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6ct0

Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Homo sapiens

UniProt P10515

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 60 No other associated polymer Consistent with protein count
2 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count
3 Protein homooligomer Homooligomer Protein 5 No other associated polymer Consistent with protein count
4 Protein homooligomer Homooligomer Protein 6 No other associated polymer Consistent with protein count
5 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1fyc 2dne 3b8k 6ct0 6ct0

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
6ct0 6ct0 6ct0 6h55 8piu

5 assemblies

Heteromeric or nucleic-acid complex
1y8n 1y8o 1y8p 2pnr 2pnr 2q8i 3crk 3crl

8 assemblies

View Construct and Data Evidence
UniProt name ODP2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain 0； PDBConstruct 1–647； UniProt 1–647

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6ct0
Deposition date deposition_date2018-03-21
Structure title titleAtomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex
Keywords keywordsPyruvate Dehydrogenase Complex, E2, Inner Core, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6ct0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6ct0__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6ct0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）99.63 Å
Rg (electron density)97.79 Å
Total Rg97.78 Å
Atom count105600
Residues13740
Excluded volume1906100 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6ct0__assembly_1__model_1 60-meric （60） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6ct0__assembly_2__model_1 monomeric （1） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 6ct0__assembly_3__model_1 pentameric （5） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 6ct0__assembly_4__model_1 hexameric （6） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 6ct0__assembly_5__model_1 monomeric （1） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd6ct00_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.43 — CoA-dependent acyltransferases
Superfamily Superfamily superfamilyc.43.1 — CoA-dependent acyltransferases
Family Family familyc.43.1.0 — automated matches
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7. Citations (1)