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6sxb

XPF-ERCC1 Cryo-EM Structure, DNA-Bound form

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA repair endonuclease XPF

Homo sapiens

UniProt Q92889

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 DNA excision repair protein ERCC-1 × 1 （P07992） ;DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3') ; × 1 ;DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
2aq0

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1z00 2a1j 2a1j 2kn7 2mut 6sxa 6sxb 9pcp 9pd3 9pd4 9qec 9qed

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name XPF_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain F； PDBConstruct 1–916； UniProt 1–916

DNA excision repair protein ERCC-1

Homo sapiens

UniProt P07992

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 2 DNA 2 DNA repair endonuclease XPF × 1 （Q92889） ;DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3') ; × 1 ;DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
2a1i 2jpd

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1z00 2a1j 2a1j 2jnw 2mut 6sxa 6sxb 9pcp 9pd3 9pd4 9qec 9qed

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ERCC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain G； PDBConstruct 1–297； UniProt 1–297

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6sxb
Deposition date deposition_date2019-09-25
Structure title titleXPF-ERCC1 Cryo-EM Structure, DNA-Bound form
Keywords keywordsDNA Repair enzyme. Nucleotide excision repair, DNA BINDING PROTEIN; DNA BINDING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6sxb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6sxb__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6sxb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）36.84 Å
Rg (electron density)35.98 Å
Total Rg36.50 Å
Atom count7341
Residues912
Excluded volume130180 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6sxb__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)