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6ppl

Cryo-EM structure of human NatE complex (NatA/Naa50)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

N-alpha-acetyltransferase 50

Homo sapiens

UniProt Q9GZZ1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 N-alpha-acetyltransferase 15, NatA auxiliary subunit × 1 （Q9BXJ9） N-alpha-acetyltransferase 10 × 1 （P41227） ACETYL COENZYME *A × 2 INOSITOL HEXAKISPHOSPHATE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2ob0 2ob0 2ob0 2psw 2psw 2psw 6wfg 6wfg 6wfg 6wfk 6wfk 6wfk

16 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3tfy 3tfy 3tfy 4x5k 6ppl 6pw9 6wf3 6wf3 6wf3 6wf3 6wf3 6wf3

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NAA50_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–169； UniProt 1–169

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Homo sapiens

UniProt Q9BXJ9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 N-alpha-acetyltransferase 50 × 1 （Q9GZZ1） N-alpha-acetyltransferase 10 × 1 （P41227） ACETYL COENZYME *A × 2 INOSITOL HEXAKISPHOSPHATE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6c95 6c9m 6c9m 6ppl 6pw9 9f1b 9f1c 9f1d 9fpz 9fq0 9gj5 9gj6

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NAA15_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–866； UniProt 1–866

N-alpha-acetyltransferase 10

Homo sapiens

UniProt P41227

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 N-alpha-acetyltransferase 50 × 1 （Q9GZZ1） N-alpha-acetyltransferase 15, NatA auxiliary subunit × 1 （Q9BXJ9） ACETYL COENZYME *A × 2 INOSITOL HEXAKISPHOSPHATE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6c95 6c9m 6c9m 6ppl 6pw9 9f1b 9f1c 9f1d 9fpz 9fq0 9gj5 9gj6

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NAA10_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 2–236； UniProt 1–235

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6ppl
Deposition date deposition_date2019-07-08
Structure title titleCryo-EM structure of human NatE complex (NatA/Naa50)
Keywords keywordsNatA, Naa50, NatE, TRANSFERASE; TRANSFERASE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6ppl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6ppl__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6ppl__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.79 Å
Rg (electron density)33.24 Å
Total Rg33.72 Å
Atom count8155
Residues980
Excluded volume145610 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6ppl__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6ppla_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.108 — Acyl-CoA N-acyltransferases (Nat)
Superfamily Superfamily superfamilyd.108.1 — Acyl-CoA N-acyltransferases (Nat)
Family Family familyd.108.1.0 — automated matches
Domain ID domain_idd6pplc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.108 — Acyl-CoA N-acyltransferases (Nat)
Superfamily Superfamily superfamilyd.108.1 — Acyl-CoA N-acyltransferases (Nat)
Family Family familyd.108.1.0 — automated matches

CATH v4.4 (2 domains)

Domain ID domain_id6pplA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology630 — Aminopeptidase
Homologous superfamily homologous superfamily30 — Gcn5-related N-acetyltransferase (GNAT)
Domain ID domain_id6pplC00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology630 — Aminopeptidase
Homologous superfamily homologous superfamily30 — Gcn5-related N-acetyltransferase (GNAT)
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7. Citations (1)