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3zo0

Mouse IgG2a in complex with mouse TRIM21 PRYSPRY

Method: X-RAY DIFFRACTION Dmax: 86.5 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

IG GAMMA-2A CHAIN C REGION, A ALLELE

OrganismNot specified

UniProt P01863

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Other combination Heteromer Protein × 4 其他Polymer 2 PDB declaration: tetrameric（4） Consistent with protein copy count Chain A； UniProt 120–327 Fragment：FC, RESIDUES 120-327 E3 UBIQUITIN-PROTEIN LIGASE TRIM21 × 2 （Q62191） ;beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 MAN alpha-D-mannopyranose × 2 FUC alpha-L-fucopyranose × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions Resolution 1.99 Å R-free 0.253

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 3ZO0 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1GGI CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN Deposited 1993-04-02 Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain H 1–107（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.80 Å
1GGI CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN Deposited 1993-04-02 Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain J 1–107（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.80 Å
1IGT STRUCTURE OF IMMUNOGLOBULIN Deposited 1996-10-25 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 1–326（326 aa）
Chain D 1–326（326 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 8；291 K；7 MICROLITERS OF 4.3 MG/ML MAB231, 3 MICROLITERS 50 MILLIMOLAR TRIS PH 8.0, AND 7 MICROLITERS 4% PEG 3350 EQUILIBRATED AGAINST 25 ML RESERVOIRS OF 4% PEG 3350, AT 18 DEGREE CELSIUS (SANDWICH PLATE)., temperature 291K
Resolution 2.80 Å R-free 0.297
1YEC STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3) Deposited 1997-04-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 1.90 Å R-free 0.252
1YEC STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3) Deposited 1997-04-15 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 PNB 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；pH 7.0
Resolution 1.90 Å R-free 0.252
1YEF STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE Deposited 1997-05-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 8 PNC PARA-NITROBENZYL GLUTARYL GLYCINIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROP METHOD. PRECIPITANT: 30% (W/V) PEG 600, 100MM CACODYLATE PH7.5, 40MM ZN ACETATE., vapor diffusion - hanging drop
Resolution 2.00 Å R-free 0.248
1YEG STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT Deposited 1997-05-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 BPN PARANITROBENZYL ALCOHOL × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROP METHOD. PRECIPITANT: 30% (W/V) PEG 600, 100MM CACODYLATE PH7.5, 40MM ZN ACETATE., vapor diffusion - hanging drop
Resolution 2.00 Å R-free 0.240
1YEG STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT Deposited 1997-05-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 BPN PARANITROBENZYL ALCOHOL × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROP METHOD. PRECIPITANT: 30% (W/V) PEG 600, 100MM CACODYLATE PH7.5, 40MM ZN ACETATE., vapor diffusion - hanging drop
Resolution 2.00 Å R-free 0.240
1YEH STRUCTURE OF IGG2A FAB FRAGMENT Deposited 1997-05-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROP METHOD. PRECIPITANT: 35% (W/V) PEG 600, 100MM CACODYLATE PH7.5, 40MM ZN ACETATE., vapor diffusion - hanging drop
Resolution 2.55 Å R-free 0.231
1YEH STRUCTURE OF IGG2A FAB FRAGMENT Deposited 1997-05-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–99（99 aa）
Not recorded ZN ZINC ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；HANGING DROP METHOD. PRECIPITANT: 35% (W/V) PEG 600, 100MM CACODYLATE PH7.5, 40MM ZN ACETATE., vapor diffusion - hanging drop
Resolution 2.55 Å R-free 0.231
3OZ9 Crystal Structure of anti-gp41 Fab NC-1 Deposited 2010-09-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–100（100 aa）
Not recorded GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；295 K；1.13M sodium citrate, 0.1M sodium borate, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K
Resolution 1.60 Å R-free 0.233
5VAA Crystal structure of mouse IgG2a Fc T370K mutant Deposited 2017-03-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 107–330（224 aa） Fragment：UNP residues 107-330
Chain B 107–330（224 aa） Fragment：UNP residues 107-330
Mutation：T370K Mutation：T370K GOL GLYCEROL × 3 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；40% (w/v) PEG 200, 0.1 M MES, pH 6.5
Resolution 1.55 Å R-free 0.195
8AQW BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local) Deposited 2022-08-13 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 98–330（233 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
9RBQ Semliki Forest virus trimer 1 in complex with ApoER2 LA5 Deposited 2025-05-27 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 13 PDB declaration: 13-meric
Chain A 99–330（232 aa）
Not recorded CA CALCIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å

10 other PDB entries and 14 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name GCAA_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–208； UniProt 120–327

E3 UBIQUITIN-PROTEIN LIGASE TRIM21

MUS MUSCULUS

UniProt Q62191

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Other combination Heteromer Protein × 4 其他Polymer 2 PDB declaration: tetrameric（4） Consistent with protein copy count Chain B； UniProt 291–470 Fragment：RESIDUES 291-470 IG GAMMA-2A CHAIN C REGION, A ALLELE × 2 （P01863） ;beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 MAN alpha-D-mannopyranose × 2 FUC alpha-L-fucopyranose × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions Resolution 1.99 Å R-free 0.253

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 3ZO0 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2VOK Murine TRIM21 Deposited 2008-02-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 291–470（180 aa）
Chain B 291–470（180 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.30 Å R-free 0.236
7HLA PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z111634612 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BE6 (8R)-2-methyl-5-(propan-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.23 Å R-free 0.190
7HLB PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z45705015 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded S9S ~{N}-[2-(4-fluorophenyl)ethyl]methanesulfonamide × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.21 Å R-free 0.197
7HLC PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1079512010 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UWS 6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.35 Å R-free 0.206
7HLD PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1401276297 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 U0S (5S)-7-(pyrazin-2-yl)-2-oxa-7-azaspiro[4.4]nonane × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.22 Å R-free 0.196
7HLE PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1696844792 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded UXG 1-(diphenylmethyl)azetidin-3-ol × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.40 Å R-free 0.209
7HLF PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2092555279 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 A1BE7 (3R)-3-ethyl-1-(5-fluoropyridin-2-yl)pyrrolidin-3-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.39 Å R-free 0.204
7HLG PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2365130785 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 A1BE8 (1r,3r)-3-[(3-fluoropyridin-2-yl)amino]-1-methylcyclobutan-1-ol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.50 Å R-free 0.208
7HLH PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z453319206 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 LWD ~{N}-quinolin-6-ylbenzamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.38 Å R-free 0.195
7HLI PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2017861827 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BE9 1-[(1S,4S)-1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalen-10-yl]ethan-1-one × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.35 Å R-free 0.211
7HLJ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1980894300 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 TU6 [4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl]methanol × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.37 Å R-free 0.198
7HLK PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z285642082 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 UUP N-cyclopropylpyrazolo[1,5-a]pyrimidine-3-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.39 Å R-free 0.212
7HLL PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1328968520 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 J4Q 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.188
7HLM PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29077827 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded GTJ ~{N}-(1-propylbenzimidazol-2-yl)propanamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.192
7HLN PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z26823525 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1A4A (2S)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)oxolane-2-carboxamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.20 Å R-free 0.194
7HLO PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z90122368 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 A1BFA 4-acetylpiperazine-1-carboxamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.190
7HLP PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29634868 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 A1BFB 2-oxo-4-propyl-2H-1-benzopyran-7-yl acetate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.19 Å R-free 0.198
7HLQ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32327641 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 JMM [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.200
7HLR PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1430613393 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 LKU 3-fluoro-N-(3-hydroxy-4-methylphenyl)benzamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.200
7HLS PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z29177127 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFC 3-(2-methylpropanamido)benzamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.195
7HLT PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z328695024 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 K1G N,1-dimethyl-N-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.187
7HLU PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z741055844 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded S0V morpholin-4-yl(1,2,3-thiadiazol-4-yl)methanone × 2 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.187
7HLV PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z79432418 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFD 2-(2-oxopyrrolidin-1-yl)-N-(1,3-thiazol-2-yl)acetamide × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.19 Å R-free 0.197
7HLW PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z438096750 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFF N-{[(3S)-1-acetylpiperidin-3-yl]methyl}methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.40 Å R-free 0.216
7HLX PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32367954 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UXA ~{N}-cyclopropyl-1,3-benzodioxole-5-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.195
7HLY PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z235449082 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 JFS [4-(1H-benzimidazol-1-yl)phenyl]methanol × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.32 Å R-free 0.199
7HLZ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z256709358 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 BP4 biphenyl-4-ylacetic acid × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.29 Å R-free 0.195
7HM0 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z374427992 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFG N-{[2-(dimethylamino)pyridin-4-yl]methyl}acetamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.43 Å R-free 0.214
7HM1 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z793778804 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded VWV ethyl (1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)acetate × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.212
7HM2 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z32400357 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded NZJ 1-(3-methylbenzene-1-carbonyl)piperidine-4-carboxamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.200
7HM3 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1359419878 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 K6U (2M)-2-(2-methoxyphenyl)-1,3,4-oxadiazole × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.23 Å R-free 0.198
7HM4 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1407673036 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded VW4 (2S)-2-phenylpropane-1-sulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.42 Å R-free 0.213
7HM5 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z192955056 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 Q4L methyl 4-(4-fluorophenyl)piperazine-1-carboxylate × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.38 Å R-free 0.202
7HM6 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1172243962 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BDJ 5-fluoro-N-(oxan-4-yl)pyridin-2-amine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.197
7HM7 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1635496816 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFH N-(6-methyl-2H-1,3-benzodioxol-5-yl)acetamide × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.193
7HM8 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z285782452 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UVA N-methyl-2-(methylsulfonyl)aniline × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.199
7HM9 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1222331430 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFI N,N-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.25 Å R-free 0.200
7HMA PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z291279160 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 LV4 1-[2-(trifluoromethyloxy)phenyl]thiourea × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.189
7HMB PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1374778753 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded B1J [1-(4-chlorophenyl)-1,2,3-triazol-4-yl]methanol × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.36 Å R-free 0.207
7HMC PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1954800564 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 NZ1 5-methoxy-1,3-benzothiazol-2-amine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.32 Å R-free 0.205
7HMD PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z425387594 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 H04 1-(2-ethoxyphenyl)piperazine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.29 Å R-free 0.191
7HME PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z319545618 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 RXS 3-[(2-methyl-1H-imidazol-1-yl)methyl]benzonitrile × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.51 Å R-free 0.204
7HMF PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1367324110 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 RZJ 1-methyl-3,4-dihydro-2~{H}-quinoline-7-sulfonamide × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.20 Å R-free 0.195
7HMG PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z274575916 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 WKS 2,4-dimethyl-6-(piperazin-1-yl)pyrimidine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.32 Å R-free 0.184
7HMH PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1636723439 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFJ (2R)-N-methylmorpholine-2-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.50 Å R-free 0.213
7HMI PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1742054999 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFK N,N-dimethyl-5-(piperidin-4-yl)-1,2,4-oxadiazol-3-amine × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.42 Å R-free 0.215
7HMJ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1578665941 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded K1P 1-(3-methyl-1,2,4-thiadiazol-5-yl)-1,4-diazepane × 1 EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.50 Å R-free 0.214
7HMK PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z271004858 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SFY 4-amino-N-(pyridin-2-yl)benzenesulfonamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.35 Å R-free 0.209
7HML PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1354416068 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded X1J 1-(5-amino-1,3-dihydro-2H-isoindol-2-yl)ethan-1-one × 1 EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.26 Å R-free 0.201
7HMM PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z165170770 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded W0Y N-methyl-4-sulfamoylbenzamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.199
7HMN PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z57478994 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UVS 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.202
7HMO PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z198194394 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 O1M 4-(4-fluorophenyl)piperazine-1-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.30 Å R-free 0.201
7HMP PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1530301542 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 ZQA 4-ethyl-2-(1H-imidazol-5-yl)-1,3-thiazole × 2 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.192
7HMQ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1267773633 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1A36 1-(2-ethyl-1,3-thiazol-5-yl)-N-methylmethanamine × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.43 Å R-free 0.203
7HMR PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1267882044 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFL N-{[(2R)-oxolan-2-yl]methyl}pyridin-4-amine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.192
7HMS PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z126932614 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded T6J 2-[(methylsulfonyl)methyl]-1H-benzimidazole × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.194
7HMT PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2004563941 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFM (1R)-1-(1-cyclopentyl-1H-pyrazol-4-yl)ethan-1-ol × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.206
7HMU PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1741966151 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded W1A N-[(piperidin-4-yl)methyl]methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.189
7HMV PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z56978034 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded U2R (4-fluorophenoxy)acetic acid × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.194
7HMW PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1492796719 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded S7G ~{N}-[(3~{R})-1,2,3,4-tetrahydroquinolin-3-yl]ethanamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.207
7HMX PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z763030030 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 WJA N-methyl-1-(5-methyl-1,2-oxazol-3-yl)methanesulfonamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.57 Å R-free 0.239
7HMY PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z111782404 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 ZTQ (2S)-2-[([1,1'-biphenyl]-4-yl)oxy]propanoic acid × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.188
7HMZ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z85893853 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFN (3S)-1-[(4-fluorophenyl)acetyl]piperidine-3-carboxylic acid × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.199
7HN0 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1217960891 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded Q49 (3S)-3-(3-fluorophenoxy)-1-methylpyrrolidin-2-one × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.204
7HN1 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2065616520 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFO N-ethyl-1-(pyridin-4-yl)piperidin-4-amine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.47 Å R-free 0.229
7HN2 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1002247062 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFP N-{[(2R)-4-methylmorpholin-2-yl]methyl}-1,3-thiazol-2-amine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.23 Å R-free 0.198
7HN3 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2301438417 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFQ 1,3-dimethyl-1H-pyrazolo[3,4-d]pyridazin-7-ol × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.198
7HN4 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z56827661 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 VZY N-(3-methylbenzene-1-carbonyl)glycine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.19 Å R-free 0.195
7HN5 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z45617795 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded JFM N-(2-phenylethyl)methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.32 Å R-free 0.194
7HN6 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1998104358 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFR (5S)-N,N-dimethyl-2,9-dioxa-6-azaspiro[4.5]decane-6-carboxamide × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.40 Å R-free 0.212
7HN7 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z198194396 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 K2M 4-(furan-2-carbonyl)piperazine-1-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.31 Å R-free 0.203
7HN8 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1318110042 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFS 4-[(but-2-yn-1-yl)(methyl)amino]-1lambda~6~-thiane-1,1-dione × 2 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.23 Å R-free 0.197
7HN9 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1787761777 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFT (3S,4S)-3-methoxy-4-methyl-1-[(1,3-thiazol-5-yl)methyl]piperidine × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.22 Å R-free 0.195
7HNA PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1929757385 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 WGM (3S)-1-(3-fluoropyridin-2-yl)-4,4-dimethylpyrrolidin-3-ol × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.29 Å R-free 0.196
7HNB PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z31478538 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded T9Q N-Benzyl-2-methoxyacetamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.52 Å R-free 0.208
7HNC PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z220996120 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded TV9 N-[(1S)-1-(pyridin-3-yl)ethyl]cyclopropanecarboxamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.203
7HND PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z52314092 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded U78 ~{N}-[2-(2-methylphenyl)ethyl]ethanamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.204
7HNE PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1343518214 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFU 1-(3-methoxyazetidine-1-sulfonyl)pyrrolidine × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.198
7HNF PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1689442171 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFV (5-fluoro-3,6-dihydropyridin-1(2H)-yl)(morpholin-4-yl)methanone × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.32 Å R-free 0.202
7HNG PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1568344634 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded O3D 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.202
7HNH PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2643472210 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFW 1-methyl-N-{[(2S)-oxolan-2-yl]methyl}-1H-pyrazole-3-carboxamide × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.194
7HNI PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z373768900 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 NUA N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.27 Å R-free 0.190
7HNJ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1162778919 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1AP3 1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]pyridin-2(1H)-one × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.43 Å R-free 0.196
7HNK PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1275599911 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded WKG 1-(2-azaspiro[5.6]dodecan-2-yl)ethan-1-one × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.39 Å R-free 0.205
7HNL PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1251207602 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 RWS 1-(5-methyl-1,3,4-thiadiazol-2-yl)piperidine × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.44 Å R-free 0.216
7HNM PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z768399682 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFX [(2R,5S)-2,5-dimethylmorpholin-4-yl](1,2,5-thiadiazol-3-yl)methanone × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.49 Å R-free 0.209
7HNN PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z31432226 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded JGP (azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.31 Å R-free 0.202
7HNO PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z57450788 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 3 RV4 N-{4-[(morpholin-4-yl)methyl]phenyl}acetamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.33 Å R-free 0.189
7HNP PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z106579662 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 NUY [4-(propan-2-yl)piperazin-1-yl](thiophen-2-yl)methanone × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.30 Å R-free 0.199
7HNQ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z30620520 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 GX4 cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.37 Å R-free 0.196
7HNR PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1545312521 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded NTV (2S)-N-(3-chloro-2-methylphenyl)oxolane-2-carboxamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.30 Å R-free 0.202
7HNS PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z2072621991 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 LQP 2-(difluoromethoxy)-1-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]ethan-1-one × 1 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.29 Å R-free 0.201
7HNT PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z383202616 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 LHR N-(1H-indazol-6-yl)acetamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.17 Å R-free 0.197
7HNU PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1614545742 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 GQJ methyl (2~{S},4~{R})-1-(furan-2-ylcarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylate × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.202
7HNV PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z404993336 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UUM 5-methyl-N-(1-methyl-1H-pyrazol-4-yl)-1,2-oxazole-3-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.34 Å R-free 0.191
7HNW PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1446981563 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BFY N-[(9S)-6-oxaspiro[4.5]decan-9-yl]methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.21 Å R-free 0.191
7HNX PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z133729708 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded WHP N-[(1R)-1-(2-chlorophenyl)ethyl]methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.27 Å R-free 0.196
7HNY PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z44592329 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 K0G N-phenyl-N'-pyridin-3-ylurea × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.28 Å R-free 0.193
7HNZ PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1245793018 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 JGD N,N-dimethylpyridin-4-amine × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.189
7HO0 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z363071686 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1A3S N-methyl-N-[2-oxo-2-(piperidin-1-yl)ethyl]methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.196
7HO1 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z369263636 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 A1BFZ N-[(1R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)ethyl]methanesulfonamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.17 Å R-free 0.193
7HO2 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z730649594 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 NUM N-[2-(4-hydroxyphenyl)ethyl]pyridine-2-carboxamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.192
7HO3 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z405825414 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BF0 N-[(3S)-1-propanoylpiperidin-3-yl]methanesulfonamide × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.45 Å R-free 0.185
7HO4 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1003146540 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 LL0 2-(difluoromethoxy)benzene-1-sulfonamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.21 Å R-free 0.194
7HO5 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1266933824 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 UXD (1H-pyrazol-4-yl)(pyrrolidin-1-yl)methanone × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.18 Å R-free 0.196
7HO6 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z3220108246 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1BF1 4-benzylpiperazine-2,6-dione × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.24 Å R-free 0.192
7HO7 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z30820160 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 JFP N-(4-methyl-1,3-thiazol-2-yl)propanamide × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.30 Å R-free 0.204
7HO8 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z993967070 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded O1J (benzyloxy)acetic acid × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.39 Å R-free 0.197
7HO9 PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z1250132788 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded A1A3W (1R)-N-methyl-1-(pyridin-4-yl)propan-1-amine × 1 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.26 Å R-free 0.199
7HOA PanDDA analysis group deposition -- Crystal Structure of TRIM21 in complex with Z275165822 Deposited 2024-11-04 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 WNY 1-[4-(4-chlorophenyl)piperazin-1-yl]ethan-1-one × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.35 Å R-free 0.201
7HOB PanDDA analysis group deposition -- Crystal Structure of TRIM21, ground state Deposited 2024-11-05 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293 K；4 % PEG 400, 2 M AmmSO4, 0.1 M HEPES pH 8
Resolution 1.15 Å R-free 0.185
9GTE Crystal structure of TRIM21 PRY-SPRY domain bound to Suramin Deposited 2024-09-17 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 291–470（180 aa）
Not recorded EDO 1,2-ETHANEDIOL × 6 SVR 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；20% PEG 6.000 10% ethylene glycol 0.2 ammonium Chlorid
Resolution 1.30 Å R-free 0.179

112 other PDB entries and 112 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RO52_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 3–182； UniProt 291–470

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 3zo0

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 3zo0
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2. Structure Basics 2. Structure Basics

Entry ID entry_id3zo0
Deposition date deposition_date2013-02-19
Structure title titleMouse IgG2a in complex with mouse TRIM21 PRYSPRY
Keywords keywordsIMMUNE SYSTEM-LIGASE COMPLEX; IMMUNE SYSTEM/LIGASE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier25.53 Å
Radius of gyration Rg (electron density) rg_electron24.79 Å
Forward intensity I(0) i035695400.00
Molecular weight molecular_weight45701.0 kDa
Excluded volume excluded_volume57044 ų
Envelope volume envelope_volume69983 ų
Hydration-shell volume shell_volume24602 ų
Envelope diameter envelope_diameter88.2 Å
Shell Rg shell_rg30.51 Å
Envelope Rg envelope_rg24.96 Å
Shape Rg shape_rg24.77 Å
Total Rg total_rg25.54 Å
Total atoms total_atoms3216
Residues n_residues388
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax86.5 Å
Rg (real space) rg_real25.56 Å
Rg uncertainty (real space) rg_real_error0.64 Å
I(0) (real space) i0_real3.5700e+07
I(0) uncertainty (real space) i0_real_error5.4550e+05
Rg (reciprocal space) rg_reciprocal25.55 Å
I(0) (reciprocal space) i0_reciprocal35700000.0000
Solution quality estimate total_estimate0.8868
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary27.9 Å
Skewness Skewness skewness0.362
Kurtosis Kurtosis kurtosis-0.346
Angular range angular_range— – 0.3100 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha6691000.0000
Real-space data points n_real_points63
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.862; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.960; Smooth: 0.977
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (6)

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7. Fold Classification (SCOP + CATH) 7 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd3zo0a1
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.0 — automated matches
Domain ID domain_idd3zo0a2
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.0 — automated matches
Domain ID domain_idd3zo0b1
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.22 — SPRY domain
Domain ID domain_idd3zo0b2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (3 domains)

Domain ID domain_id3zo0A01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3zo0A02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id3zo0B00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily920 — SPRY domain
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8. Citations (1)

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9. Files and Curves (10)