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7pzc

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

NACHT, LRR and PYD domains-containing protein 3

Homo sapiens

UniProt Q96P20

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 10 ADENOSINE-5'-DIPHOSPHATE × 10 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea × 10 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2naq 3qf2 3qf2 7alv 8etr 8ri2 8wsm 8zem 9gu4 9hg4 9mgy 9mie

14 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
7pzc 7pzd 7vtp 7zgu 8ert 8swf 8swk

7 assemblies

Heteromeric or nucleic-acid complex
6npy 8ej4 8sxn 9dh3

4 assemblies

View Construct and Data Evidence
UniProt name NLRP3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1036； UniProt 1–1036 Author chain B； PDBConstruct 1–1036； UniProt 1–1036 Author chain C； PDBConstruct 1–1036； UniProt 1–1036 Author chain D； PDBConstruct 1–1036； UniProt 1–1036 Author chain E； PDBConstruct 1–1036； UniProt 1–1036 Author chain F； PDBConstruct 1–1036； UniProt 1–1036 Author chain G； PDBConstruct 1–1036； UniProt 1–1036 Author chain H； PDBConstruct 1–1036； UniProt 1–1036 Author chain I； PDBConstruct 1–1036； UniProt 1–1036 Author chain J； PDBConstruct 1–1036； UniProt 1–1036

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7pzc
Deposition date deposition_date2021-10-12
Structure title titleCryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3
Keywords keywordsNLRP3, CP-456.773, CRID3, MCC950, AAA+ ATPase, NOD-like receptor, inflammasome, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7pzc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7pzc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7pzc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）76.69 Å
Rg (electron density)75.91 Å
Total Rg76.08 Å
Atom count72752
Residues9060
Excluded volume1302200 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7pzc__assembly_1__model_1 decameric （10） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id7pzcA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id7pzcH01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)