Hypoxia-inducible factor 1-alpha inhibitor
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 1–349 | Not recorded | MN MANGANESE (II) ION × 2 A1IF7 Enarodustat × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；Morpheus 1, well C1, 0.09 M NPS, 0.1 M Buffer System 1 pH 6.5, 30 % Precipitant Mix 1 | Resolution 2.20 Å R-free 0.208 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 9FSN | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1H2N Factor Inhibiting HIF-1 alpha Deposited 2002-08-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 AKG 2-OXOGLUTARIC ACID × 2 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.2M AMMONIUM SULPHATE, 4% PEG400, 0.1M HEPES PH7.5 ARGON ATMOSPHERE, 11MG/ML PROTEIN WITH 1MM FE(II), 2.5MM AKG AND 2.5MM PEPTIDE (SEE REMARK 400), pH 7.50
|
Resolution 2.84 Å R-free 0.257 |
| 1IZ3 Dimeric structure of FIH (Factor inhibiting HIF) Deposited 2002-09-19 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；0.4M Lithium sulfate, 20% PEG 4000, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.277 |
| 1MZE Human Factor Inhibiting HIF (FIH1) Deposited 2002-10-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 TAR D(-)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.6；294 K；potassium tartrate, CAPSO, glycerol, pH 9.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.20 Å R-free 0.237 |
| 1MZE Human Factor Inhibiting HIF (FIH1) Deposited 2002-10-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 TAR D(-)-TARTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.6；294 K；potassium tartrate, CAPSO, glycerol, pH 9.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.20 Å R-free 0.237 |
| 1MZF Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate Deposited 2002-10-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 AKG 2-OXOGLUTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.6；294 K；potassium tartrate, CAPSO, iron(II) sulfate, 2-oxoglutarate, glycerol, pH 9.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.40 Å R-free 0.244 |
| 1MZF Human Factor inhibiting HIF (FIH1) in Complex with 2-oxoglutarate Deposited 2002-10-07 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 AKG 2-OXOGLUTARIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.6；294 K；potassium tartrate, CAPSO, iron(II) sulfate, 2-oxoglutarate, glycerol, pH 9.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.40 Å R-free 0.244 |
| 1YCI Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine Deposited 2004-12-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 SO4 SULFATE ION × 6 NDF N-(CARBOXYCARBONYL)-D-PHENYLALANINE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.2M AMMONIUM SULPHATE, 4% PEG400, 0.1M HEPES PH7.5 ARGON ATMOSPHERE, 28MG/ML PROTEIN WITH 1MM FE(II), 10MM N-(CARBOXYCARBONYL)-D-PHENYLALANINE, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.70 Å R-free 0.244 |
| 2CGN FACTOR INHIBITING HIF-1 ALPHA with succinate Deposited 2006-03-09 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | FE FE (III) ION × 1 SIN SUCCINIC ACID × 1 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.25M AMMONIUM SULFATE, 100MM HEPES PH7.5, 6% PEG400, 1MM IRON (II) SULFATE, 20MM SUCCINIC ACID, pH 7.50
|
Resolution 2.40 Å R-free 0.263 |
| 2CGO FACTOR INHIBITING HIF-1 ALPHA with fumarate Deposited 2006-03-09 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | FE FE (III) ION × 1 FUM FUMARIC ACID × 1 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.25M AMMONIUM SULFATE, 100MM HEPES PH7.5, 6% PEG400, 1MM IRON (II) SULFATE, 20MM FUMARIC ACID, pH 7.50
|
Resolution 2.30 Å R-free 0.237 |
| 2ILM Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer Deposited 2006-10-03 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Mutation：D201A | FE2 FE (II) ION × 2 SO4 SULFATE ION × 4 BCT BICARBONATE ION × 2 AKG 2-OXOGLUTARIC ACID × 2 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH7.5 ARGON ATMOSPHERE, 14MG/ML PROTEIN WITH 1MM FE(II)SO4, 1MM ALPHA-KETOGLUTARATE, 1MM HIF-1ALPHA PEPTIDE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298.0K, pH 7.50
|
Resolution 2.30 Å R-free 0.267 |
| 2W0X FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID Deposited 2008-10-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 PD2 PYRIDINE-2,4-DICARBOXYLIC ACID × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.6M AMMONIUM SULFATE, 0.1M HEPES PH 7.5, 5% PEG400, 1MM FESO4, 2MM SUBSTRATE
|
Resolution 2.12 Å R-free 0.262 |
| 2WA3 FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-hydroxyphenyl)-2-oxoacetic acid Deposited 2009-02-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 A29 2-(3-HYDROXYPHENYL)-2-OXO-ETHANOIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.5 M AMMONIUM SULFATE, 100MM HEPES PH 7.5, 3% PEG400, 1MM FESO4, 28MG/ML PROTEIN, 10MM SUBSTRATE
|
Resolution 2.50 Å R-free 0.246 |
| 2WA4 FACTOR INHIBITING HIF-1 ALPHA WITH N,3-dihydroxybenzamide Deposited 2009-02-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 069 N,3-DIHYDROXYBENZAMIDE × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.5M AMMONIUM SULFATE, 100MM HEPES PH 7.5, 3% PEG400, 1MM FESO4, 28MB/ML PROTEIN, 10MM SUBSTRATE. CRYSTALS ARE DEEP RED.
|
Resolution 2.50 Å R-free 0.267 |
| 2XUM FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER) Deposited 2010-10-19 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Mutation：YES | ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH7.5, VAPOR DIFFUSION, SITTING DROP
|
Resolution 2.20 Å R-free 0.222 |
| 2XUM FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER) Deposited 2010-10-19 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Mutation：YES | ZN ZINC ION × 1 OGA N-OXALYLGLYCINE × 1 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH7.5, VAPOR DIFFUSION, SITTING DROP
|
Resolution 2.20 Å R-free 0.222 |
| 2Y0I FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER) Deposited 2010-12-02 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 AKG 2-OXOGLUTARIC ACID × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5 .
|
Resolution 2.28 Å R-free 0.248 |
| 2YC0 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE Deposited 2011-03-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 2HG (2R)-2-hydroxypentanedioic acid × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M HEPES PH7.5, 1.6M AMMONIUM SULFATE, 6% PEG400, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
|
Resolution 2.15 Å R-free 0.253 |
| 2YDE FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE Deposited 2011-03-18 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE FE (III) ION × 2 S2G (2S)-2-HYDROXYPENTANEDIOIC ACID × 4 GOL GLYCEROL × 4 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1M HEPES PH7.5, 1.6M AMMONIUM SULPHATE, 6% PEG400, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
|
Resolution 2.28 Å R-free 0.243 |
| 3D8C Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer Deposited 2008-05-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
11–349（339 aa）
|
Mutation：D201G | ZN ZINC ION × 2 SO4 SULFATE ION × 4 AKG 2-OXOGLUTARIC ACID × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH7.5, 24MG/ML PROTEIN WITH 1MM FE(II)SO4, 1MM ALPHA-KETOGLUTARATE, 1MM HIF-1ALPHA PEPTIDE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298.0K, PH 7.50
|
Resolution 2.10 Å R-free 0.256 |
| 3D8C Factor inhibiting HIF-1 alpha D201G mutant in complex with ZN(II), alpha-ketoglutarate and HIF-1 alpha 19mer Deposited 2008-05-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
11–349（339 aa）
|
Mutation：D201G | ZN ZINC ION × 1 SO4 SULFATE ION × 2 AKG 2-OXOGLUTARIC ACID × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH7.5, 24MG/ML PROTEIN WITH 1MM FE(II)SO4, 1MM ALPHA-KETOGLUTARATE, 1MM HIF-1ALPHA PEPTIDE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298.0K, PH 7.50
|
Resolution 2.10 Å R-free 0.256 |
| 3KCX Factor inhibiting HIF-1 alpha in complex with Clioquinol Deposited 2009-10-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
15–349（335 aa）
Fragment：residues 15-349
|
Not recorded | FE2 FE (II) ION × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 6 CQL 5-chloro-7-iodoquinolin-8-ol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；1.6M ammonium sulfate, 2% polyethyleneglycol 400, 0.1M Tris-HCl, pH 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 2.60 Å R-free 0.292 |
| 3KCY Factor inhibiting HIF-1 alpha in complex with 8-hydroxyquinoline Deposited 2009-10-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
15–349（335 aa）
Fragment：residues 15-349
|
Not recorded | FE2 FE (II) ION × 2 SO4 SULFATE ION × 4 HQY quinolin-8-ol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；1.6M ammonium sulfate, 2% polyethyleneglycol 400, 0.1M Tris-HCl, pH 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 2.59 Å R-free 0.335 |
| 3OD4 Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor Deposited 2010-08-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 8XQ 8-hydroxyquinoline-5-carboxylic acid × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；1.75M AMMONIUM SULFATE, 0.1M HEPES PH 7.5, 2% PEG 400, 2MM ZNCL2, 0.1MM LIGAND , VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.212 |
| 3P3N Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide Deposited 2010-10-05 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 SO4 SULFATE ION × 4 AKG 2-OXOGLUTARIC ACID × 2 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；1.6M AMMONIUM SULFATE, 4% PEG400, 0.1M HEPES PH7.5, NITROGEN ATMOSPHERE, 20MG/ML PROTEIN WITH 1MM FE(II), 2.0MM 2OG AND 10MM PEPTIDE , VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
|
Resolution 2.40 Å R-free 0.244 |
| 3P3P Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1997-2016) peptide Deposited 2010-10-05 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | FE2 FE (II) ION × 2 AKG 2-OXOGLUTARIC ACID × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；1.6M AMMONIUM SULFATE, 4% PEG400, 0.1M HEPES PH7.5, NITROGEN ATMOSPHERE, 20MG/ML PROTEIN WITH 1MM FE(II), 2.0MM 2OG AND 10MM PEPTIDE , VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
|
Resolution 2.60 Å R-free 0.259 |
| 4AI8 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE Deposited 2012-02-08 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 10 GOL GLYCEROL × 6 DZA DAMINOZIDE × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES PH7.5, 1.6 M AMMONIUM SULFATE, 6% PEG400, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
|
Resolution 2.40 Å R-free 0.248 |
| 4B7E FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-LEU PEPTIDE (20-MER) Deposited 2012-08-17 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 10 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.6M AMMONIUM SULPHATE, 6% PEG400, 0.1M HEPES PH 7.5
|
Resolution 2.50 Å R-free 0.255 |
| 4B7K FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-SER PEPTIDE (20-MER) Deposited 2012-08-20 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1.6 M AMMONIUM SULPHATE, 6% PEG 400, 0.1 M HEPES PH 7.5
|
Resolution 2.39 Å R-free 0.241 |
| 4BIO FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH 8-HYDROXYQUINOLINE-5- CARBOXYLIC ACID Deposited 2013-04-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | FE FE (III) ION × 2 8XQ 8-hydroxyquinoline-5-carboxylic acid × 2 SO4 SULFATE ION × 10 GOL GLYCEROL × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；1.2M AMMONIUM SULPHATE, 3% PEG400, PEG400, 0.001M FECL2, 0.1M HEPES PH7.5, VAPOR DIFFUSION, SITTING DROP
|
Resolution 2.45 Å R-free 0.234 |
| 4JAA Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)LEU peptide Deposited 2013-02-18 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 1 OGA N-OXALYLGLYCINE × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.39 Å R-free 0.219 |
| 4NR1 Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)allyl-GLY peptide Deposited 2013-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 1 OGA N-OXALYLGLYCINE × 1 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.68 Å R-free 0.210 |
| 4Z1V Structure of Factor Inhibiting HIF (FIH) in complex with Fe, NO, and NOG Deposited 2015-03-27 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | OGA N-OXALYLGLYCINE × 2 NO NITRIC OXIDE × 2 PEG DI(HYDROXYETHYL)ETHER × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M Hepes, 1.6mM ammonium sulfate, 3% PEG 400
|
Resolution 2.10 Å R-free 0.240 |
| 4Z2W Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate Deposited 2015-03-30 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | AKG 2-OXOGLUTARIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M Hepes, 1.6mM ammonium sulfate, 3% PEG 400
|
Resolution 2.50 Å R-free 0.246 |
| 5JWK Factor Inhibiting HIF D201E in Complex with Fe, and Alpha-Ketoglutarate Deposited 2016-05-12 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Mutation：D201E | AKG 2-OXOGLUTARIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 2 FE2 FE (II) ION × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 1.6mM ammonium sulfate, 3% PEG 400
|
Resolution 2.30 Å R-free 0.227 |
| 5JWL Factor Inhibiting HIF D201E in Complex with Zn, and Alpha-Ketoglutarate Deposited 2016-05-12 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Mutation：D201E | AKG 2-OXOGLUTARIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 1.6mM ammonium sulfate, 3% PEG 400
|
Resolution 2.40 Å R-free 0.226 |
| 5JWP Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide. Deposited 2016-05-12 | Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Mutation：D201E | AKG 2-OXOGLUTARIC ACID × 2 GOL GLYCEROL × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.1M Hepes, 1.6mM ammonium sulfate, 3% PEG 400
|
Resolution 2.10 Å R-free 0.209 |
| 5OP6 Factor Inhibiting HIF (FIH) in complex with zinc and GSK128863 Deposited 2017-08-09 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 1 SO4 SULFATE ION × 2 A0W 2-[[1,3-dicyclohexyl-4-oxidanyl-2,6-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]ethanoic acid × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；300 K；0.1M HEPES pH7.5, 1.1M ammonium sulfate, 2.5% PEG 400
|
Resolution 2.45 Å R-free 0.227 |
| 5OP8 Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat Deposited 2017-08-09 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 A1H 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)-1~{H}-pyrazol-3-one × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；300 K；0.1M HEPES pH7.5, 1.4M ammonium sulfate, 4.5% PEG400
|
Resolution 2.30 Å R-free 0.214 |
| 5OPC Factor Inhibiting HIF (FIH) in complex with zinc and Vadadustat Deposited 2017-08-09 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 10 ZN ZINC ION × 2 GOL GLYCEROL × 10 A1Z Vadadustat × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；300 K；0.1M HEPES pH7.5, 1.7M ammonium sulfate, 5.5% PEG 400
|
Resolution 2.30 Å R-free 0.214 |
| 6H9J Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) Deposited 2018-08-04 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
12–349（338 aa）
|
Not recorded | OGA N-OXALYLGLYCINE × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 8 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5,
1.8 M ammonium
sulfate, 4.5% PEG400
|
Resolution 1.83 Å R-free 0.187 |
| 6HA6 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246) Deposited 2018-08-07 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 6 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5,
1.7 M ammonium
sulfate, 5.5% PEG400
|
Resolution 1.98 Å R-free 0.203 |
| 6HC8 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339) Deposited 2018-08-14 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5,
1.6 M ammonium
sulfate, 6% PEG400
|
Resolution 1.90 Å R-free 0.189 |
| 6HKP Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP2 (970-992) Deposited 2018-09-07 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 12 GOL GLYCEROL × 10 OGA N-OXALYLGLYCINE × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5,
2.0 M ammonium
sulfate, 5.5% PEG400
|
Resolution 1.90 Å R-free 0.195 |
| 6HL5 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP1(932-954) Deposited 2018-09-10 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | GOL GLYCEROL × 8 SO4 SULFATE ION × 8 ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M Hepes pH = 7.5,
1.2 M ammonium
sulfate, 4.5% PEG400
|
Resolution 1.98 Å R-free 0.201 |
| 6HL6 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693) Deposited 2018-09-10 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | GOL GLYCEROL × 10 SO4 SULFATE ION × 6 ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；273 K；0.1 M Hepes pH = 7.5,
1.6 M ammonium
sulfate, 3.5% PEG400
|
Resolution 1.97 Å R-free 0.205 |
| 6RUJ Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)3-hydroxy-Leu peptide Deposited 2019-05-28 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 OGA N-OXALYLGLYCINE × 2 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.42 Å R-free 0.257 |
| 7A1J FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-(3-phenylpropyl)-2-oxoglutarate Deposited 2020-08-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 10 QVN 3-(3-phenylpropyl)-2-oxoglutarate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 1.90 Å R-free 0.209 |
| 7A1K FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate Deposited 2020-08-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 QVZ 3-((9,9-dimethyl-9H-fluoren-2-yl)methyl)-2-oxoglutarate × 2 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 1.99 Å R-free 0.227 |
| 7A1L FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | ROQ (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid × 1 ZN ZINC ION × 1 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.29 Å R-free 0.222 |
| 7A1M FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-propyl-2-oxoglutarate Deposited 2020-08-13 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 QVW 3-propyl-2-oxoglutarate × 2 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.18 Å R-free 0.245 |
| 7A1N FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 9 ZN ZINC ION × 1 ROQ (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.01 Å R-free 0.234 |
| 7A1O FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-ethyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 8 QVT 4-ethyl-2-oxoglutarate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.21 Å R-free 0.243 |
| 7A1P FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 4-propyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 6 QW2 (4~{S})-2-oxidanylidene-4-propyl-pentanedioic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 1.76 Å R-free 0.191 |
| 7A1Q FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER) Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 6 QVQ 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 1.75 Å R-free 0.200 |
| 7A1S FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER) Deposited 2020-08-13 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 8 ROQ (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.01 Å R-free 0.209 |
| 8IHZ FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine Deposited 2023-02-24 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 14 ZN ZINC ION × 1 P1X 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6 M AMMONIUM SULPHATE, 6% PEG 400, 0.1 M HEPES
|
Resolution 2.22 Å R-free 0.261 |
| 8II0 FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine Deposited 2023-02-24 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | P5I 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid × 1 GOL GLYCEROL × 2 ZN ZINC ION × 1 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6 M AMMONIUM SULPHATE, 6% PEG 400, 0.1 M HEPES.
|
Resolution 2.04 Å R-free 0.239 |
| 8K71 Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((2-((naphthalen-2-ylmethyl)sulfonyl)acetyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid Deposited 2023-07-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | ZN ZINC ION × 2 VIZ 2-[(2~{Z})-2-[2-(naphthalen-2-ylmethylsulfonyl)ethanoylimino]-3-oxidanyl-1,3-thiazol-4-yl]ethanoic acid × 2 SO4 SULFATE ION × 16 GOL GLYCEROL × 14 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.27 mM FIH, 0.5 mM zinc acetate, 2 mM BNS, 0.1 M HEPES, pH 7.5, 6%w/v PEG400, 1.6 M ammonium sulfate
|
Resolution 2.23 Å R-free 0.236 |
| 8K72 Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((3-(phenylsulfonamido)propanoyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid Deposited 2023-07-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 20 GOL GLYCEROL × 6 ZN ZINC ION × 2 VJF 2-[(2~{Z})-3-oxidanyl-2-[3-(phenylsulfonylamino)propanoylimino]-1,3-thiazol-4-yl]ethanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.27 mM FIH, 0.5 mM zinc acetate, 2 mM TC167, 0.1 M HEPES, pH 7.5, 6%w/v PEG400, 1.6 M ammonium sulfate
|
Resolution 2.45 Å R-free 0.239 |
| 8K73 Factor-inhibiting hypoxia-inducible factor in complex with Zn(II) and 2-(3-hydroxy-2-((1-(phenylsulfonyl)pyrrolidine-3-carbonyl)imino)-2,3-dihydrothiazol-4-yl)acetic acid Deposited 2023-07-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 14 GOL GLYCEROL × 14 ZN ZINC ION × 2 VK6 2-[(2~{Z})-3-oxidanyl-2-[(3~{R})-1-(phenylsulfonyl)pyrrolidin-3-yl]carbonylimino-1,3-thiazol-4-yl]ethanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.27 mM FIH, 0.5 mM zinc acetate, 2 mM RT105, 0.1 M HEPES, pH 7.5, 6%w/v PEG400, 1.6 M ammonium sulfate
|
Resolution 2.02 Å R-free 0.223 |
| 9I4H Factor Inhibiting HIF (FIH) in complex with manganese and 3-Hydroxy-5-(3-(4-(hydroxymethyl)-3-nitrophenyl)isoxazol-5-yl)picolinoyl)glycine Deposited 2025-01-24 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–349（349 aa）
|
Not recorded | MN MANGANESE (II) ION × 2 A1IZ5 N-[(5P)-3-hydroxy-5-{(3P)-3-[4-(hydroxymethyl)-3-nitrophenyl]-1,2-oxazol-5-yl}pyridine-2-carbonyl]glycine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；290 K；Morpheus C5
0.09 M NPS
0.1 M Buffer System 2 7.5
30 % v/v Precipitant Mix 2
|
Resolution 2.30 Å R-free 0.218 |
| 9IIF Factor inhibiting HIF-1 alpha in complex with Zn(II) and Desidustat Deposited 2024-06-20 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 8 A1L2L 2-[[1-(cyclopropylmethoxy)-2-oxidanyl-4-oxidanylidene-quinolin-3-yl]carbonylamino]ethanoic acid × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.27 mM FIH, 0.5 mM zinc acetate, 2 mM densidustat, 0.1 M HEPES, pH 7.5, 6% w/v PEG400, 1.6 M ammonium sulfate
|
Resolution 2.16 Å R-free 0.244 |
| 9JTX Factor inhibiting HIF-1 alpha in complex with Zn(II) and 2-(4-hydroxy-2-oxo-1-(thiazol-4-ylmethoxy)-1,2-dihydroquinoline-3-carboxamido)-2-methylpropanoic acid Deposited 2024-10-07 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | SO4 SULFATE ION × 7 A1L4V 2-methyl-2-[[4-oxidanyl-2-oxidanylidene-1-(1,3-thiazol-4-ylmethoxy)quinolin-3-yl]carbonylamino]propanoic acid × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；0.1 M HEPES, pH 7.5,
6%w/v PEG400,
1.6 M ammonium sulfate
|
Resolution 2.08 Å R-free 0.247 |
| 9M23 FIH [Factor Inhibiting HIF (Hypoxia Inducible Factor)] in complex with Zn(II) and N-((4-(trifluoromethyl)phenyl)sulfonyl)picolinamide (SB133) Deposited 2025-02-27 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–349（349 aa）
|
Not recorded | GOL GLYCEROL × 1 ZN ZINC ION × 1 A1L8D ~{N}-[4-(trifluoromethyl)phenyl]sulfonylpyridine-2-carboxamide × 1 SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；1.6M AMMONIUM SULPHATE, 6% PEG 400, 0.1M HEPES PH 7.5
|
Resolution 2.16 Å R-free 0.226 |
60 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | HIF1N_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 2–350； UniProt 1–349 |
