7zxe

Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transcription initiation factor IIB

Homo sapiens

UniProt Q00403

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TF2B_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain M; PDBConstruct 1–316; UniProt 1–316

TATA-box-binding protein

Homo sapiens

UniProt P20226

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TBP_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain O; PDBConstruct 1–339; UniProt 1–339

Transcription initiation factor IIA subunit 1

Homo sapiens

UniProt P52655

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name TF2AA_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain U; PDBConstruct 1–376; UniProt 1–376

Transcription initiation factor IIA subunit 2

Homo sapiens

UniProt P52657

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name T2AG_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain V; PDBConstruct 1–109; UniProt 1–109

snRNA-activating protein complex subunit 1

Homo sapiens

UniProt Q16533

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNPC1_HUMAN
Isoform —
PDB entities 7
Chains and sequence ranges Author chain a; PDBConstruct 1–368; UniProt 1–368

snRNA-activating protein complex subunit 3

Homo sapiens

UniProt Q92966

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNPC3_HUMAN
Isoform —
PDB entities 8
Chains and sequence ranges Author chain b; PDBConstruct 1–411; UniProt 1–411

snRNA-activating protein complex subunit 4

Homo sapiens

UniProt Q5SXM2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 5 × 1 (O75971) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNPC4_HUMAN
Isoform —
PDB entities 9
Chains and sequence ranges Author chain c; PDBConstruct 1–1469; UniProt 1–1469

snRNA-activating protein complex subunit 5

Homo sapiens

UniProt O75971

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Heteromer Protein 8 DNA 2 Transcription initiation factor IIB × 1 (Q00403) Non-template strand × 1 TATA-box-binding protein × 1 (P20226) Template strand × 1 Transcription initiation factor IIA subunit 1 × 1 (P52655) Transcription initiation factor IIA subunit 2 × 1 (P52657) snRNA-activating protein complex subunit 1 × 1 (Q16533) snRNA-activating protein complex subunit 3 × 1 (Q92966) snRNA-activating protein complex subunit 4 × 1 (Q5SXM2) ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SNPC5_HUMAN
Isoform —
PDB entities 10
Chains and sequence ranges Author chain d; PDBConstruct 1–98; UniProt 1–98

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7zxe
Deposition date deposition_date2022-05-20
Structure title titleStructure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC)
Keywords keywordsRNA polymerase II, Pol II, PIC, SNAPc, snRNA, U1 promoter, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7zxe__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7zxe__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7zxe__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)43.58 Å
Rg (electron density)43.06 Å
Total Rg43.40 Å
Atom count14150
Residues1593
Excluded volume246070 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7zxe__assembly_1__model_1 decameric (10) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id7zxeM01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
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7. Citations (2)