6jpb

Rabbit Cav1.1-Diltiazem Complex

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Voltage-dependent L-type calcium channel subunit alpha-1S

物种未注明

UniProt P07293

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 5 其他聚合物 7 Voltage-dependent calcium channel gamma-1 subunit × 1 (P19518) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) Voltage-dependent calcium channel subunit alpha-2/delta-1 × 1 (P13806) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CALCIUM ION × 3 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 Diltiazem × 1 ETHANOLAMINE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CAC1S_RABIT
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–1873; UniProt 1–1873

Voltage-dependent calcium channel gamma-1 subunit

物种未注明

UniProt P19518

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 5 其他聚合物 7 Voltage-dependent L-type calcium channel subunit alpha-1S × 1 (P07293) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) Voltage-dependent calcium channel subunit alpha-2/delta-1 × 1 (P13806) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CALCIUM ION × 3 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 Diltiazem × 1 ETHANOLAMINE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CCG1_RABIT
Isoform —
PDB实体 2
链与序列区间 作者链 E; PDB构建体 1–222; UniProt 1–222

Voltage-dependent L-type calcium channel subunit beta-1

Oryctolagus cuniculus

UniProt P19517

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 5 其他聚合物 7 Voltage-dependent L-type calcium channel subunit alpha-1S × 1 (P07293) Voltage-dependent calcium channel gamma-1 subunit × 1 (P19518) Voltage-dependent calcium channel subunit alpha-2/delta-1 × 1 (P13806) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CALCIUM ION × 3 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 Diltiazem × 1 ETHANOLAMINE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CACB1_RABIT
Isoform —
PDB实体 3, 4
链与序列区间 作者链 B; PDB构建体 6–450; UniProt 80–524 作者链 C; PDB构建体 1–524; UniProt 1–524

Voltage-dependent calcium channel subunit alpha-2/delta-1

物种未注明

UniProt P13806

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 5 其他聚合物 7 Voltage-dependent L-type calcium channel subunit alpha-1S × 1 (P07293) Voltage-dependent calcium channel gamma-1 subunit × 1 (P19518) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) Voltage-dependent L-type calcium channel subunit beta-1 × 1 (P19517) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CALCIUM ION × 3 1,2-Distearoyl-sn-glycerophosphoethanolamine × 4 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 1 Diltiazem × 1 ETHANOLAMINE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CA2D1_RABIT
Isoform —
PDB实体 5
链与序列区间 作者链 F; PDB构建体 1–1018; UniProt 29–1075

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6jpb
沉积日期 deposition_date2019-03-26
结构标题 titleRabbit Cav1.1-Diltiazem Complex
关键词 keywordsMembrane protein complex modulated by FDA approved drug., MEMBRANE PROTEIN; MEMBRANE PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6jpb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6jpb__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6jpb__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)56.76 Å
Rg(电子密度)56.73 Å
总 Rg56.61 Å
原子数21981
残基数2694
排除体积396150 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6jpb__assembly_1__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (14)

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6. 折叠分类 (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

结构域编号 domain_id6jpbB00
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology30 — SH3 type barrels.
同源超家族 H-superfamily homologous superfamily40 — SH3 Domains
结构域编号 domain_id6jpbC00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id6jpbE00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology140 — Butyryl-CoA Dehydrogenase, subunit A; domain 3
同源超家族 H-superfamily homologous superfamily150 —
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7. 引用文献 (1)