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7jkc

Sheep Connexin-46 at 1.9 angstroms resolution by CryoEM

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Gap junction alpha-3 protein

OrganismNot specified

UniProt Q9TU17

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 12 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE × 180 water × 12 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
6mhq 7jkc 7jmd 7jn0 7jn1 9z7p 9z81 9z8f 9z8m 9z9g 9z9s 9z9x

13 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CXA3_SHEEP
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–413； UniProt 1–413 Author chain B； PDBConstruct 1–413； UniProt 1–413 Author chain C； PDBConstruct 1–413； UniProt 1–413 Author chain D； PDBConstruct 1–413； UniProt 1–413 Author chain E； PDBConstruct 1–413； UniProt 1–413 Author chain F； PDBConstruct 1–413； UniProt 1–413 Author chain G； PDBConstruct 1–413； UniProt 1–413 Author chain H； PDBConstruct 1–413； UniProt 1–413 Author chain I； PDBConstruct 1–413； UniProt 1–413 Author chain J； PDBConstruct 1–413； UniProt 1–413 Author chain K； PDBConstruct 1–413； UniProt 1–413 Author chain L； PDBConstruct 1–413； UniProt 1–413

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7jkc
Deposition date deposition_date2020-07-28
Structure title titleSheep Connexin-46 at 1.9 angstroms resolution by CryoEM
Keywords keywordsConnexin, Gap Junction, Nanodisc, Lipid, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7jkc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7jkc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7jkc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）47.78 Å
Rg (electron density)48.57 Å
Total Rg48.79 Å
Atom count45192
Residues2352
Excluded volume407870 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7jkc__assembly_1__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 12 domains

CATH v4.4 (12 domains)

Domain ID domain_id7jkcA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcC01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcE01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcF01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcG01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcH01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcI01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcJ01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcK01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
Domain ID domain_id7jkcL01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1440 — de novo design (two linked rop proteins)
Homologous superfamily homologous superfamily80 — Gap junction channel protein cysteine-rich domain
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7. Citations (1)