYLATE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.197
|
|
3FCU
Structure of headpiece of integrin aIIBb3 in open conformation
Deposited 2008-11-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 3
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain F
27–487（461 aa）
Fragment：UNP residues 27-487
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
MG MAGNESIUM ION × 2
CAC CACODYLATE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；277 K；10% PEG 8000, 0.4 M MAGNESIUM ACETATE, 0.1 M SODIUM CACODYLATE, PH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.90 Å
R-free 0.197
|
|
3IJE
Crystal structure of the complete integrin alhaVbeta3 ectodomain plus an Alpha/beta transmembrane fragment
Deposited 2009-08-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–721（695 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
CA CALCIUM ION × 6
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；12% PEG3350, 0.1M Na acetate, 0.8M NaCl, 2.5mM CaCl2, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.90 Å
R-free 0.285
|
|
3NID
The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
GOL GLYCEROL × 7
SO4 SULFATE ION × 4
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å
R-free 0.215
|
|
3NID
The Closed Headpiece of Integrin alphaIIB beta3 and its Complex with an alpahIIB beta3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
GOL GLYCEROL × 2
SO4 SULFATE ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å
R-free 0.215
|
|
3NIF
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
NIF 2-ethyl-7-piperazin-1-yl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one × 1
GOL GLYCEROL × 7
SO4 SULFATE ION × 9
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å
R-free 0.216
|
|
3NIF
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
NIF 2-ethyl-7-piperazin-1-yl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one × 1
GOL GLYCEROL × 1
SO4 SULFATE ION × 9
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å
R-free 0.216
|
|
3NIG
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
GOL GLYCEROL × 2
SO4 SULFATE ION × 3
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.25 Å
R-free 0.212
|
|
3NIG
The Closed Headpiece of Integrin IIb 3 and its Complex with an IIb 3 -Specific Antagonist That Does Not Induce Opening
Deposited 2010-06-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
Fragment：Integrin beta-3, residues 27-497
|
Not recorded
|
CA CALCIUM ION × 6
GOL GLYCEROL × 1
SO4 SULFATE ION × 3
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.25 Å
R-free 0.212
|
|
3T3M
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Deposited 2011-07-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP residues 27-498
|
Not recorded
|
CA CALCIUM ION × 6
RC2 N-{3-[5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]phenyl}glycinamide × 1
SO4 SULFATE ION × 4
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å
R-free 0.222
|
|
3T3M
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Deposited 2011-07-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP residues 27-498
|
Not recorded
|
CA CALCIUM ION × 6
RC2 N-{3-[5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]phenyl}glycinamide × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å
R-free 0.222
|
|
3T3P
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Deposited 2011-07-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
GOL GLYCEROL × 1
CA CALCIUM ION × 6
CL CHLORIDE ION × 1
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å
R-free 0.220
|
|
3T3P
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Deposited 2011-07-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 6
CL CHLORIDE ION × 3
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å
R-free 0.220
|
|
3ZDX
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：INTEGRIN HEADPIECE, RESIDUES 27-498
|
Not recorded
|
GOL GLYCEROL × 4
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
CL CHLORIDE ION × 1
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.45 Å
R-free 0.197
|
|
3ZDX
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：INTEGRIN HEADPIECE, RESIDUES 27-498
|
Not recorded
|
GOL GLYCEROL × 2
SO4 SULFATE ION × 7
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.45 Å
R-free 0.197
|
|
3ZDY
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 14
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.45 Å
R-free 0.216
|
|
3ZDY
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 6
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.45 Å
R-free 0.216
|
|
3ZDZ
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 2
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.75 Å
R-free 0.221
|
|
3ZDZ
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 1
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.75 Å
R-free 0.221
|
|
3ZE0
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.95 Å
R-free 0.243
|
|
3ZE0
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 1
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.95 Å
R-free 0.243
|
|
3ZE1
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL PH 8.9
|
Resolution 3.00 Å
R-free 0.233
|
|
3ZE1
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL PH 8.9
|
Resolution 3.00 Å
R-free 0.233
|
|
3ZE2
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
GOL GLYCEROL × 5
SO4 SULFATE ION × 2
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.35 Å
R-free 0.204
|
|
3ZE2
Integrin alphaIIB beta3 headpiece and RGD peptide complex
Deposited 2012-12-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–498（472 aa）
Fragment：RESIDUES 27-498
|
Not recorded
|
GOL GLYCEROL × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.9；11% PEG 8000, 0.2 M AMMONIUM SULFATE, 0.1 M TRIS-HCL, PH 8.9
|
Resolution 2.35 Å
R-free 0.204
|
|
4CAK
Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc
Deposited 2013-10-08
|
Different construct
Different mutation/modification
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–716（690 aa）
Fragment：RESIDUES 27-716
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
|
ELECTRON MICROSCOPY
cryo-EM buffer
150 MM NACL, 10 MM HEPES, PH 7.4, 1 MM CACL2 AND 1 MM MGCL2；pH 7.4；150 MM NACL, 10 MM HEPES, PH 7.4, 1 MM CACL2 AND 1 MM MGCL2
cryo-EM vitrification conditions
VITRIFICATION 1 -- CRYOGEN- NONE, INSTRUMENT- NONE,
|
Resolution 20.50 Å
|
|
4G1E
Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
Deposited 2012-07-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–717（691 aa）
Fragment：unp residues 27-717
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
SO4 SULFATE ION × 6
CL CHLORIDE ION × 7
NI NICKEL (II) ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.8；293 K；2.0M ammonium sulfate, 80mM sodium cacodylate, 6mM Magnesium Chloride, 2mM Calcium Chloride, pH 5.8, EVAPORATION, temperature 293K
|
Resolution 3.00 Å
R-free 0.261
|
|
4G1E
Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
Deposited 2012-07-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Homooligomer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–717（691 aa）
Fragment：unp residues 27-717
|
Not recorded
|
CA CALCIUM ION × 2
SO4 SULFATE ION × 6
CL CHLORIDE ION × 6
|
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.8；293 K；2.0M ammonium sulfate, 80mM sodium cacodylate, 6mM Magnesium Chloride, 2mM Calcium Chloride, pH 5.8, EVAPORATION, temperature 293K
|
Resolution 3.00 Å
R-free 0.261
|
|
4G1E
Crystal structure of integrin alpha V beta 3 with coil-coiled tag.
Deposited 2012-07-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 3
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–717（691 aa）
Fragment：unp residues 27-717
|
Not recorded
|
CA CALCIUM ION × 12
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
SO4 SULFATE ION × 12
CL CHLORIDE ION × 14
NI NICKEL (II) ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.8；293 K；2.0M ammonium sulfate, 80mM sodium cacodylate, 6mM Magnesium Chloride, 2mM Calcium Chloride, pH 5.8, EVAPORATION, temperature 293K
|
Resolution 3.00 Å
R-free 0.261
|
|
4G1M
Re-refinement of alpha V beta 3 structure
Deposited 2012-07-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–718（692 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
NA SODIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4.8；298 K；12% PEG3350, 0.1M Na acetate, 0.8M NaCl, 2.5mM CaCl2, pH 4.8, EVAPORATION, temperature 298K
|
Resolution 2.90 Å
R-free 0.233
|
|
4HXJ
Crystal structure of SH3:RGT complex
Deposited 2012-11-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain C
786–788（3 aa）
|
Not recorded
|
No recorded non-water small molecule
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；100mM Tris, pH 8.0, 1.3M sodium citrate, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å
R-free 0.193
|
|
4MMX
Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin
Deposited 2013-09-09
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
Fragment：Extracellular domain (UNP residues 27-718)
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
MN MANGANESE (II) ION × 8
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.32 Å
R-free 0.269
|
|
4MMY
Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif
Deposited 2013-09-09
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
Fragment：Extracellular domain (UNP residues 27-718)
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
MN MANGANESE (II) ION × 8
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.18 Å
R-free 0.252
|
|
4MMZ
Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin
Deposited 2013-09-09
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
Fragment：Extracellular domain (UNP residues 27-718)
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8
MN MANGANESE (II) ION × 8
NA SODIUM ION × 1
GOL GLYCEROL × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277.15 K；12% PEG3350, 0.8 M sodium chloride, 0.1 M sodium acetate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K
|
Resolution 3.10 Å
R-free 0.255
|
|
4O02
AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment.
Deposited 2013-12-13
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–718（692 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MN MANGANESE (II) ION × 5
NO3 NITRATE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；298 K；13.5% PEG 4000, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.60 Å
R-free 0.312
|
|
4Z7N
Integrin alphaIIbbeta3 in complex with AGDV peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
29–497（469 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
CA CALCIUM ION × 4
SO4 SULFATE ION × 5
GOL GLYCEROL × 1
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å
R-free 0.253
|
|
4Z7N
Integrin alphaIIbbeta3 in complex with AGDV peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
29–497（469 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
CA CALCIUM ION × 4
SO4 SULFATE ION × 3
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.60 Å
R-free 0.253
|
|
4Z7O
Integrin alphaIIbbeta3 in complex with AGDV peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
29–497（469 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
SO4 SULFATE ION × 2
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.85 Å
R-free 0.257
|
|
4Z7O
Integrin alphaIIbbeta3 in complex with AGDV peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
29–497（469 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
SO4 SULFATE ION × 1
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.85 Å
R-free 0.257
|
|
4Z7Q
Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 6
PDB declaration: pentameric
|
Chain B
27–497（471 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
CA CALCIUM ION × 4
SO4 SULFATE ION × 4
GOL GLYCEROL × 1
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.70 Å
R-free 0.236
|
|
4Z7Q
Integrin alphaIIbbeta3 in complex with AGDV-NH2 peptide
Deposited 2015-04-07
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: pentameric
|
Chain D
27–497（471 aa）
Fragment：UNP residues 29-497
|
Not recorded
|
CA CALCIUM ION × 4
SO4 SULFATE ION × 3
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MAN alpha-D-mannopyranose × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.70 Å
R-free 0.236
|
|
5HDB
Integrin alphaIIbbeta3 in complex with Ro-435054
Deposited 2016-01-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 3
GOL GLYCEROL × 1
CA CALCIUM ION × 5
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
5YB N-(4-carbamimidoylbenzoyl)-beta-alanyl-L-alpha-aspartyl-L-phenylalanine × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.70 Å
R-free 0.237
|
|
5HDB
Integrin alphaIIbbeta3 in complex with Ro-435054
Deposited 2016-01-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain D
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 2
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
5YB N-(4-carbamimidoylbenzoyl)-beta-alanyl-L-alpha-aspartyl-L-phenylalanine × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.70 Å
R-free 0.237
|
|
6AVQ
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance
Deposited 2017-09-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–718（692 aa）
Fragment：UNP residues 27-718
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
|
Resolution 35.00 Å
|
|
6AVR
Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609
Deposited 2017-09-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–718（692 aa）
Fragment：UNP residues 27-718
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
|
Resolution 35.00 Å
|
|
6AVU
Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609
Deposited 2017-09-04
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–718（692 aa）
Fragment：UNP residues 27-718
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
|
Resolution 35.00 Å
|
|
6BXB
Crystal structure of an extended b3 integrin P33
Deposited 2017-12-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
27–135（109 aa）
Chain A
376–548（173 aa）
|
Not recorded
|
CA CALCIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
GOL GLYCEROL × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG 6000, 0.1 M Tris-HCl (pH 8.5)
|
Resolution 2.39 Å
R-free 0.268
|
|
6BXB
Crystal structure of an extended b3 integrin P33
Deposited 2017-12-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain B
27–135（109 aa）
Chain B
376–548（173 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG 6000, 0.1 M Tris-HCl (pH 8.5)
|
Resolution 2.39 Å
R-free 0.268
|
|
6BXF
Crystal structure of an extended b3 integrin L33
Deposited 2017-12-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
27–135（109 aa）
Chain A
376–548（173 aa）
|
Not recorded
|
GOL GLYCEROL × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
CA CALCIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG 8000, 0.2 M NaCl, 0.1 M HEPES (pH 7.5)
|
Resolution 3.20 Å
R-free 0.335
|
|
6BXF
Crystal structure of an extended b3 integrin L33
Deposited 2017-12-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain B
27–135（109 aa）
Chain B
376–548（173 aa）
|
Not recorded
|
GOL GLYCEROL × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MG MAGNESIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG 8000, 0.2 M NaCl, 0.1 M HEPES (pH 7.5)
|
Resolution 3.20 Å
R-free 0.335
|
|
6BXJ
Structure of a single-chain beta3 integrin
Deposited 2017-12-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
27–135（109 aa）
Chain A
376–714（339 aa）
|
Not recorded
|
MG MAGNESIUM ION × 2
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；10% PEG 8000, 20% 1,5-pentanediol, 4 mM alkalis, 66 mM Gly-Gly, 33 mM AMPD, pH 8.5.
|
Resolution 2.09 Å
R-free 0.234
|
|
6CKB
Crystal structure of an extended beta3 integrin P33
Deposited 2018-02-27
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain A
27–135（109 aa）
Chain A
376–548（173 aa）
|
Not recorded
|
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；20% PEG 6000, 0.1 M Tris-HCl (pH 8.5)
|
Resolution 2.80 Å
R-free 0.296
|
|
6CKB
Crystal structure of an extended beta3 integrin P33
Deposited 2018-02-27
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Insufficient information
Monomer；Protein × 1
PDB declaration: monomeric
|
Chain B
27–135（109 aa）
Chain B
376–548（173 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
CA CALCIUM ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；20% PEG 6000, 0.1 M Tris-HCl (pH 8.5)
|
Resolution 2.80 Å
R-free 0.296
|
|
6MK0
Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161
Deposited 2018-09-24
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
30–716（687 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8
MN MANGANESE (II) ION × 8
JUY (2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；100 mM Sodium Acetate pH 4.5, 800 mM Sodium Cholride, 12% PEG 4000.
|
Resolution 3.00 Å
R-free 0.253
|
|
6MSL
Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D
Deposited 2018-10-16
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–721（695 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MN MANGANESE (II) ION × 8
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；100 mM Sodium Acetate pH 4.5, 12% PEG4000, 800 mM NaCl
|
Resolution 3.10 Å
R-free 0.266
|
|
6MSU
Integrin alphaVBeta3 in complex with EETI-II 2.5F
Deposited 2018-10-18
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–721（695 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
MN MANGANESE (II) ION × 8
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；100 mM Sodium Acetate, 800 mM NaCl, 12% PEG4000
|
Resolution 3.11 Å
|
|
6NAJ
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Deposited 2018-12-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–716（690 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7
MN MANGANESE (II) ION × 8
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；100 M Sodium Acetate, PEG4000, 800 mM Sodium Chloride.
|
Resolution 3.10 Å
R-free 0.268
|
|
6V4P
Structure of the integrin AlphaIIbBeta3-Abciximab complex
Deposited 2019-11-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
1–690（690 aa）
|
Not recorded
|
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen NITROGEN
|
Resolution 2.80 Å
|
|
7KN0
Structure of the integrin aIIb(W968V)b3 transmembrane complex
Deposited 2020-11-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
712–753（42 aa）
|
Mutation：C686S
|
No recorded non-water small molecule
|
SOLUTION NMR
NMR measurement conditions
pH 7.4；313.2 K；Ionic strength (raw mmCIF value) 25；Pressure 1
NMR sample composition
0.8 mM [U-100% 13C; U-100% 15N; U-80% 2H] transmembrane complex, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided
|
|
7L8P
Integrin alphaIIbbeta3 in complex with sibrafiban
Deposited 2020-12-31
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
GOL GLYCEROL × 1
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
XQS sibrafiban (active form) × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.35 Å
R-free 0.245
|
|
7L8P
Integrin alphaIIbbeta3 in complex with sibrafiban
Deposited 2020-12-31
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
XQS sibrafiban (active form) × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.35 Å
R-free 0.245
|
|
7LA4
Integrin AlphaIIbBeta3-PT25-2 Complex
Deposited 2021-01-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å
|
|
7TCT
Integrin alpha IIB beta3 complex with UR2922
Deposited 2021-12-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 5
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I1F {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.50 Å
R-free 0.227
|
|
7TCT
Integrin alpha IIB beta3 complex with UR2922
Deposited 2021-12-28
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 3
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I1F {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.50 Å
R-free 0.227
|
|
7TD8
Integrin alpha IIB beta3 complex with Tirofiban
Deposited 2021-12-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
SO4 SULFATE ION × 5
MG MAGNESIUM ION × 1
AGG TIROFIBAN × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.60 Å
R-free 0.210
|
|
7TD8
Integrin alpha IIB beta3 complex with Tirofiban
Deposited 2021-12-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
SO4 SULFATE ION × 3
MG MAGNESIUM ION × 1
AGG TIROFIBAN × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.60 Å
R-free 0.210
|
|
7THO
Integrin alpha IIB beta3 complex with Eptifibatide
Deposited 2022-01-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 2
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.75 Å
R-free 0.222
|
|
7THO
Integrin alpha IIB beta3 complex with Eptifibatide
Deposited 2022-01-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 2
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.75 Å
R-free 0.222
|
|
7TMZ
Integrin alpha IIB beta3 complex with BMS compound 4
Deposited 2022-01-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 6
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I7R (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.20 Å
R-free 0.241
|
|
7TMZ
Integrin alpha IIB beta3 complex with BMS compound 4
Deposited 2022-01-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I7R (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.20 Å
R-free 0.241
|
|
7TPD
Integrin alpha IIB beta3 complex with EF5154
Deposited 2022-01-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 3
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
IR7 (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.60 Å
R-free 0.194
|
|
7TPD
Integrin alpha IIB beta3 complex with EF5154
Deposited 2022-01-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 6
SO4 SULFATE ION × 2
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
IR7 (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.60 Å
R-free 0.194
|
|
7U60
Integrin alpha IIB beta3 complex with cRGDfV
Deposited 2022-03-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 4
GOL GLYCEROL × 8
SO4 SULFATE ION × 6
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.55 Å
R-free 0.225
|
|
7U60
Integrin alpha IIB beta3 complex with cRGDfV
Deposited 2022-03-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 5
PDB declaration: pentameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
CA CALCIUM ION × 4
GOL GLYCEROL × 3
SO4 SULFATE ION × 2
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.55 Å
R-free 0.225
|
|
7U9F
Integrin alpha IIB beta3 complex with BMS compound 4 in Mn2+
Deposited 2022-03-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I7R (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.70 Å
R-free 0.237
|
|
7U9F
Integrin alpha IIB beta3 complex with BMS compound 4 in Mn2+
Deposited 2022-03-10
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I7R (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.70 Å
R-free 0.237
|
|
7U9V
Integrin alpha IIB beta3 complex with BMS4-1
Deposited 2022-03-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
M6K (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.25 Å
R-free 0.226
|
|
7U9V
Integrin alpha IIB beta3 complex with BMS4-1
Deposited 2022-03-11
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
M6K (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.25 Å
R-free 0.226
|
|
7UBR
Integrin alpha IIB beta3 complex with GR144053
Deposited 2022-03-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 7
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MJX {4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl}acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.05 Å
R-free 0.223
|
|
7UBR
Integrin alpha IIB beta3 complex with GR144053
Deposited 2022-03-15
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MJX {4-[4-(4-carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl}acetic acid × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.05 Å
R-free 0.223
|
|
7UCY
Integrin alpha IIB beta3 complex with gantofiban
Deposited 2022-03-17
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MV8 (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.35 Å
R-free 0.231
|
|
7UCY
Integrin alpha IIB beta3 complex with gantofiban
Deposited 2022-03-17
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MV8 (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.35 Å
R-free 0.231
|
|
7UDG
Integrin alpha IIB beta3 complex with lotrafiban
Deposited 2022-03-19
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 5
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWI Lotrafiban × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.80 Å
R-free 0.235
|
|
7UDG
Integrin alpha IIB beta3 complex with lotrafiban
Deposited 2022-03-19
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 5
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWI Lotrafiban × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.80 Å
R-free 0.235
|
|
7UDH
Integrin alpha IIB beta3 complex with BMS4-3
Deposited 2022-03-19
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWO (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.00 Å
R-free 0.214
|
|
7UDH
Integrin alpha IIB beta3 complex with BMS4-3
Deposited 2022-03-19
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWO (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid × 1
MAN alpha-D-mannopyranose × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.00 Å
R-free 0.214
|
|
7UE0
Integrin alpha IIB beta3 complex with fradafiban
Deposited 2022-03-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
GOL GLYCEROL × 1
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWX Fradafiban × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.74 Å
R-free 0.253
|
|
7UE0
Integrin alpha IIB beta3 complex with fradafiban
Deposited 2022-03-20
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 2
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWX Fradafiban × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.74 Å
R-free 0.253
|
|
7UFH
Integrin alpha IIB beta3 complex with fradafiban (Mn/Ca)
Deposited 2022-03-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
GOL GLYCEROL × 1
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWX Fradafiban × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 3.00 Å
R-free 0.245
|
|
7UFH
Integrin alpha IIB beta3 complex with fradafiban (Mn/Ca)
Deposited 2022-03-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
MWX Fradafiban × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 3.00 Å
R-free 0.245
|
|
7UH8
Integrin alpha IIB beta3 complex with roxifiban (Mn/Ca)
Deposited 2022-03-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
N9U Roxifiban × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.75 Å
R-free 0.248
|
|
7UH8
Integrin alpha IIB beta3 complex with roxifiban (Mn/Ca)
Deposited 2022-03-25
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
N9U Roxifiban × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.75 Å
R-free 0.248
|
|
7UJE
Integrin alpha IIB beta3 complex with UR2922 in Mn2+
Deposited 2022-03-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 6
CA CALCIUM ION × 4
GOL GLYCEROL × 1
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I1F {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.50 Å
R-free 0.239
|
|
7UJE
Integrin alpha IIB beta3 complex with UR2922 in Mn2+
Deposited 2022-03-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–497（471 aa）
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
I1F {5-[N-(4-carbamimidoylbenzoyl)-4-nitro-L-phenylalanyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}acetic acid × 1
CL CHLORIDE ION × 3
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；297 K；11-13% PEG 8000, 0.2 M Ammonium Sulfate, 0.1 M Tris-HCl, pH 8.9
|
Resolution 2.50 Å
R-free 0.239
|
|
7UJK
Integrin alpha IIB beta3 complex with lamifiban
Deposited 2022-03-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
GOL GLYCEROL × 1
CA CALCIUM ION × 6
CL CHLORIDE ION × 1
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NB9 Lamifiban × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.43 Å
R-free 0.247
|
|
7UJK
Integrin alpha IIB beta3 complex with lamifiban
Deposited 2022-03-30
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 6
CL CHLORIDE ION × 2
MG MAGNESIUM ION × 1
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NB9 Lamifiban × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.43 Å
R-free 0.247
|
|
7UK9
Integrin alpha IIB beta3 complex with lamifiban (Mn)
Deposited 2022-03-31
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NB9 Lamifiban × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.60 Å
R-free 0.242
|
|
7UK9
Integrin alpha IIB beta3 complex with lamifiban (Mn)
Deposited 2022-03-31
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NB9 Lamifiban × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.60 Å
R-free 0.242
|
|
7UKO
Integrin alpha IIB beta3 complex with sibrafiban (Mn)
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
GOL GLYCEROL × 2
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
XQS sibrafiban (active form) × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.60 Å
R-free 0.239
|
|
7UKO
Integrin alpha IIB beta3 complex with sibrafiban (Mn)
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 2
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
XQS sibrafiban (active form) × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.60 Å
R-free 0.239
|
|
7UKP
Integrin alpha IIB beta3 complex with a gantofiban analog
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 3
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 2
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NJ9 3-(4-{[(5S)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)propanoic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.80 Å
R-free 0.241
|
|
7UKP
Integrin alpha IIB beta3 complex with a gantofiban analog
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 2
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NJ9 3-(4-{[(5S)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)propanoic acid × 1
CL CHLORIDE ION × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.80 Å
R-free 0.241
|
|
7UKT
Integrin alpha IIB beta3 complex with BMS4.2
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 5
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NJF (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid × 1
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.37 Å
R-free 0.218
|
|
7UKT
Integrin alpha IIB beta3 complex with BMS4.2
Deposited 2022-04-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental conditions
Different structure-quality metrics
|
Assembly 2
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain D
27–498（472 aa）
Fragment：UNP Residues 27-498
|
Not recorded
|
SO4 SULFATE ION × 4
CA CALCIUM ION × 4
MN MANGANESE (II) ION × 3
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1
NJF (1-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperidin-4-yl)acetic acid × 1
CL CHLORIDE ION × 2
|
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.9；277 K；11% PEG 8000, 0.2 M ammonium sulfate, 0.1 M Tris-HCl
|
Resolution 2.37 Å
R-free 0.218
|
|
8GCD
Full length Integrin AlphaIIbBeta3 in inactive state
Deposited 2023-03-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å
|
|
8GCE
The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State
Deposited 2023-03-01
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.12 Å
|
|
8IJ5
Cryo-EM structure of Integrin AVB3
Deposited 2023-02-26
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
31–497（467 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å
|
|
8T2U
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide
Deposited 2023-06-06
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–788（762 aa）
|
Not recorded
|
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS/1mM CaCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å
|
|
8T2V
Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids
Deposited 2023-06-06
|
Different construct
Different mutation/modification
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–788（762 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6
CLR CHOLESTEROL × 2
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS/1mM CaCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å
|
|
8XEI
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 1
Deposited 2023-12-12
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å
|
|
8XEK
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 2
Deposited 2023-12-12
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å
|
|
8XEL
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 3
Deposited 2023-12-12
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å
|
|
8XEN
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 4
Deposited 2023-12-12
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å
|
|
8XER
Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 1
Deposited 2023-12-12
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1LU4 2-[(2~{R},5~{R},8~{S},11~{S})-11-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å
|
|
8XEZ
Cryo-EM structure of integrin ITGAV/ITGB3 complex, conformation 5
Deposited 2023-12-13
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.15 Å
|
|
8XF6
Cryo-EM structure of integrin ITGAV, ITGB3 and Cilengitide TFA complex, conformation 2
Deposited 2023-12-13
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1LU4 2-[(2~{R},5~{R},8~{S},11~{S})-11-(3-carbamimidamidopropyl)-7-methyl-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å
|
|
8XFG
Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 1
Deposited 2023-12-13
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1LU7 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å
|
|
8XFO
Cryo-EM structure of integrin ITGAV, ITGB3 and CYCLO (RGDFK) complex, conformation 2
Deposited 2023-12-14
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1LU7 2-[(2~{R},5~{R},8~{S},11~{S})-8-(4-azanylbutyl)-11-(3-carbamimidamidopropyl)-3,6,9,12,15-pentakis(oxidanylidene)-5-(phenylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]ethanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å
|
|
8ZDF
Cryo-EM structure of the integrin avb3 with CWHM-12, conformation 2
Deposited 2024-05-02
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1D8D (2~{S})-3-[2-azanylethanoyl-[3-oxidanyl-5-[(5-oxidanylpyrimidin-2-yl)amino]phenyl]carbonyl-amino]-2-(3-bromanyl-5-~{tert}-butyl-phenyl)propanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å
|
|
8ZDG
Cryo-EM structure of the integrin avb3 with CWHM-12, conformation 1
Deposited 2024-05-02
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
A1D8D (2~{S})-3-[2-azanylethanoyl-[3-oxidanyl-5-[(5-oxidanylpyrimidin-2-yl)amino]phenyl]carbonyl-amino]-2-(3-bromanyl-5-~{tert}-butyl-phenyl)propanoic acid × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.03 Å
|
|
9AXL
Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab
Deposited 2024-03-06
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å
|
|
9DAO
AlphaIIbbeta3 in fully-extended conformation in complex with R6H8 Fab
Deposited 2024-08-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–788（762 aa）
|
Not recorded
|
CA CALCIUM ION × 5
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å
|
|
9DAX
The structure of AlphaIIbbeta3 in apo state
Deposited 2024-08-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Protein heterocomplex
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–788（762 aa）
|
Not recorded
|
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å
|
|
9DEQ
Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban
Deposited 2024-08-29
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–788（762 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5
MG MAGNESIUM ION × 1
A1A5G N-(1,3-benzoxazole-2-carbonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine × 1
CLR CHOLESTEROL × 2
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS/1mM CaCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.10 Å
|
|
9DER
Cryo-EM Structures of Full-Length Integrin alphaIIbbeta3 in Native Lipids Complexed with Tirofiban
Deposited 2024-08-29
|
Different construct
Different mutation/modification
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–788（762 aa）
|
Not recorded
|
CA CALCIUM ION × 6
MG MAGNESIUM ION × 1
AGG TIROFIBAN × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4；TBS/1mM CaCl2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.90 Å
|
|
9E8A
Integrin aIIbb3 bent conformation from human platelet membrane crude preparation
Deposited 2024-11-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.75 Å
|
|
9E8B
Integrin aIIbb3 intermediate conformation from human platelet membrane crude preparation
Deposited 2024-11-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 2
PDB declaration: dimeric
|
Chain B
27–532（506 aa）
|
Not recorded
|
CA CALCIUM ION × 6
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.67 Å
|
|
9E8C
Integrin aIIbb3 dimer conformation from human platelet membrane crude preparation
Deposited 2024-11-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
1–788（788 aa）
Chain D
1–788（788 aa）
|
Not recorded
|
CA CALCIUM ION × 12
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8
MG MAGNESIUM ION × 2
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å
|
|
9IUJ
Integrin alpha-v beta-3 in complex with rhodostomin
Deposited 2024-07-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.78 Å
|
|
9JEI
Integrin alpha-v beta-3 in complex with Echistatin
Deposited 2024-09-03
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å
|
|
9LT3
Integrin alpha-v beta-3 in complex with Trimucrin
Deposited 2025-02-05
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Insufficient information
Heteromer；Protein × 3
PDB declaration: trimeric
|
Chain B
27–718（692 aa）
|
Not recorded
|
CA CALCIUM ION × 7
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3
MG MAGNESIUM ION × 1
|
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.79 Å
|
|
9TD2
Integrin AlphaIIbBeta3 bound to Fab of the anti-HPA-1a antibody 26.4
Deposited 2025-11-22
|
Different construct
Different mutation/modification
Different oligomeric state
Different ligand/ion
Different experimental method
Different experimental conditions
Different structure-quality metrics
|
Assembly 1
Other combination
Heteromer；Protein × 4
PDB declaration: tetrameric
|
Chain B
27–718（692 aa）
|
Not recorded
|
No recorded non-water small molecule
|
ELECTRON MICROSCOPY
mmCIF provides none of the parsed conditions
|
Resolution 2.64 Å
|
