8fz6

The human PI31 complexed with bovine 20S proteasome

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA6_BOVIN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–246； UniProt 1–246 Author chain O； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit alpha type-2

OrganismNot specified

UniProt Q3T0Y5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA2_BOVIN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–234； UniProt 1–234 Author chain P； PDBConstruct 1–234； UniProt 1–234

Proteasome subunit alpha type-4

OrganismNot specified

UniProt Q3ZCK9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA4_BOVIN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–261； UniProt 1–261 Author chain Q； PDBConstruct 1–261； UniProt 1–261

Proteasome subunit alpha type-7

OrganismNot specified

UniProt Q3ZBG0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA7_BOVIN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–248； UniProt 1–248 Author chain R； PDBConstruct 1–248； UniProt 1–248

Proteasome subunit alpha type-5

OrganismNot specified

UniProt Q5E987

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA5_BOVIN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–241； UniProt 1–241 Author chain S； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type-1

OrganismNot specified

UniProt Q3T0X5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA1_BOVIN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–263； UniProt 1–263 Author chain T； PDBConstruct 1–263； UniProt 1–263

Proteasome subunit alpha type-3

OrganismNot specified

UniProt Q58DU5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA3_BOVIN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–255； UniProt 1–255 Author chain U； PDBConstruct 1–255； UniProt 1–255

Proteasome subunit beta type-6

OrganismNot specified

UniProt Q3MHN0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB6_BOVIN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–239； UniProt 1–239 Author chain V； PDBConstruct 1–239； UniProt 1–239

Proteasome subunit beta type-7

OrganismNot specified

UniProt Q2TBP0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB7_BOVIN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–277； UniProt 1–277 Author chain W； PDBConstruct 1–277； UniProt 1–277

Proteasome subunit beta type-3

OrganismNot specified

UniProt P33672

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB3_BOVIN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–205； UniProt 1–205 Author chain X； PDBConstruct 1–205； UniProt 1–205

Proteasome subunit beta type-2

OrganismNot specified

UniProt Q5E9K0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB2_BOVIN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–201； UniProt 1–201 Author chain Y； PDBConstruct 1–201； UniProt 1–201

Proteasome subunit beta type-5

OrganismNot specified

UniProt Q32KL2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB5_BOVIN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–263； UniProt 1–263 Author chain Z； PDBConstruct 1–263； UniProt 1–263

Proteasome subunit beta type-1

OrganismNot specified

UniProt Q2TBX6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-4 × 2 （Q3T108） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB1_BOVIN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–241； UniProt 1–241 Author chain a； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit beta type-4

OrganismNot specified

UniProt Q3T108

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome inhibitor PI31 subunit × 2 （Q3SX30）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB4_BOVIN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–264； UniProt 1–264 Author chain b； PDBConstruct 1–264； UniProt 1–264

Proteasome inhibitor PI31 subunit

OrganismNot specified

UniProt Q3SX30

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 30	Proteasome subunit alpha type-6 × 2 （Q2YDE4） Proteasome subunit alpha type-2 × 2 （Q3T0Y5） Proteasome subunit alpha type-4 × 2 （Q3ZCK9） Proteasome subunit alpha type-7 × 2 （Q3ZBG0） Proteasome subunit alpha type-5 × 2 （Q5E987） Proteasome subunit alpha type-1 × 2 （Q3T0X5） Proteasome subunit alpha type-3 × 2 （Q58DU5） Proteasome subunit beta type-6 × 2 （Q3MHN0） Proteasome subunit beta type-7 × 2 （Q2TBP0） Proteasome subunit beta type-3 × 2 （P33672） Proteasome subunit beta type-2 × 2 （Q5E9K0） Proteasome subunit beta type-5 × 2 （Q32KL2） Proteasome subunit beta type-1 × 2 （Q2TBX6） Proteasome subunit beta type-4 × 2 （Q3T108）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMF1_BOVIN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain c； PDBConstruct 1–271； UniProt 1–270 Author chain d； PDBConstruct 1–271； UniProt 1–270

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8fz6
Deposition date deposition_date	2023-01-27
Structure title title	The human PI31 complexed with bovine 20S proteasome
Keywords keywords	PI31, inhibitor, 20S, proteasome, HYDROLASE; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8fz6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8fz6__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8fz6__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	60.16 Å
Rg (electron density)	59.80 Å
Total Rg	60.01 Å
Atom count	49780
Residues	6404
Excluded volume	887990 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8fz6__assembly_1__model_1`	30-meric （30）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	27432.5 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	49780

MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	25927.5 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type-4
Molecular weight formula_weight	29525.8 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK

Entity 4 Entity 4 polymer

Description description	Proteasome subunit alpha type-7
Molecular weight formula_weight	27911.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type-5
Molecular weight formula_weight	26436.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI

Entity 6 Entity 6 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	29625.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPTQPADEPAEKADEPMEH

Entity 7 Entity 7 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	28441.2 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGEITNGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM

Entity 8 Entity 8 polymer

Description description	Proteasome subunit beta type-6
Molecular weight formula_weight	25563.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

MAATLVAARGTRPAPAWGPEAIAPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQPFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAEPGVERQVLLGDQIPKFTIATLPPL

Entity 9 Entity 9 polymer

Description description	Proteasome subunit beta type-7
Molecular weight formula_weight	30045.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

MAAVSVYERPVGGFSFDNCRRNAVLEADFAKKGYKLPTARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPYSVPNKKGTRFGRYRCEKGTNAVLTEKVTTLEIEVLEETVQTMDTS

Entity 10 Entity 10 polymer

Description description	Proteasome subunit beta type-3
Molecular weight formula_weight	23016.9 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCTEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta type-2
Molecular weight formula_weight	22924.3 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADYLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISREKAVELLRKCLEELQKRFILNLPTFSVRIIDRNGIHDLDNISFPKQGS

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta type-5
Molecular weight formula_weight	28642.3 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

MALASVLERPLSVNRRGFFGLGGRADLLDLGPGSPSDGLSLAAPSWGVPEEPRIEILHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEEAYDLARRAIYQATYRDAYSGGSVSLYHVREDGWIRVSSDNVADLHDKYSGSTH

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta type-1
Molecular weight formula_weight	26278.1 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

MLSSVAAYSGAGRDLAMEPHSSVGPLQLRFSPYAFNGGTVLAIAGEDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALKVCIVTKEGIRGETVPLRKD

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta type-4
Molecular weight formula_weight	29057.0 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

MEALLESRSGLWAGGPAPGQFYRIPPTPGSSVDPVSALYGSPITRTQNPMVTGTSVLGLKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPKAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSAETNWDIAHMISGFE

Entity 15 Entity 15 polymer

Description description	Proteasome inhibitor PI31 subunit
Molecular weight formula_weight	29850.7 kDa
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c,d

MAGLEVLFASAAPAITCRQDALVCFLHWEVVTHGYFGLGVGDQPGPNDKKSELLPAGWNNNKDLYVLRYEYKDGSRKLLVKAITVESSMILNVLEYGSQQVADLTLNLDDYIDAEHLGDFHRTYKNSEELRSRIVSGIITPIHEQWEKANVSSPHREFPPATAREVDPLRIPPHHPHTSRQPPWCDPLGPFVVGGEDLDPFGPRRGGMIVDPLRSGFPRALIDPSSGLPNRLPPGAVPPGARFDPFGPIGTSPPGPNPDHLPPPGYDDMYL

▼

6. Fold Classification (SCOP + CATH) 10 domains

CATH v4.4 (10 domains)

Domain ID domain_id	8fz6B01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6C01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6D01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6E01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6I01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6P01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6Q01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6R01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6S01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	8fz6W01
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.54 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	350283

The human PI31 complexed with bovine 20S proteasome

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer