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2ybb

Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876)

Method: ELECTRON MICROSCOPY Dmax: 259.1 Å Quality: EXCELLENT
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1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1

OrganismNot specified

UniProt Q56222

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 1； UniProt 1–438 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 1 1–438（438 aa） Fragment：Hydrophilic domain
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–438（438 aa） Fragment：Hydrophilic domain
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain J 1–438（438 aa） Fragment：Hydrophilic domain
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain S 1–438（438 aa） Fragment：Hydrophilic domain
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain J 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain S 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain B 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 1 1–438（438 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO1_THET8
Isoform —
PDB entities 1
Chains and sequence ranges Author chain 1； PDBConstruct 1–438； UniProt 1–438

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2

OrganismNot specified

UniProt Q56221

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 2； UniProt 1–181 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain K 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain T 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain K 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain T 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain C 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 2 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO2_THET8
Isoform —
PDB entities 2
Chains and sequence ranges Author chain 2； PDBConstruct 1–181； UniProt 1–181

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3

OrganismNot specified

UniProt Q56223

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 3； UniProt 1–783 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain L 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain U 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain L 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain U 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 3 1–783（783 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO3_THET8
Isoform —
PDB entities 3
Chains and sequence ranges Author chain 3； PDBConstruct 1–783； UniProt 1–783

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4

OrganismNot specified

UniProt Q56220

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 4； UniProt 1–409 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain M 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain V 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain D 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain M 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain V 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain E 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 4 1–409（409 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO4_THET8
Isoform —
PDB entities 4
Chains and sequence ranges Author chain 4； PDBConstruct 1–409； UniProt 1–409

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5

OrganismNot specified

UniProt Q56219

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 5； UniProt 1–207 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain N 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain W 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain N 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain W 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
5B3P Nqo5 of the trypsin-resistant fragment (1-134) in P212121 form Deposited 2016-03-09 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–134（134 aa） Fragment：UNP residues 1-134
Not recorded CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；200mM calcium chloride, 25% PEG 4000
Resolution 1.65 Å R-free 0.209
5B3Q Nqo5 of the trypsin-resistant fragment (1-134) in P63 form Deposited 2016-03-09 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–134（134 aa） Fragment：UNP residues 1-134
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；10% PEG 1000, 10% PEG 8000
Resolution 3.00 Å R-free 0.234
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain F 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 5 1–207（207 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

18 other PDB entries and 34 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO5_THET8
Isoform —
PDB entities 5
Chains and sequence ranges Author chain 5； PDBConstruct 1–207； UniProt 1–207

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6

OrganismNot specified

UniProt Q56218

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 6； UniProt 1–181 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain F 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain O 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain X 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain F 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain F 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain F 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain O 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain X 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain G 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 6 1–181（181 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO6_THET8
Isoform —
PDB entities 6
Chains and sequence ranges Author chain 6； PDBConstruct 1–181； UniProt 1–181

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15

OrganismNot specified

UniProt Q5SKZ7

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 7； UniProt 1–129 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain H 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain H 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain H 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain Q 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain Z 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain I 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 7 1–129（129 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

15 other PDB entries and 28 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO15_THET8
Isoform —
PDB entities 7
Chains and sequence ranges Author chain 7； PDBConstruct 1–129； UniProt 1–129

NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9

OrganismNot specified

UniProt Q56224

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain 8； UniProt 1–182 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain G 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain P 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
2FUG Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus Deposited 2006-01-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain Y 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1M HEPES pH 7.5, 0.4-0.5M NaCl, 0.1M CaCl2 and 8-10% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.298
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 7 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3I9V Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 2 mol/ASU Deposited 2009-07-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain G 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 MN MANGANESE (II) ION × 5 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M MnCl2, 6% PEG4000, 2.5% PEG400, 20 mM NAD+, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.283
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAM Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain G 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.05 M NaCl, 0.1 M MgCl2, 7% PEG4000, 3 mM NADH, 5 mM sodium dithionite, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.10 Å R-free 0.262
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain G 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain P 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3IAS Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution Deposited 2009-07-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain Y 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；295 K；0.1 M HEPES pH 7.5, 0.4 M NaCl, 0.1 M CaCl2, 8% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.15 Å R-free 0.270
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
3M9S Crystal structure of respiratory complex I from Thermus thermophilus Deposited 2010-03-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；16% PEG 4000, 100 mM Bis-Tris, 100 mM KCl, 100 mM glutaric acid and 2.04 mM n-octyl- -maltoside fluorinated, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 4.50 Å
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
4HEA Crystal structure of the entire respiratory complex I from Thermus thermophilus Deposited 2012-10-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 19% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 2.2 mM FOS-CHOLINE-8 fluorinated , VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 24% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201, VAPOR DIFFUSION, SITTING DROP, temperature 295K
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 3.30 Å R-free 0.239
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I0D Respiratory complex I from Thermus thermophilus with bound Decyl-Ubiquinone Deposited 2018-10-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 DCQ 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 50 mM NDSB-201
Resolution 3.60 Å R-free 0.225
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6I1P Respiratory complex I from Thermus thermophilus with bound NADH Deposited 2018-10-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 23% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.01 mM n-tetradecyl-beta-D-maltopyranoside
Resolution 3.21 Å R-free 0.231
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8O Respiratory complex I from Thermus thermophilus with bound Piericidin A Deposited 2018-12-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQH Piericidin A × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 24% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 0.59 mM n-undecyl-beta-maltoside
Resolution 3.60 Å R-free 0.235
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8W Respiratory complex I from Thermus thermophilus with bound Aureothin. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQW Aureothin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 25% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 7.6 mM 4-cyclohexyl-1-butyl-beta-D-maltoside
Resolution 3.40 Å R-free 0.234
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Q8X Respiratory complex I from Thermus thermophilus with bound Pyridaben. Deposited 2018-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 HQK Pyridaben × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；296 K；100 mM Bis-Tris pH 6.0, 21% (w/v) PEG 4000, 100 mM KCl, 100 mM glutaric acid and 1.02 mM octyl-maltoside fluorinated
Resolution 3.51 Å R-free 0.232
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6Y11 Respiratory complex I from Thermus thermophilus Deposited 2020-02-10 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain O 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；100 mM Bis-Tris pH 6.0, 26% (w/v) polyethylene glycol (PEG) 4000, 100 mM KCl, 100 mM glutaric acid pH 6.0 and 0.6% DDM
Resolution 3.11 Å R-free 0.229
6ZIY Respiratory complex I from Thermus thermophilus, NADH dataset, major state Deposited 2020-06-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.25 Å
6ZJL Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.30 Å
6ZJN Respiratory complex I from Thermus thermophilus, NADH dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.10 Å
6ZJY Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state Deposited 2020-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 15 PDB declaration: pentadecameric
Chain 9 1–182（182 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 7 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.50 Å

16 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name NQO9_THET8
Isoform —
PDB entities 8
Chains and sequence ranges Author chain 8； PDBConstruct 1–182； UniProt 1–182

CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL

OrganismNot specified

UniProt P31800

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain A； UniProt 35–480 Chain a； UniProt 35–480 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Chain M 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 1–480（480 aa） Fragment：core protein 1
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa） Fragment：core protein 1
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 34–480（447 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa） Fragment：core protein 1
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa） Fragment：Core1
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain A 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain N 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain N 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain A 35–480（446 aa）
Chain M 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain c 35–480（446 aa）
Chain l 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 36–479（444 aa）
Chain N 36–479（444 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 1–480（480 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 1–480（480 aa）
Chain N 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 1–480（480 aa）
Chain N 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain A 1–480（480 aa）
Chain N 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 36–479（444 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain A 36–480（445 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 36–479（444 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 37–480（444 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 36–479（444 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain k 1–480（480 aa）
Chain w 1–480（480 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain k 1–480（480 aa）
Chain w 1–480（480 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain k 1–480（480 aa）
Chain w 1–480（480 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A1 1–480（480 aa）
Chain M1 1–480（480 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain A 36–480（445 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 1–480（480 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Chain N 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain A 35–480（446 aa）
Chain L 35–480（446 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

46 other PDB entries and 51 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR1_BOVIN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain A； PDBConstruct 1–446； UniProt 35–480 Author chain a； PDBConstruct 1–446； UniProt 35–480

CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL

OrganismNot specified

UniProt P23004

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain B； UniProt 15–453 Chain b； UniProt 15–453 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain B 32–453（422 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Chain N 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 15–453（439 aa）
Chain O 15–453（439 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 15–453（439 aa）
Chain O 15–453（439 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain B 31–453（423 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 1–453（453 aa） Fragment：core protein 2
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa） Fragment：core protein 2
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa） Fragment：core protein 2
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 15–453（439 aa）
Chain O 15–453（439 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa） Fragment：Core2
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain B 32–453（422 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain O 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain O 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain B 15–453（439 aa）
Chain N 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain m 15–453（439 aa）
Chain n 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 31–453（423 aa）
Chain O 31–453（423 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 1–453（453 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 1–453（453 aa）
Chain O 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 1–453（453 aa）
Chain O 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain B 1–453（453 aa）
Chain O 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 36–453（418 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain B 36–453（418 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 34–453（420 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 34–453（420 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 34–453（420 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain l 1–453（453 aa）
Chain x 1–453（453 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain l 1–453（453 aa）
Chain x 1–453（453 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain l 1–453（453 aa）
Chain x 1–453（453 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B1 1–453（453 aa）
Chain N1 1–453（453 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain B 36–453（418 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Chain O 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 15–453（439 aa）
Chain O 15–453（439 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 1–453（453 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 29–453（425 aa）
Chain O 29–453（425 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain B 29–453（425 aa）
Chain M 29–453（425 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

47 other PDB entries and 52 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR2_BOVIN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain B； PDBConstruct 1–439； UniProt 15–453 Author chain b； PDBConstruct 1–439； UniProt 15–453

CYTOCHROME B

OrganismNot specified

UniProt P00157

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain C； UniProt 1–379 Chain c； UniProt 1–379 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Chain O 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain C 2–379（378 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa） Fragment：cytochrome b
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa） Fragment：cytochrome b
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa） Fragment：cytochrome b
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa） Fragment：cytochrome b
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain C 1–379（379 aa）
Chain O 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain b 1–379（379 aa）
Chain o 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 8–379（372 aa）
Chain P 8–379（372 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 1–379（379 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 2–379（378 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain C 2–379（378 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 2–379（378 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 2–379（378 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 2–379（378 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain m 1–379（379 aa）
Chain y 1–379（379 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain m 1–379（379 aa）
Chain y 1–379（379 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain m 1–379（379 aa）
Chain y 1–379（379 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C1 1–379（379 aa）
Chain O1 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain C 1–379（379 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Chain P 1–379（379 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 1–379（379 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 2–379（378 aa）
Chain P 2–379（378 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain C 2–379（378 aa）
Chain N 2–379（378 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

45 other PDB entries and 50 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CYB_BOVIN
Isoform —
PDB entities 11
Chains and sequence ranges Author chain C； PDBConstruct 1–379； UniProt 1–379 Author chain c； PDBConstruct 1–379； UniProt 1–379

CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL

OrganismNot specified

UniProt P00125

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain D； UniProt 85–325 Chain d； UniProt 85–325 Fragment：RESIDUES 85-325 NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Chain P 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 1–241（241 aa）
Chain Q 1–241（241 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 1–241（241 aa）
Chain Q 1–241（241 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain D 167–241（75 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa） Fragment：cytochrome c1
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa） Fragment：cytochrome c1
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa） Fragment：iron sulfur protein
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 1–241（241 aa）
Chain Q 1–241（241 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–241（241 aa） Fragment：cytochrome c1
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain D 1–241（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 61–325（265 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain Q 61–325（265 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain Q 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain D 85–325（241 aa）
Chain P 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain d 85–325（241 aa）
Chain p 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 86–325（240 aa）
Chain Q 86–325（240 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 1–325（325 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 1–325（325 aa）
Chain Q 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 1–325（325 aa）
Chain Q 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain D 1–325（325 aa）
Chain Q 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 86–324（239 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain D 86–324（239 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 86–324（239 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 86–324（239 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 86–324（239 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain o 1–325（325 aa）
Chain z 1–325（325 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain o 85–325（241 aa）
Chain z 85–325（241 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain o 1–325（325 aa）
Chain z 1–325（325 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain D1 1–325（325 aa）
Chain P1 1–325（325 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain D 86–324（239 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Chain Q 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Chain Q 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 1–325（325 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Chain Q 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain D 85–325（241 aa）
Chain O 85–325（241 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

47 other PDB entries and 52 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CY1_BOVIN
Isoform —
PDB entities 12
Chains and sequence ranges Author chain D； PDBConstruct 1–241； UniProt 85–325 Author chain d； PDBConstruct 1–241； UniProt 85–325

CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL

OrganismNot specified

UniProt P13272

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain E； UniProt 79–274 Chain I； UniProt 14–78 Chain e； UniProt 79–274 Chain i； UniProt 14–78 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain A 1–4（4 aa）
Chain E 79–274（196 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Chain Q 79–274（196 aa）
Chain U 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Chain R 79–274（196 aa）
Chain V 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Chain R 79–274（196 aa）
Chain V 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain E 79–274（196 aa）
Chain I 21–48（28 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1RIE STRUCTURE OF A WATER SOLUBLE FRAGMENT OF THE RIESKE IRON-SULFUR PROTEIN OF THE BOVINE HEART MITOCHONDRIAL CYTOCHROME BC1-COMPLEX Deposited 1996-02-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 146–274（129 aa） Fragment：SOLUBLE FRAGMENT
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；pH 6.0
Resolution 1.50 Å R-free 0.211
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa） Fragment：iron sulfur protein
Chain I 1–78（78 aa） Fragment：subunit 9
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa） Fragment：iron sulfur protein
Chain I 1–78（78 aa） Fragment：subunit 9
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa） Fragment：cytochrome c1
Chain I 1–78（78 aa） Fragment：subunit 7
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Chain R 79–274（196 aa）
Chain V 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa） Fragment：Iron-sulfur protein
Chain I 1–78（78 aa） Fragment：Iron-sulfur protein signal sequence
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain E 79–274（196 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 1–274（274 aa）
Chain I 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain R 1–274（274 aa）
Chain V 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 1–274（274 aa）
Chain I 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain R 1–274（274 aa）
Chain V 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain I 1–78（78 aa）
Chain U 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain e 79–274（196 aa）
Chain i 1–78（78 aa）
Chain q 79–274（196 aa）
Chain u 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 1–274（274 aa）
Chain I 1–274（274 aa）
Chain R 1–274（274 aa）
Chain V 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 32–78（47 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 1–274（274 aa）
Chain R 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 1–274（274 aa）
Chain I 62–77（16 aa）
Chain R 1–274（274 aa）
Chain V 62–77（16 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain E 1–274（274 aa）
Chain R 1–274（274 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A1 79–274（196 aa）
Chain B5 1–78（78 aa）
Chain p 79–274（196 aa）
Chain v 1–78（78 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A0 79–274（196 aa）
Chain B1 1–78（78 aa）
Chain p 79–274（196 aa）
Chain v 1–78（78 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A0 79–274（196 aa）
Chain B3 1–78（78 aa）
Chain p 79–274（196 aa）
Chain v 1–78（78 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain E1 79–274（196 aa）
Chain I1 1–78（78 aa）
Chain Q1 79–274（196 aa）
Chain U1 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain E 79–274（196 aa）
Chain I 33–78（46 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–78（78 aa）
Chain R 79–274（196 aa）
Chain V 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–54（54 aa）
Chain R 79–274（196 aa）
Chain V 1–54（54 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 1–274（274 aa）
Chain I 1–274（274 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Chain R 79–274（196 aa）
Chain V 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain E 79–274（196 aa）
Chain I 1–57（57 aa）
Chain P 79–274（196 aa）
Chain T 1–57（57 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

48 other PDB entries and 53 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name UCRI_BOVIN
Isoform —
PDB entities 13, 17
Chains and sequence ranges Author chain E； PDBConstruct 1–196； UniProt 79–274 Author chain e； PDBConstruct 1–196； UniProt 79–274 Author chain I； PDBConstruct 1–65； UniProt 14–78 Author chain i； PDBConstruct 1–65； UniProt 14–78

CYTOCHROME B-C1 COMPLEX SUBUNIT 7

OrganismNot specified

UniProt P00129

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain F； UniProt 2–111 Chain f； UniProt 2–111 Mutation：YES NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain F 1–109（109 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Chain R 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 1–110（110 aa）
Chain S 1–110（110 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 1–110（110 aa）
Chain S 1–110（110 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain F 8–110（103 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa） Fragment：subunit 6
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa） Fragment：subunit 8
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 1–110（110 aa）
Chain S 1–110（110 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–110（110 aa） Fragment：subunit 6
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain F 1–109（109 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 2–111（110 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain f 2–111（110 aa）
Chain r 2–111（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–111（111 aa）
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 1–111（111 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 1–111（111 aa）
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 1–111（111 aa）
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain F 1–111（111 aa）
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 12–110（99 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 2–111（110 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain F 12–111（100 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 12–110（99 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 12–110（99 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 12–110（99 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A2 1–111（111 aa）
Chain q 1–111（111 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A1 1–111（111 aa）
Chain q 1–111（111 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A1 1–111（111 aa）
Chain q 1–111（111 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain F1 1–111（111 aa）
Chain R1 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain F 12–110（99 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 2–111（110 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 2–111（110 aa）
Chain S 2–111（110 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–111（111 aa）
Chain S 1–111（111 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 1–111（111 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 7–111（105 aa）
Chain S 7–111（105 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain F 7–111（105 aa）
Chain Q 7–111（105 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

45 other PDB entries and 50 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR7_BOVIN
Isoform —
PDB entities 14
Chains and sequence ranges Author chain F； PDBConstruct 1–110； UniProt 2–111 Author chain f； PDBConstruct 1–110； UniProt 2–111

CYTOCHROME B-C1 COMPLEX SUBUNIT 8

OrganismNot specified

UniProt P13271

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain G； UniProt 2–82 Chain g； UniProt 2–82 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Chain S 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 1–81（81 aa）
Chain T 1–81（81 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 1–81（81 aa）
Chain T 1–81（81 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain G 1–70（70 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa） Fragment：subunit 7
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa） Fragment：subunit 7
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa） Fragment：subunit 6
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 1–81（81 aa）
Chain T 1–81（81 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–81（81 aa） Fragment：subunit 7
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain G 1–81（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain G 2–82（81 aa）
Chain S 2–82（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–81（80 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain g 2–82（81 aa）
Chain s 2–82（81 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–82（82 aa）
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 1–82（82 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 1–82（82 aa）
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 1–82（82 aa）
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain G 1–82（82 aa）
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 3–76（74 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–81（80 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain G 3–76（74 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 2–76（75 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 3–76（74 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 3–76（74 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A3 1–82（82 aa）
Chain r 1–82（82 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A2 1–82（82 aa）
Chain r 1–82（82 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A2 1–82（82 aa）
Chain r 1–82（82 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain G1 1–82（82 aa）
Chain S1 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain G 3–76（74 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–81（80 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–81（80 aa）
Chain T 2–81（80 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–82（82 aa）
Chain T 1–82（82 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 1–82（82 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–81（80 aa）
Chain T 2–81（80 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain G 2–76（75 aa）
Chain R 2–76（75 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

47 other PDB entries and 52 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR8_BOVIN
Isoform —
PDB entities 15
Chains and sequence ranges Author chain G； PDBConstruct 1–81； UniProt 2–82 Author chain g； PDBConstruct 1–81； UniProt 2–82

CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL

OrganismNot specified

UniProt P00126

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain H； UniProt 14–91 Chain h； UniProt 14–91 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Chain T 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–78（78 aa）
Chain U 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–78（78 aa）
Chain U 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain H 18–77（60 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa） Fragment：subunit 8
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa） Fragment：subunit 8
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa） Fragment：subunit 10
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–78（78 aa）
Chain U 1–78（78 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–78（78 aa） Fragment：subunit 8
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain H 1–78（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain H 14–91（78 aa）
Chain T 14–91（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 14–91（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain h 14–91（78 aa）
Chain t 14–91（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 1–91（91 aa）
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 1–91（91 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–91（91 aa）
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 1–91（91 aa）
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain H 1–91（91 aa）
Chain U 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 27–90（64 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 14–91（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain H 27–90（64 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 27–90（64 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 26–90（65 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 26–90（65 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B7 1–91（91 aa）
Chain s 1–91（91 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B3 1–91（91 aa）
Chain s 1–91（91 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B5 1–91（91 aa）
Chain s 1–91（91 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain H1 1–91（91 aa）
Chain T1 1–91（91 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain H 26–90（65 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 14–91（78 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 14–91（78 aa）
Chain U 14–91（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 14–91（78 aa）
Chain U 14–91（78 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 25–91（67 aa）
Chain U 25–91（67 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain H 25–91（67 aa）
Chain S 25–91（67 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

46 other PDB entries and 51 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR6_BOVIN
Isoform —
PDB entities 16
Chains and sequence ranges Author chain H； PDBConstruct 1–78； UniProt 14–91 Author chain h； PDBConstruct 1–78； UniProt 14–91

CYTOCHROME B-C1 COMPLEX SUBUNIT 9

OrganismNot specified

UniProt P00130

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain J； UniProt 2–63 Chain j； UniProt 2–63 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BCC CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 U10 UBIQUINONE-10 × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 BOG octyl beta-D-glucopyranoside × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000
Resolution 3.16 Å R-free 0.310
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Chain V 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1PP9 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 1–62（62 aa）
Chain W 1–62（62 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 AZI AZIDE ION × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 9 PO4 PHOSPHATE ION × 2 GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE, pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.287
1PPJ Bovine cytochrome bc1 complex with stigmatellin and antimycin Deposited 2003-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 1–62（62 aa）
Chain W 1–62（62 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 9 PO4 PHOSPHATE ION × 5 AZI AZIDE ION × 5 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 ANY 2-METHYL-BUTYRIC ACID 3-(3-FORMYLAMINO-2-HYDROXY-BENZOYLAMINO)-8-HEPTYL-2,6-DIMETHYL-4,9-DIOXO-[1,5]DIOXONAN-7-YL ESTER × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.7, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 6.70
Resolution 2.10 Å R-free 0.260
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain J 4–62（59 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa） Fragment：subunit 10
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa） Fragment：subunit 10
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa） Fragment：subunit 11
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2A06 Bovine cytochrome bc1 complex with stigmatellin bound Deposited 2005-06-16 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 1–62（62 aa）
Chain W 1–62（62 aa）
Not recorded JZR hexyl beta-D-glucopyranoside × 6 PO4 PHOSPHATE ION × 11 AZI AZIDE ION × 4 UNL UNKNOWN LIGAND × 74 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SMA STIGMATELLIN A × 2 UQ Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer × 2 CDL CARDIOLIPIN × 4 GOL GLYCEROL × 7 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.65；277 K；PEG-3350, JEFFAMINE, GLYCEROL, CACODYLATE, HEXYLGLUCOSIDE , pH 6.65, VAPOR DIFFUSION, SITTING DROP, temperature 277K
Resolution 2.10 Å R-free 0.258
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–62（62 aa） Fragment：subunit 10
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
3BCC STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN Deposited 1998-03-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-MERIC
Chain J 1–62（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 SIG STIGMATELLIN × 2 AMY ANTIMYCIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.7；20MM KMES PH6.7, 75MM NACL, 10% GLYCEROL, AND 6% PEG4000, INHIBITOR WAS ADDED FROM ETHANOLIC SOLUTION
Resolution 3.70 Å R-free 0.321
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6T Cytochrome bc1 bound to the 4(1H)-pyridone GW844520 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 4X9 3-chloro-2,6-dimethyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；50 MM POTASSIUM PHOSPHATE BUFFER PH 6.8, 12% P4000, 1.4% HECAMEG
Resolution 3.57 Å R-free 0.252
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
4D6U Cytochrome bc1 bound to the 4(1H)-pyridone GSK932121 Deposited 2014-11-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 1 PO4 PHOSPHATE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 CDL CARDIOLIPIN × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；SITTING DROP VAPOUR DIFFUSION 50 MM KPI, PH 6.8, 100 MM NACL, 3 MM NAN3, 10 - 13 % PEG4000,1.4% HECAMEG
Resolution 4.09 Å R-free 0.271
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain J 2–63（62 aa）
Chain L 2–63（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–64（63 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain j 2–63（62 aa）
Chain v 2–63（62 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5NMI Cytochrome bc1 bound to the inhibitor MJM170 Deposited 2017-04-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–64（64 aa）
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MJM (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 CDL CARDIOLIPIN × 6 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.8；277 K；10 % PEG4000, HECAMEG
Resolution 3.50 Å R-free 0.268
5OKD Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911. Deposited 2017-07-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 1–64（64 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 9XE 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 HEC HEME C × 1 PO4 PHOSPHATE ION × 6 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.10 Å R-free 0.240
6FO0 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121 Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 1–64（64 aa）
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 G8U 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4-[3-(trifluoromethoxy)phenoxy]phenyl}pyridin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6FO2 CryoEM structure of bovine cytochrome bc1 with no ligand bound Deposited 2018-02-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 1–64（64 aa）
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.40 Å
6FO6 CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial inhibitor SCR0911 Deposited 2018-02-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain J 1–64（64 aa）
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DY2 7-methoxy-3-methyl-2-[5-[4-(trifluoromethyloxy)phenyl]pyridin-3-yl]quinolin-4-ol × 2 HEC HEME C × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot for 6 seconds with a blot force of 6 before plunge-freezing
Resolution 4.10 Å
6HAW Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7 Deposited 2018-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 3–61（59 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PGE TRIETHYLENE GLYCOL × 4 PO4 PHOSPHATE ION × 11 CDL CARDIOLIPIN × 4 PG4 TETRAETHYLENE GLYCOL × 1 PX6 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 FX2 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-12% PEG4000.
Resolution 3.45 Å R-free 0.242
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–64（63 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
6XVF Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021 Deposited 2020-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: eicosameric
Chain J 4–62（59 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 6 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 2 PO4 PHOSPHATE ION × 18 CDL CARDIOLIPIN × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 LMT DODECYL-BETA-D-MALTOSIDE × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 JAG 2-methyl-3-[4-[4-(trifluoromethyloxy)phenoxy]phenyl]-5,6,7,8-tetrahydro-3~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; Reservoir solution: 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.232
6ZFS Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor WDH-1U-4 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 4–62（59 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 PO4 PHOSPHATE ION × 7 CDL CARDIOLIPIN × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PG4 TETRAETHYLENE GLYCOL × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JGW 2-methyl-3-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-3~{H}-quinolin-4-one × 1 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.246
6ZFT Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor CK-2-68 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 3–61（59 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 4 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 1 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 PO4 PHOSPHATE ION × 6 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.30 Å R-free 0.244
6ZFU Crystal structure of bovine cytochrome bc1 in complex with quinolone inhibitor RKA066 Deposited 2020-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 4–62（59 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 JHE 3-methyl-1-oxidanyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]quinolin-4-one × 1 HEC HEME C × 1 PO4 PHOSPHATE ION × 5 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 10-13% PEG4000
Resolution 3.50 Å R-free 0.238
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B6 1–64（64 aa）
Chain u 1–64（64 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B2 1–64（64 aa）
Chain u 1–64（64 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B4 1–64（64 aa）
Chain u 1–64（64 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain J1 1–64（64 aa）
Chain V1 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7R3V Crystal structure of bovine Cytochrome bc1 in complex with inhibitor CK-2-67. Deposited 2022-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric
Chain J 4–62（59 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 1 CDL CARDIOLIPIN × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 LMT DODECYL-BETA-D-MALTOSIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 2 I2Q 3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one × 1 DMS DIMETHYL SULFOXIDE × 1 PO4 PHOSPHATE ION × 9 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；Protein 40mg/mL with 1.6% HECAMEG; reservoir solution 50mM KPi pH 6.8, 100mM NaCl, 3mM NaN3, 9-12% PEG4000
Resolution 3.20 Å R-free 0.256
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–64（63 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–64（63 aa）
Chain W 2–64（63 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–64（64 aa）
Chain W 1–64（64 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 1–64（64 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–62（61 aa）
Chain W 2–62（61 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain J 2–62（61 aa）
Chain U 2–62（61 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

47 other PDB entries and 52 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR9_BOVIN
Isoform —
PDB entities 18
Chains and sequence ranges Author chain J； PDBConstruct 1–62； UniProt 2–63 Author chain j； PDBConstruct 1–62； UniProt 2–63

CYTOCHROME B-C1 COMPLEX SUBUNIT 10

OrganismNot specified

UniProt P07552

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain K； UniProt 1–56 Chain k； UniProt 1–56 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEC HEME C × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BE3 CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.6；pH 6.6
Resolution 3.00 Å R-free 0.320
1BGY CYTOCHROME BC1 COMPLEX FROM BOVINE Deposited 1998-06-02 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Chain W 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 3.00 Å R-free 0.360
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FMX FAMOXADONE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0L structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FMX FAMOXADONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.35 Å R-free 0.306
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 3 FES FE2/S2 (INORGANIC) CLUSTER × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1L0N native structure of bovine mitochondrial cytochrome bc1 complex Deposited 2002-02-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.297
1NTK Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1 Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AY1 [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-oxidanyl-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-bis(oxidanylidene)-1,5-dioxonan-7-yl] 2-methylpropanoate × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.270
1NTM Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glyerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.40 Å R-free 0.285
1NTZ Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 UQ2 UBIQUINONE-2 × 4 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.283
1NU1 Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) Deposited 2003-01-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 QNO 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；PEG 4000, ammonium acetate, potassium chloride, glycerol, DMG/SPC, MOPS, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.20 Å R-free 0.296
1QCR CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY Deposited 1997-05-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric
Chain K 1–45（45 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；pH 7.2
Resolution 2.70 Å R-free 0.375
1SQB Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin Deposited 2004-03-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K, pH 7.20
Resolution 2.69 Å R-free 0.288
1SQP Crystal Structure Analysis of Bovine Bc1 with Myxothiazol Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa） Fragment：subunit 11
Not recorded CDL CARDIOLIPIN × 6 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 6 MYX (2Z,6E)-7-{2'-[(2E,4E)-1,6-DIMETHYLHEPTA-2,4-DIENYL]-2,4'-BI-1,3-THIAZOL-4-YL}-3,5-DIMETHOXY-4-METHYLHEPTA-2,6-DIENAMID E × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.70 Å R-free 0.314
1SQQ Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS) Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa） Fragment：subunit 11
Not recorded HEC HEME C × 6 UQ2 UBIQUINONE-2 × 2 OST METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 3.00 Å R-free 0.295
1SQV Crystal Structure Analysis of Bovine Bc1 with UHDBT Deposited 2004-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded HEC HEME C × 6 UHD 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE × 2 UQ2 UBIQUINONE-2 × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine, pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.85 Å R-free 0.285
1SQX Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A Deposited 2004-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa） Fragment：subunit 9
Not recorded UQ2 UBIQUINONE-2 × 2 HEC HEME C × 6 SMA STIGMATELLIN A × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.2；277 K；20mM ammonium acetate, 20% glycerol, 12% PEG4000, 0.5M KCl, 0.1% diheptanoyl-phosphatidylcholine , pH 7.2, VAPOR DIFFUSION, temperature 277K
Resolution 2.60 Å R-free 0.281
2FYU Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor Deposited 2006-02-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa） Fragment：subunit 11
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277.2 K；50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K
Resolution 2.26 Å R-free 0.283
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain K 1–56（56 aa）
Chain V 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5KLV Structure of bos taurus cytochrome bc1 with fenamidone inhibited Deposited 2016-06-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 2–56（55 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 GOL GLYCEROL × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FNM (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Fenamidone. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.65 Å R-free 0.269
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain k 1–56（56 aa）
Chain w 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
6NHG Rhodobacter sphaeroides Mitochondrial respiratory chain complex Deposited 2018-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 2–56（55 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 AZO METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 MC3 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.2；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 2-5 mol excess of Azoxystrobin. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57
Resolution 2.80 Å R-free 0.289
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A4 1–56（56 aa）
Chain t 1–56（56 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A3 1–56（56 aa）
Chain t 1–56（56 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A3 1–56（56 aa）
Chain t 1–56（56 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain K1 1–56（56 aa）
Chain W1 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7TAY Bos Taurus Mitochondrial BC1 in complex with Pyramoxadone Deposited 2021-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded 6PE 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE × 4 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PQU (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione × 2 8PE (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate × 2 PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE × 2 CL CHLORIDE ION × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；277 K；50 mM MOPS 7.2 pH, 20 mM Ammonium acetate, 20% glycerol. Incubation with 5 molar excess of pyramoxadone. Precipitant 12% PEG4000, 0.5 M KCL, 0.1% DHPC.
Resolution 2.95 Å R-free 0.258
7TZ6 Structure of mitochondrial bc1 in complex with ck-2-68 Deposited 2022-02-15 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Chain X 1–56（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 JHB 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-quinolin-4-one × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å
8P65 Cytochrome bc1 complex (Bos taurus) Deposited 2023-05-25 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–49（49 aa）
Chain X 1–49（49 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；Blot time of 4s with blot force of -3
Resolution 3.00 Å
9GCX Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8 Deposited 2024-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 1–56（56 aa）
Not recorded LOP (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE × 12 CDL CARDIOLIPIN × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 A1IKG 2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)-1,5,7,8-tetrahydro-4H-pyrano[4,3-b]pyridin-4-one × 2 LMT DODECYL-BETA-D-MALTOSIDE × 2 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 SO4 SULFATE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；50 mM KPi pH 6.8, 100 mM NaCl, 3 mM NaN3, 10-20% PEG4000
Resolution 3.52 Å R-free 0.241
9W2X Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 2–53（52 aa）
Chain X 2–53（52 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.20 Å
9W2Y Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2 Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric
Chain K 2–53（52 aa）
Chain V 2–53（52 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å

29 other PDB entries and 32 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name QCR10_BOVIN
Isoform —
PDB entities 19
Chains and sequence ranges Author chain K； PDBConstruct 1–56； UniProt 1–56 Author chain k； PDBConstruct 1–56； UniProt 1–56

CYTOCHROME C OXIDASE SUBUNIT 1

OrganismNot specified

UniProt P00396

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain L； UniProt 1–514 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain y 1–514（514 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain x 1–514（514 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain a 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain a 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain x 1–514（514 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain Bx 1–514（514 aa）
Chain x 1–514（514 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C3 1–514（514 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A9 1–514（514 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A9 1–514（514 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A3 1–514（514 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–513（513 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain A 1–514（514 aa）
Chain N 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain A 1–514（514 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX1_BOVIN
Isoform —
PDB entities 20
Chains and sequence ranges Author chain L； PDBConstruct 1–514； UniProt 1–514

CYTOCHROME C OXIDASE SUBUNIT 2

OrganismNot specified

UniProt P68530

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain M； UniProt 1–227 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain z 1–227（227 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain y 1–227（227 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain b 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain b 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain y 1–227（227 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain By 1–227（227 aa）
Chain y 1–227（227 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C1 1–227（227 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C4 1–227（227 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B9 1–227（227 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B3 1–227（227 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain B 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain B 1–227（227 aa）
Chain O 1–227（227 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155

88 other PDB entries and 127 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX2_BOVIN
Isoform —
PDB entities 21
Chains and sequence ranges Author chain M； PDBConstruct 1–227； UniProt 1–227

CYTOCHROME C OXIDASE SUBUNIT 3

OrganismNot specified

UniProt P00415

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain N； UniProt 1–261 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain C 3–261（259 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain P 3–261（259 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain z 1–261（261 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain c 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain c 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 2–261（260 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 2–261（260 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain z 1–261（261 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain Bz 1–261（261 aa）
Chain z 1–261（261 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 3–261（259 aa）
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 3–261（259 aa）
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 3–261（259 aa）
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 3–261（259 aa）
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A9 1–261（261 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C2 1–261（261 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B7 1–261（261 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C3 1–261（261 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain C 3–261（259 aa）
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 3–261（259 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 4–261（258 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain C 1–261（261 aa）
Chain P 1–261（261 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain C 4–259（256 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

90 other PDB entries and 132 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX3_BOVIN
Isoform —
PDB entities 22
Chains and sequence ranges Author chain N； PDBConstruct 1–261； UniProt 1–261

CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL

OrganismNot specified

UniProt P00423

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain O； UniProt 23–169 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 1–169（169 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 1–169（169 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 1 23–169（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain D 26–169（144 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain Q 26–169（144 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 1 23–169（147 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa） Fragment：residues 23-169
Chain d 23–169（147 aa） Fragment：residues 23-169
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain d 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 0 26–169（144 aa） Fragment：UNP RESIDUES 28-169
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 0 26–169（144 aa） Fragment：UNP RESIDUES 26-169
Chain B0 26–169（144 aa） Fragment：UNP RESIDUES 26-169
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 26–169（144 aa）
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 26–169（144 aa）
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 26–169（144 aa）
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 26–169（144 aa）
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A7 1–169（169 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A7 1–169（169 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A7 1–169（169 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain D3 1–169（169 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain D 26–169（144 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 26–169（144 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 32–168（137 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain D 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain D 23–169（147 aa）
Chain Q 23–169（147 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain D 33–168（136 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX41_BOVIN
Isoform —
PDB entities 23
Chains and sequence ranges Author chain O； PDBConstruct 1–147； UniProt 23–169

CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL

OrganismNot specified

UniProt P00426

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain P； UniProt 44–152 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 1–109（109 aa）
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 1–109（109 aa）
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 1–109（109 aa）
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 1–109（109 aa）
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 1–109（109 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 1–109（109 aa）
Chain R 1–109（109 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 1–152（152 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 1–152（152 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 2 44–152（109 aa） Fragment：UNP RESIDUES 44-152
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain E 48–152（105 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain R 48–152（105 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 2 44–152（109 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa） Fragment：residues 44-152
Chain e 44–152（109 aa） Fragment：residues 44-152
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain e 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 1 44–152（109 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 1 44–152（109 aa）
Chain B1 44–152（109 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 48–152（105 aa）
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 48–152（105 aa）
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 48–152（105 aa）
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 48–152（105 aa）
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B4 1–152（152 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C0 1–152（152 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A6 1–152（152 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain E3 1–152（152 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 48–152（105 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain E 49–152（104 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 49–152（104 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 49–150（102 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain E 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain E 44–152（109 aa）
Chain R 44–152（109 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain E 50–151（102 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX5A_BOVIN
Isoform —
PDB entities 24
Chains and sequence ranges Author chain P； PDBConstruct 1–109； UniProt 44–152

CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL

OrganismNot specified

UniProt P00428

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain Q； UniProt 32–129 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 1–98（98 aa）
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 1–98（98 aa）
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 1–98（98 aa）
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 1–98（98 aa）
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 1–98（98 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 1–98（98 aa）
Chain S 1–98（98 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 1–129（129 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 1–129（129 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 3 32–129（98 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain F 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 3 32–129（98 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa） Fragment：residues 32-129
Chain f 32–129（98 aa） Fragment：residues 32-129
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain f 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 2 32–129（98 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 2 32–129（98 aa）
Chain B2 32–129（98 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–125（94 aa）
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–125（94 aa）
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–125（94 aa）
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A5 1–129（129 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A6 1–129（129 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B2 1–129（129 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain F3 1–129（129 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–125（94 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain F 33–125（93 aa）
Chain S 33–125（93 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 33–125（93 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 35–125（91 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain F 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain F 32–129（98 aa）
Chain S 32–129（98 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain F 34–124（91 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX5B_BOVIN
Isoform —
PDB entities 25
Chains and sequence ranges Author chain Q； PDBConstruct 1–98； UniProt 32–129

CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB

OrganismNot specified

UniProt P07471

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain R； UniProt 13–96 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 1–97（97 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 1–97（97 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 4 13–96（84 aa） Fragment：UNP RESIDUES 13-96
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 4 13–96（84 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa） Fragment：residues 13-97
Chain g 13–97（85 aa） Fragment：residues 13-97
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain g 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 3 13–96（84 aa） Fragment：UNP RESIDUES 13-96
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 3 13–96（84 aa） Fragment：UNP RESIDUES 13-96
Chain B3 13–96（84 aa） Fragment：UNP RESIDUES 13-96
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A6 1–97（97 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A4 1–97（97 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A4 1–97（97 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain G3 1–97（97 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–96（84 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 24–95（72 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain G 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain T 13–97（85 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain G 13–97（85 aa）
Chain T 13–97（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain G 24–95（72 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CX6A2_BOVIN
Isoform —
PDB entities 26
Chains and sequence ranges Author chain R； PDBConstruct 1–84； UniProt 13–96

CYTOCHROME C OXIDASE SUBUNIT 6B1

OrganismNot specified

UniProt P00429

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain S； UniProt 2–86 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 1–85（85 aa）
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 1–85（85 aa）
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 1–85（85 aa）
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 1–85（85 aa）
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 1–85（85 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 1–85（85 aa）
Chain U 1–85（85 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 1–86（86 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 1–86（86 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 5 2–86（85 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain H 8–86（79 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain U 8–86（79 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 5 2–86（85 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain h 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain h 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 4 12–86（75 aa） Fragment：UNP RESIDUES 12-86
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 4 12–86（75 aa） Fragment：UNP RESIDUES 12-86
Chain B4 12–86（75 aa） Fragment：UNP RESIDUES 12-86
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 8–86（79 aa）
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 8–86（79 aa）
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 8–86（79 aa）
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 8–86（79 aa）
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C0 1–86（86 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A5 1–86（86 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A5 1–86（86 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain H3 1–86（86 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain H 8–86（79 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 8–86（79 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 9–86（78 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain H 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain H 2–86（85 aa）
Chain U 2–86（85 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain H 6–86（81 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CX6B1_BOVIN
Isoform —
PDB entities 27
Chains and sequence ranges Author chain S； PDBConstruct 1–85； UniProt 2–86

CYTOCHROME C OXIDASE SUBUNIT 6C

OrganismNot specified

UniProt P04038

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain T； UniProt 2–74 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 1–73（73 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 1–73（73 aa）
Chain V 1–73（73 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 1–74（74 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 1–74（74 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 1–73（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 6 2–74（73 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 6 2–74（73 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain i 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain i 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 5 2–74（73 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 5 2–74（73 aa）
Chain B5 2–74（73 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C2 1–74（74 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B4 1–74（74 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B6 1–74（74 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain I3 1–74（74 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 5–74（70 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain I 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain V 2–74（73 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain I 2–74（73 aa）
Chain V 2–74（73 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain I 4–73（70 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX6C_BOVIN
Isoform —
PDB entities 28
Chains and sequence ranges Author chain T； PDBConstruct 1–73； UniProt 2–74

CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL

OrganismNot specified

UniProt P07470

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain U； UniProt 22–80 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 1–80（80 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 1–80（80 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 7 22–80（59 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain J 22–79（58 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain W 22–79（58 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 7 22–80（59 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa） Fragment：residues 22-80
Chain j 22–80（59 aa） Fragment：residues 22-80
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain j 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 6 22–77（56 aa） Fragment：UNP RESIDUES 22-77
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 6 22–77（56 aa） Fragment：UNP RESIDUES 22-77
Chain B6 22–77（56 aa） Fragment：UNP RESIDUES 22-77
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–79（58 aa）
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–79（58 aa）
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–79（58 aa）
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–79（58 aa）
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B2 1–80（80 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C3 1–80（80 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B8 1–80（80 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain J3 1–80（80 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–79（58 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain J 22–78（57 aa）
Chain W 22–78（57 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–78（57 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–76（55 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain J 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain J 22–80（59 aa）
Chain W 22–80（59 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain J 22–76（55 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CX7A1_BOVIN
Isoform —
PDB entities 29
Chains and sequence ranges Author chain U； PDBConstruct 1–59； UniProt 22–80

CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL

OrganismNot specified

UniProt P13183

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain V； UniProt 25–80 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 33–88（56 aa）
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 33–88（56 aa）
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 33–88（56 aa）
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 33–88（56 aa）
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 33–88（56 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 33–88（56 aa）
Chain X 33–88（56 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 1–80（80 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 1–80（80 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 8 25–80（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain K 30–78（49 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain X 30–78（49 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 8 25–80（56 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa） Fragment：residues 25-80
Chain k 25–80（56 aa） Fragment：residues 25-80
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain k 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 7 30–78（49 aa） Fragment：UNP RESIDUES 30-78
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 7 30–78（49 aa） Fragment：UNP RESIDUES 30-78
Chain B7 30–78（49 aa） Fragment：UNP RESIDUES 30-78
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 30–78（49 aa）
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 30–78（49 aa）
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 30–78（49 aa）
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 30–78（49 aa）
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B3 1–80（80 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B0 1–80（80 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B0 1–80（80 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain K3 1–80（80 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 32–78（47 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain K 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain K 25–80（56 aa）
Chain X 25–80（56 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain K 30–78（49 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX7B_BOVIN
Isoform —
PDB entities 30
Chains and sequence ranges Author chain V； PDBConstruct 1–56； UniProt 25–80

CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL

OrganismNot specified

UniProt P00430

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain W； UniProt 17–63 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 1–63（63 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 1–63（63 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain 9 17–63（47 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain L 18–63（46 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain Y 18–63（46 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 9 17–63（47 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa） Fragment：residues 17-63
Chain l 17–63（47 aa） Fragment：residues 17-63
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain l 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 8 17–63（47 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 8 17–63（47 aa）
Chain B8 17–63（47 aa）
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 18–63（46 aa）
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 18–63（46 aa）
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 18–63（46 aa）
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 18–63（46 aa）
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A0 1–63（63 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain C1 1–63（63 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain B1 1–63（63 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain L3 1–63（63 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain L 18–63（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 18–63（46 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain L 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain L 17–63（47 aa）
Chain Y 17–63（47 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain L 19–62（44 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX7C_BOVIN
Isoform —
PDB entities 31
Chains and sequence ranges Author chain W； PDBConstruct 1–47； UniProt 17–63

CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL

OrganismNot specified

UniProt P10175

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain X； UniProt 25–70 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C × 1 （P62894） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；pH 6.8
Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 1–70（70 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 1–70（70 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.245
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.
Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K
Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch
Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K
Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside
Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000
Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric
Chain s 25–70（46 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen NITROGEN
Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain M 25–67（43 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain Z 25–67（43 aa）
Not recorded CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000
Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric
Chain 0 25–70（46 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.7
cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting
Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa） Fragment：residues 25-70
Chain m 25–70（46 aa） Fragment：residues 25-70
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside
Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain m 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000
Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000
Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)
Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate
Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain 9 25–67（43 aa） Fragment：UNP RESIDUES 25-67
Not recorded SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
5XTI Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2 Deposited 2017-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 138 PDB declaration: 138-meric
Chain 9 25–67（43 aa） Fragment：UNP RESIDUES 25-67
Chain B9 25–67（43 aa） Fragment：UNP RESIDUES 25-67
Not recorded SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 17.40 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate
Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate
Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000
Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–67（43 aa）
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM
Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring
Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol
Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–67（43 aa）
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–67（43 aa）
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–67（43 aa）
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer
Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A8 1–70（70 aa）
Not recorded PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A8 1–70（70 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain A8 1–70（70 aa）
Not recorded FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric
Chain M3 1–70（70 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside
Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside
Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside
Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER
Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–67（43 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric
Chain M 25–65（41 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–65（41 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer
Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO
Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113
Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol
Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000
Resolution 1.50 Å R-free 0.177
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside
Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8
Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain M 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer
Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric
Chain M 25–70（46 aa）
Chain Z 25–70（46 aa）
Not recorded HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000
Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric
Chain M 25–64（40 aa）
Not recorded HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.61 Å

90 other PDB entries and 132 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name COX8B_BOVIN
Isoform —
PDB entities 32
Chains and sequence ranges Author chain X； PDBConstruct 1–46； UniProt 25–70

CYTOCHROME C

OrganismNot specified

UniProt P62894

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 48 PDB declaration: 48-meric（48） Consistent with protein copy count Chain Y； UniProt 2–105 Not recorded NADH-QUINONE OXIDOREDUCTASE SUBUNIT 1 × 1 （Q56222） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 2 × 1 （Q56221） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 3 × 1 （Q56223） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 4 × 1 （Q56220） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 5 × 1 （Q56219） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 6 × 1 （Q56218） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 15 × 1 （Q5SKZ7） NADH-QUINONE OXIDOREDUCTASE SUBUNIT 9 × 1 （Q56224） CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL × 2 （P31800） CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL × 2 （P23004） CYTOCHROME B × 2 （P00157） CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL × 2 （P00125） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 7 × 2 （P00129） CYTOCHROME B-C1 COMPLEX SUBUNIT 8 × 2 （P13271） CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL × 2 （P00126） CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL × 2 （P13272） CYTOCHROME B-C1 COMPLEX SUBUNIT 9 × 2 （P00130） CYTOCHROME B-C1 COMPLEX SUBUNIT 10 × 2 （P07552） CYTOCHROME C OXIDASE SUBUNIT 1 × 1 （P00396） CYTOCHROME C OXIDASE SUBUNIT 2 × 1 （P68530） CYTOCHROME C OXIDASE SUBUNIT 3 × 1 （P00415） CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL × 1 （P00423） CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL × 1 （P00426） CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL × 1 （P00428） CYTOCHROME C OXIDASE POLYPEPTIDE VIA, CYTOCHROME C OXIDASE POLYPEPTIDE VB × 1 （P07471） CYTOCHROME C OXIDASE SUBUNIT 6B1 × 1 （P00429） CYTOCHROME C OXIDASE SUBUNIT 6C × 1 （P04038） CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL × 1 （P07470） CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL × 1 （P13183） CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL × 1 （P00430） CYTOCHROME C OXIDASE SUBUNIT 8B, MITOCHONDRIAL × 1 （P10175） NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT L, × 1 NADH\: UBIQUINONE OXIDOREDUCTASE, MEMBRANE SUBUNIT M, × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT N × 1 NADH-QUINONE OXIDOREDUCTASE SUBUNIT K × 1 SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1 ELECTRON MICROSCOPY cryo-EM buffer：10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions：Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING Resolution 19.00 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 2YBB Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2B4Z Crystal structure of cytochrome C from bovine heart at 1.5 A resolution. Deposited 2005-09-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–104（104 aa）
Not recorded HEM PROTOPORPHYRIN IX CONTAINING FE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions MICROSEEDING；pH 7；277 K；PEG 1000, SODIUM PHOSPHATE, pH 7.0, MICROSEEDING, temperature 277K
Resolution 1.50 Å R-free 0.218
3J2T An improved model of the human apoptosome Deposited 2012-12-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric
Chain H 2–105（104 aa）
Chain I 2–105（104 aa）
Chain J 2–105（104 aa）
Chain K 2–105（104 aa）
Chain L 2–105（104 aa）
Chain M 2–105（104 aa）
Chain N 2–105（104 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 7 ELECTRON MICROSCOPY
cryo-EM buffer low salt HEPES buffer；pH 7.5；20mM HEPES, 10mM KCl, 1.5mM MgCl2, 1mM EDTA, 1mM EGTA, 1mM DTT
cryo-EM vitrification conditions Blot for 2 seconds before plunging；77 K；Cryogen ETHANE；Blot for 2 seconds before plunging (FEI VITROBOT MARK III)
Resolution 9.50 Å
5JUY Active human apoptosome with procaspase-9 Deposited 2016-05-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric
Chain H 2–105（104 aa）
Chain I 2–105（104 aa）
Chain J 2–105（104 aa）
Chain K 2–105（104 aa）
Chain L 2–105（104 aa）
Chain M 2–105（104 aa）
Chain N 2–105（104 aa）
Not recorded DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE × 7 HEC HEME C × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；Buffer A
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
6FF5 X-ray structure of bovine heart cytochrome c at high ionic strength Deposited 2018-01-03 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–105（104 aa）
Not recorded HEC HEME C × 1 NO3 NITRATE ION × 5 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；3.2-3.4 M ammonium sulfate and 0.4-0.5 M NaNO3
Resolution 1.74 Å R-free 0.203

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CYC_BOVIN
Isoform —
PDB entities 33
Chains and sequence ranges Author chain Y； PDBConstruct 1–104； UniProt 2–105

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 2ybb

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 2ybb
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2. Structure Basics 2. Structure Basics

Entry ID entry_id2ybb
Deposition date deposition_date2011-03-02
Structure title titleFitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876)
Keywords keywordsSUPERCOMPLEX B, MITOCHONDRIA, RESPIRATORY CHAIN, OXIDOREDUCTASE, AMPHIPOL A8-35, RANDOM CONICAL TILT; OXIDOREDUCTASE
Experimental Method methodELECTRON MICROSCOPY
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier96.08 Å
Radius of gyration Rg (electron density) rg_electron96.70 Å
Forward intensity I(0) i013804600000.00
Molecular weight molecular_weight1006100.0 kDa
Excluded volume excluded_volume1258600 ų
Envelope volume envelope_volume2285800 ų
Hydration-shell volume shell_volume211350 ų
Envelope diameter envelope_diameter337.3 Å
Shell Rg shell_rg83.40 Å
Envelope Rg envelope_rg90.50 Å
Shape Rg shape_rg96.67 Å
Total Rg total_rg96.71 Å
Total atoms total_atoms70962
Residues n_residues9849
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax259.1 Å
Rg (real space) rg_real91.86 Å
Rg uncertainty (real space) rg_real_error1.00 Å
I(0) (real space) i0_real1.3270e+10
I(0) uncertainty (real space) i0_real_error2.7730e+08
Rg (reciprocal space) rg_reciprocal92.98 Å
I(0) (reciprocal space) i0_reciprocal13660000000.0000
Solution quality estimate total_estimate0.9178
Solution quality rating solution_quality EXCELLENT a EXCELLENT solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary113.4 Å
Skewness Skewness skewness0.235
Kurtosis Kurtosis kurtosis-0.629
Angular range angular_range— – 0.0800 Å−1
Current regularization parameter α current_alpha0.7374
Highest regularization parameter α highest_alpha243200000.0000
Real-space data points n_real_points17
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.001; Oscil: 1.000; Stabil: 0.977; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.002
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (52)

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8. Citations (2)

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9. Files and Curves (10)