5fur

Structure of human TFIID-IIA bound to core promoter DNA

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

TATA-BOX-BINDING PROTEIN

OrganismNot specified

UniProt P20226

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TBP_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–339； UniProt 1–339

TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1

OrganismNot specified

UniProt P52655

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2AA_HUMAN
Isoform	—
PDB entities	2, 3
Chains and sequence ranges	Author chain B； PDBConstruct 1–43； UniProt 9–51 Author chain C； PDBConstruct 1–47； UniProt 330–376

TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2

OrganismNot specified

UniProt P52657

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2AG_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–97； UniProt 3–99

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1

OrganismNot specified

UniProt P21675

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TAF1_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–1893； UniProt 1–1872

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7

OrganismNot specified

UniProt Q15545

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TAF7_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–349； UniProt 1–349

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2

OrganismNot specified

UniProt Q6P1X5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TAF2_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–1199； UniProt 1–1199

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6

OrganismNot specified

UniProt P49848

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 × 1 （Q7Z7C8）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TAF6_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–677； UniProt 1–677 Author chain K； PDBConstruct 1–677； UniProt 1–677

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8

OrganismNot specified

UniProt Q7Z7C8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 10 DNA 2	TATA-BOX-BINDING PROTEIN × 1 （P20226） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 × 1 （P52655） TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 × 1 （P52657） SUPER CORE PROMOTER × 1 SUPER CORE PROMOTER × 1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 × 1 （P21675） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 × 1 （Q15545） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 × 1 （Q6P1X5） TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 × 2 （P49848）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TAF8_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain L； PDBConstruct 1–310； UniProt 1–310

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5fur
Deposition date deposition_date	2016-01-29
Structure title title	Structure of human TFIID-IIA bound to core promoter DNA
Keywords keywords	TFIID, TFIIA, TRANSCRIPTION, RNA POLYMERASE II, GENERAL TRANSCRIPTION FACTORS, PREINITIATION COMPLEX, CORE PROMOTER, DNA BINDING; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5fur__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5fur__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5fur__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	77.50 Å
Rg (electron density)	77.33 Å
Total Rg	77.36 Å
Atom count	21485
Residues	2413
Excluded volume	374310 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5fur__assembly_1__model_1`	dodecameric （12）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Description description	TATA-BOX-BINDING PROTEIN
Molecular weight formula_weight	37729.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	21485

MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT

Entity 2 Entity 2 polymer

Description description	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
Molecular weight formula_weight	5098.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

TVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLM

Entity 3 Entity 3 polymer

Description description	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1
Molecular weight formula_weight	5594.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

DTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW

Entity 4 Entity 4 polymer

Description description	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2
Molecular weight formula_weight	11275.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

YQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACD

Entity 5 Entity 5 polymer

Description description	SUPER CORE PROMOTER
Molecular weight formula_weight	27664.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	E

GAAGGGCGCCTATAAAAGGGGGTGGGGGCGCGTTCGTCCTCAGTCGCGATCGAACACTCGAGCCGAGCAGACGTGCCTACGGACCATGG

Entity 6 Entity 6 polymer

Description description	SUPER CORE PROMOTER
Molecular weight formula_weight	28485.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	F

AATTCCATGGTCCGTAGGCACGTCTGCTCGGCTCGAGTGTTCGATCGCGACTGAGGACGAACGCGCCCCCACCCCCTTTTATAGGCGCCCTTC

Entity 7 Entity 7 polymer

Description description	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1
Molecular weight formula_weight	215152.4 kDa
EC 编号 ec_number	2.3.1.48, 2.7.11.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE

Entity 8 Entity 8 polymer

Description description	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7
Molecular weight formula_weight	40325.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDRVPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASKKKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTRWEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQDEEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAKRQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK

Entity 9 Entity 9 polymer

Description description	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2
Molecular weight formula_weight	137160.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGGGKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEAANNPSSHPQLVGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPASSRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTASKHSDHHHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD

Entity 10 Entity 10 polymer

Description description	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6
Molecular weight formula_weight	72749.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,K

MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP

Entity 11 Entity 11 polymer

Description description	TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8
Molecular weight formula_weight	34304.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEENIIDNPYLRPVKKPKIRRKKSLS

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	8.500 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	8.50 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	22050

Structure of human TFIID-IIA bound to core promoter DNA

1. Protein Identity and Related Structures Protein Identity & Related Structures

TATA-BOX-BINDING PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

5fur__assembly_1__model_1

5fur__assembly_1__model_1 | I(q)

5fur__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer