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6opn

CD4- and 17-bound HIV-1 Env B41 SOSIP in complex with small molecule GO35

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Envelope glycoprotein gp160

Human immunodeficiency virus 1

UniProt B3UES2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 其他Polymer 6 Envelope glycoprotein gp41 × 3 （B3UEZ6） T-cell surface glycoprotein CD4 × 3 （P01730） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 [3'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-3-yl](piperidin-1-yl)methanone × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5vn3 5vn8 6ch9 6edu 6mco 6mdt 6muf 6mug 6okp 6opn 6opo 6opp

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B3UES2_9HIV1
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 36–524； UniProt 29–517 Author chain D； PDBConstruct 36–524； UniProt 29–517 Author chain G； PDBConstruct 36–524； UniProt 29–517

Envelope glycoprotein gp41

Human immunodeficiency virus 1

UniProt B3UEZ6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 其他Polymer 6 Envelope glycoprotein gp160 × 3 （B3UES2） T-cell surface glycoprotein CD4 × 3 （P01730） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 [3'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-3-yl](piperidin-1-yl)methanone × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5vn3 5vn8 6ch9 6edu 6muf 6mug 6okp 6opn 6opo 6opp 6opq 6u59

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B3UEZ6_9HIV1
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–153； UniProt 516–668 Author chain E； PDBConstruct 1–153； UniProt 516–668 Author chain H； PDBConstruct 1–153； UniProt 516–668

T-cell surface glycoprotein CD4

Homo sapiens

UniProt P01730

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 9 其他Polymer 6 Envelope glycoprotein gp160 × 3 （B3UES2） Envelope glycoprotein gp41 × 3 （B3UEZ6） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ;alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 27 [3'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-3-yl](piperidin-1-yl)methanone × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cdj 1cdu 1cdy 1wbr 1wio 1wio 1wip 1wip 1wiq 1wiq 2klu

11 assemblies

Homodimer
1cdh 1cdi 3cd4

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1g9m 1g9n 1gc1 1jl4 1q68 1rzj 1rzk 2b4c 2b4c 2nxy 2nxz 2ny0

86 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CD4_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 20–198； UniProt 25–203 Author chain F； PDBConstruct 20–198； UniProt 25–203 Author chain I； PDBConstruct 20–198； UniProt 25–203

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6opn
Deposition date deposition_date2019-04-25
Structure title titleCD4- and 17-bound HIV-1 Env B41 SOSIP in complex with small molecule GO35
Keywords keywordsHIV-1, Env, CD4, receptor-bound state, small molecule, fusion inhibitor, VIRAL PROTEIN, VIRAL PROTEIN-Immune System complex; VIRAL PROTEIN/Immune System
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6opn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6opn__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6opn__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）45.66 Å
Rg (electron density)44.95 Å
Total Rg45.28 Å
Atom count14241
Residues1713
Excluded volume253740 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6opn__assembly_1__model_1 nonameric （9） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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7. Citations (2)