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4ije

Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain R312A/K319A/R322A mutant

Method: X-RAY DIFFRACTION Dmax: 86.4 Å Quality: EXCELLENT
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase cofactor VP35

Zaire ebolavirus

UniProt Q05127

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 218–340 Fragment：interferon inhibitory domain (UNP residues 218-340) Mutation：R312A, K319A, R322A NA SODIUM ION × 1 K POTASSIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4.5；298.15 K；2.2 M sodium potassium phosphate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K Resolution 1.90 Å R-free 0.228
2 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain B； UniProt 218–340 Fragment：interferon inhibitory domain (UNP residues 218-340) Mutation：R312A, K319A, R322A NA SODIUM ION × 2 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4.5；298.15 K；2.2 M sodium potassium phosphate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K Resolution 1.90 Å R-free 0.228
3 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain C； UniProt 218–340 Fragment：interferon inhibitory domain (UNP residues 218-340) Mutation：R312A, K319A, R322A PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4.5；298.15 K；2.2 M sodium potassium phosphate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K Resolution 1.90 Å R-free 0.228
4 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain D； UniProt 218–340 Fragment：interferon inhibitory domain (UNP residues 218-340) Mutation：R312A, K319A, R322A NA SODIUM ION × 2 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4.5；298.15 K；2.2 M sodium potassium phosphate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K Resolution 1.90 Å R-free 0.228

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 4IJE Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
3FKE Structure of the Ebola VP35 Interferon Inhibitory Domain Deposited 2008-12-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：UNP residues 215-340, interferon inhibitory domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；Well solution: 200 mM Sodium Citrate (pH 5.8),11% (W/V) PEG 4000; protein solution: 20 mM Tris-Cl (pH 7.0),50 mM NaCl, 5mM beta-mercaptoethanol, Vapor Diffusion, Hanging Drop, Temperature 298K, VAPOR DIFFUSION, HANGING DROP
Resolution 1.40 Å R-free 0.236
3FKE Structure of the Ebola VP35 Interferon Inhibitory Domain Deposited 2008-12-16 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：UNP residues 215-340, interferon inhibitory domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；Well solution: 200 mM Sodium Citrate (pH 5.8),11% (W/V) PEG 4000; protein solution: 20 mM Tris-Cl (pH 7.0),50 mM NaCl, 5mM beta-mercaptoethanol, Vapor Diffusion, Hanging Drop, Temperature 298K, VAPOR DIFFUSION, HANGING DROP
Resolution 1.40 Å R-free 0.236
3L25 Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA Deposited 2009-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Homooligomer；Protein × 4 PDB declaration: hexameric
Chain A 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Chain B 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Chain D 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Chain E 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Not recorded MG MAGNESIUM ION × 1 CL CHLORIDE ION × 4 NA SODIUM ION × 8 GOL GLYCEROL × 1 FMT FORMIC ACID × 24 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；3M SODIUM FORMATE, 0.1M SODIUM CITRATE, 5% GLYCEROL, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.207
3L26 Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA Deposited 2009-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Homooligomer；Protein × 4 PDB declaration: hexameric
Chain A 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Chain B 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Not recorded MG MAGNESIUM ION × 10 CL CHLORIDE ION × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.7；293 K；2.9M SODIUM FORMATE, 0.1M SODIUM CITRATE, pH 4.7, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.40 Å R-free 0.254
3L27 Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant Deposited 2009-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 215–340（126 aa） Fragment：INTERFERON INHIBITORY DOMAIN
Chain B 215–340（126 aa） Fragment：INTERFERON INHIBITORY DOMAIN
Chain C 215–340（126 aa） Fragment：INTERFERON INHIBITORY DOMAIN
Chain D 215–340（126 aa） Fragment：INTERFERON INHIBITORY DOMAIN
Mutation：R312A Mutation：R312A Mutation：R312A Mutation：R312A CL CHLORIDE ION × 6 PO4 PHOSPHATE ION × 9 GOL GLYCEROL × 10 NA SODIUM ION × 1 K POTASSIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.15；293 K；1.85 M SODIUM PHOSPHATE, 0.15 M POTASSIUM PHOSPHATE, pH 4.15, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.95 Å R-free 0.229
3L28 Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant Deposited 2009-12-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Chain B 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Chain C 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Chain D 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Chain E 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Chain F 215–340（126 aa） Fragment：VP35 INTERFERON INHIBITORY DOMAIN
Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：K339A Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 10 CL CHLORIDE ION × 12 NA SODIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 2.8；293 K；0.1M SODIUM CITRATE, 0.3M LITHIUM SULFATE, 13% PEG8000, pH 2.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.40 Å R-free 0.269
3L29 Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant Deposited 2009-12-14 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Mutation：K319A, R322A CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.75；293 K；0.1M BIS-TRIS, 0.2M AMMONIUM SULFATE, 28% PEG3350, pH 6.75, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.232
3L29 Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant Deposited 2009-12-14 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：Zaire Ebola VP35 interferon inhibitory domain
Mutation：K319A, R322A CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.75；293 K；0.1M BIS-TRIS, 0.2M AMMONIUM SULFATE, 28% PEG3350, pH 6.75, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.232
4IBB Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DK {4-[(5R)-3-hydroxy-2-oxo-4-(thiophen-2-ylcarbonyl)-5-(2,4,5-trimethylphenyl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100 mM magnesium acetate, pH7.5, 15% PEG3350, 10% DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.75 Å R-free 0.226
4IBB Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DK {4-[(5R)-3-hydroxy-2-oxo-4-(thiophen-2-ylcarbonyl)-5-(2,4,5-trimethylphenyl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100 mM magnesium acetate, pH7.5, 15% PEG3350, 10% DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.75 Å R-free 0.226
4IBC Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 12G {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100 mM magnesium acetate, pH7.5, 15% PEG3350, 10% DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.75 Å R-free 0.250
4IBC Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 12G {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100 mM magnesium acetate, pH7.5, 15% PEG3350, 10% DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.75 Å R-free 0.250
4IBD Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DL 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-methylbenzoic acid × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.84 Å R-free 0.233
4IBD Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DL 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-methylbenzoic acid × 1 GOL GLYCEROL × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.84 Å R-free 0.233
4IBE Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 11Y 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.233
4IBE Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 11Y 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.233
4IBF Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D5 (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.29 Å R-free 0.260
4IBF Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D5 (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.29 Å R-free 0.260
4IBG Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D6 {4-[(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-3-(3-methylbenzoyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 3 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.41 Å R-free 0.200
4IBI Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D8 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMS, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.47 Å R-free 0.237
4IBI Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D8 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMS, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.47 Å R-free 0.237
4IBJ Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D9 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.54 Å R-free 0.229
4IBJ Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1D9 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.54 Å R-free 0.229
4IBK Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DE 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 GOL GLYCEROL × 1 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.85 Å R-free 0.241
4IBK Ebola virus VP35 bound to small molecule Deposited 2012-12-08 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 215–340（126 aa） Fragment：unp residues 215-340
Not recorded 1DE 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；100 mM sodium citrate, pH5.5, 15% PEG3350, 10%DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.85 Å R-free 0.241
4IJF Crystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain K222A/R225A/K248A/K251A mutant Deposited 2012-12-21 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 218–340（123 aa） Fragment：interferon inhibitory domain (UNP residues 218-340)
Mutation：K222A, R225A, K248A, K251A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298.15 K；0.2 M magnesium chloride, 0.1 M HEPES, pH 7.5, 30% PEG400, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
Resolution 2.51 Å R-free 0.254
4YPI Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 Deposited 2015-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 20–47（28 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；streak seeding in well solution containing 100 mM Tris pH 7.2, 50 mM Hepes pH 7, and 23% PEG400
Resolution 3.71 Å R-free 0.285
4YPI Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 Deposited 2015-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 20–47（28 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；streak seeding in well solution containing 100 mM Tris pH 7.2, 50 mM Hepes pH 7, and 23% PEG400
Resolution 3.71 Å R-free 0.285
4YPI Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 Deposited 2015-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 20–47（28 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；streak seeding in well solution containing 100 mM Tris pH 7.2, 50 mM Hepes pH 7, and 23% PEG400
Resolution 3.71 Å R-free 0.285
4YPI Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived from Ebola VP35 Deposited 2015-03-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 20–47（28 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；streak seeding in well solution containing 100 mM Tris pH 7.2, 50 mM Hepes pH 7, and 23% PEG400
Resolution 3.71 Å R-free 0.285
4ZTA Ebola virus nucleoprotein bound to VP35 chaperoning peptide I212121 Deposited 2015-05-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 15–59（45 aa） Fragment：UNP Q05127 residues 15-59,UNP P18272 residues 33-367,UNP Q05127 residues 15-59,UNP P18272 residues 33-367
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.7；277 K；2.2M Sodium formate, 100mM NaOAc pH 4.7
Resolution 2.40 Å R-free 0.233
4ZTG Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121 Deposited 2015-05-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 15–59（45 aa） Fragment：UNP Q05127 residues 15-59, UNP P18272 residues 33-367
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；277 K；12% PEG 6000, 100 mM MES pH 5.0
Resolution 2.80 Å R-free 0.293
4ZTI Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121 Deposited 2015-05-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 15–59（45 aa） Fragment：UNP Q05127 residues 15-59,UNP P18272 residues 33-367
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.4；277 K；2.0 M sodium formate, 100 mM sodium acetate pH 4.4
Resolution 2.40 Å R-free 0.247
4ZTI Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121 Deposited 2015-05-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 15–59（45 aa） Fragment：UNP Q05127 residues 15-59,UNP P18272 residues 33-367
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.4；277 K；2.0 M sodium formate, 100 mM sodium acetate pH 4.4
Resolution 2.40 Å R-free 0.247
6GBO Crystal Structure of the oligomerization domain of Vp35 from Ebola virus Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain A 82–145（64 aa） Fragment：oligomerization domain
Chain B 82–145（64 aa） Fragment：oligomerization domain
Chain C 82–145（64 aa） Fragment：oligomerization domain
Chain D 82–145（64 aa） Fragment：oligomerization domain
Chain E 82–145（64 aa） Fragment：oligomerization domain
Chain F 82–145（64 aa） Fragment：oligomerization domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.5 M Na-acetate
Resolution 2.10 Å R-free 0.242
6GBO Crystal Structure of the oligomerization domain of Vp35 from Ebola virus Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain G 82–145（64 aa） Fragment：oligomerization domain
Chain H 82–145（64 aa） Fragment：oligomerization domain
Chain I 82–145（64 aa） Fragment：oligomerization domain
Chain J 82–145（64 aa） Fragment：oligomerization domain
Chain K 82–145（64 aa） Fragment：oligomerization domain
Chain L 82–145（64 aa） Fragment：oligomerization domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.5 M Na-acetate
Resolution 2.10 Å R-free 0.242
6GBP Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 82–145（64 aa） Fragment：oligomerization domain
Chain B 82–145（64 aa） Fragment：oligomerization domain
Chain C 82–145（64 aa） Fragment：oligomerization domain
Not recorded HG MERCURY (II) ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.6 M Na-acetate
Resolution 3.49 Å R-free 0.281
6GBP Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain D 82–145（64 aa） Fragment：oligomerization domain
Chain E 82–145（64 aa） Fragment：oligomerization domain
Chain F 82–145（64 aa） Fragment：oligomerization domain
Not recorded HG MERCURY (II) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.6 M Na-acetate
Resolution 3.49 Å R-free 0.281
6GBP Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain G 82–145（64 aa） Fragment：oligomerization domain
Chain H 82–145（64 aa） Fragment：oligomerization domain
Chain I 82–145（64 aa） Fragment：oligomerization domain
Not recorded HG MERCURY (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.6 M Na-acetate
Resolution 3.49 Å R-free 0.281
6GBP Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative Deposited 2018-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain J 82–145（64 aa） Fragment：oligomerization domain
Chain K 82–145（64 aa） Fragment：oligomerization domain
Chain L 82–145（64 aa） Fragment：oligomerization domain
Not recorded HG MERCURY (II) ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；296 K；50 mM HEPES-NaOH pH 7.5, 2.6 M Na-acetate
Resolution 3.49 Å R-free 0.281
8USN Intracellular cryo-tomography structure of EBOV nucleocapsid at 8.9 Angstrom Deposited 2023-10-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Heteromer；Protein × 7 PDB declaration: nonameric
Chain F 1–340（340 aa）
Chain K 1–340（340 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 8.90 Å
8UST In-virion structure of Ebola virus nucleocapsid-like assemblies from recombinant virus-like particles (nucleoprotein, VP24,VP35,VP40) Deposited 2023-10-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein–RNA Heteromer；Protein × 7 PDB declaration: nonameric
Chain F 1–340（340 aa）
Chain K 1–340（340 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 7.30 Å
9IP3 Cryo-EM structure of the RNA-dependent RNA polymerase complex in a compact conformation from Ebola virus Deposited 2024-07-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain B 80–340（261 aa）
Chain C 80–340（261 aa）
Chain D 80–340（261 aa）
Chain E 80–340（261 aa）
Not recorded ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；25 mM HEPES, 300 mM NaCl, 1 mM TCEP, 6 mM MgCl2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

25 other PDB entries and 43 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name VP35_EBOZM
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–129； UniProt 218–340 Author chain B； PDBConstruct 7–129； UniProt 218–340 Author chain C； PDBConstruct 7–129； UniProt 218–340 Author chain D； PDBConstruct 7–129； UniProt 218–340

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 4ije

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 4ije
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2. Structure Basics 2. Structure Basics

Entry ID entry_id4ije
Deposition date deposition_date2012-12-21
Structure title titleCrystal structure of the Zaire ebolavirus VP35 interferon inhibitory domain R312A/K319A/R322A mutant
Keywords keywordsIFN inhibition, polymerase cofactor, RNA binding protein, interferon antagonism, virus, VIRAL PROTEIN; VIRAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier27.18 Å
Radius of gyration Rg (electron density) rg_electron26.02 Å
Forward intensity I(0) i047337900.00
Molecular weight molecular_weight54245.0 kDa
Excluded volume excluded_volume68343 ų
Envelope volume envelope_volume86546 ų
Hydration-shell volume shell_volume27871 ų
Envelope diameter envelope_diameter89.9 Å
Shell Rg shell_rg33.16 Å
Envelope Rg envelope_rg25.85 Å
Shape Rg shape_rg26.01 Å
Total Rg total_rg26.86 Å
Total atoms total_atoms3805
Residues n_residues496
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax86.4 Å
Rg (real space) rg_real27.04 Å
Rg uncertainty (real space) rg_real_error0.54 Å
I(0) (real space) i0_real4.7340e+07
I(0) uncertainty (real space) i0_real_error6.1550e+05
Rg (reciprocal space) rg_reciprocal27.09 Å
I(0) (reciprocal space) i0_reciprocal47340000.0000
Solution quality estimate total_estimate0.9067
Solution quality rating solution_quality EXCELLENT a EXCELLENT solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary37.2 Å
Skewness Skewness skewness0.102
Kurtosis Kurtosis kurtosis-0.591
Angular range angular_range— – 0.2900 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha7528000.0000
Real-space data points n_real_points59
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.930; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.994
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (5)

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7. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd4ijea1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.388 — Filoviridae VP35-like
Superfamily Superfamily superfamilyd.388.1 — Filoviridae VP35-like
Family Family familyd.388.1.1 — Filoviridae VP35
Domain ID domain_idd4ijea2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4ijeb1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.388 — Filoviridae VP35-like
Superfamily Superfamily superfamilyd.388.1 — Filoviridae VP35-like
Family Family familyd.388.1.1 — Filoviridae VP35
Domain ID domain_idd4ijeb2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4ijec1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.388 — Filoviridae VP35-like
Superfamily Superfamily superfamilyd.388.1 — Filoviridae VP35-like
Family Family familyd.388.1.1 — Filoviridae VP35
Domain ID domain_idd4ijec2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd4ijed1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.388 — Filoviridae VP35-like
Superfamily Superfamily superfamilyd.388.1 — Filoviridae VP35-like
Family Family familyd.388.1.1 — Filoviridae VP35
Domain ID domain_idd4ijed2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (8 domains)

Domain ID domain_id4ijeA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Domain ID domain_id4ijeA02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
Domain ID domain_id4ijeB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Domain ID domain_id4ijeB02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
Domain ID domain_id4ijeC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Domain ID domain_id4ijeC02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
Domain ID domain_id4ijeD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Domain ID domain_id4ijeD02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
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8. Citations (1)

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9. Files and Curves (10)