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4iuf

Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

TAR DNA-binding protein 43

Homo sapiens

UniProt Q13148

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 1 5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' × 1 water × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1wf0 2cqg 2n2c 2n3x 2n4g 2n4h 2n4p 5mrg 5x4f 6t4b 6t4b 6t4b

15 assemblies; showing the first 12

Homodimer
6b1g

1 assemblies

Homotetramer
7py2

1 assemblies

Other homooligomers
5w50 5w52 5w7v 5w7v 5w7v 5whn 5whp 5wia 5wiq 5wkb 5wkd 6cfh

23 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
4bs2 4iuf 4y00 4y00 4y00 4y00 4y0f 4y0f 6n3a 7n9h 9fof 9for

12 assemblies

View Construct and Data Evidence
UniProt name TADBP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–77； UniProt 103–179

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4iuf
Deposition date deposition_date2013-01-21
Structure title titleCrystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA
Keywords keywordsRNA Recognition Motif, RNA binding, DNA binding, splicing factor, TRANSCRIPTION REGULATOR-DNA complex, PROTEIN-DNA COMPLEX; TRANSCRIPTION REGULATOR/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4iuf__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4iuf__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4iuf__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.83 Å
Rg (electron density)13.52 Å
Total Rg14.68 Å
Atom count1551
Residues85
Excluded volume14056 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4iuf__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd4iufa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.7 — RNA-binding domain, RBD, aka RNA recognition motif (RRM)
Family Family familyd.58.7.1 — Canonical RBD

CATH v4.4 (1 domains)

Domain ID domain_id4iufA00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
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7. Citations (1)