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6avu

Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Integrin alpha-V

Homo sapiens

UniProt P06756

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Integrin beta-3 × 1 （P05106） Fab LM609 heavy chain × 1 Fab LM609 light chain × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1u8c 3ije 4g1e 4g1e 4g1m 4mmx 4mmy 4mmz 4o02 4um8 4um8 4um9

66 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ITAV_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–957； UniProt 31–987

Integrin beta-3

Homo sapiens

UniProt P05106

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Integrin alpha-V × 1 （P06756） Fab LM609 heavy chain × 1 Fab LM609 light chain × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1s4x 2kv9 2l91 2ljd 2lje 2ljf 2rmz 2rn0

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1kup 1kuz 1l5g 1m1x 1m8o 1miz 1mk7 1mk7 1mk9 1mk9 1mk9 1mk9

169 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ITB3_HUMAN
Isoform P05106-3
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–692； UniProt 27–718

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6avu
Deposition date deposition_date2017-09-04
Structure title titleHuman alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609
Keywords keywordsalpha-V beta-3 integrin, LM609, vitaxin, abegrin, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6avu__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6avu__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6avu__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）59.65 Å
Rg (electron density)61.51 Å
Total Rg60.92 Å
Atom count8913
Residues1809
Excluded volume143230 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6avu__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)