9y8j
Crystal structure of the Kelch domain of human KLHL12 with compound 1
SAXS Profile
P(r) Distribution
1. Structure Basics
| entry_id | 9y8j |
| deposition_date | 2025-09-11 |
| title | Crystal structure of the Kelch domain of human KLHL12 with compound 1 |
| keywords | E3 ligase, fragment-based drug discovery, PROTAC, LIGASE; LIGASE |
| method | X-RAY DIFFRACTION |
Download Data
2. SAXS Parameters (CRYSOL)
| rg_guinier | 18.17 Å |
| rg_electron | 17.27 Å |
| i0 | 29300200.00 |
| molecular_weight | 27694.0 kDa |
| excluded_volume | 26627 ų |
| envelope_volume | 41318 ų |
| shell_volume | 19390 ų |
| envelope_diameter | 54.3 Å |
| shell_rg | 24.06 Å |
| envelope_rg | 17.38 Å |
| shape_rg | 17.25 Å |
| total_rg | 17.99 Å |
| total_atoms | 2088 |
| n_residues | 288 |
| n_harmonics | 20 |
| q_range | — – 0.5000 Å−1 |
| n_points | 101 |
| shell_type | directional |
| solvent_density | 0.3340 e/ų |
| contrast_shell | 0.0300 e/ų |
| crysol_version | 4.1.3 |
3. P(r) Analysis (GNOM)
| dmax | 53.2 Å |
| rg_real | 17.99 Å |
| rg_real_error | 0.16 Å |
| i0_real | 2.9300e+07 |
| i0_real_error | 3.3070e+05 |
| rg_reciprocal | 18.02 Å |
| i0_reciprocal | 29300000.0000 |
| total_estimate | 0.9067 |
| solution_quality | EXCELLENT a EXCELLENT solution |
| n_peaks | 2 |
| r_peak_primary | 24.4 Å |
| skewness | 0.033 |
| kurtosis | -0.556 |
| angular_range | — – 0.4400 Å−1 |
| current_alpha | 0.0000 |
| highest_alpha | 12040000.0000 |
| n_real_points | 75 |
| gnom_version | 4.1.3 |
| quality_criteria | AN1: 0.000; Oscil: 0.947; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.974; Smooth: 0.969 |