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8j4i

Unveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Prohibitin-2

Homo sapiens

UniProt Q99623

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 6 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
6iqe

1 assemblies

Homotetramer

None

Other homooligomers
8j4i

1 assemblies

Heteromeric or nucleic-acid complex
8rrh 9o6s 9o6t 9o9z 9oa0 9unl

6 assemblies

View Construct and Data Evidence
UniProt name PHB2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–190； UniProt 1–190 Author chain B； PDBConstruct 1–190； UniProt 1–190 Author chain C； PDBConstruct 1–190； UniProt 1–190 Author chain D； PDBConstruct 1–190； UniProt 1–190 Author chain E； PDBConstruct 1–190； UniProt 1–190 Author chain F； PDBConstruct 1–190； UniProt 1–190

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8j4i
Deposition date deposition_date2023-04-20
Last revision last_revision2024-06-05
Structure title titleUnveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease
Keywords keywordsMitochondria calcium uptake, Calcium channel, Prohibitin 2, Ion-conducting pore, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8j4i__assembly_1__model_10

Assembly 1 · Model 10 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8j4i__assembly_1__model_10 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8j4i__assembly_1__model_10 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.00 Å
Rg (electron density)36.39 Å
Total Rg37.32 Å
Atom count18228
Residues1140
Excluded volume160760 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8j4i__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 8j4i__assembly_1__model_2 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 8j4i__assembly_1__model_3 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 8j4i__assembly_1__model_4 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 8j4i__assembly_1__model_5 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 8j4i__assembly_1__model_6 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 8j4i__assembly_1__model_7 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 8j4i__assembly_1__model_8 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 8j4i__assembly_1__model_9 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 8j4i__assembly_1__model_10 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 8j4i__assembly_1__model_11 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 8j4i__assembly_1__model_12 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 8j4i__assembly_1__model_13 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 8j4i__assembly_1__model_14 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 8j4i__assembly_1__model_15 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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7. Citations (1)