The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links.
Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
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2. Structure Basics 2. Structure Basics
Entry ID entry_id
7u4p
Deposition date deposition_date
2022-02-28
Structure title title
Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins
Keywords keywords
;Abeta oligomer, beta-hairpin, trimer, dodecamer, Alzheimer's disease, DE NOVO PROTEIN
;; DE NOVO PROTEIN
Experimental Method method
X-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
7u4p__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
4. Crystallography and Experiment 4. Crystallography & Experiment
Unit cell Unit Cell
Unit-cell length a length_a
62.054 Å
Unit-cell length b length_b
62.054 Å
Unit-cell length c length_c
47.839 Å
Unit-cell angle α angle_alpha
90.00 °
Unit-cell angle β angle_beta
90.00 °
Unit-cell angle γ angle_gamma
120.00 °
Molecules per unit cell Z z_pdb
36
Symmetry Symmetry
Space group space_group
P 62 2 2
Space-group number int_tables_number
180
Crystal system crystal_system
—
Refinement Refinement
Resolution resolution
1.803 Å
Low-resolution limit resolution_low
31.030 Å
R factor r_factor
0.2092
R_work r_work
0.2051
R_free r_free
0.2473
Diffraction experiment Diffraction
Experimental temperature temperature
113.0 K
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5. Entities and Polymers Entities & Polymers (2)
Entity 1 Entity 1polymer
Description description
Amyloid-beta 17-36 peptide
Molecular weight formula_weight
2214.6 kDa
Source method src_method
syn
Copy count entity_count
3
Polymer Polymer
Polymer type type
polypeptide(L)
Chain IDs strand_id
A,B,C
Atom count atom_count
958
ACVFFCEDVGSNKGAIIGLAV
Entity 2 Entity 2water
Description description
water
Molecular weight formula_weight
18.0 kDa
Source method src_method
nat
Copy count entity_count
25
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7. Citations (1)
;Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.
;