4hea

Crystal structure of the entire respiratory complex I from Thermus thermophilus

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH-quinone oxidoreductase subunit 1

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO1_THET8
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 1； PDBConstruct 1–438； UniProt 1–438 Author chain B； PDBConstruct 1–438； UniProt 1–438

NADH-quinone oxidoreductase subunit 2

OrganismNot specified

UniProt Q56221

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO2_THET8
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 2； PDBConstruct 1–181； UniProt 1–181 Author chain C； PDBConstruct 1–181； UniProt 1–181

NADH-quinone oxidoreductase subunit 3

OrganismNot specified

UniProt Q56223

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO3_THET8
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 3； PDBConstruct 1–783； UniProt 1–783 Author chain D； PDBConstruct 1–783； UniProt 1–783

NADH-quinone oxidoreductase subunit 4

OrganismNot specified

UniProt Q56220

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO4_THET8
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 4； PDBConstruct 1–409； UniProt 1–409 Author chain E； PDBConstruct 1–409； UniProt 1–409

NADH-quinone oxidoreductase subunit 5

OrganismNot specified

UniProt Q56219

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO5_THET8
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 5； PDBConstruct 1–207； UniProt 1–207 Author chain F； PDBConstruct 1–207； UniProt 1–207

NADH-quinone oxidoreductase subunit 6

OrganismNot specified

UniProt Q56218

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO6_THET8
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 6； PDBConstruct 1–181； UniProt 1–181 Author chain G； PDBConstruct 1–181； UniProt 1–181

NADH-quinone oxidoreductase subunit 9

OrganismNot specified

UniProt Q56224

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO9_THET8
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain 9； PDBConstruct 1–182； UniProt 1–182 Author chain O； PDBConstruct 1–182； UniProt 1–182

NADH-quinone oxidoreductase subunit 15

OrganismNot specified

UniProt Q5SKZ7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO15_THET8
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain 7； PDBConstruct 1–129； UniProt 1–129 Author chain I； PDBConstruct 1–129； UniProt 1–129

Putative uncharacterized protein TTHA1528

OrganismNot specified

UniProt Q5SI52

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q5SI52_THET8
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain W； PDBConstruct 1–131； UniProt 1–131 Author chain X； PDBConstruct 1–131； UniProt 1–131

NADH-quinone oxidoreductase subunit 7

OrganismNot specified

UniProt Q56217

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO7_THET8
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain A； PDBConstruct 1–119； UniProt 1–119 Author chain P； PDBConstruct 1–119； UniProt 1–119

NADH-quinone oxidoreductase subunit 10

OrganismNot specified

UniProt Q56225

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO10_THET8
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain J； PDBConstruct 1–176； UniProt 1–176 Author chain R； PDBConstruct 1–176； UniProt 1–176

NADH-quinone oxidoreductase subunit 11

OrganismNot specified

UniProt Q56226

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO11_THET8
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain K； PDBConstruct 1–95； UniProt 1–95 Author chain S； PDBConstruct 1–95； UniProt 1–95

NADH-quinone oxidoreductase subunit 12

OrganismNot specified

UniProt Q56227

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO12_THET8
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain L； PDBConstruct 1–606； UniProt 1–606 Author chain T； PDBConstruct 1–606； UniProt 1–606

NADH-quinone oxidoreductase subunit 13

OrganismNot specified

UniProt Q56228

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO13_THET8
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain M； PDBConstruct 1–469； UniProt 1–469 Author chain U； PDBConstruct 1–469； UniProt 1–469

NADH-quinone oxidoreductase subunit 14

OrganismNot specified

UniProt Q56229

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 8 × 1 （Q60019） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO14_THET8
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain N； PDBConstruct 1–427； UniProt 1–427 Author chain V； PDBConstruct 1–427； UniProt 1–427

NADH-quinone oxidoreductase subunit 8

OrganismNot specified

UniProt Q60019

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	NADH-quinone oxidoreductase subunit 1 × 1 （Q56222） NADH-quinone oxidoreductase subunit 2 × 1 （Q56221） NADH-quinone oxidoreductase subunit 3 × 1 （Q56223） NADH-quinone oxidoreductase subunit 4 × 1 （Q56220） NADH-quinone oxidoreductase subunit 5 × 1 （Q56219） NADH-quinone oxidoreductase subunit 6 × 1 （Q56218） NADH-quinone oxidoreductase subunit 9 × 1 （Q56224） NADH-quinone oxidoreductase subunit 15 × 1 （Q5SKZ7） Putative uncharacterized protein TTHA1528 × 1 （Q5SI52） NADH-quinone oxidoreductase subunit 7 × 1 （Q56217） NADH-quinone oxidoreductase subunit 10 × 1 （Q56225） NADH-quinone oxidoreductase subunit 11 × 1 （Q56226） NADH-quinone oxidoreductase subunit 12 × 1 （Q56227） NADH-quinone oxidoreductase subunit 13 × 1 （Q56228） NADH-quinone oxidoreductase subunit 14 × 1 （Q56229） IRON/SULFUR CLUSTER × 7 FLAVIN MONONUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NQO8_THET8
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain H； PDBConstruct 1–365； UniProt 1–365 Author chain Q； PDBConstruct 1–365； UniProt 1–365

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id	4hea
Deposition date deposition_date	2012-10-03
Structure title title	Crystal structure of the entire respiratory complex I from Thermus thermophilus
Keywords keywords	NADH-quinone oxidoreductase, complex I, oxidoreductase, proton pump, membrane protein, NADH, menaquinone, cytoplasmic membrane; OXIDOREDUCTASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4hea__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4hea__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4hea__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	76.62 Å
Rg (electron density)	78.37 Å
Total Rg	77.90 Å
Atom count	36999
Residues	4770
Excluded volume	671340 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4hea__assembly_1__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4hea__assembly_2__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (19)

Entity 1 Entity 1 polymer

Description description	NADH-quinone oxidoreductase subunit 1
Molecular weight formula_weight	48693.7 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1,B
Atom count atom_count	73998

MTGPILSGLDPRFERTLYAHVGKEGSWTLDYYLRHGGYETAKRVLKEKTPDEVIEEVKRSGLRGRGGAGFPTGLKWSFMPKDDGKQHYLICNADESEPGSFKDRYILEDVPHLLIEGMILAGYAIRATVGYIYVRGEYRRAADRLEQAIKEARARGYLGKNLFGTDFSFDLHVHRGAGAYICGEETALMNSLEGLRANPRLKPPFPAQSGLWGKPTTINNVETLASVVPIMERGADWFAQMGTEQSKGMKLYQISGPVKRPGVYELPMGTTFRELIYEWAGGPLEPIQAIIPGGSSTPPLPFTEEVLDTPMSYEHLQAKGSMLGTGGVILIPERVSMVDAMWNLTRFYAHESCGKCTPCREGVAGFMVNLFAKIGTGQGEEKDVENLEALLPLIEGRSFCPLADAAVWPVKGSLRHFKDQYLALAREKRPVPRPSLWR

Entity 2 Entity 2 polymer

Description description	NADH-quinone oxidoreductase subunit 2
Molecular weight formula_weight	20309.2 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2,C

MGFFDDKQDFLEETFAKYPPEGRRAAIMPLLRRVQQEEGWIRPERIEEIARLVGTTPTEVMGVASFYSYYQFVPTGKYHLQVCATLSCKLAGAEELWDYLTETLGIGPGEVTPDGLFSVQKVECLGSCHTAPVIQVNDEPYVECVTRARLEALLAGLRAGKRLEEIELPGKCGHHVHEVEV

Entity 3 Entity 3 polymer

Description description	NADH-quinone oxidoreductase subunit 3
Molecular weight formula_weight	86656.2 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3,D

MVRVKVNDRIVEVPPGTSVMDAVFHAGYDVPLFCSEKHLSPIGACRMCLVRIGLPKKGPDGKPLLNEKGEPEIQWQPKLAASCVTAVADGMVVDTLSDVVREAQAGMVEFTLLNHPLDCPTCDKGGACELQDRTVEYGLYEKYYQKGPLELPVYTRFEFTRRHVDKHHPLSPFVILDRERCIHCKRCVRYFEEVPGDEVLDFIERGVHTFIGTMDFGLPSGFSGNITDICPVGALLDLTARFRARNWEMEETPTTCALCPVGCGITADTRSGELLRIRAREVPEVNEIWICDAGRFGHEWADQNRLKTPLVRKEGRLVEATWEEAFLALKEGLKEARGEEVGLYLAHDATLEEGLLASELAKALKTPHLDFQGRTAAPASLFPPASLEDLLQADFALVLGDPTEEAPILHLRLSEFVRDLKPPHRYNHGTPFADLQIKERMPRRTDKMALFAPYRAPLMKWAAIHEVHRPGEEREILLALLGDKEGSEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERARLLAERKGAKVLAMTPAANARGLEAMGVLPGAKGASWDEPGALYAYYGFVPPEEALKGKRFVVMHLSHLHPLAERYAHVVLPAPTFYEKRGHLVNLEGRVLPLSPAPIENGEAEGALQVLALLAEALGVRPPFRLHLEAQKALKARKVPEAMGRLSFRLKELRPKERKGAFYLRPTMWKAHQAVGKAQEAARAELWAHPETARAEALPEGAQVAVETPFGRVEARVVHREDVPKGHLYLSALGPAAGLRVEGRVLVPAGGEA

Entity 4 Entity 4 polymer

Description description	NADH-quinone oxidoreductase subunit 4
Molecular weight formula_weight	46428.0 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4,E

MREEFLEEIPLDAPPEEAKELRTEVMTLNVGPQHPSTHGVLRLMVTLSGEEVLEVVPHIGYLHTGFEKTMEHRTYLQNITYTPRMDYLHSFAHDLAYALAVEKLLGAVVPPRAETIRVILNELSRLASHLVFLGTGLLDLGALTPFFYAFRERETILDLFEWVTGQRFHHNYIRIGGVKEDLPEEFVPELKKLLEVLPHRIDEYEALFAESPIFYERARGVGVIPPEVAIDLGLTGGSLRASGVNYDVRKAYPYSGYETYTFDVPLGERGDVFDRMLVRIREMRESVKIIKQALERLEPGPVRDPNPQITPPPRHLLETSMEAVIYHFKHYTEGFHPPKGEVYVPTESARGELGYYIVSDGGSMPYRVKVRAPSFVNLQSLPYACKGEQVPDMVAIIASLDPVMGDVDR

Entity 5 Entity 5 polymer

Description description	NADH-quinone oxidoreductase subunit 5
Molecular weight formula_weight	23893.3 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5,F

MRLERVLEEARAKGYPIEDNGLGNLWVVLPRERFKEEMAHYKAMGFNFLADIVGLDYLTYPDPRPERFAVVYELVSLPGWKDGDGSRFFVRVYVPEEDPRLPTVTDLWGSANFLEREVYDLFGIVFEGHPDLRKILTPEDLEGHPLRKDYPLGETPTLFREGRYIIPAEFRAALTGKDPGLTFYKGGSRKGYRSLWADLKKAREVKG

Entity 6 Entity 6 polymer

Description description	NADH-quinone oxidoreductase subunit 6
Molecular weight formula_weight	20262.6 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6,G

MALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDLARFGSEVFRASPRQADVMIVAGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNNYAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRGQAYNERGERLPPVAAWKRTRG

Entity 7 Entity 7 polymer

Description description	NADH-quinone oxidoreductase subunit 9
Molecular weight formula_weight	20106.3 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	9,O

MTLKALAQSLGITLKYLFSKPVTVPYPDAPVALKPRFHGRHVLTRHPNGLEKCIGCSLCAAACPAYAIYVEPAENDPENPVSAGERYAKVYEINMLRCIFCGLCEEACPTGAIVLGYDFEMADYEYSDLVYGKEDMLVDVVGTKPQRREAKRTGKPVKVGYVVPYVRPELEGFKAPTEGGKR

Entity 8 Entity 8 polymer

Description description	NADH-quinone oxidoreductase subunit 15
Molecular weight formula_weight	14812.1 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7,I

MSASSERELYEAWVELLSWMREYAQAKGVRFEKEADFPDFIYRMERPYDLPTTIMTASLSDGLGEPFLLADVSPRHAKLKRIGLRLPRAHIHLHAHYEPGKGLVTGKIPLTKERFFALADRAREALAFA

Entity 9 Entity 9 polymer

Description description	Putative uncharacterized protein TTHA1528
Molecular weight formula_weight	14201.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W,X

MVRVGMRAAPRVSLEALKAALGGLKLSEAKVYLITDWQDKRDQARYALLLHTGKKDLLVPDAFGPAFPGGEEALSELVGLLLAQGARRFYEAVVSPGEMTALLDLPPEELLKRVMAIANPTDPGIYLKRAA

Entity 10 Entity 10 polymer

Description description	NADH-quinone oxidoreductase subunit 7
Molecular weight formula_weight	13154.7 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,P

MAPIQEYVGTLIYVGVALFIGVAALLVGALLGPKKPGRAKLMPYESGNDPAGEVKRFPVHFYVVAMLFILFDVEVAFLWPYAVSAGGLGLYGFLGVLAFTLLLFVGFLYEWWKGVMRWH

Entity 11 Entity 11 polymer

Description description	NADH-quinone oxidoreductase subunit 10
Molecular weight formula_weight	18563.3 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,R

MSLLEGLALFLLLLSGVLVVTLRNAIHAALALILNFLVLAGVYVALDARFLGFIQVIVYAGAIVVLFLFVIMLLFAAQGEIGFDPLVRSRPLAALLALGVAGILAAGLWGLDLAFTQDLKGGLPQALGPLLYGDWLFVLLAVGFLLMAATVVAVALVEPGKASRAKEAEKREEVAR

Entity 12 Entity 12 polymer

Description description	NADH-quinone oxidoreductase subunit 11
Molecular weight formula_weight	10002.8 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,S

MSYLLTSALLFALGVYGVLTRRTAILVFLSIELMLNAANLSLVGFARAYGLDGQVAALMVIAVAAAEVAVGLGLIVAIFRHRESTAVDDLSELRG

Entity 13 Entity 13 polymer

Description description	NADH-quinone oxidoreductase subunit 12
Molecular weight formula_weight	65189.9 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,T

MALLGTILLPLLGFALLGLFGKRMREPLPGVLASGLVLASFLLGAGLLLSGGARFQAEWLPGIPFSLLLDNLSGFMLLIVTGVGFLIHVYAIGYMGGDPGYSRFFAYFNLFIAMMLTLVLADSYPVMFIGWEGVGLASFLLIGFWYKNPQYADSARKAFIVNRIGDLGFMLGMAILWALYGTLSISELKEAMEGPLKNPDLLALAGLLLFLGAVGKSAQIPLMVWLPDAMAGPTPVSALIHAATMVTAGVYLIARSSFLYSVLPDVSYAIAVVGLLTAAYGALSAFGQTDIKKIVAYSTISQLGYMFLAAGVGAYWVALFHVFTHAFFKALLFLASGSVIHALGGEQDVRKMGGLWKHLPQTRWHALIGALALGGLPLLSGFWSKDAILAATLTYPFGGVGFYVGALLVAVLTAMYAMRWFVLVFLGEERGHHHPHEAPPVMLWPNHLLALGSVLAGYLALPHPLPNVLEPFLKPALAEVEAHHLSLGAEWGLIALSAAVALLGLWAGFVFFQRKVFPAWYLAFEAASREAFYVDRAYNALIVNPLKALAEALFYGDRGLLSGYFGLGGAARSLGQGLARLQTGYLRVYALLFVLGALLLLGVMRW

Entity 14 Entity 14 polymer

Description description	NADH-quinone oxidoreductase subunit 13
Molecular weight formula_weight	49247.1 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,U

MVVLAVLLPVVFGALLLLGLPRALGVLGAGLSFLLNLYLFLTHPGGVAHAFQAPLLPGAGVYWAFGLDGLSALFFLTIALTVFLGALVARVEGRFLGLALLMEGLLLGLFAARDLLVFYVFFEAALIPALLMLYLYGGEGRTRALYTFVLFTLVGSLPMLAAVLGARLLSGSPTFLLEDLLAHPLQEEAAFWVFLGFALAFAIKTPLFPLHAWLPPFHQENHPSGLADALGTLYKVGVFAFFRFAIPLAPEGFAQAQGLLLFLAALSALYGAWVAFAAKDFKTLLAYAGLSHMGVAALGVFSGTPEGAMGGLYLLAASGVYTGGLFLLAGRLYERTGTLEIGRYRGLAQSAPGLAALALILFLAMVGLPGLSGFPGEFLTLLGAYKASPWLAALAFLSVIASAAYALTAFQKTFWEEGGSGVKDLAGAEWGFALLSVLALLLMGVFPGYFARGLHPLAEAFAKLLGGGA

Entity 15 Entity 15 polymer

Description description	NADH-quinone oxidoreductase subunit 14
Molecular weight formula_weight	44463.9 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,V

MTLAILAVFSVALTLLGFVLPPQGVKRATLLGLALALASLLLTWGKPFAFGPYAVDGVSQVFTLLALLGALWTVGLVRSGRFEFYLLVLYAALGMHLLASTRHLLLMLVALEALSLPLYALATWRRGQGLEAALKYFLLGALAAAFFLYGAALFYGATGSLVLGAPGEGPLYALALGLLLVGLGFKAALAPFHFWTPDVYQGSPTPVVLFMATSVKAAAFAALLRVAAPPEALALLVALSVVVGNLAALAQKEAKRLLAYSSIAHAGYMALALYTGNAQALGFYLLTYVLATGLAFAVLSQISPDRVPLEALRGLYRKDPLLGLAFLVAMLSLLGLPPLAGFWGKYLAFAEAARAGAWGVLVLALVTSAVSAYYYLGLGLAVFARPEETPFRPGPPWARAAVVAAGVLLLALGLLPGLVLPALAAGG

Entity 16 Entity 16 polymer

Description description	NADH-quinone oxidoreductase subunit 8
Molecular weight formula_weight	41034.5 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,Q

MTWSYPVDPYWMVALKALLVVVGLLTAFAFMTLIERRLLARFQVRMGPNRVGPFGLLQPLADAIKSIFKEDIVVAQADRFLFVLAPLISVVFALLAFGLIPFGPPGSFFGYQPWVINLDLGILYLFAVSELAVYGIFLSGWASGSKYSLLGSLRSSASLISYELGLGLALLAPVLLVGSLNLNDIVNWQKEHGWLFLYAFPAFLVYLIASMAEAARTPFDLPEAEQELVGGYHTEYSSIKWALFQMAEYIHFITASALIPTLFLGGWTMPVLEVPYLWMFLKIAFFLFFFIWIRATWFRLRYDQLLRFGWGFLFPLALLWFLVTALVVALDLPRTYLLYLSALSFLVLLGAVLYTPKPARKGGGA

Entity 17 Entity 17 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	14

Entity 18 Entity 18 non-polymer

Description description	FLAVIN MONONUCLEOTIDE
Molecular weight formula_weight	456.3 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 19 Entity 19 non-polymer

Description description	FE2/S2 (INORGANIC) CLUSTER
Molecular weight formula_weight	175.8 kDa
Source method src_method	syn
Copy count entity_count	4

▼

6. Fold Classification (SCOP + CATH) 30 domains

CATH v4.4 (30 domains)

Domain ID domain_id	4hea101
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	1450 —

Domain ID domain_id	4hea102
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	11540 — NADH-ubiquinone oxidoreductase 51kDa subunit

Domain ID domain_id	4hea103
Class class	3 — Alpha Beta
Architecture architecture	10 — Roll
Topology topology	20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily	600 —

Domain ID domain_id	4hea104
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily	230 — NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

Domain ID domain_id	4hea201
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	1590 — NADH-quinone oxidoreductase subunit E

Domain ID domain_id	4hea202
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	30 — Glutaredoxin
Homologous superfamily homologous superfamily	10 — Glutaredoxin

Domain ID domain_id	4hea400
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	645 — Cytochrome-c3 Hydrogenase; chain B
Homologous superfamily homologous superfamily	10 — Cytochrome-c3 Hydrogenase, chain B

Domain ID domain_id	4hea600
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	12280 —

Domain ID domain_id	4hea700
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	920 — Metal Transport, Frataxin; Chain A
Homologous superfamily homologous superfamily	80 — NADH-quinone oxidoreductase, subunit 15

Domain ID domain_id	4hea900
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3270 —

Domain ID domain_id	4heaA00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	1610 — NADH:ubiquinone/plastoquinone oxidoreductase, chain 3

Domain ID domain_id	4heaB01
Class class	6 — Special
Architecture architecture	10 — Helix non-globular
Topology topology	250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	1450 —

Domain ID domain_id	4heaB02
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	11540 — NADH-ubiquinone oxidoreductase 51kDa subunit

Domain ID domain_id	4heaB03
Class class	3 — Alpha Beta
Architecture architecture	10 — Roll
Topology topology	20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily	600 —

Domain ID domain_id	4heaB04
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily	230 — NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

Domain ID domain_id	4heaC01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily	1590 — NADH-quinone oxidoreductase subunit E

Domain ID domain_id	4heaC02
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	30 — Glutaredoxin
Homologous superfamily homologous superfamily	10 — Glutaredoxin

Domain ID domain_id	4heaE00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	645 — Cytochrome-c3 Hydrogenase; chain B
Homologous superfamily homologous superfamily	10 — Cytochrome-c3 Hydrogenase, chain B

Domain ID domain_id	4heaG00
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	12280 —

Domain ID domain_id	4heaI00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	920 — Metal Transport, Frataxin; Chain A
Homologous superfamily homologous superfamily	80 — NADH-quinone oxidoreductase, subunit 15

Domain ID domain_id	4heaJ00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1200 — NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ

Domain ID domain_id	4heaK00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	3510 —

Domain ID domain_id	4heaL02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	2700 —

Domain ID domain_id	4heaO00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3270 —

Domain ID domain_id	4heaP00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	1610 — NADH:ubiquinone/plastoquinone oxidoreductase, chain 3

Domain ID domain_id	4heaR00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1200 — NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ

Domain ID domain_id	4heaS00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	3510 —

Domain ID domain_id	4heaT02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily	2700 —

Domain ID domain_id	4heaW00
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	1530 — hypothetical protein tt1805
Homologous superfamily homologous superfamily	10 — TTHA1528-like

Domain ID domain_id	4heaX00
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	1530 — hypothetical protein tt1805
Homologous superfamily homologous superfamily	10 — TTHA1528-like

▶

Unit-cell length a length_a	96.280 Å
Unit-cell length b length_b	340.890 Å
Unit-cell length c length_c	263.300 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	100.57 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	3.303 Å
Low-resolution limit resolution_low	39.998 Å
R factor r_factor	0.2034
R_work r_work	0.2024
R_free r_free	0.2393

Crystal structure of the entire respiratory complex I from Thermus thermophilus

1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH-quinone oxidoreductase subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 15

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Putative uncharacterized protein TTHA1528

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

NADH-quinone oxidoreductase subunit 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer