5xti

Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2

Method: ELECTRON MICROSCOPY D_max: 353.4 Å Quality: GOOD

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1. Protein Identity and Related Structures Protein Identity & Related Structures

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

OrganismNot specified

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain A； UniProt 27–457 Chain BA； UniProt 27–457	Fragment：UNP RESIDUES 27-457	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain A 27–457（431 aa） Fragment：UNP RESIDUES 27-457	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain A 27–457（431 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A 27–457（431 aa） Fragment：UNP RESIDUES 27-457	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain A 1–464（464 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain C 1–464（464 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain C 27–460（434 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUV1_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–431； UniProt 27–457 Author chain BA； PDBConstruct 1–431； UniProt 27–457

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

OrganismNot specified

UniProt O00217

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain B； UniProt 35–210 Chain BB； UniProt 35–210	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain B 35–210（176 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain B 35–210（176 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B 35–210（176 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain B 1–210（210 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain D 1–210（210 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain D 35–210（176 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS8_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–176； UniProt 35–210 Author chain BB； PDBConstruct 1–176； UniProt 35–210

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

OrganismNot specified

UniProt O75251

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BC； UniProt 58–213 Chain C； UniProt 58–213	Fragment：UNP RESIDUES 58-213	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain C 58–213（156 aa） Fragment：UNP RESIDUES 58-213	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain C 58–213（156 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C 58–213（156 aa） Fragment：UNP RESIDUES 58-213	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain C 1–213（213 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain E 1–213（213 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain E 53–213（161 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS7_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain BC； PDBConstruct 1–156； UniProt 58–213 Author chain C； PDBConstruct 1–156； UniProt 58–213

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

OrganismNot specified

UniProt P56556

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BE； UniProt 42–154 Chain E； UniProt 42–154	Fragment：UNP RESIDUES 42-154	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain E 42–154（113 aa） Fragment：UNP RESIDUES 42-154	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain E 42–154（113 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain E 42–154（113 aa） Fragment：UNP RESIDUES 42-154	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain E 1–128（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain F 1–128（128 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain F 11–128（118 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA6_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain BE； PDBConstruct 1–113； UniProt 42–154 Author chain E； PDBConstruct 1–113； UniProt 42–154

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

OrganismNot specified

UniProt O43678

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BF； UniProt 14–96 Chain F； UniProt 14–96	Fragment：UNP RESIDUES 14-96	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1S3A NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8) Deposited 2004-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 0–98（99 aa）	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 6；300 K；Ionic strength (raw mmCIF value) 20mM phosphate, 50mM NaCl；Pressure ambient NMR sample composition U-15N, 90% H2O, 10% D2O \| 90% H2O/10% D2O NMR sample composition U-15N, U-13C, 90% H2O, 10% D2O \| 90% H2O/10% D2O NMR sample composition U-15N, U-13C, 100% D2O \| 100% D2O	Resolution not provided
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain F 14–96（83 aa） Fragment：UNP RESIDUES 14-96	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain F 14–96（83 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain F 14–96（83 aa） Fragment：UNP RESIDUES 14-96	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain F 1–99（99 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain G 1–99（99 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain G 14–98（85 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

7 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA2_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain BF； PDBConstruct 1–83； UniProt 14–96 Author chain F； PDBConstruct 1–83； UniProt 14–96

Acyl carrier protein, mitochondrial

OrganismNot specified

UniProt O14561

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BG； UniProt 72–156 Chain BX； UniProt 72–156 Chain G； UniProt 72–156 Chain X； UniProt 72–156	Fragment：UNP RESIDUES 72-196	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
2DNW Solution structure of RSGI RUH-059, an ACP domain of acyl carrier protein, mitochondrial [Precursor] from human cDNA Deposited 2006-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 69–156（88 aa） Fragment：acyl carrier protein	Not recorded	No recorded non-water small molecule	SOLUTION NMR NMR measurement conditions pH 7；298 K；Ionic strength (raw mmCIF value) 120mM；Pressure ambient NMR sample composition 0.91mM RSGI RUH-059 U-15N, 13C; 20mM d-Tris-HCl; 1mM d-DTT; 0.02% NaN3; 10% D2O, 90% H2O \| 90% H2O/10% D2O	Resolution not provided
5OOL Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA Deposited 2017-08-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 54 PDB declaration: 56-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 92 ZN ZINC ION × 3 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.45；2 mM Synercid (Santa Cruz Biotechnology, Inc) was added to reduce preferential orientation. cryo-EM vitrification conditions Cryogen ETHANE；Sample incubated for 30 s prior to freezing.	Resolution 3.06 Å
5OOM Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA Deposited 2017-08-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 53 PDB declaration: 55-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 49 ZN ZINC ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.45；2 mM Synercid (Santa Cruz Biotechnology, Inc) was added to reduce preferential orientation. cryo-EM vitrification conditions Cryogen ETHANE；Sample incubated for 30 s prior to freezing.	Resolution 3.03 Å
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain G 72–156（85 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain X 72–156（85 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain G 72–156（85 aa） Chain X 72–156（85 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain G 72–156（85 aa） Fragment：UNP RESIDUES 72-156 Chain X 72–156（85 aa） Fragment：UNP RESIDUES 72-156	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
6ODD Crystal structure of the human complex ACP-ISD11 Deposited 2019-03-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric	Chain A 72–156（85 aa）	Not recorded	8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 CA CALCIUM ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；The drop was a 1:1 mix of protein (in 10 mM Tris buffer, 25 mM NaCl, pH 7.5) and reservoir solution (0.1 M Tris pH 9.1, 0.1 M CaCl2, 23% tert-butanol)	Resolution 2.00 Å R-free 0.216
6ODD Crystal structure of the human complex ACP-ISD11 Deposited 2019-03-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 72–156（85 aa）	Not recorded	8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 CA CALCIUM ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；The drop was a 1:1 mix of protein (in 10 mM Tris buffer, 25 mM NaCl, pH 7.5) and reservoir solution (0.1 M Tris pH 9.1, 0.1 M CaCl2, 23% tert-butanol)	Resolution 2.00 Å R-free 0.216
7A5H Structure of the split human mitoribosomal large subunit with rescue factors mtRF-R and MTRES1 Deposited 2020-08-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 56 PDB declaration: 59-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 92 ZN ZINC ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.30 Å
7A5J Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs Deposited 2020-08-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 59 PDB declaration: 63-meric	Chain w 1–156（156 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	MG MAGNESIUM ION × 92 ZN ZINC ION × 3 CL CHLORIDE ION × 2 NA SODIUM ION × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
7O9K Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1, the MALSU module, GTPBP5 and mtEF-Tu Deposited 2021-04-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 67 PDB declaration: 69-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 93 SAM S-ADENOSYLMETHIONINE × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
7O9M Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1 and the MALSU module Deposited 2021-04-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 64 PDB declaration: 66-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 104 GDP GUANOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 2 SAM S-ADENOSYLMETHIONINE × 1 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.60 Å
7ODR State A of the human mitoribosomal large subunit assembly intermediate Deposited 2021-04-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 55 PDB declaration: 57-meric	Chain w 1–156（156 aa）	Not recorded	PM8 S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE × 1 SAM S-ADENOSYLMETHIONINE × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 97 K POTASSIUM ION × 2 FES FE2/S2 (INORGANIC) CLUSTER × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；4 uL of the sample was blotted for 2-6 sec before plunging	Resolution 2.90 Å
7ODS State B of the human mitoribosomal large subunit assembly intermediate Deposited 2021-04-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 56 PDB declaration: 58-meric	Chain w 1–156（156 aa）	Not recorded	PM8 S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE × 1 SAM S-ADENOSYLMETHIONINE × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 88 K POTASSIUM ION × 8 N ANY 5'-MONOPHOSPHATE NUCLEOTIDE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；4 uL of the sample was blotted for 2-6 sec before plunging	Resolution 3.10 Å
7ODT State C of the human mitoribosomal large subunit assembly intermediate Deposited 2021-04-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 56 PDB declaration: 58-meric	Chain w 1–156（156 aa）	Not recorded	GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 95 PM8 S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE × 1 SAM S-ADENOSYLMETHIONINE × 1 ZN ZINC ION × 2 K POTASSIUM ION × 10 FES FE2/S2 (INORGANIC) CLUSTER × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE；4 uL of the sample was blotted for 2-6 sec before plunging	Resolution 3.10 Å
7OF0 Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with MTERF4-NSUN4 (dataset1). Deposited 2021-05-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 54 PDB declaration: 56-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 3 MG MAGNESIUM ION × 61	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.20 Å
7OF2 Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with GTPBP6. Deposited 2021-05-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 54 PDB declaration: 56-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 3 MG MAGNESIUM ION × 85 GTP GUANOSINE-5'-TRIPHOSPHATE × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å
7OF3 Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with MTERF4-NSUN4 (dataset2). Deposited 2021-05-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 54 PDB declaration: 56-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 3 MG MAGNESIUM ION × 58 GTP GUANOSINE-5'-TRIPHOSPHATE × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.70 Å
7OF5 Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with MTERF4-NSUN4 and GTPBP5 (dataset2). Deposited 2021-05-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 55 PDB declaration: 57-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 3 MG MAGNESIUM ION × 70 GTP GUANOSINE-5'-TRIPHOSPHATE × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.90 Å
7OF7 Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with MTERF4-NSUN4 and GTPBP5 (dataset1). Deposited 2021-05-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 55 PDB declaration: 57-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 3 MG MAGNESIUM ION × 74	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.50 Å
7OI6 Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 1 Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 50 PDB declaration: 52-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 48 ZN ZINC ION × 1 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.70 Å
7OI7 Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 2 Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 52 PDB declaration: 54-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 49 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.50 Å
7OI8 Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3A Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 52 PDB declaration: 55-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 49 ZN ZINC ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.50 Å
7OI9 Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3B Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 52 PDB declaration: 54-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 49 ZN ZINC ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.30 Å
7OIC Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 4 Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 55 PDB declaration: 58-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 76 ZN ZINC ION × 3 PNS 4'-PHOSPHOPANTETHEINE × 1 SAM S-ADENOSYLMETHIONINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
7OID Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5A Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 53 PDB declaration: 56-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
7OIE Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5B Deposited 2021-05-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 53 PDB declaration: 55-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 2 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.50 Å
7PD3 Structure of the human mitoribosomal large subunit in complex with NSUN4.MTERF4.GTPBP7 and MALSU1.L0R8F8.mt-ACP Deposited 2021-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 58 PDB declaration: 60-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 91 PNS 4'-PHOSPHOPANTETHEINE × 1 SAM S-ADENOSYLMETHIONINE × 1 GCP PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
7PO4 Assembly intermediate of human mitochondrial ribosome large subunit (largely unfolded rRNA with MALSU1, L0R8F8 and ACP) Deposited 2021-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 58 PDB declaration: 60-meric	Chain zc 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 35 K POTASSIUM ION × 8 ZN ZINC ION × 1 FES FE2/S2 (INORGANIC) CLUSTER × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.56 Å
7QH6 Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 1 Deposited 2021-12-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 44 PDB declaration: 46-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.08 Å
7QH7 Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4 Deposited 2021-12-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 47 PDB declaration: 49-meric	Chain w 74–152（79 aa）	Not recorded	MG MAGNESIUM ION × 50 ZN ZINC ION × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.89 Å
8K2B Cryo-EM structure of the human 39S mitoribosome with Tigecycline Deposited 2023-07-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 53 PDB declaration: 55-meric	Chain w 1–156（156 aa）	Not recorded	MG MAGNESIUM ION × 95 T1C TIGECYCLINE × 1 ZN ZINC ION × 3 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
8PK0 human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7 Deposited 2023-06-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 56 PDB declaration: 58-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 1 PM8 S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE × 1 SAM S-ADENOSYLMETHIONINE × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 2 MG MAGNESIUM ION × 96 K POTASSIUM ION × 10	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.03 Å
8QSJ Human mitoribosomal large subunit assembly intermediate 2 with GTPBP7 Deposited 2023-10-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 56 PDB declaration: 58-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 38 FES FE2/S2 (INORGANIC) CLUSTER × 1 PM8 S-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE × 1 SAM S-ADENOSYLMETHIONINE × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.6 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.00 Å
8QU5 mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 2 Deposited 2023-10-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 53 PDB declaration: 55-meric	Chain w 1–156（156 aa）	Not recorded	ZN ZINC ION × 2 MG MAGNESIUM ION × 48 PNS 4'-PHOSPHOPANTETHEINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.42 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain G 1–156（156 aa） Chain X 1–156（156 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain H 1–156（156 aa） Chain X 1–156（156 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9N50 Crosslinked Crystal Structure of Human Mitochondrial Ketosynthase, OXSM, and Crosslinker-crypto Human Mitochondrial Acyl Carrier Protein, C8aBr-mACP Deposited 2025-02-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain C 69–156（88 aa）	Not recorded	A1BMZ N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-octanamidoethyl)-beta-alaninamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5 M ammonium sulfate, 1 M lithium sulfate, and 0.1 M sodium citrate pH 5.6	Resolution 2.50 Å
9N51 Crosslinked Crystal Structure of Human Mitochondrial Ketosynthase, OXSM, and Crosslinker-crypto Human Mitochondrial Acyl Carrier Protein, C8Cl-mACP Deposited 2025-02-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain C 69–156（88 aa）	Not recorded	A1BMZ N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-octanamidoethyl)-beta-alaninamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5 M ammonium sulfate, 1 M lithium sulfate, and 0.1 M sodium citrate pH 5.6	Resolution 2.31 Å R-free 0.273
9N51 Crosslinked Crystal Structure of Human Mitochondrial Ketosynthase, OXSM, and Crosslinker-crypto Human Mitochondrial Acyl Carrier Protein, C8Cl-mACP Deposited 2025-02-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric	Chain F 69–156（88 aa）	Not recorded	A1BMZ N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-octanamidoethyl)-beta-alaninamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.5 M ammonium sulfate, 1 M lithium sulfate, and 0.1 M sodium citrate pH 5.6	Resolution 2.31 Å R-free 0.273
9PRA In Situ Structure of the Human Mitoribosome Large Subunit 39S in Complex with EF-Tu Deposited 2025-07-23	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein–RNA Heteromer；Protein × 64 PDB declaration: 66-meric	Chain Af 1–156（156 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	ZN ZINC ION × 2 K POTASSIUM ION × 36 MG MAGNESIUM ION × 141 FES FE2/S2 (INORGANIC) CLUSTER × 1 SPD SPERMIDINE × 2 PUT 1,4-DIAMINOBUTANE × 1 VAL VALINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.83 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain H 72–156（85 aa） Chain X 72–156（85 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

41 other PDB entries and 43 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	ACPM_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain BG； PDBConstruct 1–85； UniProt 72–156 Author chain BX； PDBConstruct 1–85； UniProt 72–156 Author chain G； PDBConstruct 1–85； UniProt 72–156 Author chain X； PDBConstruct 1–85； UniProt 72–156

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

OrganismNot specified

UniProt Q16718

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BH； UniProt 5–116 Chain H； UniProt 5–116	Fragment：UNP RESIDUES 5-116	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain H 5–116（112 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain H 5–116（112 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain H 5–116（112 aa） Fragment：UNP RESIDUES 5-116	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain H 1–116（116 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain I 1–116（116 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain I 5–116（112 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA5_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain BH； PDBConstruct 1–112； UniProt 5–116 Author chain H； PDBConstruct 1–112； UniProt 5–116

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

OrganismNot specified

UniProt O95182

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BI； UniProt 4–113 Chain I； UniProt 4–113	Fragment：UNP RESIDUES 4-113	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain I 4–113（110 aa） Fragment：UNP RESIDUES 4-113	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain I 4–113（110 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain I 4–113（110 aa） Fragment：UNP RESIDUES 4-113	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain I 1–113（113 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain t 1–113（113 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain t 1–113（113 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA7_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain BI； PDBConstruct 1–110； UniProt 4–113 Author chain I； PDBConstruct 1–110； UniProt 4–113

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

OrganismNot specified

UniProt Q16795

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BJ； UniProt 40–376 Chain J； UniProt 40–376	Fragment：UNP RESIDUES 40-376	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain J 40–376（337 aa） Fragment：UNP RESIDUES 40-375	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain J 40–376（337 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain J 40–376（337 aa） Fragment：UNP RESIDUES 40-376	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain J 1–377（377 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain J 1–377（377 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain J 36–376（341 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA9_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain BJ； PDBConstruct 1–337； UniProt 40–376 Author chain J； PDBConstruct 1–337； UniProt 40–376

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

OrganismNot specified

UniProt P56181

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BK； UniProt 74–106 Chain K； UniProt 74–106	Fragment：UNP RESIDUES 74-106	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain K 74–106（33 aa） Fragment：UNP RESIDUES 74-106	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain K 74–106（33 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain K 74–106（33 aa） Fragment：UNP RESIDUES 74-106	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain K 1–108（108 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain K 1–108（108 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain K 68–106（39 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å
9W2U Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain s 64–108（45 aa）	Not recorded	FME N-FORMYLMETHIONINE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 11 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 18 CDL CARDIOLIPIN × 6 CHD CHOLIC ACID × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 MYR MYRISTIC ACID × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.60 Å
9W2V Cryo-EM structure of complex I on the bovine heart submitochondrial particles, closed Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain s 64–108（45 aa）	Not recorded	FME N-FORMYLMETHIONINE × 4 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 19 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 SF4 IRON/SULFUR CLUSTER × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 FMN FLAVIN MONONUCLEOTIDE × 1 K POTASSIUM ION × 1 CDL CARDIOLIPIN × 6 MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.80 Å

8 other PDB entries and 8 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUV3_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain BK； PDBConstruct 1–33； UniProt 74–106 Author chain K； PDBConstruct 1–33； UniProt 74–106

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

OrganismNot specified

UniProt O43181

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BL； UniProt 58–175 Chain L； UniProt 58–175	Fragment：UNP RESIDUES 58-175	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain L 58–175（118 aa） Fragment：UNP RESIDUES 58-175	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain L 58–175（118 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain L 58–175（118 aa） Fragment：UNP RESIDUES 58-175	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain L 1–175（175 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain L 1–175（175 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain L 55–175（121 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS4_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain BL； PDBConstruct 1–118； UniProt 58–175 Author chain L； PDBConstruct 1–118； UniProt 58–175

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

OrganismNot specified

UniProt P28331

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BM； UniProt 30–716 Chain M； UniProt 30–716	Fragment：UNP RESIDUES 30-716	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain M 30–716（687 aa） Fragment：UNP RESIDUES 30-716	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain M 30–716（687 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain M 30–716（687 aa） Fragment：UNP RESIDUES 30-716	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain M 1–727（727 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain M 1–727（727 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain M 30–716（687 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS1_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain BM； PDBConstruct 1–687； UniProt 30–716 Author chain M； PDBConstruct 1–687； UniProt 30–716

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

OrganismNot specified

UniProt Q9UI09

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BN； UniProt 2–144 Chain N； UniProt 2–144	Fragment：UNP RESIDUES 2-144	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain N 2–144（143 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain N 2–144（143 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain N 2–144（143 aa） Fragment：UNP RESIDUES 2-144	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain N 1–145（145 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain N 1–145（145 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain N 1–144（144 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUAC_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain BN； PDBConstruct 1–143； UniProt 2–144 Author chain N； PDBConstruct 1–143； UniProt 2–144

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

OrganismNot specified

UniProt P19404

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BO； UniProt 36–247 Chain O； UniProt 36–247	Fragment：UNP RESIDUES 36-247	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain O 36–247（212 aa） Fragment：UNP RESIDUES 36-247	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain O 36–247（212 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain O 36–247（212 aa） Fragment：UNP RESIDUES 36-247	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain O 1–249（249 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain O 1–249（249 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain O 36–247（212 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUV2_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain BO； PDBConstruct 1–212； UniProt 36–247 Author chain O； PDBConstruct 1–212； UniProt 36–247

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

OrganismNot specified

UniProt O75489

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BP； UniProt 43–250 Chain P； UniProt 43–250	Fragment：UNP RESIDUES 43-250	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain P 43–250（208 aa） Fragment：UNP RESIDUES 43-250	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain P 43–250（208 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain P 43–250（208 aa） Fragment：UNP RESIDUES 43-250	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain P 1–264（264 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain P 1–264（264 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain P 43–250（208 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS3_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain BP； PDBConstruct 1–208； UniProt 43–250 Author chain P； PDBConstruct 1–208； UniProt 43–250

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

OrganismNot specified

UniProt O75306

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BQ； UniProt 34–463 Chain Q； UniProt 34–463	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain Q 79–463（385 aa） Fragment：UNP RESIDUES 79-463	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain Q 34–79（46 aa） Fragment：UNP RESIDUES 34-79	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Q 34–463（430 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain Q 34–463（430 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Q 1–463（463 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Q 1–463（463 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Q 34–463（430 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

7 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS2_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain BQ； PDBConstruct 1–397； UniProt 34–463 Author chain Q； PDBConstruct 1–397； UniProt 34–463

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

OrganismNot specified

UniProt O15239

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BS； UniProt 1–70 Chain S； UniProt 1–70	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain S 1–70（70 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain S 1–70（70 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain S 1–70（70 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain S 1–70（70 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain S 1–70（70 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain S 1–70（70 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA1_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain BS； PDBConstruct 1–70； UniProt 1–70 Author chain S； PDBConstruct 1–70； UniProt 1–70

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

OrganismNot specified

UniProt O75380

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BT； UniProt 29–123 Chain T； UniProt 29–123	Fragment：UNP RESIDUES 29-123	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain T 29–123（95 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain T 29–123（95 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain T 29–123（95 aa） Fragment：UNP RESIDUES 29-123	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain T 1–124（124 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain T 1–124（124 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain T 29–124（96 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS6_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain BT； PDBConstruct 1–95； UniProt 29–123 Author chain T； PDBConstruct 1–95； UniProt 29–123

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

OrganismNot specified

UniProt O95167

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BU； UniProt 2–84 Chain U； UniProt 2–84	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain U 2–84（83 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain U 2–84（83 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain U 2–84（83 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain U 1–84（84 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain U 1–84（84 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain U 2–84（83 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA3_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain BU； PDBConstruct 1–83； UniProt 2–84 Author chain U； PDBConstruct 1–83； UniProt 2–84

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

OrganismNot specified

UniProt Q86Y39

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BV； UniProt 2–141 Chain V； UniProt 2–141	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain V 2–141（140 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain V 2–141（140 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain V 2–141（140 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain V 1–141（141 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain V 1–141（141 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain V 2–141（140 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUAB_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain BV； PDBConstruct 1–140； UniProt 2–141 Author chain V； PDBConstruct 1–140； UniProt 2–141

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

OrganismNot specified

UniProt Q9P0J0

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BW； UniProt 7–144 Chain W； UniProt 7–144	Fragment：UNP RESIDUES 7-144	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTB Cryo-EM structure of human respiratory complex I matrix arm Deposited 2017-06-18	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 18 PDB declaration: octadecameric	Chain W 7–28（22 aa） Fragment：UNP RESIDUES 7-28	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain W 29–144（116 aa） Fragment：UNP RESIDUES 29-144	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain W 7–144（138 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain W 7–144（138 aa） Fragment：UNP RESIDUES 7-144	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain W 1–144（144 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain W 1–144（144 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain W 5–144（140 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

7 other PDB entries and 7 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUAD_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain BW； PDBConstruct 1–138； UniProt 7–144 Author chain W； PDBConstruct 1–138； UniProt 7–144

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

OrganismNot specified

UniProt O95178

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BY； UniProt 39–97 Chain Y； UniProt 39–97	Fragment：UNP RESIDUES 39-97	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain Y 39–97（59 aa） Fragment：UNP RESIDUES 39-97	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Y 39–97（59 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain Y 39–97（59 aa） Fragment：UNP RESIDUES 39-97	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Y 1–105（105 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Y 1–105（105 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Y 37–97（61 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB2_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain BY； PDBConstruct 1–59； UniProt 39–97 Author chain Y； PDBConstruct 1–59； UniProt 39–97

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

OrganismNot specified

UniProt O43676

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain BZ； UniProt 10–89 Chain Z； UniProt 10–89	Fragment：UNP RESIDUES 10-89	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain Z 10–89（80 aa） Fragment：UNP RESIDUES 10-89	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Z 10–89（80 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain Z 10–89（80 aa） Fragment：UNP RESIDUES 10-89	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Z 1–98（98 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Z 1–98（98 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain Z 10–92（83 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB3_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain BZ； PDBConstruct 1–80； UniProt 10–89 Author chain Z； PDBConstruct 1–80； UniProt 10–89

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

OrganismNot specified

UniProt O43674

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Ba； UniProt 52–189 Chain a； UniProt 52–189	Fragment：UNP RESIDUES 52-189	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain a 52–189（138 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain a 52–189（138 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain a 52–189（138 aa） Fragment：UNP RESIDUES 52-189	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain a 1–189（189 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain a 1–189（189 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain a 52–189（138 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB5_HUMAN
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain Ba； PDBConstruct 1–138； UniProt 52–189 Author chain a； PDBConstruct 1–138； UniProt 52–189

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

OrganismNot specified

UniProt O95139

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bb； UniProt 3–126 Chain b； UniProt 3–126	Fragment：UNP RESIDUES 3-126	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain b 1–128（128 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain b 1–128（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain b 3–126（124 aa） Fragment：UNP RESIDUES 3-126	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain b 1–128（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain b 1–128（128 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain b 2–122（121 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB6_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain Bb； PDBConstruct 1–124； UniProt 3–126 Author chain b； PDBConstruct 1–124； UniProt 3–126

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

OrganismNot specified

UniProt O95169

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bc； UniProt 34–186 Chain c； UniProt 34–186	Fragment：UNP RESIDUES 34-186	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain c 34–186（153 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain c 34–186（153 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain c 34–186（153 aa） Fragment：UNP RESIDUES 34-186	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain c 1–186（186 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain c 1–186（186 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain c 31–182（152 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB8_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain Bc； PDBConstruct 1–153； UniProt 34–186 Author chain c； PDBConstruct 1–153； UniProt 34–186

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

OrganismNot specified

UniProt O96000

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bd； UniProt 1–171 Chain d； UniProt 1–171	Fragment：UNP RESIDUES 1-171	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain d 1–171（171 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain d 1–171（171 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain d 1–171（171 aa） Fragment：UNP RESIDUES 1-171	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain d 1–172（172 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain d 1–172（172 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain d 2–170（169 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUBA_HUMAN
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain Bd； PDBConstruct 1–171； UniProt 1–171 Author chain d； PDBConstruct 1–171； UniProt 1–171

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

OrganismNot specified

UniProt Q9NX14

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Be； UniProt 54–150 Chain e； UniProt 54–150	Fragment：UNP RESIDUES 54-150	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain e 54–150（97 aa） Fragment：UNP RESIDUES 54-150	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain e 54–150（97 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain e 54–150（97 aa） Fragment：UNP RESIDUES 54-150	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain e 1–153（153 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain e 1–153（153 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain e 45–151（107 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUBB_HUMAN
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain Be； PDBConstruct 1–97； UniProt 54–150 Author chain e； PDBConstruct 1–97； UniProt 54–150

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

OrganismNot specified

UniProt O43677

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bf； UniProt 28–74 Chain f； UniProt 28–74	Fragment：UNP RESIDUES 28-74	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain f 28–74（47 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain f 28–74（47 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain f 28–74（47 aa） Fragment：UNP RESIDUES 28-74	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain f 1–76（76 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain f 1–76（76 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain f 27–75（49 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUC1_HUMAN
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain Bf； PDBConstruct 1–47； UniProt 28–74 Author chain f； PDBConstruct 1–47； UniProt 28–74

NADH dehydrogenase [ubiquinone] 1 subunit C2

OrganismNot specified

UniProt O95298

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bg； UniProt 1–119 Chain g； UniProt 1–119	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain g 1–119（119 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain g 1–119（119 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain g 1–119（119 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain g 1–119（119 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain g 1–119（119 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain g 1–119（119 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUC2_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain Bg； PDBConstruct 1–119； UniProt 1–119 Author chain g； PDBConstruct 1–119； UniProt 1–119

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

OrganismNot specified

UniProt O43920

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bh； UniProt 2–105 Chain h； UniProt 2–105	Fragment：UNP RESIDUES 2-105	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain h 2–105（104 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain h 2–105（104 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain h 2–105（104 aa） Fragment：UNP RESIDUES 2-105	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain h 1–106（106 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain h 1–106（106 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain h 1–105（105 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUS5_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain Bh； PDBConstruct 1–104； UniProt 2–105 Author chain h； PDBConstruct 1–104； UniProt 2–105

NADH-ubiquinone oxidoreductase chain 2

OrganismNot specified

UniProt Q4GRX1

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bi； UniProt 1–347 Chain i； UniProt 1–347	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain i 1–347（347 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain i 1–347（347 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain i 1–347（347 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q4GRX1_HUMAN
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain Bi； PDBConstruct 1–347； UniProt 1–347 Author chain i； PDBConstruct 1–347； UniProt 1–347

NADH-ubiquinone oxidoreductase chain 3

OrganismNot specified

UniProt B9EE38

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bj； UniProt 1–115 Chain j； UniProt 1–115	Fragment：UNP RESIDUES 1-115	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain j 1–115（115 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain j 1–115（115 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain j 1–115（115 aa） Fragment：UNP RESIDUES 1-115	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	B9EE38_HUMAN
Isoform	—
PDB entities	33
Chains and sequence ranges	Author chain Bj； PDBConstruct 1–115； UniProt 1–115 Author chain j； PDBConstruct 1–115； UniProt 1–115

NADH-ubiquinone oxidoreductase chain 4L

OrganismNot specified

UniProt V9JN72

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bk； UniProt 1–97 Chain k； UniProt 1–97	Fragment：UNP RESIDUES 1-97	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain k 1–97（97 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain k 1–97（97 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain k 1–97（97 aa） Fragment：UNP RESIDUES 1-97	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	V9JN72_HUMAN
Isoform	—
PDB entities	34
Chains and sequence ranges	Author chain Bk； PDBConstruct 1–97； UniProt 1–97 Author chain k； PDBConstruct 1–97； UniProt 1–97

NADH-ubiquinone oxidoreductase chain 5

OrganismNot specified

UniProt X5BVZ3

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bl； UniProt 1–603 Chain l； UniProt 1–603	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain l 1–603（603 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain l 1–603（603 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain l 1–603（603 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	X5BVZ3_HUMAN
Isoform	—
PDB entities	35
Chains and sequence ranges	Author chain Bl； PDBConstruct 1–603； UniProt 1–603 Author chain l； PDBConstruct 1–603； UniProt 1–603

NADH-ubiquinone oxidoreductase chain 6

OrganismNot specified

UniProt Q8HAX7

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bm； UniProt 1–174 Chain m； UniProt 1–174	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain m 1–174（174 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain m 1–174（174 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain m 1–174（174 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	Q8HAX7_HUMAN
Isoform	—
PDB entities	36
Chains and sequence ranges	Author chain Bm； PDBConstruct 1–174； UniProt 1–174 Author chain m； PDBConstruct 1–174； UniProt 1–174

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

OrganismNot specified

UniProt O75438

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bn； UniProt 3–58 Chain n； UniProt 3–58	Fragment：UNP RESIDUES 3-58	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain n 3–58（56 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain n 3–58（56 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain n 3–58（56 aa） Fragment：UNP RESIDUES 3-58	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain n 1–58（58 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain n 1–58（58 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain n 5–58（54 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB1_HUMAN
Isoform	—
PDB entities	37
Chains and sequence ranges	Author chain Bn； PDBConstruct 1–56； UniProt 3–58 Author chain n； PDBConstruct 1–56； UniProt 3–58

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

OrganismNot specified

UniProt O95168

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bo； UniProt 2–129 Chain o； UniProt 2–129	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain o 2–129（128 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain o 2–129（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain o 2–129（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain o 1–129（129 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain o 1–129（129 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain o 2–129（128 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB4_HUMAN
Isoform	—
PDB entities	38
Chains and sequence ranges	Author chain Bo； PDBConstruct 1–128； UniProt 2–129 Author chain o； PDBConstruct 1–128； UniProt 2–129

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

OrganismNot specified

UniProt Q9Y6M9

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bp； UniProt 8–179 Chain p； UniProt 8–179	Fragment：UNP RESIDUES 8-179	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain p 8–179（172 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain p 8–179（172 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain p 8–179（172 aa） Fragment：UNP RESIDUES 8-179	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain p 1–179（179 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain p 1–179（179 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain p 7–179（173 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB9_HUMAN
Isoform	—
PDB entities	39
Chains and sequence ranges	Author chain Bp； PDBConstruct 1–172； UniProt 8–179 Author chain p； PDBConstruct 1–172； UniProt 8–179

NADH-ubiquinone oxidoreductase chain 4

OrganismNot specified

UniProt B2XJG5

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Br； UniProt 1–459 Chain r； UniProt 1–459	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain r 1–459（459 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain r 1–459（459 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain r 1–459（459 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	B2XJG5_HUMAN
Isoform	—
PDB entities	40
Chains and sequence ranges	Author chain Br； PDBConstruct 1–459； UniProt 1–459 Author chain r； PDBConstruct 1–459； UniProt 1–459

NADH-ubiquinone oxidoreductase chain 1

OrganismNot specified

UniProt H9PGF0

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bs； UniProt 1–318 Chain s； UniProt 1–318	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain s 1–318（318 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain s 1–318（318 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain s 1–318（318 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å

3 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	H9PGF0_HUMAN
Isoform	—
PDB entities	41
Chains and sequence ranges	Author chain Bs； PDBConstruct 1–318； UniProt 1–318 Author chain s； PDBConstruct 1–318； UniProt 1–318

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

OrganismNot specified

UniProt P51970

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bu； UniProt 4–172 Chain u； UniProt 4–172	Fragment：UNP RESIDUES 4-172	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain u 4–172（169 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain u 4–172（169 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain u 4–172（169 aa） Fragment：UNP RESIDUES 4-172	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain u 1–172（172 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain u 1–172（172 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain u 2–172（171 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUA8_HUMAN
Isoform	—
PDB entities	42
Chains and sequence ranges	Author chain Bu； PDBConstruct 1–169； UniProt 4–172 Author chain u； PDBConstruct 1–169； UniProt 4–172

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

OrganismNot specified

UniProt P17568

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bv； UniProt 3–124 Chain v； UniProt 3–124	Fragment：UNP RESIDUES 3-124	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain v 3–124（122 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain v 1–137（137 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain v 3–124（122 aa） Fragment：UNP RESIDUES 3-124	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CWT Human kidney respiratory complex I Deposited 2024-07-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain v 1–137（137 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 ZMP S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.44 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain v 1–137（137 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain v 2–122（121 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

6 other PDB entries and 6 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUB7_HUMAN
Isoform	—
PDB entities	43
Chains and sequence ranges	Author chain Bv； PDBConstruct 1–122； UniProt 3–124 Author chain v； PDBConstruct 1–122； UniProt 3–124

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

OrganismNot specified

UniProt O95299

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bw； UniProt 36–355 Chain w； UniProt 36–355	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTC Cryo-EM structure of human respiratory complex I transmembrane arm Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric	Chain w 36–355（320 aa）	Not recorded	PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTD Cryo-EM structure of human respiratory complex I Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain w 36–355（320 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 9 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 CDL CARDIOLIPIN × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.70 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain w 36–355（320 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9I4I High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-01-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain w 1–355（355 aa）	Not recorded	PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 CDL CARDIOLIPIN × 6 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.63 Å
9TI4 High resolution Cryo-EM structure of human complex I in mitochondria Deposited 2025-12-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 45 PDB declaration: 45-meric	Chain w 36–355（320 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 7 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 7 ZN ZINC ION × 1 CDL CARDIOLIPIN × 6 DGT 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) Lauryl Maltose Neopentyl Glycol (LMNG), 0.001 % cardiolipin, 0.001 % glycol-diosgenin (GDN, Sigma-Aldrich), 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å

5 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	NDUAA_HUMAN
Isoform	—
PDB entities	44
Chains and sequence ranges	Author chain Bw； PDBConstruct 1–320； UniProt 36–355 Author chain w； PDBConstruct 1–320； UniProt 36–355

Cytochrome c oxidase subunit 1

OrganismNot specified

UniProt P00396

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bx； UniProt 1–514 Chain x； UniProt 1–514	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain L 1–514（514 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain y 1–514（514 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain x 1–514（514 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain a 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain a 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain x 1–514（514 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C3 1–514（514 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A9 1–514（514 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A9 1–514（514 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A3 1–514（514 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–513（513 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain A 1–514（514 aa） Chain N 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain A 1–514（514 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX1_BOVIN
Isoform	—
PDB entities	45
Chains and sequence ranges	Author chain Bx； PDBConstruct 1–514； UniProt 1–514 Author chain x； PDBConstruct 1–514； UniProt 1–514

Cytochrome c oxidase subunit 2

OrganismNot specified

UniProt P68530

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain By； UniProt 1–227 Chain y； UniProt 1–227	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain M 1–227（227 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain z 1–227（227 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain y 1–227（227 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain b 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain b 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain y 1–227（227 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C1 1–227（227 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C4 1–227（227 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B9 1–227（227 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B3 1–227（227 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain B 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain B 1–227（227 aa） Chain O 1–227（227 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155

88 other PDB entries and 127 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX2_BOVIN
Isoform	—
PDB entities	46
Chains and sequence ranges	Author chain By； PDBConstruct 1–227； UniProt 1–227 Author chain y； PDBConstruct 1–227； UniProt 1–227

Cytochrome c oxidase subunit 3

OrganismNot specified

UniProt P00415

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain Bz； UniProt 1–261 Chain z； UniProt 1–261	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain N 1–261（261 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain C 3–261（259 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain P 3–261（259 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain z 1–261（261 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain c 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain c 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 2–261（260 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 2–261（260 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain z 1–261（261 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 3–261（259 aa） Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 3–261（259 aa） Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 3–261（259 aa） Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 3–261（259 aa） Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A9 1–261（261 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C2 1–261（261 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B7 1–261（261 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C3 1–261（261 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain C 3–261（259 aa） Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 3–261（259 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 4–261（258 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain C 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain C 1–261（261 aa） Chain P 1–261（261 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain C 4–259（256 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

90 other PDB entries and 132 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX3_BOVIN
Isoform	—
PDB entities	47
Chains and sequence ranges	Author chain Bz； PDBConstruct 1–261； UniProt 1–261 Author chain z； PDBConstruct 1–261； UniProt 1–261

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

OrganismNot specified

UniProt P00423

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 0； UniProt 26–169 Chain B0； UniProt 26–169	Fragment：UNP RESIDUES 26-169	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 1–169（169 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 1–169（169 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain O 23–169（147 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 1 23–169（147 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain D 26–169（144 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain Q 26–169（144 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 1 23–169（147 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Fragment：residues 23-169 Chain d 23–169（147 aa） Fragment：residues 23-169	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain d 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 0 26–169（144 aa） Fragment：UNP RESIDUES 28-169	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 26–169（144 aa） Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 26–169（144 aa） Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 26–169（144 aa） Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 26–169（144 aa） Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A7 1–169（169 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A7 1–169（169 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A7 1–169（169 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain D3 1–169（169 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain D 26–169（144 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 26–169（144 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 32–168（137 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain D 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain D 23–169（147 aa） Chain Q 23–169（147 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain D 33–168（136 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX41_BOVIN
Isoform	—
PDB entities	48
Chains and sequence ranges	Author chain 0； PDBConstruct 1–144； UniProt 26–169 Author chain B0； PDBConstruct 1–144； UniProt 26–169

Cytochrome c oxidase subunit 5A, mitochondrial

OrganismNot specified

UniProt P00426

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 1； UniProt 44–152 Chain B1； UniProt 44–152	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 1–109（109 aa） Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 1–109（109 aa） Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 1–109（109 aa） Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 1–109（109 aa） Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 1–109（109 aa） Chain R 1–109（109 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 1–152（152 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 1–152（152 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain P 44–152（109 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 2 44–152（109 aa） Fragment：UNP RESIDUES 44-152	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain E 48–152（105 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain R 48–152（105 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 2 44–152（109 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Fragment：residues 44-152 Chain e 44–152（109 aa） Fragment：residues 44-152	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain e 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 1 44–152（109 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 48–152（105 aa） Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 48–152（105 aa） Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 48–152（105 aa） Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 48–152（105 aa） Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B4 1–152（152 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C0 1–152（152 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A6 1–152（152 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain E3 1–152（152 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 48–152（105 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain E 49–152（104 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 49–152（104 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 49–150（102 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain E 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain E 44–152（109 aa） Chain R 44–152（109 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain E 50–151（102 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX5A_BOVIN
Isoform	—
PDB entities	49
Chains and sequence ranges	Author chain 1； PDBConstruct 1–109； UniProt 44–152 Author chain B1； PDBConstruct 1–109； UniProt 44–152

Cytochrome c oxidase subunit 5B, mitochondrial

OrganismNot specified

UniProt P00428

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 2； UniProt 32–129 Chain B2； UniProt 32–129	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 1–98（98 aa） Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 1–98（98 aa） Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 1–98（98 aa） Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 1–98（98 aa） Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 1–98（98 aa） Chain S 1–98（98 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 1–129（129 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 1–129（129 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain Q 32–129（98 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 3 32–129（98 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain F 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 3 32–129（98 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Fragment：residues 32-129 Chain f 32–129（98 aa） Fragment：residues 32-129	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain f 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 2 32–129（98 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–125（94 aa） Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–125（94 aa） Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–125（94 aa） Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A5 1–129（129 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A6 1–129（129 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B2 1–129（129 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain F3 1–129（129 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–125（94 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain F 33–125（93 aa） Chain S 33–125（93 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 33–125（93 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 35–125（91 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain F 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain F 32–129（98 aa） Chain S 32–129（98 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain F 34–124（91 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX5B_BOVIN
Isoform	—
PDB entities	50
Chains and sequence ranges	Author chain 2； PDBConstruct 1–98； UniProt 32–129 Author chain B2； PDBConstruct 1–98； UniProt 32–129

Cytochrome c oxidase subunit 6A2, mitochondrial

OrganismNot specified

UniProt P07471

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 3； UniProt 13–96 Chain B3； UniProt 13–96	Fragment：UNP RESIDUES 13-96	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 1–97（97 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 1–97（97 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain R 13–96（84 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 4 13–96（84 aa） Fragment：UNP RESIDUES 13-96	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 4 13–96（84 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Fragment：residues 13-97 Chain g 13–97（85 aa） Fragment：residues 13-97	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain g 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 3 13–96（84 aa） Fragment：UNP RESIDUES 13-96	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A6 1–97（97 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A4 1–97（97 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A4 1–97（97 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain G3 1–97（97 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain G 13–96（84 aa） Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–96（84 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 24–95（72 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain G 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain T 13–97（85 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain G 13–97（85 aa） Chain T 13–97（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain G 24–95（72 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CX6A2_BOVIN
Isoform	—
PDB entities	51
Chains and sequence ranges	Author chain 3； PDBConstruct 1–84； UniProt 13–96 Author chain B3； PDBConstruct 1–84； UniProt 13–96

Cytochrome c oxidase subunit 6B1

OrganismNot specified

UniProt P00429

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 4； UniProt 12–86 Chain B4； UniProt 12–86	Fragment：UNP RESIDUES 12-86	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 1–85（85 aa） Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 1–85（85 aa） Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 1–85（85 aa） Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 1–85（85 aa） Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 1–85（85 aa） Chain U 1–85（85 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 1–86（86 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 1–86（86 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain S 2–86（85 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 5 2–86（85 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain H 8–86（79 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain U 8–86（79 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 5 2–86（85 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain h 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain h 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 4 12–86（75 aa） Fragment：UNP RESIDUES 12-86	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 8–86（79 aa） Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 8–86（79 aa） Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 8–86（79 aa） Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 8–86（79 aa） Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C0 1–86（86 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A5 1–86（86 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A5 1–86（86 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain H3 1–86（86 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain H 8–86（79 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 8–86（79 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 9–86（78 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain H 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain H 2–86（85 aa） Chain U 2–86（85 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain H 6–86（81 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CX6B1_BOVIN
Isoform	—
PDB entities	52
Chains and sequence ranges	Author chain 4； PDBConstruct 1–75； UniProt 12–86 Author chain B4； PDBConstruct 1–75； UniProt 12–86

Cytochrome c oxidase subunit 6C

OrganismNot specified

UniProt P04038

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 5； UniProt 2–74 Chain B5； UniProt 2–74	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 1–73（73 aa） Chain V 1–73（73 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 1–74（74 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 1–74（74 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain T 2–74（73 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 1–73（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 6 2–74（73 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 6 2–74（73 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain i 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain i 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 5 2–74（73 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C2 1–74（74 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B4 1–74（74 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B6 1–74（74 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain I3 1–74（74 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 5–74（70 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF)	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain I 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain V 2–74（73 aa）	Non-standard monomer：Yes (specific site not provided by mmCIF)	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain I 2–74（73 aa） Chain V 2–74（73 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain I 4–73（70 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX6C_BOVIN
Isoform	—
PDB entities	53
Chains and sequence ranges	Author chain 5； PDBConstruct 1–73； UniProt 2–74 Author chain B5； PDBConstruct 1–73； UniProt 2–74

Cytochrome c oxidase subunit 7A1, mitochondrial

OrganismNot specified

UniProt P07470

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 6； UniProt 22–77 Chain B6； UniProt 22–77	Fragment：UNP RESIDUES 22-77	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 1–80（80 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 1–80（80 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain U 22–80（59 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 7 22–80（59 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain J 22–79（58 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain W 22–79（58 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 7 22–80（59 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Fragment：residues 22-80 Chain j 22–80（59 aa） Fragment：residues 22-80	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain j 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 6 22–77（56 aa） Fragment：UNP RESIDUES 22-77	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–79（58 aa） Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–79（58 aa） Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–79（58 aa） Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–79（58 aa） Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B2 1–80（80 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C3 1–80（80 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B8 1–80（80 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain J3 1–80（80 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–79（58 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain J 22–78（57 aa） Chain W 22–78（57 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–78（57 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–76（55 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain J 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain J 22–80（59 aa） Chain W 22–80（59 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain J 22–76（55 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CX7A1_BOVIN
Isoform	—
PDB entities	54
Chains and sequence ranges	Author chain 6； PDBConstruct 1–56； UniProt 22–77 Author chain B6； PDBConstruct 1–56； UniProt 22–77

Cytochrome c oxidase subunit 7B, mitochondrial

OrganismNot specified

UniProt P13183

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 7； UniProt 30–78 Chain B7； UniProt 30–78	Fragment：UNP RESIDUES 30-78	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 33–88（56 aa） Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 33–88（56 aa） Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 33–88（56 aa） Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 33–88（56 aa） Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 33–88（56 aa） Chain X 33–88（56 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 1–80（80 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 1–80（80 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain V 25–80（56 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 8 25–80（56 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain K 30–78（49 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain X 30–78（49 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 8 25–80（56 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Fragment：residues 25-80 Chain k 25–80（56 aa） Fragment：residues 25-80	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain k 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 7 30–78（49 aa） Fragment：UNP RESIDUES 30-78	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 30–78（49 aa） Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 30–78（49 aa） Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 30–78（49 aa） Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 30–78（49 aa） Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B3 1–80（80 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B0 1–80（80 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B0 1–80（80 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain K3 1–80（80 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 32–78（47 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain K 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain K 25–80（56 aa） Chain X 25–80（56 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain K 30–78（49 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX7B_BOVIN
Isoform	—
PDB entities	55
Chains and sequence ranges	Author chain 7； PDBConstruct 1–49； UniProt 30–78 Author chain B7； PDBConstruct 1–49； UniProt 30–78

Cytochrome c oxidase subunit 7C, mitochondrial

OrganismNot specified

UniProt P00430

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 8； UniProt 17–63 Chain B8； UniProt 17–63	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 1–63（63 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 1–63（63 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain W 17–63（47 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain 9 17–63（47 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain L 18–63（46 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain Y 18–63（46 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 9 17–63（47 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Fragment：residues 17-63 Chain l 17–63（47 aa） Fragment：residues 17-63	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain l 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 8 17–63（47 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 18–63（46 aa） Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 18–63（46 aa） Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 18–63（46 aa） Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 18–63（46 aa） Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A0 1–63（63 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain C1 1–63（63 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain B1 1–63（63 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain L3 1–63（63 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain L 18–63（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8D4T Mammalian CIV with GDN bound Deposited 2022-06-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 18–63（46 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 9Z9 (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en × 1 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE-PROPANE	Resolution 3.10 Å
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain L 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain L 17–63（47 aa） Chain Y 17–63（47 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain L 19–62（44 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

91 other PDB entries and 133 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX7C_BOVIN
Isoform	—
PDB entities	56
Chains and sequence ranges	Author chain 8； PDBConstruct 1–47； UniProt 17–63 Author chain B8； PDBConstruct 1–47； UniProt 17–63

Cytochrome c oxidase subunit 8B, mitochondrial

OrganismNot specified

UniProt P10175

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain 9； UniProt 25–67 Chain B9； UniProt 25–67	Fragment：UNP RESIDUES 25-67	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
1OCC STRUCTURE OF BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1996-04-18	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.252
1OCO BOVINE HEART CYTOCHROME C OXIDASE IN CARBON MONOXIDE-BOUND STATE Deposited 1998-07-09	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 CMO CARBON MONOXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.80 Å R-free 0.256
1OCR BOVINE HEART CYTOCHROME C OXIDASE IN THE FULLY REDUCED STATE Deposited 1998-07-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.35 Å R-free 0.247
1OCZ BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE Deposited 1998-07-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 AZI AZIDE ION × 4 HEA HEME-A × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.90 Å R-free 0.255
1V54 Bovine heart cytochrome c oxidase at the fully oxidized state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
1V55 Bovine heart cytochrome c oxidase at the fully reduced state Deposited 2003-11-21	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 UNX UNKNOWN LIGAND × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.230
2DYR Bovine heart cytochrome C oxidase at the fully oxidized state Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.227
2DYS Bovine heart cytochrome C oxidase modified by DCCD Deposited 2006-09-16	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DCW DICYCLOHEXYLUREA × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.242
2EIJ Bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.90 Å R-free 0.234
2EIK Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 6 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.228
2EIL Cadmium ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CD CADMIUM ION × 3 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.231
2EIM Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully reduced state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 ZN ZINC ION × 6 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CHD CHOLIC ACID × 8 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.60 Å R-free 0.256
2EIN Zinc ion binding structure of bovine heart cytochrome C oxidase in the fully oxidized state Deposited 2007-03-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 ZN ZINC ION × 14 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.70 Å R-free 0.258
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PER PEROXIDE ION × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2OCC BOVINE HEART CYTOCHROME C OXIDASE AT THE FULLY OXIDIZED STATE Deposited 1998-05-26	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PER PEROXIDE ION × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions pH 6.8；pH 6.8	Resolution 2.30 Å R-free 0.244
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 1–70（70 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2Y69 Bovine heart cytochrome c oxidase re-refined with molecular oxygen Deposited 2011-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 1–70（70 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 OXY OXYGEN MOLECULE × 1 MG MAGNESIUM ION × 1 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.245
2YBB Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876) Deposited 2011-03-02	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 48 PDB declaration: 48-meric	Chain X 25–70（46 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 7 FMN FLAVIN MONONUCLEOTIDE × 1 NAI 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE × 1 MG MAGNESIUM ION × 7 FES FE2/S2 (INORGANIC) CLUSTER × 4 CA CALCIUM ION × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 5 SMA STIGMATELLIN A × 2 UQ1 UBIQUINONE-1 × 2 HEC HEME C × 2 CDL CARDIOLIPIN × 4 HEA HEME-A × 2 CU COPPER (II) ION × 3 ZN ZINC ION × 1	ELECTRON MICROSCOPY cryo-EM buffer 10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE；pH 7.7；10 MM KCL, 15 MM HEPES, RESIDUAL TREHALOSE cryo-EM vitrification conditions Cryogen ETHANE；VITRIFICATION 1 -- CRYOGEN- ETHANE, HUMIDITY- 70, TEMPERATURE- 95, INSTRUMENT- CUSTOM-MADE HAND PLUNGER, METHOD- ONE- SIDED BLOTTING FOR 26 - 30 SECONDS BEFORE PLUNGING, DETAILS- SAMPLE WAS ADSORBED TO CARBON FILM FOR 30 SECONDS BEFORE BLOTTING	Resolution 19.00 Å
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
2ZXW Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) Deposited 2009-01-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.50 Å R-free 0.233
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABK Bovine heart cytochrome c oxidase at the NO-bound fully reduced state (50K) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.00 Å R-free 0.219
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABL Bovine heart cytochrome c oxidase at the fully oxidized state (15-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.10 Å R-free 0.210
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3ABM Bovine heart cytochrome c oxidase at the fully oxidized state (200-s X-ray exposure dataset) Deposited 2009-12-16	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 1 PER PEROXIDE ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 HEA HEME-A × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.95 Å R-free 0.214
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG1 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 280 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CMO CARBON MONOXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.20 Å R-free 0.192
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 39 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG2 Bovine Heart Cytochrome c Oxidase in the Carbon Monoxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；0.2 % decal maltose in 40 mM sodium phosphate buffer, 9.0 % (w/v) protein concentration, PEG 4000 as the precipitant.	Resolution 1.80 Å R-free 0.208
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG3 Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 1.80 Å R-free 0.203
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3AG4 Bovine Heart Cytochrome c Oxidase in the Cyanide Ion-bound Fully Reduced State at 100 K Deposited 2010-03-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CYN CYANIDE ION × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION mmCIF provides none of the parsed conditions	Resolution 2.05 Å R-free 0.219
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASN Bovine heart cytochrome C oxidase in the fully oxidized state measured at 1.7470 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 3.00 Å R-free 0.187
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3ASO Bovine heart cytochrome C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength Deposited 2010-12-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH；pH 6.8；277 K；40mM sodium phosphate, 0.2% decylmaltoside , pH 6.8, BATCH, temperature 277K	Resolution 2.30 Å R-free 0.205
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3WG7 A 1.9 angstrom radiation damage free X-ray structure of large (420KDa) protein by femtosecond crystallography Deposited 2013-07-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions Batch；pH 5.7；277 K；40mM sodium phosphate, 0.2% decylmaltoside, pH 5.7, BATCH, temperature 277K, Batch	Resolution 1.90 Å R-free 0.230
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
3X2Q X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 angstrom resolution Deposited 2014-12-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	CYN CYANIDE ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions batch；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, PEG 4000, pH 6.8, batch, temperature 277K	Resolution 2.00 Å R-free 0.214
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1A Bovine heart cytochrome c oxidase in the fully oxidized state at 1.5 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.50 Å R-free 0.172
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 29 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B1B Bovine heart cytochrome c oxidase in the fully reduced state at 1.6 angstrom resolution Deposited 2015-12-01	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 EDO 1,2-ETHANEDIOL × 33 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate, Decylmaltoside	Resolution 1.60 Å R-free 0.191
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 52 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 12 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5B3S Bovine heart cytochrome c oxidase in the carbon monoxide-bound mixed-valence state at 1.68 angstrom resolution (50 K) Deposited 2016-03-11	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 42 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40mM Sodium phosphate, 0.2% decylmaltoside, 2% EG, PEG 4000	Resolution 1.68 Å R-free 0.177
5GPN Architecture of mammalian respirasome Deposited 2016-08-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 84 PDB declaration: 84-meric	Chain s 25–70（46 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 4 SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 ZN ZINC ION × 1 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.2 cryo-EM vitrification conditions Cryogen NITROGEN	Resolution 5.40 Å
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain M 25–67（43 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 6 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5IY5 Electron transfer complex of cytochrome c and cytochrome c oxidase at 2.0 angstrom resolution Deposited 2016-03-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric	Chain Z 25–67（43 aa）	Not recorded	CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 HEA HEME-A × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 2 CUA DINUCLEAR COPPER ION × 1 EDO 1,2-ETHANEDIOL × 3 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 CDL CARDIOLIPIN × 2 UNL UNKNOWN LIGAND × 10 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1 HEC HEME C × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 8；277 K；15mM sodium phosphate, pH 8.0, 0.7% fluorinated octylmaltoside, 0.2% decylmaltoside, 3% ethylene glycol, 5% PEG 4000	Resolution 2.00 Å R-free 0.207
5LUF Cryo-EM of bovine respirasome Deposited 2016-09-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 62 PDB declaration: 62-meric	Chain 0 25–70（46 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 SF4 IRON/SULFUR CLUSTER × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 7.7 cryo-EM vitrification conditions Cryogen ETHANE；10 s blotting	Resolution 9.10 Å
5W97 Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature Deposited 2017-06-22	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Fragment：residues 25-70 Chain m 25–70（46 aa） Fragment：residues 25-70	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, decylmaltoside	Resolution 2.30 Å R-free 0.252
5WAU Crystal Structure of CO-bound Cytochrome c Oxidase determined by Synchrotron X-Ray Crystallography at 100 K Deposited 2017-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain m 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；.2 % decylmaltoside and 2.5 % PEG4000	Resolution 1.95 Å R-free 0.244
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X19 CO bound cytochrome c oxidase at 100 micro sec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 6 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.210
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 16 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1B CO bound cytochrome c oxidase at 20 nsec after pump laser irradiation to release CO from O2 reduction center Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 2 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2% decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.40 Å R-free 0.230
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 17 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5X1F CO bound cytochrome c oxidase without pump laser irradiation at 278K Deposited 2017-01-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CMO CARBON MONOXIDE × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate, 0.2 % decyl maltoside, 2% ethylene glycol, PEG 4000	Resolution 2.20 Å R-free 0.209
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 31 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDQ Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution Deposited 2017-03-29	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 EDO 1,2-ETHANEDIOL × 25 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% polythylene glycol (PEG), 0.35% decal maltose, 0.70% fluorinated octyl-maltoside, 33mM sodium acetate, 25mM Tris-HCL (pH 7.3)	Resolution 1.77 Å R-free 0.190
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XDX Bovine heart cytochrome c oxidase in the reduced state with pH 7.3 at 1.99 angstrom resolution Deposited 2017-03-30	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 7.3；277 K；3% PEG 1500, 0.20% decal maltoside, 0.35% fluorinated octyl-maltoside, 25mM Tris-HCL(pH 7.3), 20mM sodium acetate	Resolution 1.99 Å R-free 0.203
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain 9 25–67（43 aa） Fragment：UNP RESIDUES 25-67	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 45 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z84 The structure of azide-bound cytochrome c oxidase determined using the crystals exposed to 20 mM azide solution for 4 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 37 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z85 The structure of azide-bound cytochrome c oxidase determined using the another batch crystals exposed to 20 mM azide solution for 2 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate	Resolution 1.85 Å R-free 0.189
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5Z86 azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 3 days Deposited 2018-01-31	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.85 Å R-free 0.196
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCO azide-bound cytochrome c oxidase structure determined using the crystals exposed to 2 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.90 Å R-free 0.189
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 26 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCP azide-bound cytochrome c oxidase structure determined using the crystals exposed to 20 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.197
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 32 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
5ZCQ Azide-bound cytochrome c oxidase structure determined using the crystals exposed to 10 mM azide solution for 2 days Deposited 2018-02-19	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 AZI AZIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 UNX UNKNOWN LIGAND × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate	Resolution 1.65 Å R-free 0.182
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6J8M Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray Deposited 2019-01-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.8；277 K；PEG 4000	Resolution 1.90 Å R-free 0.199
6JUW BOVINE HEART CYTOCHROME C OXIDASE IN CATALITIC INTERMEDIATES AT 1.80 ANGSTROM RESOLUTION Deposited 2019-04-15	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–67（43 aa） Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 25 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 TGL TRISTEAROYLGLYCEROL × 6 EDO 1,2-ETHANEDIOL × 80 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 9 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.188
6JY3 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CDL CARDIOLIPIN × 3 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 8 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.85 Å R-free 0.192
6JY4 Monomeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2019-04-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CQX (2S,3S,4S,5S,6R)-2-(2-decoxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol × 7 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CDL CARDIOLIPIN × 3 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；sodium phosphate, PEG 4000, DM	Resolution 1.95 Å R-free 0.205
6NKN Time-resolved SFX structure of the PR intermediate of cytochrome c oxidase at room temperature Deposited 2019-01-07	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 O OXYGEN ATOM × 2 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.50 Å R-free 0.217
6NMF SFX structure of reduced cytochrome c oxidase at room temperature Deposited 2019-01-10	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 CDL CARDIOLIPIN × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.80 Å R-free 0.232
6NMP SFX structure of oxidized cytochrome c oxidase at room temperature Deposited 2019-01-11	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 HEA HEME-A × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 TGL TRISTEAROYLGLYCEROL × 6 PER PEROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 8 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；36 hour crystallization in a cold room with stirring	Resolution 2.90 Å R-free 0.244
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 14 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7COH Dimeric Form of Bovine Heart Cytochrome c Oxidase in the Fully Oxidized State Deposited 2020-08-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CDL CARDIOLIPIN × 3 CHD CHOLIC ACID × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 21 PER PEROXIDE ION × 1 LFA EICOSANE × 13 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 UNX UNKNOWN LIGAND × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate pH 6.8, 0.2% decylmaltoside, 1% polyethylene glycol 4000, 2% ethylene glycol	Resolution 1.30 Å R-free 0.170
7CP5 Bovine heart cytochrome c oxidase in a catalytic intermediate of E at 1.76 angstrom resolution Deposited 2020-08-06	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–67（43 aa） Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 PER PEROXIDE ION × 2 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CDL CARDIOLIPIN × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.76 Å R-free 0.189
7D5W Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–67（43 aa） Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 PER PEROXIDE ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 EDO 1,2-ETHANEDIOL × 80 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.84 Å R-free 0.184
7D5X Bovine heart cytochrome c oxidase in a catalytic intermediate, IO10, at 1.74 angstrom resolution Deposited 2020-09-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–67（43 aa） Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 OXY OXYGEN MOLECULE × 2 EDO 1,2-ETHANEDIOL × 81 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 23 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 7 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 ZN ZINC ION × 2 PO4 PHOSPHATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.7；277 K；PEG 4000, Sodium Phosphate Buffer	Resolution 1.74 Å R-free 0.184
7DGQ Activity optimized supercomplex state1 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A8 1–70（70 aa）	Not recorded	PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 CU COPPER (II) ION × 3 HEA HEME-A × 2 MG MAGNESIUM ION × 1 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 UQ2 UBIQUINONE-2 × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 5.00 Å
7DGR Activity optimized supercomplex state2 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A8 1–70（70 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 CDL CARDIOLIPIN × 3 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.60 Å
7DGS Activity optimized supercomplex state3 Deposited 2020-11-12	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain A8 1–70（70 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 3 CDL CARDIOLIPIN × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 5 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 7.80 Å
7DKF Activity optimized supercomplex state4 Deposited 2020-11-24	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain M3 1–70（70 aa）	Not recorded	HEM PROTOPORPHYRIN IX CONTAINING FE × 4 HEC HEME C × 2 FES FE2/S2 (INORGANIC) CLUSTER × 3 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 3 CDL CARDIOLIPIN × 1 FMN FLAVIN MONONUCLEOTIDE × 1 SF4 IRON/SULFUR CLUSTER × 6 ZN ZINC ION × 2 NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 HEA HEME-A × 2 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 8.30 Å
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 71 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 6 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7EV7 Bovine heart cytochrome c oxidase in the carbon monoxide-bound fully reduced state at a 50 K Deposited 2021-05-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CMO CARBON MONOXIDE × 1 EDO 1,2-ETHANEDIOL × 64 TGL TRISTEAROYLGLYCEROL × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.70 Å R-free 0.178
7THU Structure of reduced bovine cytochrome c oxidase at 1.93 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-12	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 10 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Postassium phosphate, Decylmaltoside	Resolution 1.93 Å R-free 0.212
7TIE Structure of oxidized bovine cytochrome c oxidase at 1.90 Angstrom resolution obtained by synchrotron X-rays Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 91 TGL TRISTEAROYLGLYCEROL × 6 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 1.90 Å R-free 0.215
7TIH Structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 EDO 1,2-ETHANEDIOL × 84 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium phosphate, Decylmaltoside	Resolution 2.35 Å R-free 0.235
7TII Annealed structure of oxidized bovine cytochrome c oxidase with reduced metal centers induced by synchrotron X-ray exposure Deposited 2022-01-13	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 EDO 1,2-ETHANEDIOL × 8 OH HYDROXIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 6 CUA DINUCLEAR COPPER ION × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 CHD CHOLIC ACID × 8 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Potassium Phosphate, Decylmaltoside	Resolution 2.45 Å R-free 0.253
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 142 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VUW Bovine heart cytochrome c oxidase in the cyanide-bound fully oxidized state at 50 K Deposited 2021-11-04	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 107 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER	Resolution 1.60 Å R-free 0.175
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 48 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 8 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7VVR Bovine cytochrome c oxidese in CN-bound mixed valence state at 50 K Deposited 2021-11-08	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–67（43 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 42 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CHD CHOLIC ACID × 5 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.65 Å R-free 0.176
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 19 PDB declaration: tridecameric	Chain M 25–65（41 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 4 CYN CYANIDE ION × 2 TGL TRISTEAROYLGLYCEROL × 5 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 7 EDO 1,2-ETHANEDIOL × 46 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7W3E Bovine cytochrome c oxidese in CN-bound fully reduced state at 50 K Deposited 2021-11-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–65（41 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 CYN CYANIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 27 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 3 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 9 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, Sodium phosphate buffer	Resolution 1.45 Å R-free 0.182
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMA Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Insufficient information Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO	Resolution 2.20 Å R-free 0.213
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7XMB Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 Deposited 2022-04-25	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 TGL TRISTEAROYLGLYCEROL × 3 J6X 2-(4-methyl-1,3-thiazol-2-yl)-1-benzothiophen-3-ol × 1 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 3 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；sodium phosphate, PEG4000, decyl maltoside, ethylene glycol, DMSO, T113	Resolution 2.20 Å R-free 0.204
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 19 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 13 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 5 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7Y44 Re-refinement of damage free X-ray structure of bovine cytochrome c oxidase at 1.9 angstrom resolution Deposited 2022-06-14	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 30 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 10 TGL TRISTEAROYLGLYCEROL × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 CDL CARDIOLIPIN × 2 CHD CHOLIC ACID × 6 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 5.7；277 K；40mM sodium phosphate buffer, 0.2% decylmaltoside, 1% PEG 4000, 2% ethylene glycol	Resolution 1.90 Å R-free 0.227
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 56 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
7YPY Bovine heart cytochrome c oxidase in fully oxidized state at 1.5 angstrom resolution Deposited 2022-08-05	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 TGL TRISTEAROYLGLYCEROL × 3 EDO 1,2-ETHANEDIOL × 45 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 11 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 5 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 CDL CARDIOLIPIN × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 ZN ZINC ION × 1 PO4 PHOSPHATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；Sodium phosphate buffer, PEG 4000	Resolution 1.50 Å R-free 0.177
8GBT Time-resolve SFX structure of a photoproduct of carbon monoxide complex of bovine cytochrome c oxidase Deposited 2023-02-28	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 CMO CARBON MONOXIDE × 2 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 8 OH HYDROXIDE ION × 2 CDL CARDIOLIPIN × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.80 Å R-free 0.269
8GCQ SFX structure of oxidized cytochrome c oxidase at 2.38 Angstrom resolution Deposited 2023-03-02	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 8 HEA HEME-A × 4 OH HYDROXIDE ION × 2 CUA DINUCLEAR COPPER ION × 2 TGL TRISTEAROYLGLYCEROL × 6 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 2 CHD CHOLIC ACID × 10 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 6 CDL CARDIOLIPIN × 4 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 6 ZN ZINC ION × 2 SAC N-ACETYL-SERINE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium Phosphate, decylmaltoside	Resolution 2.38 Å R-free 0.266
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 5 EDO 1,2-ETHANEDIOL × 39 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 5 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 5 CDL CARDIOLIPIN × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 4 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8GVM The structure of azide-bound cytochrome C oxidase determined using the crystals exposed to 20 mm azide solution for 4 days Deposited 2022-09-15	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 2 AZI AZIDE ION × 2 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 3 EDO 1,2-ETHANEDIOL × 28 TGL TRISTEAROYLGLYCEROL × 3 CHD CHOLIC ACID × 3 CUA DINUCLEAR COPPER ION × 1 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 CDL CARDIOLIPIN × 3 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG 4000, SODIUM PHOSPHATE BUFFER PH 6.8	Resolution 1.85 Å R-free 0.188
8H8R Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Oxidized State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 PER PEROXIDE ION × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.153
8H8S Bovine Heart Cytochrome c Oxidase in the Calcium-bound Fully Reduced State Deposited 2022-10-24	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 CA CALCIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.70 Å R-free 0.156
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain M 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 7 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 2 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
8IJN Bovine Heart Cytochrome c Oxidase in the Nitric Oxide-Bound Fully Reduced State at 100 K Deposited 2023-02-27	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric	Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 2 NO NITRIC OXIDE × 1 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 NA SODIUM ION × 1 TGL TRISTEAROYLGLYCEROL × 3 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 EDO 1,2-ETHANEDIOL × 15 CUA DINUCLEAR COPPER ION × 1 CHD CHOLIC ACID × 4 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 3 CDL CARDIOLIPIN × 2 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 4 PSC (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE × 1 ZN ZINC ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；PEG4000, Sodium phosphate buffer	Resolution 1.80 Å R-free 0.192
9IKF Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.167
9IKG Bovine Heart Cytochrome c Oxidase in the Carbon Dioxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CO2 CARBON DIOXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.85 Å R-free 0.170
9IKH Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Oxidized State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.174
9IKI Bovine Heart Cytochrome c Oxidase in the Nitrous Oxide-bound Fully Reduced State Deposited 2024-06-27	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 N2O NITROUS OXIDE × 2 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 CDL CARDIOLIPIN × 6 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.75 Å R-free 0.189
9KUK Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Aerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.156
9KUL Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Oxidized State under Anaerobic Condition Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 PER PEROXIDE ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 14 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.155
9KUM Bovine Heart Cytochrome c Oxidase in the Xenon-bound Fully Reduced State Deposited 2024-12-04	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 XE XENON × 16 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.80 Å R-free 0.169
9M56 Bovine Heart Cytochrome c Oxidase in the Fully Reduced State Deposited 2025-03-05	Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric	Chain M 25–70（46 aa） Chain Z 25–70（46 aa）	Not recorded	HEA HEME-A × 4 CU COPPER (II) ION × 2 MG MAGNESIUM ION × 2 NA SODIUM ION × 2 CDL CARDIOLIPIN × 6 LFA EICOSANE × 26 DMU DECYL-BETA-D-MALTOPYRANOSIDE × 42 EDO 1,2-ETHANEDIOL × 29 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 4 CUA DINUCLEAR COPPER ION × 2 CHD CHOLIC ACID × 6 UNX UNKNOWN LIGAND × 2 ZN ZINC ION × 2 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 2	X-RAY DIFFRACTION X-ray crystallization conditions BATCH MODE；pH 6.8；277 K；40 mM sodium phosphate buffer, pH 6.8 0.2% (w/v) decyl-maltoside 1% (w/v) polyethylene glycol 4000	Resolution 1.60 Å R-free 0.155
9W2Z Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A Deposited 2025-07-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: 14-meric	Chain M 25–64（40 aa）	Not recorded	HEA HEME-A × 2 CU COPPER (II) ION × 1 MG MAGNESIUM ION × 1 PER PEROXIDE ION × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 CUA DINUCLEAR COPPER ION × 1 NA SODIUM ION × 1 ZN ZINC ION × 1 PEK (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.61 Å

90 other PDB entries and 132 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	COX8B_BOVIN
Isoform	—
PDB entities	57
Chains and sequence ranges	Author chain 9； PDBConstruct 1–43； UniProt 25–67 Author chain B9； PDBConstruct 1–43； UniProt 25–67

Cytochrome b-c1 complex subunit 8

OrganismNot specified

UniProt O14949

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AA； UniProt 2–82 Chain AN； UniProt 2–82	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain A 2–82（81 aa） Chain N 2–82（81 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AA 2–82（81 aa） Chain AN 2–82（81 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain A 1–82（82 aa） Chain N 1–82（82 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain A 1–82（82 aa） Chain N 1–82（82 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR8_HUMAN
Isoform	—
PDB entities	58
Chains and sequence ranges	Author chain AA； PDBConstruct 1–81； UniProt 2–82 Author chain AN； PDBConstruct 1–81； UniProt 2–82

Cytochrome b-c1 complex subunit Rieske, mitochondrial

OrganismNot specified

UniProt P47985

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AB； UniProt 1–57 Chain AC； UniProt 79–274 Chain AO； UniProt 1–57 Chain AP； UniProt 79–274	Fragment：UNP RESIDUES 1-57	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain B 1–57（57 aa） Fragment：UNP RESIDUES 1-57 Chain C 79–274（196 aa） Chain O 1–57（57 aa） Fragment：UNP RESIDUES 1-57 Chain P 79–274（196 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AB 1–57（57 aa） Fragment：UNP RESIDUES 1-57 Chain AC 79–274（196 aa） Chain AO 1–57（57 aa） Fragment：UNP RESIDUES 1-57 Chain AP 79–274（196 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain C 1–274（274 aa） Chain P 1–274（274 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain B 1–274（274 aa） Chain C 1–274（274 aa） Chain O 1–274（274 aa） Chain P 1–274（274 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	UCRI_HUMAN
Isoform	—
PDB entities	59, 60
Chains and sequence ranges	Author chain AB； PDBConstruct 1–57； UniProt 1–57 Author chain AO； PDBConstruct 1–57； UniProt 1–57 Author chain AC； PDBConstruct 1–196； UniProt 79–274 Author chain AP； PDBConstruct 1–196； UniProt 79–274

Cytochrome b-c1 complex subunit 9

OrganismNot specified

UniProt Q9UDW1

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AD； UniProt 2–63 Chain AQ； UniProt 2–63	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain D 2–63（62 aa） Chain Q 2–63（62 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AD 2–63（62 aa） Chain AQ 2–63（62 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain D 1–63（63 aa） Chain Q 1–63（63 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain D 1–63（63 aa） Chain Q 1–63（63 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR9_HUMAN
Isoform	—
PDB entities	61
Chains and sequence ranges	Author chain AD； PDBConstruct 1–62； UniProt 2–63 Author chain AQ； PDBConstruct 1–62； UniProt 2–63

Cytochrome b-c1 complex subunit 6, mitochondrial

OrganismNot specified

UniProt P07919

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AE； UniProt 18–91 Chain AR； UniProt 18–91	Fragment：UNP RESIDUES 18-91	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain E 17–91（75 aa） Chain R 17–91（75 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AE 18–91（74 aa） Fragment：UNP RESIDUES 18-91 Chain AR 18–91（74 aa） Fragment：UNP RESIDUES 18-91	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain E 1–91（91 aa） Chain R 1–91（91 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain E 1–91（91 aa） Chain R 1–91（91 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR6_HUMAN
Isoform	—
PDB entities	62
Chains and sequence ranges	Author chain AE； PDBConstruct 1–74； UniProt 18–91 Author chain AR； PDBConstruct 1–74； UniProt 18–91

Cytochrome b-c1 complex subunit 7

OrganismNot specified

UniProt P14927

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AF； UniProt 6–111 Chain AS； UniProt 6–111	Fragment：UNP RESIDUES 6-111	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain F 6–111（106 aa） Fragment：UNP RESIDUES 6-111 Chain S 6–111（106 aa） Fragment：UNP RESIDUES 6-111	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AF 6–111（106 aa） Fragment：UNP RESIDUES 6-111 Chain AS 6–111（106 aa） Fragment：UNP RESIDUES 6-111	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain F 1–111（111 aa） Chain S 1–111（111 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain F 1–111（111 aa） Chain S 1–111（111 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR7_HUMAN
Isoform	—
PDB entities	63
Chains and sequence ranges	Author chain AF； PDBConstruct 1–106； UniProt 6–111 Author chain AS； PDBConstruct 1–106； UniProt 6–111

Cytochrome b-c1 complex subunit 10

OrganismNot specified

UniProt O14957

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AG； UniProt 2–52 Chain AT； UniProt 2–52	Fragment：UNP RESIDUES 2-52	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain G 2–52（51 aa） Fragment：UNP RESIDUES 2-52 Chain T 2–52（51 aa） Fragment：UNP RESIDUES 2-52	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AG 2–52（51 aa） Fragment：UNP RESIDUES 2-52 Chain AT 2–52（51 aa） Fragment：UNP RESIDUES 2-52	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain G 1–56（56 aa） Chain T 1–56（56 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain G 1–56（56 aa） Chain T 1–56（56 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR10_HUMAN
Isoform	—
PDB entities	64
Chains and sequence ranges	Author chain AG； PDBConstruct 1–51； UniProt 2–52 Author chain AT； PDBConstruct 1–51； UniProt 2–52

Cytochrome c1, heme protein, mitochondrial

OrganismNot specified

UniProt P08574

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AH； UniProt 85–325 Chain AU； UniProt 85–325	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain H 85–325（241 aa） Chain U 85–325（241 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AH 85–325（241 aa） Chain AU 85–325（241 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain H 1–325（325 aa） Chain U 1–325（325 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain H 1–325（325 aa） Chain U 1–325（325 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CY1_HUMAN
Isoform	—
PDB entities	65
Chains and sequence ranges	Author chain AH； PDBConstruct 1–241； UniProt 85–325 Author chain AU； PDBConstruct 1–241； UniProt 85–325

Cytochrome b

OrganismNot specified

UniProt P00156

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AJ； UniProt 2–379 Chain AV； UniProt 2–379	Fragment：UNP RESIDUES 2-479	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain J 2–379（378 aa） Chain V 2–379（378 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AJ 2–379（378 aa） Fragment：UNP RESIDUES 1-379 Chain AV 2–379（378 aa） Fragment：UNP RESIDUES 1-379	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain J 1–380（380 aa） Chain V 1–380（380 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain J 1–380（380 aa） Chain V 1–380（380 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	CYB_HUMAN
Isoform	—
PDB entities	66
Chains and sequence ranges	Author chain AJ； PDBConstruct 1–378； UniProt 2–379 Author chain AV； PDBConstruct 1–378； UniProt 2–379

Cytochrome b-c1 complex subunit 2, mitochondrial

OrganismNot specified

UniProt P22695

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AK； UniProt 35–453 Chain AW； UniProt 35–453	Fragment：UNP RESIDUES 35-453	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 1, mitochondrial × 2 （P31930） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain K 35–453（419 aa） Fragment：UNP RESIDUES 35-453 Chain W 35–453（419 aa） Fragment：UNP RESIDUES 35-453	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AK 35–453（419 aa） Fragment：UNP RESIDUES 35-453 Chain AW 35–453（419 aa） Fragment：UNP RESIDUES 35-453	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain K 1–453（453 aa） Chain W 1–453（453 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain K 1–453（453 aa） Chain W 1–453（453 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR2_HUMAN
Isoform	—
PDB entities	67
Chains and sequence ranges	Author chain AK； PDBConstruct 1–419； UniProt 35–453 Author chain AW； PDBConstruct 1–419； UniProt 35–453

Cytochrome b-c1 complex subunit 1, mitochondrial

OrganismNot specified

UniProt P31930

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 138 PDB declaration: 138-meric（138） Consistent with protein copy count	Chain AL； UniProt 35–480 Chain AY； UniProt 35–480	Not recorded	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial × 2 （P49821） NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial × 2 （O00217） NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial × 2 （O75251） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 × 2 （P56556） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 × 2 （O43678） Acyl carrier protein, mitochondrial × 4 （O14561） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 × 2 （Q16718） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 × 2 （O95182） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial × 2 （Q16795） NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial × 2 （P56181） NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial × 2 （O43181） NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial × 2 （P28331） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 × 2 （Q9UI09） NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial × 2 （P19404） NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial × 2 （O75489） NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial × 2 （O75306） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 × 2 （O15239） NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial × 2 （O75380） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 × 2 （O95167） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 × 2 （Q86Y39） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 × 2 （Q9P0J0） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial × 2 （O95178） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 × 2 （O43676） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial × 2 （O43674） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 × 2 （O95139） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial × 2 （O95169） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 × 2 （O96000） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial × 2 （Q9NX14） NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial × 2 （O43677） NADH dehydrogenase [ubiquinone] 1 subunit C2 × 2 （O95298） NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 × 2 （O43920） NADH-ubiquinone oxidoreductase chain 2 × 2 （Q4GRX1） NADH-ubiquinone oxidoreductase chain 3 × 2 （B9EE38） NADH-ubiquinone oxidoreductase chain 4L × 2 （V9JN72） NADH-ubiquinone oxidoreductase chain 5 × 2 （X5BVZ3） NADH-ubiquinone oxidoreductase chain 6 × 2 （Q8HAX7） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 × 2 （O75438） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 × 2 （O95168） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 × 2 （Q9Y6M9） NADH-ubiquinone oxidoreductase chain 4 × 2 （B2XJG5） NADH-ubiquinone oxidoreductase chain 1 × 2 （H9PGF0） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 × 2 （P51970） NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 × 2 （P17568） NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial × 2 （O95299） Cytochrome c oxidase subunit 1 × 2 （P00396） Cytochrome c oxidase subunit 2 × 2 （P68530） Cytochrome c oxidase subunit 3 × 2 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 2 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 2 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 2 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 2 （P07471） Cytochrome c oxidase subunit 6B1 × 2 （P00429） Cytochrome c oxidase subunit 6C × 2 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 2 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 2 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 2 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 2 （P10175） Cytochrome b-c1 complex subunit 8 × 2 （O14949） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit Rieske, mitochondrial × 2 （P47985） Cytochrome b-c1 complex subunit 9 × 2 （Q9UDW1） Cytochrome b-c1 complex subunit 6, mitochondrial × 2 （P07919） Cytochrome b-c1 complex subunit 7 × 2 （P14927） Cytochrome b-c1 complex subunit 10 × 2 （O14957） Cytochrome c1, heme protein, mitochondrial × 2 （P08574） Cytochrome b × 2 （P00156） Cytochrome b-c1 complex subunit 2, mitochondrial × 2 （P22695） SF4 IRON/SULFUR CLUSTER × 12 FMN FLAVIN MONONUCLEOTIDE × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 21 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 4 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 6 CDL CARDIOLIPIN × 19 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 14 CU COPPER (II) ION × 6 MG MAGNESIUM ION × 2 HEA HEME-A × 4 ZN ZINC ION × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer：pH 7.4 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 17.40 Å

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 5XTI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
5XTE Cryo-EM structure of human respiratory complex III (cytochrome bc1 complex) Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain L 35–480（446 aa） Chain Y 35–480（446 aa）	Not recorded	CDL CARDIOLIPIN × 9 FES FE2/S2 (INORGANIC) CLUSTER × 2 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 6 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 3	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.40 Å
5XTH Cryo-EM structure of human respiratory supercomplex I1III2IV1 Deposited 2017-06-19	Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 80 PDB declaration: 80-meric	Chain AL 35–480（446 aa） Chain AY 35–480（446 aa）	Not recorded	SF4 IRON/SULFUR CLUSTER × 6 FMN FLAVIN MONONUCLEOTIDE × 1 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 12 8Q1 S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate × 2 NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 FES FE2/S2 (INORGANIC) CLUSTER × 4 CDL CARDIOLIPIN × 14 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 CU COPPER (II) ION × 3 MG MAGNESIUM ION × 1 HEA HEME-A × 2 ZN ZINC ION × 1 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
9CG3 Human kidney respiratory complex III Deposited 2024-06-28	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 20 PDB declaration: 20-meric	Chain L 1–480（480 aa） Chain Y 1–480（480 aa）	Not recorded	FES FE2/S2 (INORGANIC) CLUSTER × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4	ELECTRON MICROSCOPY cryo-EM buffer pH 7.5 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.96 Å
9HZL High resolution cryo-EM structure of human complex III in mitochondria Deposited 2025-01-14	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 22 PDB declaration: 22-meric	Chain L 1–480（480 aa） Chain Y 1–480（480 aa）	Not recorded	CDL CARDIOLIPIN × 9 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 6 FES FE2/S2 (INORGANIC) CLUSTER × 2 PLX (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL × 2 HEC HEME C × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 U10 UBIQUINONE-10 × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 7.4；25 mM HEPES-KOH pH=7.5, 50 mM KCl, 20 mM Mg(OAc)2, 0.01% (v/v) LMNG, 0.001 % cardiolipin, 0.001 % GD, 0.1mM DTT cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.52 Å

4 other PDB entries and 4 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	QCR1_HUMAN
Isoform	—
PDB entities	68
Chains and sequence ranges	Author chain AL； PDBConstruct 1–446； UniProt 35–480 Author chain AY； PDBConstruct 1–446； UniProt 35–480

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5xti
Deposition date deposition_date	2017-06-19
Structure title title	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2
Keywords keywords	Homo sapiens, Oxidoreductase, Respiratory, OXIDOREDUCTASE-ELECTRON TRANSPORT complex; OXIDOREDUCTASE/ELECTRON TRANSPORT
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	— Å
Radius of gyration Rg (electron density) rg_electron	113.80 Å
Forward intensity I(0) i0	97635700000.00
Molecular weight molecular_weight	2798100.0 kDa
Excluded volume excluded_volume	3547500 Å³
Envelope volume envelope_volume	5811000 Å³
Hydration-shell volume shell_volume	423410 Å³
Envelope diameter envelope_diameter	372.2 Å
Shell Rg shell_rg	108.40 Å
Envelope Rg envelope_rg	108.60 Å
Shape Rg shape_rg	113.70 Å
Total Rg total_rg	113.90 Å
Total atoms total_atoms	196753
Residues n_residues	24164
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	353.4 Å
Rg (real space) rg_real	116.40 Å
Rg uncertainty (real space) rg_real_error	1.39 Å
I(0) (real space) i0_real	9.5880e+10
I(0) uncertainty (real space) i0_real_error	2.1170e+09
Rg (reciprocal space) rg_reciprocal	115.30 Å
I(0) (reciprocal space) i0_reciprocal	97750000000.0000
Solution quality estimate total_estimate	0.8995
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	151.4 Å
Skewness Skewness skewness	0.232
Kurtosis Kurtosis kurtosis	-0.466
Angular range angular_range	— – 0.0700 Å⁻¹
Current regularization parameter α current_alpha	1.7950
Highest regularization parameter α highest_alpha	1989000000.0000
Real-space data points n_real_points	15
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.988; Stabil: 0.914; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.000

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (82)

Entity 1 Entity 1 polymer

Description description	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Molecular weight formula_weight	47323.9 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,BA
Atom count atom_count	196753

PKKTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRGDWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREILRHDPHKLLEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQH

Entity 2 Entity 2 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Molecular weight formula_weight	20314.0 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,BB

TYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR

Entity 3 Entity 3 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Molecular weight formula_weight	17887.9 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,BC

SRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALLYGILQLQRKIKRERRLQIWYRR

Entity 4 Entity 4 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
Molecular weight formula_weight	13758.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,BE

FVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHQFQLDITVKMGRDKVREMFMKNAHVTDPRVVDLLVIKGKIELEETIKVWKQRTHVMRFFHETEAPRPKDFLSKFYVGHDP

Entity 5 Entity 5 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Molecular weight formula_weight	9535.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,BF

LGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSADQVTRALENVLS

Entity 6 Entity 6 polymer

Description description	Acyl carrier protein, mitochondrial
Molecular weight formula_weight	9845.2 kDa
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,X,BG,BX

PPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE

Entity 7 Entity 7 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Molecular weight formula_weight	13119.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,BH

LKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEQITNEKLAMVKAEPDVKKLEDQLQGGQLEEVILQAEHELNLARKMREWKLWEPLVEEPPADQWKWPI

Entity 8 Entity 8 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Molecular weight formula_weight	12282.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,BI

ATRLIQRLRNWASGHDLQGKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRRESVPPSIIMSSQKALVSGKPAESSAVAATEKKAVTPAPPIKRWELSSDQPYL

Entity 9 Entity 9 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Molecular weight formula_weight	38387.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,BJ

LMPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVN

Entity 10 Entity 10 polymer

Description description	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Molecular weight formula_weight	3900.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,BK

LQHHDYSTYTFLDLNLELSKFRMPQPSSGRESP

Entity 11 Entity 11 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Molecular weight formula_weight	13721.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,BL

KLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK

Entity 12 Entity 12 polymer

Description description	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Molecular weight formula_weight	75471.5 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,BM

NLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTE

Entity 13 Entity 13 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Molecular weight formula_weight	16880.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,BN

ELVQVLKRGLQQITGHGGLRGYLRVFFRTNDAKVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYTTEMNGKNTFWDVDGSMVPPEWHRWLHSMTDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTRKKIQEWIPPSTPY

Entity 14 Entity 14 polymer

Description description	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Molecular weight formula_weight	23430.9 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O,BO

GALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQA

Entity 15 Entity 15 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Molecular weight formula_weight	24432.7 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P,BP

TRPTVRPRNDVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPE

Entity 16 Entity 16 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Molecular weight formula_weight	49236.5 kDa
EC 编号 ec_number	1.6.5.3,1.6.99.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q,BQ

VRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR

Entity 17 Entity 17 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Molecular weight formula_weight	8084.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S,BS

MWFEILPGLSVMGVCLLIPGLATAYIHRFTNGGKEKRVAHFGYHWSLMERDRRISGVDRYYVSKGLENID

Entity 18 Entity 18 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Molecular weight formula_weight	10578.8 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T,BT

GVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQKEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFRQHH

Entity 19 Entity 19 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Molecular weight formula_weight	9156.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U,BU

AARVGAFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL

Entity 20 Entity 20 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
Molecular weight formula_weight	14736.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V,BV

APKVFRQYWDIPDGTDCHRKAYSTTSIASVAGLTAAAYRVTLNPPGTFLEGVAKVGQYTFTAAAVGAVFGLTTCISAHVREKPDDPLNYFLGGCAGGLTLGARTHNYGIGAAACVYFGIAASLVKMGRLEGWEVFAKPKV

Entity 21 Entity 21 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Molecular weight formula_weight	16132.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W,BW

KQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

Entity 22 Entity 22 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Molecular weight formula_weight	7468.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y,BY

HIEPRYRQFPQLTRSQVFQSEFFSGLMWFWILWRFWHDSEEVLGHFPYPDPSQWTDEEL

Entity 23 Entity 23 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Molecular weight formula_weight	9261.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z,BZ

GHHKMELPDYRQWKIEGTPLETIQKKLAAKGLRDPWGRNEAWRYMGGFAKSVSFSDVFFKGFKWGFAAFVVAVGAEYYLE

Entity 24 Entity 24 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Molecular weight formula_weight	16573.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a,Ba

KRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN

Entity 25 Entity 25 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
Molecular weight formula_weight	15008.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b,Bb

GYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQ

Entity 26 Entity 26 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Molecular weight formula_weight	18267.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c,Bc

KDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI

Entity 27 Entity 27 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Molecular weight formula_weight	20721.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d,Bd

MPDSWDKDVYPEPPRRTPVQPNPIVYMMKAFDLIVDRPVTLVREFIERQHAKNRYYYYHRQYRRVPDITECKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQNYQQNCIKEVEQFTQVAKAYQDRYQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAAT

Entity 28 Entity 28 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Molecular weight formula_weight	11494.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e,Be

PWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANGLPIMESNCFDPSKIQLP

Entity 29 Entity 29 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Molecular weight formula_weight	5704.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f,Bf

KFYVREPPNAKPDWLKVGFTLGTTVFLWIYLIKQHNEDILEYKRRNG

Entity 30 Entity 30 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 subunit C2
Molecular weight formula_weight	14209.5 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g,Bg

MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR

Entity 31 Entity 31 polymer

Description description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Molecular weight formula_weight	12314.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	h,Bh

PFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPR

Entity 32 Entity 32 polymer

Description description	NADH-ubiquinone oxidoreductase chain 2
Molecular weight formula_weight	39007.7 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	i,Bi

MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVNLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Entity 33 Entity 33 polymer

Description description	NADH-ubiquinone oxidoreductase chain 3
Molecular weight formula_weight	13147.9 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	j,Bj

MNFALILMTNTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWAE

Entity 34 Entity 34 polymer

Description description	NADH-ubiquinone oxidoreductase chain 4L
Molecular weight formula_weight	10702.1 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	k,Bk

MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIMPIVMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQ

Entity 35 Entity 35 polymer

Description description	NADH-ubiquinone oxidoreductase chain 5
Molecular weight formula_weight	67096.0 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	l,Bl

MTMHTTMATLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENNPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSIMHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Entity 36 Entity 36 polymer

Description description	NADH-ubiquinone oxidoreductase chain 6
Molecular weight formula_weight	18661.0 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	m,Bm

MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGFIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN

Entity 37 Entity 37 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Molecular weight formula_weight	6741.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	n,Bn

NLLQIVRDHWVHVLVPMGFVIGCYLDRKSDERLTAFRNKSMLFKRELQPSEEVTWK

Entity 38 Entity 38 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Molecular weight formula_weight	15100.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	o,Bo

SFPKYKPSSLRTLPETLDPAEYNISPETRRAQAERLAIRAQLKREYLLQYNDPNRRGLIENPALLRWAYARTINVYPNFRPTPKNSLMGALCGFGPLIFIYYIIKTERDRKEKLIQEGKLDRTFHLSY

Entity 39 Entity 39 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Molecular weight formula_weight	21189.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	p,Bp

PYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTSYERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVKQLQEETPPGGPLTEALPPARKEGDLPPLWWYIVTRPRERPM

Entity 40 Entity 40 polymer

Description description	NADH-ubiquinone oxidoreductase chain 4
Molecular weight formula_weight	51689.7 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r,Br

MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSLTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLIFLQISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS

Entity 41 Entity 41 polymer

Description description	NADH-ubiquinone oxidoreductase chain 1
Molecular weight formula_weight	35621.2 kDa
EC 编号 ec_number	1.6.5.3
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	s,Bs

MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRAPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWHVSMPITISSIPPQT

Entity 42 Entity 42 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Molecular weight formula_weight	19853.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	u,Bu

IVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK

Entity 43 Entity 43 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Molecular weight formula_weight	14997.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	v,Bv

AHLVRRYLGDASVEPDPLQMPTFPPDYGFPERKEREMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEHRDYVMRMKEFERERRLLQRKKRREKKAAELAK

Entity 44 Entity 44 polymer

Description description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Molecular weight formula_weight	37200.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	w,Bw

LRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFRELPGRKYSPGYNTEVGDKWIWLK

Entity 45 Entity 45 polymer

Description description	Cytochrome c oxidase subunit 1
Molecular weight formula_weight	57065.8 kDa
EC 编号 ec_number	1.9.3.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	x,Bx

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK

Entity 46 Entity 46 polymer

Description description	Cytochrome c oxidase subunit 2
Molecular weight formula_weight	26040.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	y,By

MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML

Entity 47 Entity 47 polymer

Description description	Cytochrome c oxidase subunit 3
Molecular weight formula_weight	29957.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	z,Bz

MTHQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Entity 48 Entity 48 polymer

Description description	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Molecular weight formula_weight	16913.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	0,B0

SVVKSEDYALPSYVDRRDYPLPDVAHVKNLSASQKALKEKEKASWSSLSIDEKVELYRLKFKESFAEMNRSTNEWKTVVGAAMFFIGFTALLLIWEKHYVYGPIPHTFEEEWVAKQTKRMLDMKVAPIQGFSAKWDYDKNEWKK

Entity 49 Entity 49 polymer

Description description	Cytochrome c oxidase subunit 5A, mitochondrial
Molecular weight formula_weight	12453.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1,B1

SHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Entity 50 Entity 50 polymer

Description description	Cytochrome c oxidase subunit 5B, mitochondrial
Molecular weight formula_weight	10684.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2,B2

ASGGGVPTDEEQATGLEREVMLAARKGQDPYNILAPKATSGTKEDPNLVPSITNKRIVGCICEEDNSTVIWFWLHKGEAQRCPSCGTHYKLVPHQLAH

Entity 51 Entity 51 polymer

Description description	Cytochrome c oxidase subunit 6A2, mitochondrial
Molecular weight formula_weight	9452.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3,B3

ASAAKGDHGGTGARTWRFLTFGLALPSVALCTLNSWLHSGHRERPAFIPYHHLRIRTKPFSWGDGNHTFFHNPRVNPLPTGYEK

Entity 52 Entity 52 polymer

Description description	Cytochrome c oxidase subunit 6B1
Molecular weight formula_weight	8926.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4,B4

YQTAPFDSRFPNQNQTRNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRVYKSLCPISWVSTWDDRRAEGTFPGKI

Entity 53 Entity 53 polymer

Description description	Cytochrome c oxidase subunit 6C
Molecular weight formula_weight	8495.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5,B5

STALAKPQMRGLLARRLRFHIVGAFMVSLGFATFYKFAVAEKRKKAYADFYRNYDSMKDFEEMRKAGIFQSAK

Entity 54 Entity 54 polymer

Description description	Cytochrome c oxidase subunit 7A1, mitochondrial
Molecular weight formula_weight	6286.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6,B6

FENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASFP

Entity 55 Entity 55 polymer

Description description	Cytochrome c oxidase subunit 7B, mitochondrial
Molecular weight formula_weight	5442.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7,B7

APDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWR

Entity 56 Entity 56 polymer

Description description	Cytochrome c oxidase subunit 7C, mitochondrial
Molecular weight formula_weight	5449.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	8,B8

SHYEEGPGKNIPFSVENKWRLLAMMTLFFGSGFAAPFFIVRHQLLKK

Entity 57 Entity 57 polymer

Description description	Cytochrome c oxidase subunit 8B, mitochondrial
Molecular weight formula_weight	4738.5 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	9,B9

ITAKPAKTPTSPKEQAIGLSVTFLSFLLPAGWVLYHLDNYKKS

Entity 58 Entity 58 polymer

Description description	Cytochrome b-c1 complex subunit 8
Molecular weight formula_weight	9791.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AA,AN

GREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIYTWGTEEFERSKRKNPAAYENDK

Entity 59 Entity 59 polymer

Description description	Cytochrome b-c1 complex subunit Rieske, mitochondrial
Molecular weight formula_weight	5893.8 kDa
EC 编号 ec_number	1.10.2.2
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AB,AO

MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSG

Entity 60 Entity 60 polymer

Description description	Cytochrome b-c1 complex subunit Rieske, mitochondrial
Molecular weight formula_weight	21645.6 kDa
EC 编号 ec_number	1.10.2.2
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AC,AP

SHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG

Entity 61 Entity 61 polymer

Description description	Cytochrome b-c1 complex subunit 9
Molecular weight formula_weight	7189.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AD,AQ

AAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKYENK

Entity 62 Entity 62 polymer

Description description	Cytochrome b-c1 complex subunit 6, mitochondrial
Molecular weight formula_weight	8861.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AE,AR

EEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSHTEEDCTEELFDFLHARDHCVAHKLFNNLK

Entity 63 Entity 63 polymer

Description description	Cytochrome b-c1 complex subunit 7
Molecular weight formula_weight	13037.8 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AF,AS

AVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK

Entity 64 Entity 64 polymer

Description description	Cytochrome b-c1 complex subunit 10
Molecular weight formula_weight	5958.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AG,AT

VTRFLGPRYRELVKNWVPTAYTWGAVGAVGLVWATDWRLILDWVPYINGKF

Entity 65 Entity 65 polymer

Description description	Cytochrome c1, heme protein, mitochondrial
Molecular weight formula_weight	27388.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AH,AU

SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Entity 66 Entity 66 polymer

Description description	Cytochrome b
Molecular weight formula_weight	42543.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AJ,AV

TPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKW

Entity 67 Entity 67 polymer

Description description	Cytochrome b-c1 complex subunit 2, mitochondrial
Molecular weight formula_weight	44946.6 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AK,AW

PQDLEFTKLPNGLVIASLENYSPVSRIGLFIKAGSRYEDFSNLGTTHLLRLTSSLTTKGASSFKITRGIEAVGGKLSVTATRENMAYTVECLRGDVDILMEFLLNVTTAPEFRRWEVADLQPQLKIDKAVAFQNPQTHVIENLHAAAYRNALANPLYCPDYRIGKVTSEELHYFVQNHFTSARMALIGLGVSHPVLKQVAEQFLNMRGGLGLSGAKANYRGGEIREQNGDSLVHAAFVAESAVAGSAEANAFSVLQHVLGAGPHVKRGSNTTSHLHQAVAKATQQPFDVSAFNASYSDSGLFGIYTISQATAAGDVIKAAYNQVKTIAQGNLSNTDVQAAKNKLKAGYLMSVESSECFLEEVGSQALVAGSYMPPSTVLQQIDSVANADIINAAKKFVSGQKSMAASGNLGHTPFVDEL

Entity 68 Entity 68 polymer

Description description	Cytochrome b-c1 complex subunit 1, mitochondrial
Molecular weight formula_weight	49181.4 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AL,AY

TATFAQALQFVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDVGSRFETEKNNGAGYFLEHLAFKGTKNRPGSALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLGDIVQNCSLEDSQIEKERDVILREMQENDASMRDVVFNYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLSTHYKAPRMVLAAAGGVEHQQLLDLAQKHLGGIPWTYAEDAVPTLTPCRFTGSEIRHRDDALPFAHVAIAVEGPGWASPDNVALQVANAIIGHYDCTYGGGVHLSSPLASGAVANKLCQSFQTFSICYAETGLLGAHFVCDRMKIDDMMFVLQGQWMRLCTSATESEVARGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDASVVREICSKYIYDQCPAVAGYGPIEQLPDYNRIRSGMFWLRF

Entity 69 Entity 69 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	12

Entity 70 Entity 70 non-polymer

Description description	FLAVIN MONONUCLEOTIDE
Molecular weight formula_weight	456.3 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 71 Entity 71 non-polymer

Description description	;(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL ;
Molecular weight formula_weight	767.1 kDa
Source method src_method	syn
Copy count entity_count	21

Entity 72 Entity 72 non-polymer

Description description	S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
Molecular weight formula_weight	540.7 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 73 Entity 73 non-polymer

Description description	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Molecular weight formula_weight	745.4 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 74 Entity 74 non-polymer

Description description	FE2/S2 (INORGANIC) CLUSTER
Molecular weight formula_weight	175.8 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 75 Entity 75 non-polymer

Description description	CARDIOLIPIN
Molecular weight formula_weight	1464.0 kDa
Source method src_method	syn
Copy count entity_count	19

Entity 76 Entity 76 non-polymer

Description description	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
Molecular weight formula_weight	744.0 kDa
Source method src_method	syn
Copy count entity_count	14

Entity 77 Entity 77 non-polymer

Description description	COPPER (II) ION
Molecular weight formula_weight	63.5 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 78 Entity 78 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 79 Entity 79 non-polymer

Description description	HEME-A
Molecular weight formula_weight	852.8 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 80 Entity 80 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 81 Entity 81 non-polymer

Description description	HEME C
Molecular weight formula_weight	618.5 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 82 Entity 82 non-polymer

Description description	PROTOPORPHYRIN IX CONTAINING FE
Molecular weight formula_weight	616.5 kDa
Source method src_method	syn
Copy count entity_count	4

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8. Citations (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	17.40 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	8600

fit	/app/data/saxs_computation/xt/5xti/5xti.fit
pddf	/app/data/pr_computation/xt/5xti/5xti.pr.out
profile	/app/data/saxs_computation/xt/5xti/5xti.dat