SAXSdb — 7u5p

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Activin receptor type-2A

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 2	Inhibin beta A chain × 1 （P08476） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 1	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 2	Inhibin beta A chain × 1 （P08476） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	Consistent with protein count
3	Protein heterocomplex	Heteromer	Protein 2	Inhibin beta A chain × 1 （P08476） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 1	Consistent with protein count
4	Protein heterocomplex	Heteromer	Protein 2	Inhibin beta A chain × 1 （P08476） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	AVR2A_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–121； UniProt 1–121 Author chain C； PDBConstruct 1–121； UniProt 1–121 Author chain E； PDBConstruct 1–121； UniProt 1–121 Author chain G； PDBConstruct 1–121； UniProt 1–121

Inhibin beta A chain

Homo sapiens

UniProt P08476

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 2	Activin receptor type-2A × 1 （P27037） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 1	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 2	Activin receptor type-2A × 1 （P27037） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	Consistent with protein count
3	Protein heterocomplex	Heteromer	Protein 2	Activin receptor type-2A × 1 （P27037） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 1	Consistent with protein count
4	Protein heterocomplex	Heteromer	Protein 2	Activin receptor type-2A × 1 （P27037） 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INHBA_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–116； UniProt 311–426 Author chain D； PDBConstruct 1–116； UniProt 311–426 Author chain F； PDBConstruct 1–116； UniProt 311–426 Author chain H； PDBConstruct 1–116； UniProt 311–426

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7u5p
Deposition date deposition_date	2022-03-02
Structure title title	CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A
Keywords keywords	Cell Signaling, Receptor-ligand complex, Growth factor, Receptor interaction, Activin A, ActRIIa, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7u5p__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7u5p__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7u5p__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	21.59 Å
Rg (electron density)	21.08 Å
Total Rg	21.66 Å
Atom count	1600
Residues	206
Excluded volume	27925 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7u5p__assembly_1__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`7u5p__assembly_2__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`7u5p__assembly_3__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
4	1	`7u5p__assembly_4__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Activin receptor type-2A
Molecular weight formula_weight	13804.6 kDa
EC 编号 ec_number	2.7.11.30
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,C,E,G
Atom count atom_count	6332

MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEME

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Cricetulus griseus

Entity 2 Entity 2 polymer

Description description	Inhibin beta A chain
Molecular weight formula_weight	12991.9 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,D,F,H

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Cricetulus griseus

Entity 3 Entity 3 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	syn
Copy count entity_count	8

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	4

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Unit-cell length a length_a	82.610 Å
Unit-cell length b length_b	82.540 Å
Unit-cell length c length_c	151.335 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	16

Space group space_group	P 21 21 21
Space-group number int_tables_number	19
Crystal system crystal_system	—

Resolution resolution	3.140 Å
Low-resolution limit resolution_low	24.690 Å
R factor r_factor	0.2232
R_work r_work	0.2173
R_free r_free	0.2761

CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A

1. Protein Identity and Related Structures Protein Identity & Related Structures

Activin receptor type-2A

State in the Current Structure

Other States of the Same Protein in the Database

Inhibin beta A chain

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

7u5p__assembly_1__model_1

7u5p__assembly_1__model_1 | I(q)

7u5p__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

7. Citations (1)

CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A

1. Protein Identity and Related Structures Protein Identity & Related Structures

Activin receptor type-2A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Inhibin beta A chain

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

7u5p__assembly_1__model_1

7u5p__assembly_1__model_1 | I(q)

7u5p__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

7. Citations (1)