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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：J7RUA5 New Search
16PDB entries
16Biological assembly
17chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
5AXW Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM) Deposited 2015-08-01 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Mutation：N580A/C946A NA SODIUM ION × 4 PO4 PHOSPHATE ION × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；PEG4000, NaCl, Na2HPO4, NaN3
Resolution 2.70 Å R-free 0.230
5CZZ Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGAAT PAM) Deposited 2015-08-01 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Mutation：N580A/C946A NA SODIUM ION × 5 PO4 PHOSPHATE ION × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；PEG4000, NaCl, Na2HPO4, NaN3
Resolution 2.60 Å R-free 0.241
7EL1 Structure of a protein from bacteria Deposited 2021-04-07 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 1–1053（1053 aa）
Mutation：N580A, C946A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；1.0M sodium citrate dihydrate, 0.3M imidazol-Hcl (pH 10.0), 0.02M sodium malonate (pH 7.0)
Resolution 2.22 Å R-free 0.242
7ENH Crystal structure of cas and anti-cas protein complex Deposited 2021-04-17 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 481–646（166 aa） Fragment：HNH domain
Not recorded NI NICKEL (II) ION × 11 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289.15 K；PEG 3350, sodium iodide
Resolution 2.10 Å R-free 0.208
7ENI Crystal structure of cas and anti-cas protein complex Deposited 2021-04-17 Assembly 1 Protein–RNA Heteromer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded PO4 PHOSPHATE ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289.15 K；Tris, Ammonium phosphate dibasic
Resolution 2.63 Å R-free 0.237
7ENR Crystal structure of cas and anti-cas protein complex Deposited 2021-04-19 Assembly 1 Protein–RNA Heteromer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289.15 K；PEG 3350, EG, Bicine
Resolution 4.21 Å R-free 0.307
7VW3 Cryo-EM structure of SaCas9-sgRNA-DNA ternary complex Deposited 2021-11-09 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 2–1053（1052 aa）
Mutation：D10A N580A MG MAGNESIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20mM Tris-Cl (pH 7.5), 100mM KCl, 5mM MgCl2, 1mM DTT
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8JFT Cryo-EM structure of SaCas9-AcrIIA15 CTD-sgRNA complex Deposited 2023-05-18 Assembly 1 Protein–RNA Heteromer；Protein × 2 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.31 Å
8JG9 Cryo-EM structure of the SaCas9-sgRNA-AcrIIA15-promoter DNA dimer Deposited 2023-05-20 Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: octameric（8） Consistent with all polymers
Chain A 1–1053（1053 aa）
Chain D 1–1053（1053 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.82 Å
8Y0D Crystal structure of SauCas9 in complex with sgRNA and 20nt ssDNA target Deposited 2024-01-22 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；0.2 M Sodium chloride, 0.1 M Sodium HEPES, pH 7.0, 11% PEG 8000
Resolution 3.92 Å R-free 0.318
8ZCY Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in an interrogation state Deposited 2024-04-30 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.17 Å
8ZCZ Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in an intermediate state Deposited 2024-04-30 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8ZD0 Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in a translocation state Deposited 2024-04-30 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.76 Å
8ZDA Cryo-EM structure of eSaCas9_NNG-guide RNA-target DNA complex in a catalytically active state Deposited 2024-05-01 Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: pentameric（5） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded MG MAGNESIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.14 Å
9MB6 Cryo-EM structure of wild-type SaCas9-guide RNA-mismatched target DNA complex Deposited 2025-03-15 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
9MB7 Cryo-EM structure of eSaCas9-NNG-guide RNA-mismatched target DNA complex Deposited 2025-03-15 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: tetrameric（4） Consistent with all polymers
Chain A 1–1053（1053 aa）
Not recorded MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.6
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.88 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.