9noc

CCT G beta 5 S123L complex state 3

Method: ELECTRON MICROSCOPY Dmax: 163.2 Å Quality: GOOD

1. Protein Identity and Related Structures Protein Identity & Related Structures

T-complex protein 1 subunit alpha

Homo sapiens

UniProt P17987

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain A; UniProt 1–556 Chain a; UniProt 1–556 Not recorded T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

64 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPA_HUMAN
Isoform
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–556; UniProt 1–556 Author chain a; PDBConstruct 1–556; UniProt 1–556

T-complex protein 1 subunit beta

Homo sapiens

UniProt P78371

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain B; UniProt 1–535 Chain b; UniProt 1–535 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

64 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPB_HUMAN
Isoform
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–535; UniProt 1–535 Author chain b; PDBConstruct 1–535; UniProt 1–535

T-complex protein 1 subunit delta

Homo sapiens

UniProt P50991

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain D; UniProt 1–539 Chain d; UniProt 1–539 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

65 other PDB entries and 65 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPD_HUMAN
Isoform
PDB entities 3
Chains and sequence ranges Author chain D; PDBConstruct 1–539; UniProt 1–539 Author chain d; PDBConstruct 1–539; UniProt 1–539

T-complex protein 1 subunit epsilon

Homo sapiens

UniProt P48643

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain E; UniProt 1–541 Chain e; UniProt 1–541 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

68 other PDB entries and 68 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPE_HUMAN
Isoform
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–541; UniProt 1–541 Author chain e; PDBConstruct 1–541; UniProt 1–541

T-complex protein 1 subunit gamma

Homo sapiens

UniProt P49368

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain G; UniProt 1–545 Chain g; UniProt 1–545 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

65 other PDB entries and 65 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPG_HUMAN
Isoform
PDB entities 5
Chains and sequence ranges Author chain G; PDBConstruct 1–545; UniProt 1–545 Author chain g; PDBConstruct 1–545; UniProt 1–545

T-complex protein 1 subunit eta

Homo sapiens

UniProt Q99832

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain H; UniProt 1–543 Chain h; UniProt 1–543 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

63 other PDB entries and 63 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPH_HUMAN
Isoform
PDB entities 6
Chains and sequence ranges Author chain H; PDBConstruct 1–543; UniProt 1–543 Author chain h; PDBConstruct 1–543; UniProt 1–543

T-complex protein 1 subunit theta

Homo sapiens

UniProt P50990

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain Q; UniProt 1–548 Chain q; UniProt 1–548 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

64 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPQ_HUMAN
Isoform
PDB entities 7
Chains and sequence ranges Author chain Q; PDBConstruct 1–548; UniProt 1–548 Author chain q; PDBConstruct 1–548; UniProt 1–548

T-complex protein 1 subunit zeta

Homo sapiens

UniProt P40227

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain Z; UniProt 1–531 Chain z; UniProt 1–531 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) Phosducin-like protein × 1 (Q13371) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

64 other PDB entries and 64 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name TCPZ_HUMAN
Isoform
PDB entities 8
Chains and sequence ranges Author chain Z; PDBConstruct 1–531; UniProt 1–531 Author chain z; PDBConstruct 1–531; UniProt 1–531

Phosducin-like protein

Homo sapiens

UniProt Q13371

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain P; UniProt 1–301 Not recorded T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Guanine nucleotide-binding protein subunit beta-5 × 1 (O14775) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

18 other PDB entries and 18 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name PHLP_HUMAN
Isoform
PDB entities 9
Chains and sequence ranges Author chain P; PDBConstruct 1–301; UniProt 1–301

Guanine nucleotide-binding protein subunit beta-5

Homo sapiens

UniProt O14775

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 18 PDB declaration: 18-meric(18) Consistent with protein copy count Chain N; UniProt 1–395 Mutation:S123L T-complex protein 1 subunit alpha × 2 (P17987) T-complex protein 1 subunit beta × 2 (P78371) T-complex protein 1 subunit delta × 2 (P50991) T-complex protein 1 subunit epsilon × 2 (P48643) T-complex protein 1 subunit gamma × 2 (P49368) T-complex protein 1 subunit eta × 2 (Q99832) T-complex protein 1 subunit theta × 2 (P50990) T-complex protein 1 subunit zeta × 2 (P40227) Phosducin-like protein × 1 (Q13371) ADP ADENOSINE-5'-DIPHOSPHATE × 16 MG MAGNESIUM ION × 16 AF3 ALUMINUM FLUORIDE × 16 ELECTRON MICROSCOPY cryo-EM buffer:pH 7.6 cryo-EM vitrification conditions:Cryogen ETHANE Resolution 3.17 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

31 other PDB entries and 31 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name GNB5_HUMAN
Isoform
PDB entities 10
Chains and sequence ranges Author chain N; PDBConstruct 33–427; UniProt 1–395

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 9noc

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 9noc
Download Download

2. Structure Basics 2. Structure Basics

Entry ID entry_id9noc
Deposition date deposition_date2025-03-09
Structure title titleCCT G beta 5 S123L complex state 3
Keywords keywordsCCT, TRiC, protein folding, G beta 5, CHAPERONE; CHAPERONE
Experimental Method methodELECTRON MICROSCOPY

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier65.30
Radius of gyration Rg (electron density) rg_electron64.21
Forward intensity I(0) i012485800000.00
Molecular weight molecular_weight942570.0 kDa
Excluded volume excluded_volume1179900 ų
Envelope volume envelope_volume1859900 ų
Hydration-shell volume shell_volume226610 ų
Envelope diameter envelope_diameter177.2
Shell Rg shell_rg78.55
Envelope Rg envelope_rg60.00
Shape Rg shape_rg64.23
Total Rg total_rg64.34
Total atoms total_atoms65877
Residues n_residues8571
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 −1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax163.2
Rg (real space) rg_real64.44
Rg uncertainty (real space) rg_real_error0.49
I(0) (real space) i0_real1.2490e+10
I(0) uncertainty (real space) i0_real_error2.0920e+08
Rg (reciprocal space) rg_reciprocal66.01
I(0) (reciprocal space) i0_reciprocal12520000000.0000
Solution quality estimate total_estimate0.8442
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary95.2
Skewness Skewness skewness-0.212
Kurtosis Kurtosis kurtosis-0.638
Angular range angular_range— – 0.1200 −1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha4007000000.0000
Real-space data points n_real_points25
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.991; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.000

5. Crystallography and Experiment 5. Crystallography & Experiment

6. Entities and Polymers Entities & Polymers (14)

8. Citations (1)

9. Files and Curves (10)