← Back to search
6tiw

Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)

Method: ELECTRON MICROSCOPY
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Kinesin-like protein KIF11

Homo sapiens

UniProt P52732

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Tubulin beta chain × 1 （P02554） Tubulin alpha-1B chain × 1 （Q2XVP4） 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one × 1 PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 2 MAGNESIUM ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1q0b 1q0b 1x88 1x88 1yrs 1yrs 2fky 2fky 2fl2 2fl2 2fl6 2fl6

88 assemblies; showing the first 12

Homodimer
1ii6 2pg2 3k3b 3k5e 3k5e 4a1z 4a28 4zca 6hkx 8yhh

10 assemblies

Homotetramer

None

Other homooligomers
2x2r 2xae 4a5y 4bbg

4 assemblies

Heteromeric or nucleic-acid complex
4aqv 4aqw 4ck5 4ck6 4ck7 5jv3 5jv3 6ta3 6ta4 6tiw

10 assemblies

View Construct and Data Evidence
UniProt name KIF11_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain K； PDBConstruct 23–391； UniProt 1–369

Tubulin beta chain

OrganismNot specified

UniProt P02554

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Kinesin-like protein KIF11 × 1 （P52732） Tubulin alpha-1B chain × 1 （Q2XVP4） 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one × 1 PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 2 MAGNESIUM ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2wbe

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ffx 1ia0 1sa0 1sa1 1tub 1tvk 2hxf 2hxh 3edl 3edl 3edl 3j6e

159 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TBB_PIG
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–429； UniProt 1–429

Tubulin alpha-1B chain

OrganismNot specified

UniProt Q2XVP4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Kinesin-like protein KIF11 × 1 （P52732） Tubulin beta chain × 1 （P02554） 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one × 1 PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 2 MAGNESIUM ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3j8x 3j8y 3jak 3jal 3jar 3jas 3jat 3jaw 4zhq 4zi7 4zol 5ca0

244 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TBA1B_PIG
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–438； UniProt 1–438

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id6tiw
Deposition date deposition_date2019-11-22
Structure title titleHuman kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)
Keywords keywordskinesin, microtubule, mitosis, inhibition, motor, CELL CYCLE; CELL CYCLE
Experimental Method methodELECTRON MICROSCOPY
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6tiw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6tiw__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6tiw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.53 Å
Rg (electron density)33.12 Å
Total Rg33.60 Å
Atom count9491
Residues1201
Excluded volume168020 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6tiw__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (6)

▼

6. Fold Classification (SCOP + CATH) 11 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd6tiwa1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.32 — Tubulin nucleotide-binding domain-like
Superfamily Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
Family Family familyc.32.1.1 — Tubulin, GTPase domain
Domain ID domain_idd6tiwa2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.79 — Bacillus chorismate mutase-like
Superfamily Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
Family Family familyd.79.2.1 — Tubulin, C-terminal domain
Domain ID domain_idd6tiwb1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.32 — Tubulin nucleotide-binding domain-like
Superfamily Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
Family Family familyc.32.1.1 — Tubulin, GTPase domain
Domain ID domain_idd6tiwb2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.79 — Bacillus chorismate mutase-like
Superfamily Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
Family Family familyd.79.2.1 — Tubulin, C-terminal domain

CATH v4.4 (7 domains)

Domain ID domain_id6tiwA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
Domain ID domain_id6tiwA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
Homologous superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
Domain ID domain_id6tiwA03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily600 — Helix hairpin bin
Domain ID domain_id6tiwB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
Domain ID domain_id6tiwB02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
Homologous superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
Domain ID domain_id6tiwB03
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily600 — Helix hairpin bin
Domain ID domain_id6tiwK00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology850 — Kinesin
Homologous superfamily homologous superfamily10 — Kinesin motor domain
▶

7. Citations (2)