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9uvu

Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant, focused on receptor

Method: ELECTRON MICROSCOPY D_max: 84.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uvu
deposition_date	2025-05-11
title	Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant, focused on receptor
keywords	GPCR, B2R, bradykinin, icatibant, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	21.95 Å
rg_electron	21.49 Å
i0	28894300.00
molecular_weight	29087.0 kDa
excluded_volume	28961 Å³
envelope_volume	47013 Å³
shell_volume	19464 Å³
envelope_diameter	86.3 Å
shell_rg	26.90 Å
envelope_rg	22.28 Å
shape_rg	21.49 Å
total_rg	22.07 Å
total_atoms	2209
n_residues	269
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	84.1 Å
rg_real	22.23 Å
rg_real_error	0.84 Å
i0_real	2.8890e+07
i0_real_error	4.3050e+05
rg_reciprocal	22.17 Å
i0_reciprocal	28890000.0000
total_estimate	0.7575
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	22.6 Å
skewness	0.702
kurtosis	0.255
angular_range	— – 0.3600 Å⁻¹
current_alpha	0.0000
highest_alpha	3925000.0000
n_real_points	68
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.467; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.492; Smooth: 0.951

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	icatibant
formula_weight	1307.5 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B
atom_count	2209

RRPPGASXXR

Entity 2 polymer

description	B2 bradykinin receptor,Soluble cytochrome b562
formula_weight	54839.9 kDa
mutation	M258W/H353I/R357L
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A

GPLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQLEVLFQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.690 Å
resolution_low	3.690 Å
r_factor	—
r_work	0.4451
r_free	—

resolution	3.69 Å
resolution_method	—
num_particles	187522

fit	/app/data/saxs_computation/uv/9uvu/9uvu.fit
pddf	/app/data/pr_computation/uv/9uvu/9uvu.pr.out
profile	/app/data/saxs_computation/uv/9uvu/9uvu.dat

Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant, focused on receptor

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Entity 2 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)