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6hpj

Structure of human SRSF1 RRM1 bound to AACAAA RNA

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1

Homo sapiens

UniProt P19909

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 RNA 1 ;RNA (5'-R(*AP*AP*CP*AP*AP*A)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1fcl 1fd6 1gb4 1gjs 1gjt 1p7e 1p7f 1zxh 2gi9 2igg 2jsv 2kq4

86 assemblies; showing the first 12

Homodimer
3fil 3v3x 3v3x 6nl8 6nla

5 assemblies

Homotetramer

None

Other homooligomers
2kwd

1 assemblies

Heteromeric or nucleic-acid complex
10dv 1fcc 1ibx 2i2y 2i38 2khu 2khw 2kn4 3ui3 5lde 6hka 6hpj

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SPG2_STRSG
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 3–56； UniProt 304–357

Immunoglobulin G-binding protein G,Serine/arginine-rich splicing factor 1

Homo sapiens

UniProt Q07955

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 RNA 1 ;RNA (5'-R(*AP*AP*CP*AP*AP*A)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
1x4a 2m7s 2o3d

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2m8d 3beg 4c0o 4c0o 6hpj 7abg 8qo9 9r8v

8 assemblies

View Construct and Data Evidence
UniProt name SRSF1_HUMAN
Isoform Q07955-2
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 65–161； UniProt 1–97

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6hpj
Deposition date deposition_date2018-09-21
Structure title titleStructure of human SRSF1 RRM1 bound to AACAAA RNA
Keywords keywordssplicing, SR protein, SRSF1, RRM, spinal muscular atrophy, SMA, RNA, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6hpj__assembly_1__model_19

Assembly 1 · Model 19 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6hpj__assembly_1__model_19 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6hpj__assembly_1__model_19 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.49 Å
Rg (electron density)13.07 Å
Total Rg14.23 Å
Atom count1506
Residues90
Excluded volume13524 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6hpj__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 6hpj__assembly_1__model_2 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 6hpj__assembly_1__model_3 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 6hpj__assembly_1__model_4 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 6hpj__assembly_1__model_5 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 6hpj__assembly_1__model_6 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 6hpj__assembly_1__model_7 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 6hpj__assembly_1__model_8 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 6hpj__assembly_1__model_9 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 6hpj__assembly_1__model_10 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 6hpj__assembly_1__model_11 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 6hpj__assembly_1__model_12 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 6hpj__assembly_1__model_13 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 6hpj__assembly_1__model_14 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 6hpj__assembly_1__model_15 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 6hpj__assembly_1__model_16 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 6hpj__assembly_1__model_17 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 6hpj__assembly_1__model_18 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 6hpj__assembly_1__model_19 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 6hpj__assembly_1__model_20 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)