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7zez

Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 3 of Peptidyl-prolyl cis-trans isomerase E

Homo sapiens

UniProt Q9UNP9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 MLL cleavage product N320 × 1 （Q03164） Histone H3 × 1 （B4E380） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1zmf 2cqb 2kyx 2r99 3lpy 3lpy 3mdf 3mdf 3uch 7zev

10 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
3uch

1 assemblies

Heteromeric or nucleic-acid complex
2ku7 5mqf 5yzg 5z56 5z57 6ff7 6icz 6id0 6id1 7a5p 7abi 7w59

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PPIE_HUMAN
Isoform Q9UNP9-3
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–93； UniProt 1–90

MLL cleavage product N320

Homo sapiens

UniProt Q03164

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Isoform 3 of Peptidyl-prolyl cis-trans isomerase E × 1 （Q9UNP9） Histone H3 × 1 （B4E380） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2j2s 2jyi 2kyu 2w5y 3lqh 5f5e

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2agh 2kkf 2ku7 2lxs 2lxt 2msr 2mtn 2w5z 3eg6 3lqi 3lqi 3lqi

57 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KMT2A_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–64； UniProt 1564–1627

Histone H3

OrganismNot specified

UniProt B4E380

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Isoform 3 of Peptidyl-prolyl cis-trans isomerase E × 1 （Q9UNP9） MLL cleavage product N320 × 1 （Q03164） ZINC ION × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7zez

1 assemblies

View Construct and Data Evidence
UniProt name B4E380_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D； PDBConstruct 1–13； UniProt 2–14

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7zez
Deposition date deposition_date2022-03-31
Structure title titleTrimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3
Keywords keywords;RRM, RNA BINDING PROTEIN-STRUCTURAL PROTEIN COMPLEX, HISTONE 3, H3K4me3, EPIGENETIC, MLL1 Transcription regulation, infant leukemia, TRANSCRIPTION ;; TRANSCRIPTION
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7zez__assembly_1__model_17

Assembly 1 · Model 17 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7zez__assembly_1__model_17 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7zez__assembly_1__model_17 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.89 Å
Rg (electron density)16.69 Å
Total Rg17.68 Å
Atom count2620
Residues169
Excluded volume23617 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7zez__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 7zez__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 7zez__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 7zez__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 7zez__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 7zez__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 7zez__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 7zez__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 7zez__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 7zez__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 7zez__assembly_1__model_11 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 7zez__assembly_1__model_12 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 7zez__assembly_1__model_13 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 7zez__assembly_1__model_14 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 7zez__assembly_1__model_15 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 7zez__assembly_1__model_16 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 7zez__assembly_1__model_17 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 7zez__assembly_1__model_18 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 7zez__assembly_1__model_19 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 7zez__assembly_1__model_20 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id7zezA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily330 — RRM (RNA recognition motif) domain
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7. Citations (1)