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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P01556 New Search
27PDB entries
36Biological assembly
180chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1CHP SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS Deposited 1995-02-15 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Mutation：G33D Mutation：G33D Mutation：G33D Mutation：G33D Mutation：G33D CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；pH 7.5
Resolution 2.00 Å
1CHQ SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS Deposited 1995-02-15 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 29–131（103 aa）
Chain E 29–131（103 aa）
Chain F 29–131（103 aa）
Chain G 29–131（103 aa）
Chain H 29–131（103 aa）
Mutation：R35D Mutation：R35D Mutation：R35D Mutation：R35D Mutation：R35D No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.4；pH 6.4
Resolution 2.10 Å
1CT1 CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE Deposited 1997-06-03 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa） Fragment：B-PENTAMER
Chain E 22–124（103 aa） Fragment：B-PENTAMER
Chain F 22–124（103 aa） Fragment：B-PENTAMER
Chain G 22–124（103 aa） Fragment：B-PENTAMER
Chain H 22–124（103 aa） Fragment：B-PENTAMER
Mutation：G33R Mutation：G33R Mutation：G33R Mutation：G33R Mutation：G33R CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions PROTEIN, 20 MM TRIS, 1 MM GM1-OS, PH 7.5 200 MM MGCL2, 100 MM CACODYLATE, 19% PEG 1000, 0.2% AGAROSE, PH 7.2
Resolution 2.30 Å R-free 0.250
1FGB TOXIN Deposited 1996-02-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.40 Å
1G8Z HIS57ALA MUTANT OF CHOLERA TOXIN B-PENATMER Deposited 2000-11-21 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Mutation：H57A Mutation：H57A Mutation：H57A Mutation：H57A Mutation：H57A GAL beta-D-galactopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；298 K；PEG 5000, NaCl, Tris HCl, galactose, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.239
1JR0 CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0011 Deposited 2001-08-09 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded A24 (3-NITRO-5-(2-MORPHOLIN-4-YL-ETHYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；PEG 3000, NaCl, MgCl2, Tris HCl, pH 7.5, VAPOR DIFFUSION, SITTING DROP
Resolution 1.30 Å R-free 0.183
1JR0 CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0011 Deposited 2001-08-09 Assembly 2 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded A24 (3-NITRO-5-(2-MORPHOLIN-4-YL-ETHYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；PEG 3000, NaCl, MgCl2, Tris HCl, pH 7.5, VAPOR DIFFUSION, SITTING DROP
Resolution 1.30 Å R-free 0.183
1RCV Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1 Deposited 2003-11-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded BV1 [3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO] -2-(3-{4-[3-(3-NITRO-5-[GALACTOPYRANOSYLOXY]-BENZOYLAMINO)-PROPYL]-PIPERAZIN-1-YL} -PROPYL-AMINO)-3,4-DIOXO-CYCLOBUTENE × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；30% PEG 300, 50 mM NaCl, 100 mM Tris-HCl, and 2.3mM BV1, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
Resolution 1.60 Å R-free 0.193
1RD9 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2 Deposited 2003-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded BV2 1,3-BIS-([3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYL-AMINO]-CARBONYLOXY)-2-AMINO-PROPANE × 5 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 P6G HEXAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；38% PEG 300, 50 mM NaCl, 100 mM Tris-HCl, and 2.3mM BV2, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.44 Å R-free 0.184
1RDP Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV3 Deposited 2003-11-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded BV3 1,3-BIS-([[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBU TENYL]-AMINO-ETHYL]-AMINO-CARBONYLOXY)-2-AMINO-PROPANE × 5 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；12% PEG 8000, 50 mM NaCl, 100 mM Tris-HCl, 20mM MgCl2, and 2.3mM BV3, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
Resolution 1.35 Å R-free 0.171
1RF2 Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV4 Deposited 2003-11-07 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded BV4 1,3-BIS-([3-[3-[3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO-3,4-DIOXO-CYCLOBUTENYL]-AMINO-PROPOXY-ETHOXY-ETHOXY]-PROPYL-]AMINO-CARBONYLOXY)-2-AMINO-PROPANE × 5 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 PGE TRIETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；16% PEG 8000, 50 mM NaCl, 100 mM Tris-HCl, 20mM MgCl2, and 2.3mM BV4, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
Resolution 1.35 Å R-free 0.174
1S5B Cholera holotoxin with an A-subunit Y30S mutation Form 3 Deposited 2004-01-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；PEG 2000mme, MES, kemptide, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.13 Å R-free 0.224
1S5C Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1 Deposited 2004-01-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；PEG 2000mme, MES, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.50 Å R-free 0.262
1S5D Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 2 Deposited 2004-01-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GOL GLYCEROL × 5 GAL beta-D-galactopyranose × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, sodium citrate, galactose, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.75 Å R-free 0.191
1S5E Cholera holotoxin, Crystal form 1 Deposited 2004-01-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, magnesium acetate, galactose, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.90 Å R-free 0.205
1S5E Cholera holotoxin, Crystal form 1 Deposited 2004-01-20 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain J 22–124（103 aa）
Chain K 22–124（103 aa）
Chain L 22–124（103 aa）
Chain M 22–124（103 aa）
Chain N 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, magnesium acetate, galactose, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.90 Å R-free 0.205
1S5F Cholera holotoxin, Crystal form 2 Deposited 2004-01-20 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, lithium citrate, galactose, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.60 Å R-free 0.260
1S5F Cholera holotoxin, Crystal form 2 Deposited 2004-01-20 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298 K；PEG 3350, lithium citrate, galactose, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.60 Å R-free 0.260
1XTC CHOLERA TOXIN Deposited 1996-01-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.40 Å
2CHB CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE Deposited 1997-06-03 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa） Fragment：B-PENTAMER
Chain E 22–124（103 aa） Fragment：B-PENTAMER
Chain F 22–124（103 aa） Fragment：B-PENTAMER
Chain G 22–124（103 aa） Fragment：B-PENTAMER
Chain H 22–124（103 aa） Fragment：B-PENTAMER
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；200 MM MGCL2 100 MM CACODYLATE 5% PEG 1000 PH 7.5
Resolution 2.00 Å
3CHB CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE Deposited 1998-03-24 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 1–124（124 aa） Fragment：B-PENTAMER
Chain E 1–124（124 aa） Fragment：B-PENTAMER
Chain F 1–124（124 aa） Fragment：B-PENTAMER
Chain G 1–124（124 aa） Fragment：B-PENTAMER
Chain H 1–124（124 aa） Fragment：B-PENTAMER
Mutation：H94R Mutation：H94R Mutation：H94R Mutation：H94R Mutation：H94R UNX UNKNOWN LIGAND × 5 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；SITTING DROP, pH 7.0, vapor diffusion - sitting drop
Resolution 1.25 Å R-free 0.180
5ELC Cholera toxin El Tor B-pentamer in complex with Lewis-y Deposited 2015-11-04 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Not recorded CA CALCIUM ION × 10 BCN BICINE × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 12.5% PEG1000, 12.5% PEG3350, 12.5% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride
Resolution 1.50 Å R-free 0.260
5ELC Cholera toxin El Tor B-pentamer in complex with Lewis-y Deposited 2015-11-04 Assembly 2 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Not recorded FUC alpha-L-fucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 12.5% PEG1000, 12.5% PEG3350, 12.5% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride
Resolution 1.50 Å R-free 0.260
5ELE Cholera toxin El Tor B-pentamer in complex with A Lewis-y Deposited 2015-11-04 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Not recorded CA CALCIUM ION × 10 FUC alpha-L-fucopyranose × 1 BCN BICINE × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 9% PEG1000, 9% PEG3350, 9% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride
Resolution 1.60 Å R-free 0.226
5ELE Cholera toxin El Tor B-pentamer in complex with A Lewis-y Deposited 2015-11-04 Assembly 2 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Not recorded FUC alpha-L-fucopyranose × 3 1PE PENTAETHYLENE GLYCOL × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 9% PEG1000, 9% PEG3350, 9% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride
Resolution 1.60 Å R-free 0.226
5ELF Cholera toxin El Tor B-pentamer in complex with A-pentasaccharide Deposited 2015-11-04 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Not recorded CA CALCIUM ION × 10 BCN BICINE × 10 FUC alpha-L-fucopyranose × 1 GLC alpha-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 9% PEG1000, 9% PEG3350, 9% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride. Microseeding.
Resolution 1.55 Å R-free 0.220
5ELF Cholera toxin El Tor B-pentamer in complex with A-pentasaccharide Deposited 2015-11-04 Assembly 2 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Not recorded FUC alpha-L-fucopyranose × 1 GLC alpha-D-glucopyranose × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Bicine-Tris, 9% PEG1000, 9% PEG3350, 9% MPD, 0.03 M calcium chloride, 0.03 M magnesium chloride. Microseeding.
Resolution 1.55 Å R-free 0.220
5LZG Cholera toxin El Tor B-pentamer in complex with inhibitor PC262 Deposited 2016-09-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Not recorded 7BN (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid × 5 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 IMD IMIDAZOLE × 2 PEG DI(HYDROXYETHYL)ETHER × 1 MRD (4R)-2-METHYLPENTANE-2,4-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MES/Imidazole buffer, pH 6.5, 10% PEG 1000, 10 % PEG 3350, 10 % MPD, 0.03 M divalent cations
Resolution 1.13 Å R-free 0.198
5LZJ Cholera toxin El Tor B-pentamer in complex with inhibitor Laura237 Deposited 2016-09-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Not recorded SO4 SULFATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2 PGE TRIETHYLENE GLYCOL × 2 7BT (~{Z})-~{N}-[2-[(2~{R},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1M MES pH 6, 30% PEG 400, 3% PGA-LM
Resolution 1.20 Å R-free 0.228
8OXS Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions) Deposited 2023-05-02 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 6 GLA alpha-D-galactopyranose × 4 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；Crystallization mix: 20% w/v PEG 6K 0.1 M HEPES pH 7.0 0.2 M NH4Cl Protein storage buffer: 0.05 M Tris/HCl pH 7.5 0.2 M NaCl 0.05 M D-(+)-galactose
Resolution 1.60 Å R-free 0.224
8OXS Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions) Deposited 2023-05-02 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Chain K 22–124（103 aa）
Chain L 22–124（103 aa）
Not recorded NA SODIUM ION × 1 GAL beta-D-galactopyranose × 4 GLA alpha-D-galactopyranose × 3 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293.15 K；Crystallization mix: 20% w/v PEG 6K 0.1 M HEPES pH 7.0 0.2 M NH4Cl Protein storage buffer: 0.05 M Tris/HCl pH 7.5 0.2 M NaCl 0.05 M D-(+)-galactose
Resolution 1.60 Å R-free 0.224
8Q6I Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 1 C-terminal substitution) Deposited 2023-08-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 2 GOL GLYCEROL × 11 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；293.15 K；Crystallization mix: 20% PEG6000 0.2 M lithium chloride 0.1 M Tris pH 8.0 Protein storage buffer: 0.05 M Tris/HCl pH 7.5 0.2 M NaCl
Resolution 1.60 Å R-free 0.222
8QRE Cholera holotoxin (wildtype) Deposited 2023-10-06 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded NA SODIUM ION × 2 GAL beta-D-galactopyranose × 6 GOL GLYCEROL × 7 ACT ACETATE ION × 2 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；293.15 K；Crystallization mix: 0.125 M Magnesium acetate 24% PEG 3350 300 mM galactose (in protein storage buffer) Protein storage buffer: 50 mM Tris pH 7.4 200 mM NaCl 1 mM EDTA 3 mM sodium azide
Resolution 2.30 Å R-free 0.263
8QRE Cholera holotoxin (wildtype) Deposited 2023-10-06 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain C 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Chain K 22–124（103 aa）
Chain L 22–124（103 aa）
Not recorded NA SODIUM ION × 2 GAL beta-D-galactopyranose × 4 GOL GLYCEROL × 7 ACT ACETATE ION × 1 GLA alpha-D-galactopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.4；293.15 K；Crystallization mix: 0.125 M Magnesium acetate 24% PEG 3350 300 mM galactose (in protein storage buffer) Protein storage buffer: 50 mM Tris pH 7.4 200 mM NaCl 1 mM EDTA 3 mM sodium azide
Resolution 2.30 Å R-free 0.263
9EWF Cholera toxin B subunit in complex with fluorinated GM1 Deposited 2024-04-03 Assembly 1 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 22–124（103 aa）
Chain B 22–124（103 aa）
Chain C 22–124（103 aa）
Chain I 22–124（103 aa）
Chain J 22–124（103 aa）
Not recorded A1H7V (2R,3S,4S,5R,6R)-6-dodecoxy-5-fluoranyl-2-(hydroxymethyl)oxane-3,4-diol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1M MES/Imidazole pH 7.5, 0.03M MgCl2, 0.03M CaCl2, 16% PEG1000, 12% PEG3350 and 10% MPD
Resolution 2.10 Å R-free 0.221
9EWF Cholera toxin B subunit in complex with fluorinated GM1 Deposited 2024-04-03 Assembly 2 Other combination Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain D 22–124（103 aa）
Chain E 22–124（103 aa）
Chain F 22–124（103 aa）
Chain G 22–124（103 aa）
Chain H 22–124（103 aa）
Not recorded A1H7V (2R,3S,4S,5R,6R)-6-dodecoxy-5-fluoranyl-2-(hydroxymethyl)oxane-3,4-diol × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1M MES/Imidazole pH 7.5, 0.03M MgCl2, 0.03M CaCl2, 16% PEG1000, 12% PEG3350 and 10% MPD
Resolution 2.10 Å R-free 0.221

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.