p53 cancer mutant V143A in complex with DARPin C10

entry_id	9spm
deposition_date	2025-09-17
last_revision	2026-04-22
title	p53 cancer mutant V143A in complex with DARPin C10
keywords	;p53, tumor suppressor, cancer mutation, protein stability, protein unfolding disease, designed ankyrin repeat proteins, thermostabilization, mutant p53 reactivation, cancer therapy, TRANSCRIPTION ;; TRANSCRIPTION
method	X-RAY DIFFRACTION

rg_guinier	21.55 Å
rg_electron	20.57 Å
i0	23086000.00
molecular_weight	35065.0 kDa
excluded_volume	43258 ų
envelope_volume	50849 ų
shell_volume	20942 ų
envelope_diameter	73.7 Å
shell_rg	26.93 Å
envelope_rg	20.72 Å
shape_rg	20.54 Å
total_rg	21.47 Å
total_atoms	2453
n_residues	320
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	73.5 Å
rg_real	21.54 Å
rg_real_error	0.66 Å
i0_real	2.3090e+07
i0_real_error	3.6100e+05
rg_reciprocal	21.54 Å
i0_reciprocal	23090000.0000
total_estimate	0.8749
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	24.9 Å
skewness	0.354
kurtosis	-0.307
angular_range	— – 0.3700 Å−1
current_alpha	0.0000
highest_alpha	5222000.0000
n_real_points	69
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.804; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.963; Smooth: 0.995

Unit Cell

length_a	37.803 Å
length_b	93.729 Å
length_c	53.143 Å
angle_alpha	90.00 °
angle_beta	110.34 °
angle_gamma	90.00 °
z_pdb	2

Symmetry

space_group	P 1 21 1
int_tables_number	4
crystal_system	monoclinic

Refinement

resolution	1.710 Å
resolution_low	46.900 Å
r_factor	0.1808
r_work	0.1789
r_free	0.2182

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/sp/9spm/pr_distribution.json
• pr_output /app/data/pr_computation/sp/9spm/9spm.pr.out
• pr_plot /app/data/visualization/pr_computation/sp/9spm/9spm_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/sp/9spm/9spm.dat
• saxs_fit /app/data/saxs_computation/sp/9spm/9spm.fit
• saxs_log /app/data/saxs_computation/sp/9spm/9spm.log
• saxs_plot /app/data/visualization/saxs_computation/sp/9spm/9spm_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/sp/9spm/9spm.fit
pddf	/app/data/pr_computation/sp/9spm/9spm.pr.out
profile	/app/data/saxs_computation/sp/9spm/9spm.dat