7vni

AHR-ARNT PAS-B heterodimer

Method: X-RAY DIFFRACTION D_max: 85.3 Å Quality: REASONABLE

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ahr homolog spineless

Drosophila melanogaster

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain B； UniProt 264–381	Not recorded	Aryl hydrocarbon receptor nuclear translocator × 1 （P53762） SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium arsenate (pH 6.5), 0.2 M MgCl2, 2 M (NH4)2SO4	Resolution 2.00 Å R-free 0.219
2	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain A； UniProt 264–381	Not recorded	Aryl hydrocarbon receptor nuclear translocator × 1 （P53762） SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium arsenate (pH 6.5), 0.2 M MgCl2, 2 M (NH4)2SO4	Resolution 2.00 Å R-free 0.219

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 7VNI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
7VNA drosophlia AHR PAS-B domain Deposited 2021-10-10	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 264–381（118 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl pH 7.0, 0.2 M NaCl, 0.8 M sodium citrate	Resolution 2.60 Å R-free 0.250
7VNH drosophlia AHR PAS-B domain bound by the antagonist alpha-naphthoflavone Deposited 2021-10-11	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 264–381（118 aa）	Not recorded	BHF 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl pH 7.0, 0.2 M NaCl, 0.8 M sodium citrate	Resolution 2.40 Å R-free 0.268
7VNH drosophlia AHR PAS-B domain bound by the antagonist alpha-naphthoflavone Deposited 2021-10-11	Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 264–381（118 aa）	Not recorded	BHF 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl pH 7.0, 0.2 M NaCl, 0.8 M sodium citrate	Resolution 2.40 Å R-free 0.268

2 other PDB entries and 3 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	O61543_DROME
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 3–120； UniProt 264–381 Author chain B； PDBConstruct 3–120； UniProt 264–381

Aryl hydrocarbon receptor nuclear translocator

Mus musculus

UniProt P53762

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain D； UniProt 358–466	Not recorded	Ahr homolog spineless × 1 （O61543） SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium arsenate (pH 6.5), 0.2 M MgCl2, 2 M (NH4)2SO4	Resolution 2.00 Å R-free 0.219
2	Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count	Chain C； UniProt 358–466	Not recorded	Ahr homolog spineless × 1 （O61543） SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium arsenate (pH 6.5), 0.2 M MgCl2, 2 M (NH4)2SO4	Resolution 2.00 Å R-free 0.219

Other States of the Same Protein in the Database

Other PDB	Difference from Current Entry 7VNI	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
4ZP4 Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex Deposited 2015-05-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.35 Å R-free 0.232
4ZP4 Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex Deposited 2015-05-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain C 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.35 Å R-free 0.232
4ZPH Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine Deposited 2015-05-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	PRL PROFLAVIN × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.80 Å R-free 0.221
4ZPH Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine Deposited 2015-05-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain C 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.80 Å R-free 0.221
4ZPK Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA Deposited 2015-05-08	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain A 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；289 K；4% Tacsimate, pH 6.0, 10% PEG3350	Resolution 3.60 Å R-free 0.321
4ZPR Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA Deposited 2015-05-08	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain A 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；100 mM MES, pH 6.0, 100 mM calcium acetate, 15% PEG400	Resolution 3.90 Å R-free 0.341
4ZQD Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 Deposited 2015-05-09	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	0X3 N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.87 Å R-free 0.254
4ZQD Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 Deposited 2015-05-09	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain C 82–464（383 aa） Fragment：UNP residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate, pH 7.0, 6% PEG3350	Resolution 2.87 Å R-free 0.254
5NJ8 Structural basis for aryl hydrocarbon receptor mediated gene activation Deposited 2017-03-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain B 85–345（261 aa）	Mutation：C256S	ER3 ERBIUM (III) ION × 7 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；277 K；10 mM HEPES/NaOH pH 6.8, 18% PEG3350, 200 mM ammonium formate	Resolution 3.30 Å R-free 0.333
5NJ8 Structural basis for aryl hydrocarbon receptor mediated gene activation Deposited 2017-03-28	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain D 85–345（261 aa）	Mutation：C256S	ER3 ERBIUM (III) ION × 5	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；277 K；10 mM HEPES/NaOH pH 6.8, 18% PEG3350, 200 mM ammonium formate	Resolution 3.30 Å R-free 0.333
5SY5 Crystal Structure of the Heterodimeric NPAS1-ARNT Complex Deposited 2016-08-10	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa） Fragment：unp residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate pH 7.0, 3% PEG3350	Resolution 3.20 Å R-free 0.247
5SY5 Crystal Structure of the Heterodimeric NPAS1-ARNT Complex Deposited 2016-08-10	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain C 82–464（383 aa） Fragment：unp residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate pH 7.0, 3% PEG3350	Resolution 3.20 Å R-free 0.247
5SY5 Crystal Structure of the Heterodimeric NPAS1-ARNT Complex Deposited 2016-08-10	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain E 82–464（383 aa） Fragment：unp residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate pH 7.0, 3% PEG3350	Resolution 3.20 Å R-free 0.247
5SY5 Crystal Structure of the Heterodimeric NPAS1-ARNT Complex Deposited 2016-08-10	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 4 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric	Chain A 82–464（383 aa） Fragment：unp residues 82-464 Chain C 82–464（383 aa） Fragment：unp residues 82-464 Chain E 82–464（383 aa） Fragment：unp residues 82-464	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% Tacsimate pH 7.0, 3% PEG3350	Resolution 3.20 Å R-free 0.247
5SY7 Crystal Structure of the Heterodimeric NPAS3-ARNT Complex with HRE DNA Deposited 2016-08-10	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain A 82–464（383 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；289 K；100 mM NH4F, 9% PEG 3350	Resolution 4.20 Å R-free 0.361
6E3S Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385 Deposited 2018-07-15	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	79A 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% TACSIMATE, PH 7.0, 6% PEG3350	Resolution 3.00 Å R-free 0.249
6E3T Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001 Deposited 2018-07-15	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	HO7 (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；2% TACSIMATE, PH 7.0, 6% PEG3350	Resolution 3.00 Å R-free 0.306
6E3U Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001 Deposited 2018-07-15	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	HNJ 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；2% TACSIMATE, PH 7.0, 6% PEG3350	Resolution 2.85 Å R-free 0.258
7V7L Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex Deposited 2021-08-21	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Sodium citrate tribasic dihydrate, 2-Propanol, PEG 4000	Resolution 2.30 Å R-free 0.245
7V7W Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) Deposited 2021-08-21	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa） Fragment：Hydrocarbon receptor nuclear translocator ARNT	Not recorded	5YM (Z)-N-(2-hydroxyethyl)octadec-9-enamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Sodium citrate tribasic dihydrate, 2-Propanol, PEG 4000	Resolution 2.51 Å R-free 0.260
7W80 Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan Deposited 2021-12-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	72Q 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；289 K；Tacsimate, PEG3350	Resolution 2.75 Å R-free 0.274
7XHV Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA Deposited 2022-04-10	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain A 82–360（279 aa） Fragment：ARNT	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；pH 8；289 K；ammonium tartrate dibasic, PEG3350	Resolution 4.00 Å R-free 0.331
7XI4 Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA Deposited 2022-04-12	Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein–DNA Heteromer；Protein × 2 PDB declaration: tetrameric	Chain A 82–464（383 aa） Fragment：ARNT	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION；pH 8；289 K；ammonium tartrate dibasic, PEG3350	Resolution 4.71 Å R-free 0.351
9LJX Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-26 Deposited 2025-01-15	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	A1EKB 4-fluoranyl-~{N}-(3-fluoranyl-2-pyrrolidin-1-yl-phenyl)-1,1-bis(oxidanylidene)-1,2-benzothiazol-3-amine × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；PEG 3350, Succinic Acid pH 7.0	Resolution 2.80 Å R-free 0.268
9LJY Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-14 Deposited 2025-01-15	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	A1EJ9 4-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；PEG 3350, Succinic Acid pH 7.0	Resolution 3.20 Å R-free 0.248
9LOH Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-10 Deposited 2025-01-23	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	A1EJ8 4-fluoranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；PEG 3350, Succinic Acid pH 7.0	Resolution 3.02 Å R-free 0.262
9LOI Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-16 Deposited 2025-01-23	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric	Chain A 82–464（383 aa）	Not recorded	A1EKA 6-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；289 K；PEG 3350, Succinic Acid pH 7.0	Resolution 2.78 Å R-free 0.275

20 other PDB entries and 27 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	ARNT_MOUSE
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain C； PDBConstruct 3–111； UniProt 358–466 Author chain D； PDBConstruct 3–111； UniProt 358–466

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7vni
Deposition date deposition_date	2021-10-11
Structure title title	AHR-ARNT PAS-B heterodimer
Keywords keywords	transcription factor, ligand binding domain, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	X-RAY DIFFRACTION

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	26.98 Å
Radius of gyration Rg (electron density) rg_electron	26.32 Å
Forward intensity I(0) i0	43559600.00
Molecular weight molecular_weight	50685.0 kDa
Excluded volume excluded_volume	63080 Å³
Envelope volume envelope_volume	79088 Å³
Hydration-shell volume shell_volume	25656 Å³
Envelope diameter envelope_diameter	82.5 Å
Shell Rg shell_rg	32.84 Å
Envelope Rg envelope_rg	26.09 Å
Shape Rg shape_rg	26.31 Å
Total Rg total_rg	27.03 Å
Total atoms total_atoms	3565
Residues n_residues	432
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	85.3 Å
Rg (real space) rg_real	26.98 Å
Rg uncertainty (real space) rg_real_error	0.60 Å
I(0) (real space) i0_real	4.3560e+07
I(0) uncertainty (real space) i0_real_error	6.3900e+05
Rg (reciprocal space) rg_reciprocal	26.99 Å
I(0) (reciprocal space) i0_reciprocal	43560000.0000
Solution quality estimate total_estimate	0.6429
Solution quality rating solution_quality	REASONABLE a REASONABLE solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	24.6 Å
Skewness Skewness skewness	0.252
Kurtosis Kurtosis kurtosis	-0.678
Angular range angular_range	— – 0.2950 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	14600000.0000
Real-space data points n_real_points	60
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.941; Stabil: 1.000; Sysdev: 0.199; Positv: 1.000; Valcen: 0.934; Smooth: 0.000

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Ahr homolog spineless
Molecular weight formula_weight	13811.7 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,A
Atom count atom_count	3990

GSIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGGYDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQLMDEEGHDLLGKR

来源 Source

来源生物 organism	Drosophila melanogaster
通用名 common_name	Fruit fly
NCBI Class编号 ncbi_taxonomy_id	7227
宿主生物 host_organism	Escherichia coli

Entity 2 Entity 2 polymer

Description description	Aryl hydrocarbon receptor nuclear translocator
Molecular weight formula_weight	13097.9 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,C

GSCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEIEYIICTNTNVKN

来源 Source

来源生物 organism	Mus musculus
通用名 common_name	Mouse
NCBI Class编号 ncbi_taxonomy_id	10090
宿主生物 host_organism	Escherichia coli

Entity 3 Entity 3 non-polymer

Description description	SULFATE ION
Molecular weight formula_weight	96.1 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	421

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8. Citations (1)

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Unit-cell length a length_a	136.030 Å
Unit-cell length b length_b	55.553 Å
Unit-cell length c length_c	77.095 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	103.05 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	1.997 Å
Low-resolution limit resolution_low	44.908 Å
R factor r_factor	0.1816
R_work r_work	0.1795
R_free r_free	0.2187

fit	/app/data/saxs_computation/vn/7vni/7vni.fit
pddf	/app/data/pr_computation/vn/7vni/7vni.pr.out
profile	/app/data/saxs_computation/vn/7vni/7vni.dat

AHR-ARNT PAS-B heterodimer

1. Protein Identity and Related Structures Protein Identity & Related Structures

Ahr homolog spineless

State in the Current Structure

Other States of the Same Protein in the Database

Aryl hydrocarbon receptor nuclear translocator

State in the Current Structure

Other States of the Same Protein in the Database

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

6. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

来源 Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)