SAXSdb — 9fof

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1. Protein Identity and Related Structures Protein Identity & Related Structures

TAR DNA-binding protein 43

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 12	Annexin A11 × 6 （P50995）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TADBP_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–64； UniProt 282–345 Author chain C； PDBConstruct 1–64； UniProt 282–345 Author chain E； PDBConstruct 1–64； UniProt 282–345 Author chain G； PDBConstruct 1–64； UniProt 282–345 Author chain I； PDBConstruct 1–64； UniProt 282–345 Author chain q； PDBConstruct 1–64； UniProt 282–345

Annexin A11

OrganismNot specified

UniProt P50995

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 12	TAR DNA-binding protein 43 × 6 （Q13148）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ANX11_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–36； UniProt 39–74 Author chain D； PDBConstruct 1–36； UniProt 39–74 Author chain F； PDBConstruct 1–36； UniProt 39–74 Author chain H； PDBConstruct 1–36； UniProt 39–74 Author chain J； PDBConstruct 1–36； UniProt 39–74 Author chain r； PDBConstruct 1–36； UniProt 39–74

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9fof
Deposition date deposition_date	2024-06-11
Structure title title	Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)
Keywords keywords	TDP-43, ANXA11, amyloid, heteromeric amyloid, FTLD-TDP, neurodegeneration, dementia, brain, protein filament, PROTEIN FIBRIL; PROTEIN FIBRIL
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9fof__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9fof__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9fof__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	25.48 Å
Rg (electron density)	24.52 Å
Total Rg	25.06 Å
Atom count	4176
Residues	600
Excluded volume	72058 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9fof__assembly_1__model_1`	12-meric （12）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.900 Å
Low-resolution limit resolution_low	96.000 Å
R factor r_factor	0.6862
R_work r_work	0.6862
R_free r_free	—

Resolution resolution	2.90 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	10842

Description description	TAR DNA-binding protein 43
Molecular weight formula_weight	6231.9 kDa
Source method src_method	nat
Copy count entity_count	6

Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)

1. Protein Identity and Related Structures Protein Identity & Related Structures

TAR DNA-binding protein 43

State in the Current Structure

Other States of the Same Protein in the Database

Annexin A11

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

9fof__assembly_1__model_1

9fof__assembly_1__model_1 | I(q)

9fof__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer

Polymer Polymer

7. Citations (3)

Polymer type type	polypeptide(L)
Chain IDs strand_id	q,A,C,E,G,I
Atom count atom_count	4176

Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)

1. Protein Identity and Related Structures Protein Identity & Related Structures

TAR DNA-binding protein 43

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Annexin A11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

9fof__assembly_1__model_1

9fof__assembly_1__model_1 | I(q)

9fof__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer

Polymer Polymer

7. Citations (3)