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7pzd

Cryo-EM structure of the NLRP3 PYD filament

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

NACHT, LRR and PYD domains-containing protein 3

Homo sapiens

UniProt Q96P20

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 18 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2naq 3qf2 3qf2 7alv 8etr 8ri2 8wsm 8zem 9gu4 9hg4 9mgy 9mie

14 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
7pzc 7pzd 7vtp 7zgu 8ert 8swf 8swk

7 assemblies

Heteromeric or nucleic-acid complex
6npy 8ej4 8sxn 9dh3

4 assemblies

View Construct and Data Evidence
UniProt name NLRP3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain G； PDBConstruct 1–108； UniProt 3–110 Author chain H； PDBConstruct 1–108； UniProt 3–110 Author chain I； PDBConstruct 1–108； UniProt 3–110 Author chain J； PDBConstruct 1–108； UniProt 3–110 Author chain K； PDBConstruct 1–108； UniProt 3–110 Author chain L； PDBConstruct 1–108； UniProt 3–110 Author chain M； PDBConstruct 1–108； UniProt 3–110 Author chain N； PDBConstruct 1–108； UniProt 3–110 Author chain O； PDBConstruct 1–108； UniProt 3–110 Author chain P； PDBConstruct 1–108； UniProt 3–110 Author chain Q； PDBConstruct 1–108； UniProt 3–110 Author chain R； PDBConstruct 1–108； UniProt 3–110 Author chain S； PDBConstruct 1–108； UniProt 3–110 Author chain T； PDBConstruct 1–108； UniProt 3–110 Author chain U； PDBConstruct 1–108； UniProt 3–110 Author chain V； PDBConstruct 1–108； UniProt 3–110 Author chain W； PDBConstruct 1–108； UniProt 3–110 Author chain X； PDBConstruct 1–108； UniProt 3–110

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7pzd
Deposition date deposition_date2021-10-12
Structure title titleCryo-EM structure of the NLRP3 PYD filament
Keywords keywordsNLRP3, Pyrin domain, filament, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7pzd__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7pzd__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7pzd__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.97 Å
Rg (electron density)37.19 Å
Total Rg37.75 Å
Atom count13644
Residues1656
Excluded volume243840 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7pzd__assembly_1__model_1 octadecameric （18） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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7. Citations (1)