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6r1r

RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

RIBONUCLEOTIDE REDUCTASE R1 PROTEIN

Escherichia coli

UniProt P00452

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 2 （P69924） water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 1 （P69924） water × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 1 （P69924） water × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 12 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 6 （P69924） water × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 12 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 6 （P69924） water × 6 Consistent with protein count
6 Protein homooligomer Homooligomer Protein 6 water × 6 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 4 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 2 （P69924） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 4 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 2 （P69924） water × 2 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R2 PROTEIN × 1 （P69924） water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1rlr

1 assemblies

Homodimer
8vhn 8vho 8vhp 8vhp 8vhp 8vhp 8vhq 8vhq 8vhr 8vhr

10 assemblies

Homotetramer

None

Other homooligomers
1r1r 3r1r 5r1r 6r1r 7r1r

5 assemblies

Heteromeric or nucleic-acid complex
1qfn 1r1r 1r1r 1r1r 1r1r 1r1r 2r1r 2r1r 2r1r 2r1r 2r1r 2r1r

89 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RIR1_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–761； UniProt 1–761 Author chain B； PDBConstruct 1–761； UniProt 1–761 Author chain C； PDBConstruct 1–761； UniProt 1–761

RIBONUCLEOTIDE REDUCTASE R2 PROTEIN

Escherichia coli

UniProt P69924

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 1 （P00452） water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 1 （P00452） water × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 1 （P00452） water × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 12 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 6 （P00452） water × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 12 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 6 （P00452） water × 6 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 4 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 2 （P00452） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 4 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 2 （P00452） water × 2 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 RIBONUCLEOTIDE REDUCTASE R1 PROTEIN × 1 （P00452） water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2x0x 2xak 2xap 2xav 2xaw 2xax 2xay 2xaz 2xo4 2xo5

10 assemblies

Homodimer
1av8 1biq 1jpr 1jqc 1mrr 1mxr 1pfr 1pim 1piu 1piy 1piz 1pj0

37 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1r1r 1r1r 1r1r 1r1r 1r1r 2r1r 2r1r 2r1r 2r1r 2r1r 2r1r 2r1r

80 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RIR2_ECOLI
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 1–20； UniProt 356–375 Author chain E； PDBConstruct 1–20； UniProt 356–375 Author chain F； PDBConstruct 1–20； UniProt 356–375 Author chain P； PDBConstruct 1–20； UniProt 356–375

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6r1r
Deposition date deposition_date1997-09-17
Structure title titleRIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Keywords keywords;RIBONUCLEOTIDE REDUCTASE, DEOXYRIBONUCLEOTIDE SYNTHESIS, RADICAL CHEMISTRY, ALLOSTERIC REGULATION, SPECIFICITY, COMPLEX (OXIDOREDUCTASE-PEPTIDE), COMPLEX (OXIDOREDUCTASE-PEPTIDE) complex ;; COMPLEX (OXIDOREDUCTASE/PEPTIDE)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6r1r__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6r1r__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6r1r__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.58 Å
Rg (electron density)27.62 Å
Total Rg28.36 Å
Atom count6014
Residues756
Excluded volume106790 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6r1r__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6r1r__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6r1r__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6r1r__assembly_4__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 6r1r__assembly_5__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 6r1r__assembly_6__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 6r1r__assembly_7__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 6r1r__assembly_8__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
9 1 6r1r__assembly_9__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 9 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd6r1ra1
Class classa — All alpha proteins
Fold Fold folda.98 — R1 subunit of ribonucleotide reductase, N-terminal domain
Superfamily Superfamily superfamilya.98.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Family Family familya.98.1.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Domain ID domain_idd6r1ra2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.7 — PFL-like glycyl radical enzymes
Superfamily Superfamily superfamilyc.7.1 — PFL-like glycyl radical enzymes
Family Family familyc.7.1.2 — R1 subunit of ribonucleotide reductase, C-terminal domain
Domain ID domain_idd6r1rb1
Class classa — All alpha proteins
Fold Fold folda.98 — R1 subunit of ribonucleotide reductase, N-terminal domain
Superfamily Superfamily superfamilya.98.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Family Family familya.98.1.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Domain ID domain_idd6r1rb2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.7 — PFL-like glycyl radical enzymes
Superfamily Superfamily superfamilyc.7.1 — PFL-like glycyl radical enzymes
Family Family familyc.7.1.2 — R1 subunit of ribonucleotide reductase, C-terminal domain
Domain ID domain_idd6r1rc1
Class classa — All alpha proteins
Fold Fold folda.98 — R1 subunit of ribonucleotide reductase, N-terminal domain
Superfamily Superfamily superfamilya.98.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Family Family familya.98.1.1 — R1 subunit of ribonucleotide reductase, N-terminal domain
Domain ID domain_idd6r1rc2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.7 — PFL-like glycyl radical enzymes
Superfamily Superfamily superfamilyc.7.1 — PFL-like glycyl radical enzymes
Family Family familyc.7.1.2 — R1 subunit of ribonucleotide reductase, C-terminal domain

CATH v4.4 (3 domains)

Domain ID domain_id6r1rA02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homologous superfamily homologous superfamily20 —
Domain ID domain_id6r1rB02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homologous superfamily homologous superfamily20 —
Domain ID domain_id6r1rC02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology70 — Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Homologous superfamily homologous superfamily20 —
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7. Citations (3)