7t5q

Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Actin-related protein 3

物种未注明

UniProt P61157

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARP3_BOVIN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–418; UniProt 1–418

Actin-related protein 2

物种未注明

UniProt A7MB62

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARP2_BOVIN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–394; UniProt 1–394

Actin-related protein 2/3 complex subunit 1A

物种未注明

UniProt Q1JP79

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARC1A_BOVIN
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–370; UniProt 1–370

Actin-related protein 2/3 complex subunit 2

物种未注明

UniProt Q3MHR7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARPC2_BOVIN
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–300; UniProt 1–300

Actin-related protein 2/3 complex subunit 3

物种未注明

UniProt Q3T035

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARPC3_BOVIN
Isoform —
PDB实体 5
链与序列区间 作者链 E; PDB构建体 1–178; UniProt 1–178

Actin-related protein 2/3 complex subunit 4

物种未注明

UniProt Q148J6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARPC4_BOVIN
Isoform —
PDB实体 6
链与序列区间 作者链 F; PDB构建体 1–168; UniProt 1–168

Actin-related protein 2/3 complex subunit 5

物种未注明

UniProt Q3SYX9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARPC5_BOVIN
Isoform —
PDB实体 7
链与序列区间 作者链 G; PDB构建体 1–151; UniProt 1–151

Actin, alpha skeletal muscle

物种未注明

UniProt P68135

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACTS_RABIT
Isoform —
PDB实体 8
链与序列区间 作者链 H; PDB构建体 1–375; UniProt 3–377

F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera

Mus musculus

UniProt P52907

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera × 1 (P47756,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CAZA1_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 I; PDB构建体 1–280; UniProt 1–280

F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera

Mus musculus

UniProt Q91YD9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 WASL_MOUSE
Isoform —
PDB实体 9, 10
链与序列区间 作者链 I; PDB构建体 281–346; UniProt 436–501 作者链 J; PDB构建体 272–333; UniProt 440–501

F-actin-capping protein subunit beta/Actin nucleation-promoting factor WASL chimera

Mus musculus

UniProt P47756

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 10 Actin-related protein 3 × 1 (P61157) Actin-related protein 2 × 1 (A7MB62) Actin-related protein 2/3 complex subunit 1A × 1 (Q1JP79) Actin-related protein 2/3 complex subunit 2 × 1 (Q3MHR7) Actin-related protein 2/3 complex subunit 3 × 1 (Q3T035) Actin-related protein 2/3 complex subunit 4 × 1 (Q148J6) Actin-related protein 2/3 complex subunit 5 × 1 (Q3SYX9) Actin, alpha skeletal muscle × 1 (P68135) F-actin-capping protein subunit alpha-1/Actin nucleation-promoting factor WASL chimera × 1 (P52907,Q91YD9) MAGNESIUM ION × 3 ADENOSINE-5'-TRIPHOSPHATE × 2 ADENOSINE-5'-DIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CAPZB_HUMAN
Isoform P47756-1
PDB实体 10
链与序列区间 作者链 J; PDB构建体 1–271; UniProt 1–271

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id7t5q
沉积日期 deposition_date2021-12-13
结构标题 titleCryo-EM Structure of a Transition State of Arp2/3 Complex Activation
关键词 keywords;actin, ATPase, actin related protein, arp, cytoskeleton, Arp2-3 complex, actin nucleation, actin branching, CONTRACTILE PROTEIN, CapZ ;; CONTRACTILE PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

7t5q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

7t5q__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

7t5q__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)52.15 Å
Rg(电子密度)51.82 Å
总 Rg51.86 Å
原子数21671
残基数2702
排除体积385840 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 7t5q__assembly_1__model_1 decameric (10) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (13)

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6. 折叠分类 (SCOP + CATH) 3 domains

CATH v4.4 (3 domains)

结构域编号 domain_id7t5qC01
类 Class class2 — Mainly Beta
架构 Architecture architecture130 — 7 Propeller
拓扑 Topology topology10 — Methylamine Dehydrogenase; Chain H
同源超家族 H-superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
结构域编号 domain_id7t5qD01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1460 — Yope Regulator; Chain: A,
同源超家族 H-superfamily homologous superfamily20 —
结构域编号 domain_id7t5qD02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1460 — Yope Regulator; Chain: A,
同源超家族 H-superfamily homologous superfamily20 —
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7. 引用文献 (1)