3m9s

Crystal structure of respiratory complex I from Thermus thermophilus

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH-quinone oxidoreductase subunit 1

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO1_THET8
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 1； PDBConstruct 1–438； UniProt 1–438 Author chain A； PDBConstruct 1–438； UniProt 1–438

NADH-quinone oxidoreductase subunit 2

OrganismNot specified

UniProt Q56221

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO2_THET8
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 2； PDBConstruct 1–181； UniProt 1–181 Author chain B； PDBConstruct 1–181； UniProt 1–181

NADH-quinone oxidoreductase subunit 3

OrganismNot specified

UniProt Q56223

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO3_THET8
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 3； PDBConstruct 1–783； UniProt 1–783 Author chain C； PDBConstruct 1–783； UniProt 1–783

NADH-quinone oxidoreductase subunit 4

OrganismNot specified

UniProt Q56220

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO4_THET8
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 4； PDBConstruct 1–409； UniProt 1–409 Author chain D； PDBConstruct 1–409； UniProt 1–409

NADH-quinone oxidoreductase subunit C

OrganismNot specified

UniProt Q56219

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO5_THET8
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 5； PDBConstruct 1–207； UniProt 1–207 Author chain E； PDBConstruct 1–207； UniProt 1–207

NADH-quinone oxidoreductase subunit B

OrganismNot specified

UniProt Q56218

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO6_THET8
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 6； PDBConstruct 1–181； UniProt 1–181 Author chain F； PDBConstruct 1–181； UniProt 1–181

NADH-quinone oxidoreductase subunit I

OrganismNot specified

UniProt Q56224

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO9_THET8
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain 9； PDBConstruct 1–182； UniProt 1–182 Author chain G； PDBConstruct 1–182； UniProt 1–182

NADH-quinone oxidoreductase subunit 15

OrganismNot specified

UniProt Q5SKZ7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 13	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit C × 1 （Q56219） NADH-quinone oxidoreductase subunit B × 1 （Q56218） NADH-quinone oxidoreductase subunit I × 1 （Q56224） NADH-quinone oxidoreductase subunit 12 × 1 NADH-quinone oxidoreductase subunit 13 × 1 NADH-quinone oxidoreductase subunit 14 × 1 NADH-quinone oxidoreductase subunits 7, 10 and 11 × 1 NADH-quinone oxidoreductase subunit 8 × 1 IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO15_THET8
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain 7； PDBConstruct 1–129； UniProt 1–129 Author chain J； PDBConstruct 1–129； UniProt 1–129

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	3m9s
Deposition date deposition_date	2010-03-22
Structure title title	Crystal structure of respiratory complex I from Thermus thermophilus
Keywords keywords	MEMBRANE PROTEIN, COMPLEX I, OXIDOREDUCTASE, ELECTRON TRANSPORT, RESPIRATORY CHAIN; OXIDOREDUCTASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3m9s__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3m9s__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

3m9s__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	70.07 Å
Rg (electron density)	68.99 Å
Total Rg	64.87 Å
Atom count	23832
Residues	4061
Excluded volume	412950 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`3m9s__assembly_1__model_1`	tridecameric （13）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`3m9s__assembly_2__model_1`	tridecameric （13）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Description description	NADH-quinone oxidoreductase subunit 1
Molecular weight formula_weight	48693.7 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1,A
Atom count atom_count	47664

MTGPILSGLDPRFERTLYAHVGKEGSWTLDYYLRHGGYETAKRVLKEKTPDEVIEEVKRSGLRGRGGAGFPTGLKWSFMPKDDGKQHYLICNADESEPGSFKDRYILEDVPHLLIEGMILAGYAIRATVGYIYVRGEYRRAADRLEQAIKEARARGYLGKNLFGTDFSFDLHVHRGAGAYICGEETALMNSLEGLRANPRLKPPFPAQSGLWGKPTTINNVETLASVVPIMERGADWFAQMGTEQSKGMKLYQISGPVKRPGVYELPMGTTFRELIYEWAGGPLEPIQAIIPGGSSTPPLPFTEEVLDTPMSYEHLQAKGSMLGTGGVILIPERVSMVDAMWNLTRFYAHESCGKCTPCREGVAGFMVNLFAKIGTGQGEEKDVENLEALLPLIEGRSFCPLADAAVWPVKGSLRHFKDQYLALAREKRPVPRPSLWR

Entity 2 Entity 2 polymer

Description description	NADH-quinone oxidoreductase subunit 2
Molecular weight formula_weight	20309.2 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2,B

MGFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEVMGVASFYSYYQFVPTGKYHLQVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQKVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAGKRLEEIELPGKCGHHVHEVEV

Entity 3 Entity 3 polymer

Description description	NADH-quinone oxidoreductase subunit 3
Molecular weight formula_weight	86656.2 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3,C

MVRVKVNDRIVEVPPGTSVMDAVFHAGYDVPLFCSEKHLSPIGACRMCLVRIGLPKKGPDGKPLLNEKGEPEIQWQPKLAASCVTAVADGMVVDTLSDVVREAQAGMVEFTLLNHPLDCPTCDKGGACELQDRTVEYGLYEKYYQKGPLELPVYTRFEFTRRHVDKHHPLSPFVILDRERCIHCKRCVRYFEEVPGDEVLDFIERGVHTFIGTMDFGLPSGFSGNITDICPVGALLDLTARFRARNWEMEETPTTCALCPVGCGITADTRSGELLRIRAREVPEVNEIWICDAGRFGHEWADQNRLKTPLVRKEGRLVEATWEEAFLALKEGLKEARGEEVGLYLAHDATLEEGLLASELAKALKTPHLDFQGRTAAPASLFPPASLEDLLQADFALVLGDPTEEAPILHLRLSEFVRDLKPPHRYNHGTPFADLQIKERMPRRTDKMALFAPYRAPLMKWAAIHEVHRPGEEREILLALLGDKEGSEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERARLLAERKGAKVLAMTPAANARGLEAMGVLPGAKGASWDEPGALYAYYGFVPPEEALKGKRFVVMHLSHLHPLAERYAHVVLPAPTFYEKRGHLVNLEGRVLPLSPAPIENGEAEGALQVLALLAEALGVRPPFRLHLEAQKALKARKVPEAMGRLSFRLKELRPKERKGAFYLRPTMWKAHQAVGKAQEAARAELWAHPETARAEALPEGAQVAVETPFGRVEARVVHREDVPKGHLYLSALGPAAGLRVEGRVLVPAGGEA

Entity 4 Entity 4 polymer

Description description	NADH-quinone oxidoreductase subunit 4
Molecular weight formula_weight	46428.0 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4,D

MREEFLEEIPLDAPPEEAKELRTEVMTLNVGPQHPSTHGVLRLMVTLSGEEVLEVVPHIGYLHTGFEKTMEHRTYLQNITYTPRMDYLHSFAHDLAYALAVEKLLGAVVPPRAETIRVILNELSRLASHLVFLGTGLLDLGALTPFFYAFRERETILDLFEWVTGQRFHHNYIRIGGVKEDLPEEFVPELKKLLEVLPHRIDEYEALFAESPIFYERARGVGVIPPEVAIDLGLTGGSLRASGVNYDVRKAYPYSGYETYTFDVPLGERGDVFDRMLVRIREMRESVKIIKQALERLEPGPVRDPNPQITPPPRHLLETSMEAVIYHFKHYTEGFHPPKGEVYVPTESARGELGYYIVSDGGSMPYRVKVRAPSFVNLQSLPYACKGEQVPDMVAIIASLDPVMGDVDR

Entity 5 Entity 5 polymer

Description description	NADH-quinone oxidoreductase subunit C
Molecular weight formula_weight	23893.3 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5,E

MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTYPDPRPERFAVVYELVSLPGWKDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYDLFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFREGRYIIPAEFRAALTGKDPGLTFYKGGSRKGYRSLWADLKKAREVKG

Entity 6 Entity 6 polymer

Description description	NADH-quinone oxidoreductase subunit B
Molecular weight formula_weight	20262.6 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6,F

MALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDLARFGSEVFRASPRQADVMIVAGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNNYAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRGQAYNERGERLPPVAAWKRTRG

Entity 7 Entity 7 polymer

Description description	NADH-quinone oxidoreductase subunit I
Molecular weight formula_weight	20106.3 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	9,G

MTLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCAAACPAYAIYVEPAENDPENPVSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFEMADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVGYVVPYVRPELEGFKAPTEGGKR

Entity 8 Entity 8 polymer

Description description	NADH-quinone oxidoreductase subunit 15
Molecular weight formula_weight	14812.1 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7,J

MSASSERELYEAWVELLSWMREYAQAKGVRFEKEADFPDFIYRMERPYDLPTTIMTASLSDGLGEPFLLADVSPRHAKLKRIGLRLPRAHIHLHAHYEPGKGLVTGKIPLTKERFFALADRAREALAFA

Entity 9 Entity 9 polymer

Description description	NADH-quinone oxidoreductase subunit 12
Molecular weight formula_weight	39932.2 kDa
EC 编号 ec_number	1.6.99.5
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,O

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

Entity 10 Entity 10 polymer

Description description	NADH-quinone oxidoreductase subunit 13
Molecular weight formula_weight	33379.1 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,P

Entity 11 Entity 11 polymer

Description description	NADH-quinone oxidoreductase subunit 14
Molecular weight formula_weight	32272.7 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,Q

Entity 12 Entity 12 polymer

Description description	NADH-quinone oxidoreductase subunits 7, 10 and 11
Molecular weight formula_weight	23336.6 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R,S

Entity 13 Entity 13 polymer

Description description	NADH-quinone oxidoreductase subunit 8
Molecular weight formula_weight	15422.0 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,T

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

Entity 14 Entity 14 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	14

Entity 15 Entity 15 non-polymer

Description description	FLAVIN MONONUCLEOTIDE
Molecular weight formula_weight	456.3 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 16 Entity 16 non-polymer

Description description	FE2/S2 (INORGANIC) CLUSTER
Molecular weight formula_weight	175.8 kDa
Source method src_method	syn
Copy count entity_count	4

▶

Unit-cell length a length_a	96.390 Å
Unit-cell length b length_b	336.090 Å
Unit-cell length c length_c	262.240 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	100.59 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	4.500 Å
Low-resolution limit resolution_low	30.000 Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Crystal structure of respiratory complex I from Thermus thermophilus

1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH-quinone oxidoreductase subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit C

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit I

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 15

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

3m9s__assembly_1__model_1

3m9s__assembly_1__model_1 | I(q)

3m9s__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (16)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer