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9r9b

Crystal structure of clathrin heavy chain in complex with a peptidomimetic inhibitor of the TACC3 interaction

Method: X-RAY DIFFRACTION D_max: 115.8 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9r9b
deposition_date	2025-05-19
last_revision	2026-04-08
title	Crystal structure of clathrin heavy chain in complex with a peptidomimetic inhibitor of the TACC3 interaction
keywords	Mitotic spindle Hydrocarbon stapled peptide Microtubule-binding, CELL CYCLE; CELL CYCLE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	35.60 Å
rg_electron	35.70 Å
i0	64758300.00
molecular_weight	65794.0 kDa
excluded_volume	83123 Å³
envelope_volume	113320 Å³
shell_volume	28395 Å³
envelope_diameter	125.7 Å
shell_rg	39.18 Å
envelope_rg	35.31 Å
shape_rg	35.68 Å
total_rg	36.02 Å
total_atoms	4628
n_residues	587
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	115.8 Å
rg_real	36.01 Å
rg_real_error	1.27 Å
i0_real	6.4760e+07
i0_real_error	1.1610e+06
rg_reciprocal	35.76 Å
i0_reciprocal	64740000.0000
total_estimate	0.7524
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	29.0 Å
skewness	0.502
kurtosis	-0.580
angular_range	— – 0.2200 Å⁻¹
current_alpha	0.0000
highest_alpha	6521000.0000
n_real_points	45
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.709; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.574; Smooth: 0.075

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Clathrin heavy chain 1
formula_weight	64355.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	4695

MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGKTIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNR

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Escherichia coli

Entity 2 polymer

description	SP-TACC3
formula_weight	2552.0 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

KESALRKLELLLEFDPLFRDS

Entity 3 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	67

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6. Citations (1)

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length_a	111.218 Å
length_b	111.218 Å
length_c	212.862 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	12

space_group	P 61 2 2
int_tables_number	178
crystal_system	—

resolution	2.146 Å
resolution_low	96.318 Å
r_factor	—
r_work	0.2036
r_free	0.2684

fit	/app/data/saxs_computation/r9/9r9b/9r9b.fit
pddf	/app/data/pr_computation/r9/9r9b/9r9b.pr.out
profile	/app/data/saxs_computation/r9/9r9b/9r9b.dat

Crystal structure of clathrin heavy chain in complex with a peptidomimetic inhibitor of the TACC3 interaction

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Entity 3 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)