Current Protein Identity：O75581
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 21KR A Wnt3a/Fzd8-CRD/LRP6-E3E4 complex with FKBP Deposited 2025-12-17 | Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
630–1245（616 aa）
Chain F
630–1245（616 aa）
|
Mutation：C715S Mutation：C715S | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 2.90 Å |
| 21KS A Wnt3a/Fzd8-CRD/LRP6-E3E4-LA complex with FKBP Deposited 2025-12-17 | Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain B
630–1370（741 aa）
Chain F
630–1370（741 aa）
|
Mutation：C840S Mutation：C840S | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 3.01 Å |
| 21KT Wnt3a signalosome extracellular complex Deposited 2025-12-17 | Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain B
630–1245（616 aa）
Chain F
630–1245（616 aa）
|
Mutation：C715S Mutation：C715S | No recorded non-water small molecule | ELECTRON MICROSCOPY | mmCIF provides none of the parsed conditions | Resolution 3.33 Å |
| 3S2K Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. Deposited 2011-05-16 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
630–1246（617 aa）
Fragment：ectodomain repeats 3, 4 UNP residues 630-1246
Chain B
630–1246（617 aa）
Fragment：ectodomain repeats 3, 4 UNP residues 630-1246
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；295 K；10-15% PEG3350, 100 mM Tris-Cl (pH 8.5), 100 mM Lithium sulfate, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.80 Å R-free 0.251 |
| 3S8V Crystal structure of LRP6-Dkk1 complex Deposited 2011-05-31 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
629–1243（615 aa）
Fragment：E3E4, residues 629-1243
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.8；298 K；20mM citric acid, 80mM Bis-tris propane pH 8.8, 19-20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.292 |
| 3S8V Crystal structure of LRP6-Dkk1 complex Deposited 2011-05-31 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
629–1243（615 aa）
Fragment：E3E4, residues 629-1243
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.8；298 K；20mM citric acid, 80mM Bis-tris propane pH 8.8, 19-20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.292 |
| 3S8Z Crystal structure of LRP6-E3E4 Deposited 2011-05-31 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
629–1243（615 aa）
Fragment：E3E4, residues 629-1243
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；100mM ADA pH 6.5, 100mM MgCl2, 12% PEG6000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.282 |
| 3S94 Crystal structure of LRP6-E1E2 Deposited 2011-05-31 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
20–630（611 aa）
Fragment：E1E2, residues 20-630
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；80mM sodium citrate pH 5.5, 20-21% PEG3350, 40mM KSCN, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.296 |
| 3S94 Crystal structure of LRP6-E1E2 Deposited 2011-05-31 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
20–630（611 aa）
Fragment：E1E2, residues 20-630
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；80mM sodium citrate pH 5.5, 20-21% PEG3350, 40mM KSCN, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.296 |
| 3SOB The structure of the first YWTD beta propeller domain of LRP6 in complex with a FAB Deposited 2011-06-30 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
20–335（316 aa）
Fragment：UNP residues 20-335
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；0.2 M NaCl, 0.1 M Tris pH 8, 25% (w/v) PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.212 |
| 3SOQ The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide Deposited 2011-06-30 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
20–326（307 aa）
Fragment：UNP residues 20-335
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FUC alpha-L-fucopyranose × 1 GOL GLYCEROL × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；0.1M potassium thiocyanate and 30% (w/v) PEG MME 2000, pH 8, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.90 Å R-free 0.221 |
| 3SOV The structure of a beta propeller domain in complex with peptide S Deposited 2011-06-30 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
20–326（307 aa）
Fragment：UNP residues 20-335
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 FUC alpha-L-fucopyranose × 4 GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；0.1M potassium thiocyanate and 30% (w/v) PEG MME 2000, pH 8, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.27 Å R-free 0.180 |
| 4A0P Crystal structure of LRP6P3E3P4E4 Deposited 2011-09-11 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
629–1244（616 aa）
Fragment：P3E3P4E4, RESIDUES 629-1244
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 3 CL CHLORIDE ION × 3 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å R-free 0.211 |
| 4DG6 Crystal structure of domains 1 and 2 of LRP6 Deposited 2012-01-25 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
20–635（616 aa）
Fragment：UNP residues 20-635
|
Not recorded | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
hanging drop；pH 5.9；292 K；20% PEG 8000, 20mM ammonium sulfate, pH 5.9, hanging drop, temperature 292K
|
Resolution 2.90 Å R-free 0.313 |
| 5AIR Structural analysis of mouse GSK3beta fused with LRP6 peptide. Deposited 2015-02-17 | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1565–1575（11 aa）
Fragment：;RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420
;
Chain B
1565–1575（11 aa）
Fragment：;RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420,RESIDUES 1565-1574, KINASE DOMAIN, RESIDUES 6-420
;
|
Not recorded | MLI MALONATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；290 K；200 MM SODIUM MALONATE, 20 % (V/V) PEG 3350, pH 7
|
Resolution 2.53 Å R-free 0.260 |
| 5FWW Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4) Deposited 2016-02-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
630–1246（617 aa）
Fragment：PE3PE4, RESIDUES 630-1246
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.5；20 %W/V PEG3350 0.2 M NA/K-PHOSPHATE, pH 7.5
|
Resolution 3.50 Å R-free 0.355 |
| 5GJE Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1 Deposited 2016-06-29 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–630（611 aa）
Fragment：UNP residues 20-630
Chain B
631–1246（616 aa）
Fragment：UNP residues 631-1246
|
Mutation：V1062I | PO4 PHOSPHATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 GOL GLYCEROL × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.2
|
Resolution 21.00 Å |
| 6H15 Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-B10 Deposited 2018-07-11 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
630–1244（615 aa）
Chain B
630–1244（615 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 CL CHLORIDE ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；0.1 M sodium citrate, 0.2 M sodium acetate trihydrate pH 5.5, 10 % PEG w/v 4000
|
Resolution 2.60 Å R-free 0.247 |
| 6H16 Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07 Deposited 2018-07-11 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
630–1244（615 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291.15 K；0.1 M MES pH 5.0, 10 % w/v PEG 6000
|
Resolution 2.90 Å R-free 0.252 |
| 6L6R Crystal structure of LRP6 E1E2-SOST complex Deposited 2019-10-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
21–630（610 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 MG MAGNESIUM ION × 2 ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；301 K；PEG 8000, magnesium acetate, sodium citrate, HEPES
|
Resolution 3.80 Å R-free 0.256 |
| 6L6R Crystal structure of LRP6 E1E2-SOST complex Deposited 2019-10-29 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
21–630（610 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 MG MAGNESIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；301 K；PEG 8000, magnesium acetate, sodium citrate, HEPES
|
Resolution 3.80 Å R-free 0.256 |
| 7NAM LRP6_E1 in complex with Lr-EET-3.5 Deposited 2021-06-21 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
20–326（307 aa）
|
Not recorded | NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；20% w/v PEG 3350, 0.2 M Na malate, pH 7.0
|
Resolution 1.60 Å R-free 0.193 |
| 8CTG Extracellular architecture of an engineered canonical Wnt signaling ternary complex Deposited 2022-05-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
20–629（610 aa）
|
Not recorded | PAM PALMITOLEIC ACID × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE；3 s blotting before plunging
|
Resolution 3.80 Å |
| 8DVL Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18 Deposited 2022-07-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
631–1253（623 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 3 EDO 1,2-ETHANEDIOL × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.3；293 K；0.1 M Bis-Tris 6.3, 18% PEG 10K
|
Resolution 2.50 Å R-free 0.245 |
| 8DVM Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6 Deposited 2022-07-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
631–1253（623 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CA CALCIUM ION × 3 EDO 1,2-ETHANEDIOL × 14 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.3；293 K；100 mM MES pH 6.3, 12% PEG 20K
|
Resolution 2.00 Å R-free 0.221 |
| 8DVN Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.10 Deposited 2022-07-29 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
631–1253（623 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CA CALCIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；20% PEG3350, 0.2 M KSCN
|
Resolution 2.53 Å R-free 0.246 |
| 8FFE Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide Deposited 2022-12-08 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
20–631（612 aa）
|
Not recorded | GOL GLYCEROL × 7 NA SODIUM ION × 3 SIN SUCCINIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；100 mM SPG (succinate/phosphate/glycine buffer), 25% PEG 1500
|
Resolution 1.72 Å R-free 0.231 |
| 8S7C Ternary Complex of Cachd1, FZD5 and LRP6 Deposited 2024-02-29 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
629–1244（616 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4.5；296 K；0.1 M Calcium Acetate
0.1 M Sodium Acetate
10% PEG 4000
pH 4.5
|
Resolution 4.70 Å R-free 0.261 |
| 8S7C Ternary Complex of Cachd1, FZD5 and LRP6 Deposited 2024-02-29 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain F
629–1244（616 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 11 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4.5；296 K；0.1 M Calcium Acetate
0.1 M Sodium Acetate
10% PEG 4000
pH 4.5
|
Resolution 4.70 Å R-free 0.261 |
| 8S7C Ternary Complex of Cachd1, FZD5 and LRP6 Deposited 2024-02-29 | Assembly 3 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain I
629–1244（616 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4.5；296 K；0.1 M Calcium Acetate
0.1 M Sodium Acetate
10% PEG 4000
pH 4.5
|
Resolution 4.70 Å R-free 0.261 |
| 9FIW MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH LRP6 INTERNALIZATION PEPTIDE SYRHFA Deposited 2024-05-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1516–1521（6 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2.0-2.2 M NaCl
0.4M Na/K phosphate
0.1M MES PH 7.1
15-20% glycerol
|
Resolution 2.82 Å R-free 0.246 |
| 9FIX MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH LRP6 INTERNALIZATION PEPTIDE SYRPYSYRHFA Deposited 2024-05-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1516–1526（11 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2.0-2.2 M NaCl
0.4M Na/K phosphate
0.1M MES PH 7.1
15-20% glycerol
|
Resolution 2.78 Å R-free 0.233 |
| 9FIY MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH LRP6 INTERNALIZATION PEPTIDE SYRHFA Deposited 2024-05-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1521–1526（6 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2.0-2.2 M NaCl
0.4M Na/K phosphate
0.1M MES PH 7.1
15-20% glycerol
|
Resolution 2.88 Å R-free 0.242 |